Environmental heavy metals and cardiovascular diseases: Status and future direction

Chronic Diseases and Translational Medicine - Tập 6 - Trang 251-259 - 2020
Ai-Min Yang1,2,3, Kenneth Lo2,3, Tong-Zhang Zheng3, Jing-Li Yang4, Ya-Na Bai4, Ying-Qing Feng5, Ning Cheng4, Si-Min Liu1,2
1Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, China
2Centre for Global Cardiometabolic Health, Department of Epidemiology, Surgery, and Medicine, Brown University, Providence, RI 02903, USA
3Department of Epidemiology, School of Public Health, Brown University, Providence, RI 02903, USA
4Department of Epidemiology, School of Public Health, Lanzhou University, Lanzhou, Gansu 730000, China
5Department of Cardiology and Endocrinology, Guangdong Provincial People's Hospital, Guandong Academy of Medical Sciences, Guangzhou, Guangdong 510080, China

Tóm tắt

AbstractCardiovascular disease (CVD) and environmental degradation are leading global health problems of our time. Recent studies have linked exposure to heavy metals to the risks of CVD and diabetes, particularly in populations from low‐ and middle‐income countries, where concomitant rapid development occurs. In this review, we 1) assessed the totality, quantity, and consistency of the available epidemiological studies, linking heavy metal exposures to the risk of CVD (including stroke and coronary heart disease); 2) discussed the potential biological mechanisms underlying some tantalizing observations in humans; and 3) identified gaps in our knowledge base that must be investigated in future work. An accumulating body of evidence from both experimental and observational studies implicates exposure to heavy metals, in a dose‐response manner, in the increased risk of CVD. The limitations of most existing studies include insufficient statistical power, lack of comprehensive assessment of exposure, and cross‐sectional design. Given the widespread exposure to heavy metals, an urgent need has emerged to investigate these putative associations of environmental exposures, either independently or jointly, with incident CVD outcomes prospectively in well‐characterized cohorts of diverse populations, and to determine potential strategies to prevent and control the impacts of heavy metal exposure on the cardiometabolic health outcomes of individuals and populations.

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Chronic Diseases and Translational Medicine

Tập 6

251-259

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