EphB2/R-Ras Signaling Regulates Glioma Cell Adhesion, Growth, and Invasion

Lemke, 1997, A coherent nomenclature for Eph receptors and their ligands, Mol Cell Neurosci, 9, 331, 10.1006/mcne.1997.0630

Kullander, 2002, Mechanisms and functions of Eph and ephrin signalling, Nat Rev Mol Cell Biol, 3, 475, 10.1038/nrm856

Wilkinson, 2001, Multiple roles of EPH receptors and ephrins in neural development, Nat Rev Neurosci, 2, 155, 10.1038/35058515

Mellitzer, 2000, Control of cell behaviour by signalling through Eph receptors and ephrins, Curr Opin Neurobiol, 10, 400, 10.1016/S0959-4388(00)00095-7

Dodelet, 2000, Eph receptors and ephrin ligands: embryogenesis to tumorigenesis, Oncogene, 19, 5614, 10.1038/sj.onc.1203856

Klein, 2001, Excitatory Eph receptors and adhesive ephrin ligands, Curr Opin Cell Biol, 13, 196, 10.1016/S0955-0674(00)00197-6

Holland, 1996, Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands, Nature, 383, 722, 10.1038/383722a0

Marston, 2003, Rac-dependent trans-endocytosis of ephrinBs regulates Eph-ephrin contact repulsion, Nat Cell Biol, 5, 879, 10.1038/ncb1044

Zimmer, 2003, EphB-ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion, Nat Cell Biol, 5, 869, 10.1038/ncb1045

Self, 2001, Analysis of R-Ras signalling pathways, J Cell Sci, 114, 1357, 10.1242/jcs.114.7.1357

Lowe, 1987, Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes, Cell, 48, 137, 10.1016/0092-8674(87)90364-3

Guha, 1997, Proliferation of human malignant astrocytomas is dependent on Ras activation, Oncogene, 15, 2755, 10.1038/sj.onc.1201455

Nakada, 2004, The phosphorylation of EphB2 receptor regulates migration and invasion of human glioma cells, Cancer Res, 64, 3179, 10.1158/0008-5472.CAN-03-3667

Kiyokawa, 1994, Overexpression of ERK, an EPH family receptor protein tyrosine kinase, in various human tumors, Cancer Res, 54, 3645

Tang, 1999, Coexpression of transcripts encoding EPHB receptor protein tyrosine kinases and their ephrin-B ligands in human small cell lung carcinoma, Clin Cancer Res, 5, 455

Wu, 2004, Expression of Ephb2 and Ephb4 in breast carcinoma, Pathol Oncol Res, 10, 26, 10.1007/BF02893405

Mao, 2004, EphB2 as a therapeutic antibody drug target for the treatment of colorectal cancer, Cancer Res, 64, 781, 10.1158/0008-5472.CAN-03-1047

Tang, 2001, Association among EPHB2, TrkA, and MYCN expression in low-stage neuroblastomas, Med Pediatr Oncol, 36, 80, 10.1002/1096-911X(20010101)36:1<80::AID-MPO1019>3.0.CO;2-N

Vogt, 1998, Overexpression of Lerk-5/Eplg5 messenger RNA: a novel marker for increased tumorigenicity and metastatic potential in human malignant melanomas, Clin Cancer Res, 4, 791

Giese, 1994, Determinants of human astrocytoma migration, Cancer Res, 54, 3897

Dudley, 1995, A synthetic inhibitor of the mitogen-activated protein kinase cascade, Proc Natl Acad Sci USA, 92, 7686, 10.1073/pnas.92.17.7686

Zisch, 1998, Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region, Oncogene, 16, 2657, 10.1038/sj.onc.1201823

Nakada, 1999, Ets-1 positively regulates expression of urokinase-type plasminogen activator (uPA) and invasiveness of astrocytic tumors, J Neuropathol Exp Neurol, 58, 329, 10.1097/00005072-199904000-00003

Tran, 2003, The human Fn14 receptor gene is up-regulated in migrating glioma cells in vitro and overexpressed in advanced glial tumors, Am J Pathol, 162, 1313, 10.1016/S0002-9440(10)63927-2

Kita, 2001, Expression of dominant-negative form of Ets-1 suppresses fibronectin-stimulated cell adhesion and migration through down-regulation of integrin alpha5 expression in U251 glioma cell line, Cancer Res, 61, 7985

Mariani, 2001, Death-associated protein 3 (Dap-3) is overexpressed in invasive glioblastoma cells in vivo and in glioma cell lines with induced motility phenotype in vitro, Clin Cancer Res, 7, 2480

Cavenee, 2000, Diffusely infiltrating astrocytomas. Tumours of the Nervous System, 10

Mariani, 2001, Identification and validation of P311 as a glioblastoma invasion gene using laser capture microdissection, Cancer Res, 61, 4190

Zou, 1999, An Eph receptor regulates integrin activity through R-Ras, Proc Natl Acad Sci USA, 96, 13813, 10.1073/pnas.96.24.13813

Ruoslahti, 1999, Fibronectin and its integrin receptors in cancer, Adv Cancer Res, 76, 1, 10.1016/S0065-230X(08)60772-1

Zou, 2002, Activated SRC oncogene phosphorylates R-ras and suppresses integrin activity, J Biol Chem, 277, 1824, 10.1074/jbc.M103133200

Zhang, 1996, Integrin activation by R-ras, Cell, 85, 61, 10.1016/S0092-8674(00)81082-X

Furuhjelm, 2003, The C-terminal end of R-Ras contains a focal adhesion targeting signal, J Cell Sci, 116, 3729, 10.1242/jcs.00689

Kwong, 2003, R-Ras promotes focal adhesion formation through focal adhesion kinase and p130(Cas) by a novel mechanism that differs from integrins, Mol Cell Biol, 23, 933, 10.1128/MCB.23.3.933-949.2003

Kapoor, 2003, Mitogenic signaling cascades in glial tumors, Neurosurgery, 52, 1425, 10.1227/01.NEU.0000065135.28143.39

Elowe, 2001, Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction, Mol Cell Biol, 21, 7429, 10.1128/MCB.21.21.7429-7441.2001

Rincon-Arano, 2003, R-Ras promotes tumor growth of cervical epithelial cells, Cancer, 97, 575, 10.1002/cncr.11093

Marte, 1997, R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways, Curr Biol, 7, 63, 10.1016/S0960-9822(06)00028-5

Giese, 2003, Cost of migration: invasion of malignant gliomas and implications for treatment, J Clin Oncol, 21, 1624, 10.1200/JCO.2003.05.063

Keely, 1999, R-Ras signals through specific integrin alpha cytoplasmic domains to promote migration and invasion of breast epithelial cells, J Cell Biol, 145, 1077, 10.1083/jcb.145.5.1077

Joy, 2003, Migrating glioma cells activate the PI3-K pathway and display decreased susceptibility to apoptosis, J Cell Sci, 116, 4409, 10.1242/jcs.00712