Enrichment of cancer stem-like cells by controlling oxygen, glucose and fluid shear stress in a microfluidic spheroid culture device

Maryam Barisam1, Fazeleh Ranjbar Niavol2, Moslem Afrasiabi Kinj3, Mohammad Said Saidi1, Hossein Ghanbarian4, Navid Kashaninejad5
1Department of Mechanical Engineering, Sharif University of Technology, Tehran, Iran
2Department of Stem Cells and Developmental Biology, Cell Science Research Centre, Royan Institute for Stem Biology and Technology, ACECR, Tehran, Iran
3Thermo and Fluids Department, Faculty of Mechanical Engineering, University of Guilan, Rasht, Iran
4Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran
5Queensland Micro-and Nanotechnology Centre (QMNC), Griffith University, Nathan Campus, QLD, 4111, Australia

Tài liệu tham khảo

Ferlay, 2020, 2018 Herbst, 2018, The biology and management of non-small cell lung cancer, Nature, 553, 446, 10.1038/nature25183 Zhu, 2017 Jordan, 2006, Cancer stem cells, N. Engl. J. Med., 355, 1253, 10.1056/NEJMra061808 Gupta, 2009, Identification of selective inhibitors of cancer stem cells by high-throughput screening, Cell, 138, 645, 10.1016/j.cell.2009.06.034 Liu, 2016 Rao, 2014, Enhanced enrichment of prostate cancer stem-like cells with miniaturized 3D culture in liquid core-hydrogel shell microcapsules, Biomaterials, 35, 7762, 10.1016/j.biomaterials.2014.06.011 Morata-Tarifa, 2016, Low adherent cancer cell subpopulations are enriched in tumorigenic and metastatic epithelial-to-mesenchymal transition-induced cancer stem-like cells, Sci. Rep., 6, 1, 10.1038/srep18772 Guo, 2019, Enrichment of cancer stem cells by agarose multi-well dishes and 3D spheroid culture, Cell Tissue Res., 375, 397, 10.1007/s00441-018-2920-0 Pandit, 2018, Enrichment of cancer stem cells via β-catenin contributing to the tumorigenesis of hepatocellular carcinoma, BMC Cancer, 18, 1, 10.1186/s12885-018-4683-0 Liotta, 2004, Cancer and the homeless cell, Nature, 430, 973, 10.1038/430973a Ip, 2016, Stemness and chemoresistance in epithelial ovarian carcinoma cells under shear stress, Sci. Rep., 6, 1, 10.1038/srep26788 Triantafillu, 2017, Fluid shear stress induces cancer stem cell-like phenotype in MCF7 breast cancer cell line without inducing epithelial to mesenchymal transition, Int. J. Oncol., 50, 993, 10.3892/ijo.2017.3865 Najafi, 2020, Hypoxia in solid tumors: a key promoter of cancer stem cell (CSC) resistance, J. Cancer Res. Clin. Oncol., 146, 19, 10.1007/s00432-019-03080-1 Heddleston, 2009, The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype, Cell Cycle, 8, 3274, 10.4161/cc.8.20.9701 Lan, 2018, Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment, Proc. Natl. Acad. Sci. Unit. States Am., 115, E9640, 10.1073/pnas.1809695115 De Francesco, 2018, Cancer stem cells (CSCs): metabolic strategies for their identification and eradication, Biochem. J., 475, 1611, 10.1042/BCJ20170164 Shibuya, 2015, Targeting the facilitative glucose transporter GLUT1 inhibits the self-renewal and tumor-initiating capacity of cancer stem cells, Oncotarget, 6, 651, 10.18632/oncotarget.2892 Lin, 2016, Regulatory role of hexosamine biosynthetic pathway on hepatic cancer stem cell marker CD133 under low glucose conditions, Sci. Rep., 6, 1 Zhang, 2012, Applications of microfluidics in stem cell biology, Bionanoscience, 2, 277, 10.1007/s12668-012-0051-8 Kashaninejad, 2016, Organ-Tumor-on-a-Chip for chemosensitivity assay: a critical review, Micromachines, 7, 10.3390/mi7080130 Barisam, 2018, Prediction of necrotic core and hypoxic zone of multicellular spheroids in a microbioreactor with a U-shaped barrier, Micromachines, 9, 94, 10.3390/mi9030094 Barisam, 2017, Numerical simulation of the behavior of toroidal and spheroidal multicellular aggregates in microfluidic devices with microwell and U-shaped barrier, Micromachines, 8, 358, 10.3390/mi8120358 Moshksayan, 2018, Spheroids-on-a-chip: recent advances and design considerations in microfluidic platforms for spheroid formation and culture, Sensor. Actuator. B Chem., 263, 151, 10.1016/j.snb.2018.01.223 Xu, 2016, A mathematical model coupling tumor growth and angiogenesis, PLoS One, 11 Datta, 2016, Mathematical model of oxygen transport in tuberculosis granulomas, Ann. Biomed. Eng., 44, 863, 10.1007/s10439-015-1415-3 Jackson, 2011 Zhang, 2013, Studying cancer stem cell dynamics on PDMS surfaces for microfluidics device design, Sci. Rep., 3, 1 Yan, 2013, Identification of CD90 as a marker for lung cancer stem cells in A549 and H446 cell lines, Oncol. Rep., 30, 2733, 10.3892/or.2013.2784 Lien, 2013, Mechanical regulation of cancer cell apoptosis and autophagy: roles of bone morphogenetic protein receptor, Smad1/5, and p38 MAPK, Biochim. Biophys. Acta Mol. Cell Res., 1833, 3124, 10.1016/j.bbamcr.2013.08.023 Teng, 2010, Wnt/β-catenin signaling regulates cancer stem cells in lung cancer A549 cells, Biochem. Biophys. Res. Commun., 392, 373, 10.1016/j.bbrc.2010.01.028 Zhang, 2020, Co-expression of stem cell and epithelial mesenchymal transition markers in circulating tumor cells of bladder cancer patients, OncoTargets Ther., 13, 10739, 10.2147/OTT.S259240 Wright, 2006, Inexpensive low-oxygen incubators, Nat. Protoc., 1, 2088, 10.1038/nprot.2006.374 Wang, 2015, Hypoxia and TGF-β1 lead to endostatin resistance by cooperatively increasing cancer stem cells in A549 transplantation tumors, Cell Biosci., 5, 1, 10.1186/s13578-015-0064-4 Zhao, 2015, Hypoxia-induced cell stemness leads to drug resistance and poor prognosis in lung adenocarcinoma, Lung Cancer, 87, 98, 10.1016/j.lungcan.2014.11.017 Yusuf, 2003, Regulation of quiescence in lymphocytes, Trends Immunol., 24, 380, 10.1016/S1471-4906(03)00141-8 Warburg, 1956, On the origin of cancer cells, Science, 123, 309, 10.1126/science.123.3191.309 Hastreiter, 2016, Nanog dynamics in single embryonic stem cells, Cell Cycle, 15, 770, 10.1080/15384101.2015.1137711 Chiou, 2010, Coexpression of Oct4 and Nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell–like properties and epithelial–mesenchymal transdifferentiation, Cancer Res., 70, 10433, 10.1158/0008-5472.CAN-10-2638 Gemmill, 2011, ZEB1-responsive genes in non-small cell lung cancer, Cancer Lett., 300, 66, 10.1016/j.canlet.2010.09.007 Liu, 2014, Metabolic regulation of cancer cell side population by glucose through activation of the Akt pathway, Cell Death Differ., 21, 124, 10.1038/cdd.2013.131 Phoomak, 2017, High glucose levels boost the aggressiveness of highly metastatic cholangiocarcinoma cells via O-GlcNAcylation, Sci. Rep., 7, 1, 10.1038/srep43842 Christensen, 2015, GLUT3 and PKM2 regulate OCT4 expression and support the hypoxic culture of human embryonic stem cells, Sci. Rep., 5, 1, 10.1038/srep17500 Roudi, 2016, Evidence for embryonic stem-like signature and epithelial-mesenchymal transition features in the spheroid cells derived from lung adenocarcinoma, Tumor Biol., 37, 11843, 10.1007/s13277-016-5041-y Balla, 2019, Tumorsphere assay provides a better in vitro method for cancer stem-like cells enrichment in A549 lung adenocarcinoma cells, Tissue Cell, 60, 21, 10.1016/j.tice.2019.07.003 Doktorova, 2015, Hypoxia-induced chemoresistance in cancer cells: the role of not only HIF-1, Biomed. Pap. Med. Fac. Palacky Univ. Olomouc Czech Repub., 159, 10.5507/bp.2015.025 Yang, 2019, High blood sugar levels but not diabetes mellitus significantly enhance oxaliplatin chemoresistance in patients with stage III colorectal cancer receiving adjuvant FOLFOX6 chemotherapy, Therapeut. Adv. Med. Oncol., 11