Epac activator critically regulates action potential duration by decreasing potassium current in rat adult ventricle

Bers, 2002, Cardiac excitation–contraction coupling, Nature, 415, 198, 10.1038/415198a Bers, 2001 de Rooij, 1998, Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP, Nature, 396, 474, 10.1038/24884 Kawasaki, 1998, A family of cAMP-binding proteins that directly activate Rap1, Science, 282, 2275, 10.1126/science.282.5397.2275 Metrich, 2008, Epac mediates beta-adrenergic receptor-induced cardiomyocyte hypertrophy, Circ Res, 102, 959, 10.1161/CIRCRESAHA.107.164947 Oestreich, 2007, Epac-mediated activation of phospholipase C(epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes, J Biol Chem, 282, 5488, 10.1074/jbc.M608495200 Oestreich, 2009, Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II, J Biol Chem, 284, 1514, 10.1074/jbc.M806994200 Pereira, 2007, The cAMP binding protein Epac modulates Ca2+ sparks by a Ca2+/calmodulin kinase signalling pathway in rat cardiac myocytes, J Physiol, 583, 685, 10.1113/jphysiol.2007.133066 Pereira, 2012, Epac enhances excitation-transcription coupling in cardiac myocytes, J Mol Cell Cardiol, 52, 283, 10.1016/j.yjmcc.2011.10.016 Bers, 2007, Going to cAMP just got more complicated, J Physiol, 583, 415, 10.1113/jphysiol.2007.140764 Cazorla, 2009, The cAMP binding protein Epac regulates cardiac myofilament function, Proc Natl Acad Sci U S A, 106, 14144, 10.1073/pnas.0812536106 Morel, 2005, cAMP-binding protein Epac induces cardiomyocyte hypertrophy, Circ Res, 97, 1296, 10.1161/01.RES.0000194325.31359.86 Helms, 2006, Dopamine regulation of amiloride-sensitive sodium channels in lung cells, Am J Physiol Lung Cell Mol Physiol, 290, L710, 10.1152/ajplung.00486.2004 Novara, 2004, Exposure to cAMP and beta-adrenergic stimulation recruits Ca(V)3 T-type channels in rat chromaffin cells through Epac cAMP-receptor proteins, J Physiol, 558, 433, 10.1113/jphysiol.2004.061184 Kang, 2006, cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells, J Physiol, 573, 595, 10.1113/jphysiol.2006.107391 Purves, 2009, Exchange protein activated by cAMP (Epac) mediates cAMP-dependent but protein kinase A-insensitive modulation of vascular ATP-sensitive potassium channels, J Physiol, 587, 3639, 10.1113/jphysiol.2009.173534 Ster, 2007, Exchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca2+-dependent K+ channels in cerebellar neurons, Proc Natl Acad Sci U S A, 104, 2519, 10.1073/pnas.0611031104 Aromataris, 2006, Glucagon activates Ca2+ and Cl- channels in rat hepatocytes, J Physiol, 573, 611, 10.1113/jphysiol.2006.109819 Hamill, 1981, Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches, Pflugers Arch, 391, 85, 10.1007/BF00656997 Brette, 2006, Ca2+ currents in cardiac myocytes: old story, new insights, Prog Biophys Mol Biol, 91, 1, 10.1016/j.pbiomolbio.2005.01.001 Himmel, 1999, Four different components contribute to outward current in rat ventricular myocytes, Am J Physiol, 277, H107 Komukai, 2002, K(+) current distribution in rat sub-epicardial ventricular myocytes, Pflugers Arch, 444, 532, 10.1007/s00424-002-0851-8 Brette, 2004, Differential modulation of L-type Ca2+ current by SR Ca2+ release at the T-tubules and surface membrane of rat ventricular myocytes, Circ Res, 95, e1, 10.1161/01.RES.0000135547.53927.F6 Salle, 2008, Mechanisms underlying adaptation of action potential duration by pacing rate in rat myocytes, Prog Biophys Mol Biol, 96, 305, 10.1016/j.pbiomolbio.2007.07.008 Nerbonne, 2000, Molecular basis of functional voltage-gated K+ channel diversity in the mammalian myocardium, J Physiol, 525, 285, 10.1111/j.1469-7793.2000.t01-1-00285.x Enserink, 2002, A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK, Nat Cell Biol, 4, 901, 10.1038/ncb874 Chepurny, 2009, Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2′-O-Me-cAMP-AM, J Biol Chem, 284, 10728, 10.1074/jbc.M900166200 Vliem, 2008, 8-pCPT-2′-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue, Chembiochem, 9, 2052, 10.1002/cbic.200800216 Tsalkova, 2012, Isoform-specific antagonists of exchange proteins directly activated by cAMP, Proc Natl Acad Sci U S A, 109, 18613, 10.1073/pnas.1210209109 Ruiz-Hurtado, 2012, Sustained Epac activation induces calmodulin dependent positive inotropic effect in adult cardiomyocytes, J Mol Cell Cardiol, 53, 617, 10.1016/j.yjmcc.2012.08.004 Calaghan, 2012, Local signalling in myocytes, J Mol Cell Cardiol, 52, 295, 10.1016/j.yjmcc.2011.10.019 Fischmeister, 2006, Compartmentation of cyclic nucleotide signaling in the heart: the role of cyclic nucleotide phosphodiesterases, Circ Res, 99, 816, 10.1161/01.RES.0000246118.98832.04 Laxman, 2006, Hydrolysis products of cAMP analogs cause transformation of Trypanosoma brucei from slender to stumpy-like forms, Proc Natl Acad Sci U S A, 103, 19194, 10.1073/pnas.0608971103 Poppe, 2008, Cyclic nucleotide analogs as probes of signaling pathways, Nat Methods, 5, 277, 10.1038/nmeth0408-277 Kane, 2005, Cardiac KATP channels in health and disease, J Mol Cell Cardiol, 38, 937, 10.1016/j.yjmcc.2005.02.026 Hume, 2000, Anion transport in heart, Physiol Rev, 80, 31, 10.1152/physrev.2000.80.1.31 Findlay, 1992, Inhibition of ATP-sensitive K+ channels in cardiac muscle by the sulphonylurea drug glibenclamide, J Pharmacol Exp Ther, 261, 540 Niwa, 2010, Molecular determinants of cardiac transient outward potassium current (I(to)) expression and regulation, J Mol Cell Cardiol, 48, 12, 10.1016/j.yjmcc.2009.07.013 Colinas, 2006, Differential modulation of Kv4.2 and Kv4.3 channels by calmodulin-dependent protein kinase II in rat cardiac myocytes, Am J Physiol Heart Circ Physiol, 291, H1978, 10.1152/ajpheart.01373.2005 Tessier, 1999, Regulation of the transient outward K(+) current by Ca(2+)/calmodulin-dependent protein kinases II in human atrial myocytes, Circ Res, 85, 810, 10.1161/01.RES.85.9.810 Bogdanov, 1998, Modulation of the transient outward current in adult rat ventricular myocytes by polyunsaturated fatty acids, Am J Physiol, 274, H571 Christ, 2001, Autoantibodies against the beta1 adrenoceptor from patients with dilated cardiomyopathy prolong action potential duration and enhance contractility in isolated cardiomyocytes, J Mol Cell Cardiol, 33, 1515, 10.1006/jmcc.2001.1414 Scamps, 1996, Characterization of a beta-adrenergically inhibited K+ current in rat cardiac ventricular cells, J Physiol, 491, 81, 10.1113/jphysiol.1996.sp021198 Ulucan, 2007, Developmental changes in gene expression of Epac and its upregulation in myocardial hypertrophy, Am J Physiol Heart Circ Physiol, 293, H1662, 10.1152/ajpheart.00159.2007 Beuckelmann, 1992, Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure, Circulation, 85, 1046, 10.1161/01.CIR.85.3.1046 Nabauer, 1998, Potassium channel down-regulation in heart failure, Cardiovasc Res, 37, 324, 10.1016/S0008-6363(97)00274-5 Hondeghem, 2001, Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic, Circulation, 103, 2004, 10.1161/01.CIR.103.15.2004 Hothi, 2008, Epac activation, altered calcium homeostasis and ventricular arrhythmogenesis in the murine heart, Pflugers Arch, 457, 253, 10.1007/s00424-008-0508-3 Nerbonne, 2005, Molecular physiology of cardiac repolarization, Physiol Rev, 85, 1205, 10.1152/physrev.00002.2005 Apkon, 1991, Characterization of two distinct depolarization-activated K+ currents in isolated adult rat ventricular myocytes, J Gen Physiol, 97, 973, 10.1085/jgp.97.5.973 Casis, 1998, Differences in regional distribution of K+ current densities in rat ventricle, Life Sci, 63, 391, 10.1016/S0024-3205(98)00287-2 Komukai, 2002, Electrophysiological response of rat ventricular myocytes to acidosis, Am J Physiol Heart Circ Physiol, 283, H412, 10.1152/ajpheart.01042.2001 Komukai, 2002, Electrophysiological response of rat atrial myocytes to acidosis, Am J Physiol Heart Circ Physiol, 283, H715, 10.1152/ajpheart.01000.2001 Mitchell, 1984, Strontium, nifedipine and 4-aminopyridine modify the time course of the action potential in cells from rat ventricular muscle, Br J Pharmacol, 81, 551, 10.1111/j.1476-5381.1984.tb10108.x Gomez, 1997, Modulation of electrical heterogeneity by compensated hypertrophy in rat left ventricle, Am J Physiol, 272, H1078 Dilly, 2006, Mechanisms underlying variations in excitation–contraction coupling across the mouse left ventricular free wall, J Physiol, 572, 227, 10.1113/jphysiol.2005.102020 Brette, 2006, Quantification of calcium entry at the T-tubules and surface membrane in rat ventricular myocytes, Biophys J, 90, 381, 10.1529/biophysj.105.069013