Enteroendocrine cells: a site of ‘taste’ in gastrointestinal chemosensing

Current Opinion in Endocrinology, Diabetes and Obesity - Tập 15 Số 1 - Trang 73-78 - 2008
Catia Sternini1,2,3,4,5, Laura Anselmi1, Enrique Rozengurt1
1Division of Digestive Diseases and CURE: Digestive Diseases Research Center, and Departments of Medicine, USA
2Neurobiology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA
3e-mail: [email protected]
4fax: +1 310 268 4615
5to Catia Sternini, CURE Bldg 115, Room 224, VAGLAHS, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA Tel: +1 310 312 9477

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Tài liệu tham khảo

Buchan, 1999, Nutrient tasting and signaling mechanisms in the gut. III. Endocrine cell recognition of luminal nutrients, Am J Physiol, 277, G1103

Dockray, 2003, Luminal sensing in the gut: an overview, J Physiol Pharmacol, 54, 9

Hofer, 1999, Chemosensory perception in the gut, News Physiol Sci, 14, 18

Furness, 1999, Nutrient tasting and signaling mechanisms in the gut. II. The intestine as a sensory organ: neural, endocrine, and immune responses, Am J Physiol, 277, G922

Rehfeld, 1998, The new biology of gastrointestinal hormones, Physiol Rev, 78, 1087, 10.1152/physrev.1998.78.4.1087

Dockray, 1996, Gastric endocrine cells: gene expression, processing, and targeting of active products, Physiol Rev, 76, 767, 10.1152/physrev.1996.76.3.767

Dockray, 2004, Gut endocrine secretions and their relevance to satiety, Curr Opin Pharmacol, 4, 557, 10.1016/j.coph.2004.05.005

Strader, 2005, Gastrointestinal hormones and food intake, Gastroenterology, 128, 175, 10.1053/j.gastro.2004.10.043

Rozengurt, 2001, Gastrin, CCK, signaling, and cancer, Annu Rev Physiol, 63, 49, 10.1146/annurev.physiol.63.1.49

Havel, 2001, Peripheral signals conveying metabolic information to the brain: short-term and long-term regulation of food intake and energy homeostasis, Exp Biol Med (Maywood), 226, 963, 10.1177/153537020122601102

Glatzle, 2003, Chylomicron components activate duodenal vagal afferents via a cholecystokinin. A receptor-mediated pathway to inhibit gastric motor function in the rat, J Physiol, 550, 657, 10.1113/jphysiol.2003.041673

Spiller, 1984, The ileal brake: inhibition of jejunal motility after ileal fat perfusion in man, Gut, 25, 365, 10.1136/gut.25.4.365

Batterham, 2003, Inhibition of food intake in obese subjects by peptide YY3-36, N Engl J Med, 349, 941, 10.1056/NEJMoa030204

Halatchev, 2005, Peripheral administration of PYY(3-36) produces conditioned taste aversion in mice, Cell Metab, 1, 159, 10.1016/j.cmet.2005.02.003

Gautier, 2005, Biological actions of the incretins GIP and GLP-1 and therapeutic perspectives in patients with type 2 diabetes, Diabetes Metab, 31, 233, 10.1016/S1262-3636(07)70190-8

Giralt, 1999, Glucagonlike peptide-1 (GLP-1) participation in ileal brake induced by intraluminal peptones in rat, Dig Dis Sci, 44, 322, 10.1023/A:1026654417697

Cummings, 2007, Gastrointestinal regulation of food intake, J Clin Invest, 117, 13, 10.1172/JCI30227

Raybould, 2003, Expression of 5-HT3 receptors by extrinsic duodenal afferents contribute to intestinal inhibition of gastric emptying, Am J Physiol Gastrointest Liver Physiol, 284, G367, 10.1152/ajpgi.00292.2001

Lindemann, 2001, Receptors and transduction in taste, Nature, 413, 219, 10.1038/35093032

Chandrashekar, 2000, T2Rs function as bitter taste receptors, Cell, 100, 703, 10.1016/S0092-8674(00)80706-0

Li, 2002, Human receptors for sweet and umami taste, Proc Natl Acad Sci U S A, 99, 4692, 10.1073/pnas.072090199

Adler, 2000, A novel family of mammalian taste receptors, Cell, 100, 693, 10.1016/S0092-8674(00)80705-9

Margolskee, 2002, Molecular mechanisms of bitter and sweet taste transduction, J Biol Chem, 277, 1, 10.1074/jbc.R100054200

Caicedo, 2003, Role of the G-protein subunit alpha-gustducin in taste cell responses to bitter stimuli, J Neurosci, 23, 9947, 10.1523/JNEUROSCI.23-30-09947.2003

Wong, 1996, Transduction of bitter and sweet taste by gustducin, Nature, 381, 796, 10.1038/381796a0

Rozengurt, 2006, Co-localization of the {alpha} subunit of gustducin with PYY and GLP-1 in L cells of human colon, Am J Physiol Gastrointest Liver Physiol, 291, G792, 10.1152/ajpgi.00074.2006

Wu, 2005, Genomic organization, expression, and function of bitter taste receptors (T2R) in mouse and rat, Physiol Genomics, 22, 139, 10.1152/physiolgenomics.00030.2005

Wu, 2002, Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells, Proc Natl Acad Sci U S A, 99, 2392, 10.1073/pnas.042617699

Dyer, 2005, Expression of sweet taste receptors of the T1R family in the intestinal tract and enteroendocrine cells, Biochem Soc Trans, 33, 302, 10.1042/BST0330302

Mace, 2007, Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2, J Physiol, 582, 379, 10.1113/jphysiol.2007.130906

Margolskee, 2007, T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1, Proc Natl Acad Sci U S A, 104, 15075, 10.1073/pnas.0706678104

Bezencon, 2007, Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells, Chem Senses, 32, 41, 10.1093/chemse/bjl034

Sternini, 2007, Taste receptors in the gastrointestinal tract. IV. Functional implications of bitter taste receptors in gastrointestinal chemosensing, Am J Physiol Gastrointest Liver Physiol, 292, G457, 10.1152/ajpgi.00411.2006

Hofer, 1998, Identification of the taste cell G-protein, alpha-gustducin, in brush cells of the rat pancreatic duct system, Histochem Cell Biol, 110, 303, 10.1007/s004180050292

Hofer, 1996, Taste receptor-like cells in the rat gut identified by expression of alpha-gustducin, Proc Natl Acad Sci U S A, 93, 6631, 10.1073/pnas.93.13.6631

Rozengurt, 2006, Taste receptors in the gastrointestinal tract. I. Bitter taste receptors and {alpha}-gustducin in the mammalian gut, Am J Physiol Gastrointest Liver Physiol, 291, G171, 10.1152/ajpgi.00073.2006

Jang, 2007, Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1, Proc Natl Acad Sci U S A, 104, 15069, 10.1073/pnas.0706890104

Sutherland, 2007, Phenotypic characterization of taste cells of the mouse intestine, Am J Physiol Gastrointest Liver Physiol, 292, G1420, 10.1152/ajpgi.00504.2006

Chen, 2006, Bitter stimuli induce Ca2+ signaling and CCK release in enteroendocrine STC-1 cells: role of L-type voltage-sensitive Ca2+ channels, Am J Physiol Cell Physiol, 291, C726, 10.1152/ajpcell.00003.2006