Enhancing Permeation of Drug Molecules Across the Skin via Delivery in Nanocarriers: Novel Strategies for Effective Transdermal Applications

Albery, 1979, Percutaneous absorption: in vivo experiments., J. Pharm. Pharmacol., 31, 140, 10.1111/j.2042-7158.1979.tb13456.x

Arora, 2017, Solid lipid nanoparticles and nanostructured lipid carrier-based nanotherapeutics in treatment of psoriasis: a comparative study., Expert Opin. Drug Deliv., 14, 165, 10.1080/17425247.2017.1264386

Balakrishnan, 2009, Formulation and in vitro assessment of minoxidil niosomes for enhanced skin delivery., Int. J. Pharm., 377, 1, 10.1016/j.ijpharm.2009.04.020

Barry, 2001, Novel mechanisms and devices to enable successful transdermal drug delivery., Eur. J. Pharm. Sci., 14, 101, 10.1016/s0928-0987(01)00167-1

Belikov, 2015, Multi-beam laser-induced hydrodynamic shock waves used for delivery of microparticles and liquids in skin., Lasers Surg. Med., 47, 723, 10.1002/lsm.22417

Berner, 1998, Electronically assisted drug delivery: an overview, Electronically Controlled Drug Delivery, 3, 10.1201/9780429262838-2

Bi, 2019, Liposomal Vitamin D3 as an anti-aging agent for the skin., Pharmaceutics, 11, 10.3390/pharmaceutics11070311

Bodde, 1991, Visualization of in vitro percutaneous penetration of mercuric chloride; transport through intercellular space versus cellular uptake through desmosomes., J. Control. Release, 15, 227, 10.1016/0168-3659(91)90114-s

Boisseau, 2011, Nanomedicine, nanotechnology in medicine., Compt. Ren. Phys., 12, 620, 10.1016/j.crhy.2011.06.001

Bommannan, 1992, Sonophoresis. II. Examination of the mechanism (s) of ultrasound-enhanced transdermal drug delivery., Pharm. Res., 9, 1043, 10.1023/A:1015806528336

Bommannan, 1994, Effect of electroporation on transdermal lontophoretic delivery of luteinizing hormone releasing hormone (LHRH) in vitro., Pharm. Res., 11, 1809, 10.1023/A:1018983804635

Borgia, 2005, Lipid nanoparticles for skin penetration enhancement—correlation to drug localization within the particle matrix as determined by fluorescence and parelectric spectroscopy., J. Control. Release, 110, 151, 10.1016/j.jconrel.2005.09.045

Bragagni, 2015, Development and ex vivo evaluation of 5-aminolevulinic acid-loaded niosomal formulations for topical photodynamic therapy., Int. J. Pharm., 494, 258, 10.1016/j.ijpharm.2015.08.036

Burnette, 1987, Characterization of the permselective properties of excised human skin during iontophoresis., J. Pharm. Sci., 76, 765, 10.1002/jps.2600761003

Carolina Oliveira Dos Santos, 2019, Caffeic acid skin absorption: delivery of microparticles to hair follicles., Saudi Pharm. J., 27, 791, 10.1016/j.jsps.2019.04.015

Carpentieri-Rodrigues, 2007, Percutaneous absorption enhancers: mechanisms and potential., Braz. Arch. Biol. Technol., 50, 949, 10.1590/s1516-89132007000700006

Cevc, 2010, Nanotechnology and the transdermal route: a state of the art review and critical appraisal., J. Control. Release, 141, 277, 10.1016/j.jconrel.2009.10.016

Chantaburanan, 2017, Effect of binary solid lipid matrix of wax and triglyceride on lipid crystallinity, drug-lipid interaction and drug release of ibuprofen-loaded solid lipid nanoparticles (SLN) for dermal delivery., J. Colloid Interface Sci., 504, 247, 10.1016/j.jcis.2017.05.038

Charoenputtakun, 2015, Iontophoretic delivery of lipophilic and hydrophilic drugs from lipid nanoparticles across human skin., Int. J. Pharm., 495, 318, 10.1016/j.ijpharm.2015.08.094

Choi, 2005, Liposomes and niosomes as topical drug delivery systems., Skin Pharmacol. Physiol., 18, 209, 10.1159/000086666

Christophers, 1971, Cellular architecture of the stratum corneum., J. Invest. Dermatol., 56, 165, 10.1111/1523-1747.ep12260765

Cloninger, 2002, Biological applications of dendrimers., Curr. Opin. Chem. Biol., 6, 742, 10.1016/S1367-5931(02)00400-3

Cristiano, 2020, Sulforaphane-loaded ultradeformable vesicles as a potential natural nanomedicine for the treatment of skin cancer diseases., Pharmaceutics, 12, 10.3390/pharmaceutics12010006

Davis, 1993, Supersaturated solutions as topical drug delivery systems., Drugs Pharm. Sci., 59, 243

D’Emanuele, 2005, Dendrimer–drug interactions., Adv. Drug Deliv. Rev., 57, 2147, 10.1016/j.addr.2005.09.012

Desai, 2013, Investigation of follicular and non-follicular pathways for polyarginine and oleic acid-modified nanoparticles., Pharm. Res., 30, 1037, 10.1007/s11095-012-0939-6

Di Francesco, 2017, Acronychiabaueri analogue derivative-loaded ultradeformable vesicles: physicochemical characterization and potential applications., Planta Med., 83, 482, 10.1055/s-0042-112225

Díaz-Torres, 2010, Transdermal nanocarriers, Current Technologies to Increase the Transdermal Delivery of Drugs, 120, 10.2174/978160805191511001010120

Ding, 2011, Transcutaneous immunization studies in mice using diphtheria toxoid-loaded vesicle formulations and a microneedle array., Pharm. Res., 28, 145, 10.1007/s11095-010-0093-y

Döge, 2016, Ethyl cellulose nanocarriers and nanocrystals differentially deliver dexamethasone into intact, tape-stripped or sodium lauryl sulfate-exposed ex vivo human skin-assessment by intradermal microdialysis and extraction from the different skin layers., J. Control. Release, 242, 25, 10.1016/j.jconrel.2016.07.009

Dragicevic, 2018, Combined use of nanocarriers and physical methods for percutaneous penetration enhancement., Adv. Drug Deliv. Rev., 127, 58, 10.1016/j.addr.2018.02.003

Egbaria, 1990, Topical delivery of ciclosporin: evaluation of various formulations using in vitro diffusion studies in hairless mouse skin., Skin Pharm. Physiol., 3, 21, 10.1159/000210837

Eid, 2019, Essential oils in niosomes for enhanced transdermal delivery of felodipine., Pharm. Dev. Technol., 24, 157, 10.1080/10837450.2018.1441302

El Maghraby, 2008, Liposomes and skin: from drug delivery to model membranes., Eur. J. Pharm. Sci., 34, 203, 10.1016/j.ejps.2008.05.002

Elias, 1981, Lipids and the epidermal permeability barrier., Arch. Dermatol. Res., 270, 95, 10.1007/bf00417155

Elias, 1983, Epidermal lipids, barrier function, and desquamation., J. Invest. Dermatol., 80, 44s, 10.1038/jid.1983.12

Engelke, 2018, Application of water-soluble polyvinyl alcohol-based film patches on laser microporated skin facilitates intradermal macromolecule and nanoparticle delivery., Eur. J. Pharm. Biopharm., 128, 119, 10.1016/j.ejpb.2018.04.008

Escobar-Chávez, 2016, Physical Penetration Enhancers: Therapeutic Applications and Devices.

Escobar-Chávez, 2012, Nanocarriers for transdermal drug delivery., Res. Rep. Trans. Drug Deliv., 1, 3, 10.2147/rrtd.s32621

Esfand, 2001, Poly (amidoamine)(PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications., Drug Discov. Today, 6, 427, 10.1016/s1359-6446(01)01757-3

Fang, 2014, Delivery and targeting of nanoparticles into hair follicles., Ther. Deliv., 5, 991, 10.4155/tde.14.61

Fang, 2008, Lipid nanoparticles as vehicles for topical psoralen delivery: solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC)., Eur. J. Pharm. Biopharm, 70, 633, 10.1016/j.ejpb.2008.05.008

Fang, 2004, Transdermal delivery of macromolecules by erbium: YAG laser., J. Control. Release, 100, 75, 10.1016/j.jconrel.2004.08.009

Fang, 2001, Bin, Tsai Y-HH. vitro skin permeation of estradiol from various proniosome formulations., Int. J. Pharm., 215, 91, 10.1016/s0378-5173(00)00669-4

Finnin, 1999, Transdermal penetration enhancers: applications, limitations, and potential., J. Pharm. Sci., 88, 955, 10.1021/js990154g

Garcês, , Formulations based on solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for cutaneous use: a review., Eur. J. Pharm. Sci., 112, 159, 10.1016/j.ejps.2017.11.023

Garcês, , Formulations based on solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for cutaneous use: a review., Eur. J. Pharm. Sci., 112, 159, 10.1016/j.ejps.2017.11.023

Geinoz, 2004, Quantitative structure-permeation relationships (QSPeRs) to predict skin permeation: a critical evaluation., Pharm. Res., 21, 83, 10.1023/b:pham.0000012155.27488.2b

Genina, 2013, Transcutaneous delivery of micro-and nanoparticles with laser microporation., J. Biomed. Opt., 18, 10.1117/1.jbo.18.11.111406

Genina, 2019, A simple non-invasive approach toward efficient transdermal drug delivery based on biodegradable particulate system., ACS Appl. Mater. Interfaces, 11, 17270, 10.1021/acsami.9b04305

Genina, 2016, In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers., Biomed. Opt. Express, 7, 2082, 10.1364/boe.7.002082

Ghasemiyeh, 2019, Cyproterone acetate-loaded nanostructured lipid carriers: effect of particle size on skin penetration and follicular targeting., Pharm. Dev. Technol., 24, 812, 10.1080/10837450.2019.1596133

Ghasemiyeh, 2017, Cyproterone acetate-loaded solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs): preparation and optimization., Trends Pharm. Sci., 3, 275

Golden, 1987, Role of stratum corneum lipid fluidity in transdermal drug flux., J. Pharm. Sci., 76, 25, 10.1002/jps.2600760108

Gray, 1982, Lipid composition of the superficial stratum corneum cells of pig epidermis., Br. J. Dermatol., 106, 59, 10.1111/j.1365-2133.1982.tb00902.x

Gupta, 2016, Dermal drug delivery for cutaneous malignancies: literature at a glance., J. Pharm. Innov., 11, 1, 10.1007/s12247-015-9236-3

Guy, 1992, Advanced Drug Delivery Reviews, Theme Issue: Iontophoresis.

Guy, 1998, Iontophoresis–recent developments., J. Pharm. Pharmacol., 50, 371, 10.1111/j.2042-7158.1998.tb06875.x

Guy, 2000, Iontophoresis: electrorepulsion and electroosmosis., J. Control. Release, 64, 129, 10.1016/s0168-3659(99)00132-7

Hadgraft, 2005, Skin permeation: the years of enlightenment., Int. J. Pharm., 305, 2, 10.1016/j.ijpharm.2005.07.014

Hadgraft, 1985, Facilitated transport of sodium salicylate across an artificial lipid membrane by Azone., J. Pharm. Pharmacol., 37, 725, 10.1111/j.2042-7158.1985.tb04951.x

Hao, 2016, Heat effects on drug delivery across human skin., Expert Opin. Drug Deliv., 13, 755, 10.1517/17425247.2016.1136286

Harrison, 1996, The relative effect of Azone and Transcutol on permeant diffusivity and solubility in human stratum corneum., Pharm. Res., 13, 542, 10.1023/A:1016037803128

Hendriks, 2006, The relative contributions of different skin layers to the mechanical behavior of human skin in vivo using suction experiments., Med. Eng. Phys., 28, 259, 10.1016/j.medengphy.2005.07.001

Hoogstraate, 1994, Iontophoretic enhancement of peptides: behaviour of leuprolide versus model permeants., J. Control. Release, 31, 41, 10.1016/0168-3659(94)90249-6

Huber, 2015, Topical skin cancer therapy using doxorubicin-loaded cationic lipid nanoparticles and iontophoresis., J. Biomed. Nanotechnol., 11, 1975, 10.1166/jbn.2015.2139

Hughes, 2005, Nanostructure-mediated drug delivery., Nanomed. Nanotechnol. Biol. Med., 1, 22, 10.1016/j.nano.2004.11.009

Idson, 1975, Percutaneous absorption., J. Pharm. Sci., 64, 901, 10.1002/jps.2600640604

Illel, 1997, Formulation for transfollicular drug administration: some recent advances., Crit. Rev. Ther. Drug Carrier Syst., 14, 207, 10.1615/CritRevTherDrugCarrierSyst.v14.i3.10

Jadoul, 1995, Quantification and localization of fentanyl and TRH delivered by iontophoresis in the skin., Int. J. Pharm., 120, 221, 10.1016/0378-5173(94)00417-4

Johnson, 1997, Evaluation of solute permeation through the stratum corneum: lateral bilayer diffusion as the primary transport mechanism., J. Pharm. Sci., 86, 1162, 10.1021/js960198e

Kabri, 2011, Physico-chemical characterization of nano-emulsions in cosmetic matrix enriched on omega-3., J. Nanobiotechnol., 9, 10.1186/1477-3155-9-41

Kai, 1990, Mechanism of percutaneous penetration enhancement: effect of n-alkanols on the permeability barrier of hairless mouse skin., J. Control. Release, 12, 103, 10.1016/0168-3659(90)90086-9

Kapoor, 2018, Stable liposome in cosmetic platforms for transdermal Folic acid delivery for fortification and treatment of micronutrient deficiencies., Sci. Rep., 8, 16122, 10.1038/s41598-018-34205-0

Khavari, 1998, Gene therapy for genetic skin disease., J. Invest. Dermatol., 110, 462, 10.1046/j.1523-1747.1998.00157.x

Kline-Schoder, 2019, Optimization of ultrasound-mediated drug delivery for treatment of Onychomycosis., J. Am. Podiatr. Med. Assoc., 10.7547/18-084

Kong, 2011, Investigations on skin permeation of hyaluronic acid based nanoemulsion as transdermal carrier., Carbohydr. Polym., 86, 837, 10.1016/j.carbpol.2011.05.027

Lee, 2015, T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial., Lancet, 385, 517, 10.1016/S0140-6736(14)61403-3

Lee, 2015, Fractional thermolysis by bipolar radiofrequency facilitates cutaneous delivery of peptide and siRNA with minor loss of barrier function., Pharm. Res., 32, 1704, 10.1007/s11095-014-1568-z

Lee, 1989, Prodrugs for improved ocular drug delivery., Adv. Drug Deliv. Rev., 3, 1, 10.1016/0169-409x(89)90003-3

Lengert, 2019, Mesoporous carriers for transdermal delivery of antifungal drug., Mater. Lett., 248, 211, 10.1016/j.matlet.2019.04.028

Levy, 1989, Effect of ultrasound on transdermal drug delivery to rats and guinea pigs., J. Clin. Invest., 83, 2074, 10.1172/jci114119

Lieb, 1992, Topical delivery enhancement with multilamellar liposomes into pilosebaceous units: I. In vitro evaluation using fluorescent techniques with the hamster ear model., J. Invest. Dermatol., 99, 108, 10.1111/1523-1747.ep12611886

Lieckfeldt, 1994, Influence of oleic acid on the structure of a mixture of hydrated model stratum corneum fatty acids and their soaps., Colloids Surfaces A Physicochem. Eng. Aspects, 90, 225, 10.1016/0927-7757(94)02919-9

Loftsson, 2002, Cyclodextrins and the biopharmaceutics classification system of drugs., J.Incl. Phenom. Macrocycl. Chem., 44, 63, 10.1515/fv-2016-0040

Long, 2000, Combined effect of low-frequency ultrasound and iontophoresis: applications for transdermal heparin delivery., Pharm. Res., 17

Lopez, 2011, Enhancing the transdermal delivery of rigid nanoparticles using the simultaneous application of ultrasound and sodium lauryl sulfate., Biomaterials, 32, 933, 10.1016/j.biomaterials.2010.09.060

Lu, 2019, Niosomal nanocarriers for enhanced skin delivery of quercetin with functions of anti-tyrosinase and antioxidant., Molecules, 24, 10.3390/molecules24122322

Ly, 2004, The influence of short-chain alcohols on interfacial tension, mechanical properties, area/molecule, and permeability of fluid lipid bilayers., Biophys. J., 87, 1013, 10.1529/biophysj.103.034280

Maghraby, 2006, Can drug-bearing liposomes penetrate intact skin?, J. Pharm. Pharmacol., 58, 415, 10.1211/jpp.58.4.0001

Mandawgade, 2008, Development of SLNs from natural lipids: application to topical delivery of tretinoin., Int. J. Pharm., 363, 132, 10.1016/j.ijpharm.2008.06.028

Medintz, 2005, Quantum dot bioconjugates for imaging, labelling and sensing., Nat. Mater., 4, 435, 10.1038/nmat1390

Merino, 2017, Iontophoresis for therapeutic drug delivery and non-invasive sampling applications, Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement, 77, 10.1007/978-3-662-53273-7_6

Migdadi, 2019, Microneedles for Transdermal Drug Delivery, Imaging Technologies and Transdermal Delivery in Skin Disorders, 223, 10.1002/9783527814633.ch10

Mitragotri, 2003, Modeling skin permeability to hydrophilic and hydrophobic solutes based on four permeation pathways., J. Control. Release, 86, 69, 10.1016/s0168-3659(02)00321-8

Mitragotri, 2017, Sonophoresis: ultrasound-mediated transdermal drug delivery, Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement, 3, 10.1007/978-3-662-53273-7_1

Mitragotri, , Ultrasound-mediated transdermal protein delivery., Science, 269, 850, 10.1126/science.7638603

Mitragotri, , A mechanistic study of ultrasonically-enhanced transdermal drug delivery., J. Pharm. Sci., 84, 697, 10.1002/jps.2600840607

Mitragotri, 1996, Transdermal drug delivery using low-frequency sonophoresis., Pharm. Res., 13, 411, 10.1023/A:1016096626810

Montenegro, 2018, Solid lipid nanoparticles loading idebenone ester with pyroglutamic acid: in vitro antioxidant activity and in vivo topical efficacy., Nanomaterials, 9, 10.3390/nano9010043

Müller, 2011, State of the art of nanocrystals–special features, production, nanotoxicology aspects and intracellular delivery., Eur. Opean J. Pharm. Biopharm., 78, 1, 10.1016/j.ejpb.2011.01.007

Muzzalupo, 2017, Pharmaceutical versatility of cationic niosomes derived from amino acid-based surfactants: skin penetration behavior and controlled drug release., Int. J. Pharm., 529, 245, 10.1016/j.ijpharm.2017.06.083

Naik, 2000, Transdermal drug delivery: overcoming the skin’s barrier function., Pharm. Sci. Technol. Today, 3, 318, 10.1016/S1461-5347(00)00295-9

Naik, 1995, Mechanism of oleic acid-induced skin penetration enhancement in vivo in humans., J. Control. Release, 37, 299, 10.1016/0168-3659(95)00088-7

Nair, 2009, An ex vivo toe model used to assess applicators for the iontophoretic ungual delivery of terbinafine., Pharm. Res., 26, 2194, 10.1007/s11095-009-9934-y

Nakkam, 2018, HLA pharmacogenetic markers of drug hypersensitivity in a thai population., Front. Genet., 9, 10.3389/fgene.2018.00277

Nemanic, 1980, In situ precipitation: a novel cytochemical technique for visualization of permeability pathways in mammalian stratum corneum., J. Histochem. Cytochem., 28, 573, 10.1177/28.6.7190175

Neubert, 2011, Potentials of new nanocarriers for dermal and transdermal drug delivery., Eur. J. Pharm.Biopharm., 77, 1, 10.1016/j.ejpb.2010.11.003

Nguyen, 2019, Developing pharmacogenetic screening methods for an emergent country: vietnam., World Allergy Organ. J., 12, 10.1016/j.waojou.2019.100037

Niederhafner, 2005, Peptide dendrimers., J. Peptide Sci., 11, 757, 10.1002/psc.721

Noh, 2017, Ceramide-based nanostructured lipid carriers for transdermal delivery of isoliquiritigenin: development, physicochemical characterization, and in vitro skin permeation studies., Korean J. Chem. Eng., 34, 400, 10.1007/s11814-016-0267-3

Ongpipattanakul, 1991, Evidence that oleic acid exists in a separate phase within stratum corneum lipids., Pharm. Res., 8, 350, 10.1023/A:1015845632280

Osborne, 1990, Surfactant association colloids as topical drug delivery vehicles., Drugs Pharm. Sci., 42, 349

Paolino, 2012, Paclitaxel-loaded ethosomes: potential treatment of squamous cell carcinoma, a malignant transformation of actinic keratoses., Eur. J. Pharm. Biopharm., 81, 102, 10.1016/j.ejpb.2012.02.008

Parekh, 2007, The advance of dendrimers-a versatile targeting platform for gene/drug delivery., Curr. Pharm. Des., 13, 2837, 10.2174/138161207781757024

Park, 2019, Enhanced transdermal drug delivery by sonophoresis and simultaneous application of sonophoresis and iontophoresis., AAPS PharmSciTech, 20, 1, 10.1208/s12249-019-1309-z

Patzelt, 2017, Do nanoparticles have a future in dermal drug delivery?, J. Control. Release, 246, 174, 10.1016/j.jconrel.2016.09.015

Paudel, 2010, Challenges and opportunities in dermal/transdermal delivery., Ther. Deliv., 1, 109, 10.4155/tde.10.16

Pettit, 1998, The development of site-specific drug-delivery systems for protein and peptide biopharmaceuticals., Trends Biotechnol., 16, 343, 10.1016/S0167-7799(98)01186-X

Pireddu, 2016, Diclofenac acid nanocrystals as an effective strategy to reduce in vivo skin inflammation by improving dermal drug bioavailability., Colloids Surf. B, 143, 64, 10.1016/j.colsurfb.2016.03.026

Pivetta, 2018, Development of nanoparticles from natural lipids for topical delivery of thymol: investigation of its anti-inflammatory properties., Colloids Surf. B, 164, 281, 10.1016/j.colsurfb.2018.01.053

Pokharkar, 2014, Skin delivery aspects of benzoyl peroxide-loaded solid lipid nanoparticles for acne treatment., Ther. Deliv., 5, 635, 10.4155/tde.14.31

Polat, 2011, Ultrasound-mediated transdermal drug delivery: mechanisms, scope, and emerging trends., J. Control. Release, 152, 330, 10.1016/j.jconrel.2011.01.006

Potts, 1990, Lipid biophysics of water loss through the skin., Proc. Natl. Acad. Sci. U.S.A., 87, 3871, 10.1073/pnas.87.10.3871

Potts, 1991, The influence of stratum corneum morphology on water permeability., J. Invest. Dermatol., 96, 495, 10.1111/1523-1747.ep12470197

Prausnitz, 1993, Electroporation of mammalian skin: a mechanism to enhance transdermal drug delivery., Proc. Natl. Acad. Sci. U.S.A., 90, 10504, 10.1073/pnas.90.22.10504

Prausnitz, 2008, Transdermal drug delivery., Nat. Biotechnol., 26, 1261, 10.1038/nbt.1504

Prausnitz, 2004, Current status and future potential of transdermal drug delivery., Nat. Rev. Drug Discov., 3, 115, 10.1038/nrd1304

Pyo, 2017, Dermal miconazole nitrate nanocrystals–formulation development, increased antifungal efficacy & skin penetration., Int. J. Pharm., 531, 350, 10.1016/j.ijpharm.2017.08.108

Qiu, 2016, DNA-based vaccination against hepatitis B virus using dissolving microneedle arrays adjuvanted by cationic liposomes and CpG ODN., Drug Deliv., 23, 2391, 10.3109/10717544.2014.992497

Rajkumar, 2019, IN VIVO EVALUATION OF TAZAROTENE SOLID LIPID NANOPARTICLES GEL FOR TOPICAL DELIVERY., Int. J. Pharm. Sci. Drug Res., 11, 45, 10.25004/IJPSDR.2019.110107

Ribeiro, 2017, Natural lipids-based NLC containing lidocaine: from pre-formulation to in vivo studies., Eur. J. Pharm. Sci., 106, 102, 10.1016/j.ejps.2017.05.060

Ricci, 2005, Evaluation of indomethacin percutaneous absorption from nanostructured lipid carriers (NLC): in vitro and in vivo studies., J. Pharm. Sci., 94, 1149, 10.1002/jps.20335

Rizwan, 2009, Enhanced transdermal drug delivery techniques: an extensive review of patents., Recent Patents Drug Deliv. Formul., 3, 105, 10.2174/187221109788452285

Roosterman, 2006, Neuronal control of skin function: the skin as a neuroimmunoendocrine organ., Physiol. Rev., 86, 1309, 10.1152/physrev.00026.2005

Ruela, 2016, Evaluation of skin absorption of drugs from topical and transdermal formulations., Braz. J. Pharm. Sci., 52, 527, 10.1590/s1984-82502016000300018

Sala, 2018, Lipid nanocarriers as skin drug delivery systems: Properties, mechanisms of skin interactions and medical applications., Int. J. Pharm., 535, 1, 10.1016/j.ijpharm.2017.10.046

Salinger, 2019, Innovations in topical ocular corticosteroid therapy for the management of postoperative ocular inflammation and pain., Am. J. Manag. Care, 25, S215

Schätzlein, 1998, Non-uniform cellular packing of the stratum corneum and permeability barrier function of intact skin: a high-resolution confocal laser scanning microscopy study using highly deformable vesicles (Transfersomes)., Br. J. Dermatol., 138, 583, 10.1046/j.1365-2133.1998.02166.x

Scheuplein, 1971, Permeability of the skin., Physiol. Rev., 51, 702, 10.1152/physrev.1971.51.4.702

Schmitt, 2018, Comprehensive molecular characterization of microneedling therapy in a human three-dimensional skin model., PLoS One, 13, 10.1371/journal.pone.0204318

Schroeder, 2007, Development and characterization of film forming polymeric solutions for skin drug delivery., Eur. J. Pharm. Biopharm., 65, 111, 10.1016/j.ejpb.2006.07.015

Schwarz, 2013, Ultra-small NLC for improved dermal delivery of coenyzme Q10., Int. J. Pharm., 447, 213, 10.1016/j.ijpharm.2013.02.037

Scott, 1992, Direct imaging of ionic pathways in stratum corneum using scanning electrochemical microscopy., Solid State Ionics, 53, 176, 10.1016/0167-2738(92)90380-8

Shaw, 1983, Dermal drug delivery systems: a review., J. Toxicol., 2, 249

Shegokar, 2016, What nanocrystals can offer to cosmetic and dermal formulations, Nanobiomaterials in Galenic Formulations and Cosmetics, 69, 10.1016/B978-0-323-42868-2.00004-8

Sintov, 2003, Radiofrequency-driven skin microchanneling as a new way for electrically assisted transdermal delivery of hydrophilic drugs., J. Control. Release, 89, 311, 10.1016/S0168-3659(03)00123-8

Song, 2018, Transdermal delivery of human growth hormone via laser-generated micropores., Drug Deliv. Transl. Res., 8, 450, 10.1007/s13346-017-0370-y

Stecová, 2007, Cyproterone acetate loading to lipid nanoparticles for topical acne treatment: particle characterisation and skin uptake., Pharm. Res., 24, 991, 10.1007/s11095-006-9225-9

Svenskaya, 2020, Enhanced topical psoralen–ultraviolet A therapy via targeting to hair follicles., Br. J. Dermatol., 182, 1479, 10.1111/bjd.18800

Svenskaya, 2019, A simple non-invasive approach toward efficient transdermal drug delivery based on biodegradable particulate system., ACS Appl. Mater. Interfaces, 11, 17270, 10.1021/acsami.9b04305

Szunerits, 2018, Heat: a highly efficient skin enhancer for transdermal drug delivery., Front. Bioeng. Biotechnol., 6, 10.3389/fbioe.2018.00015

Tachibana, 1992, Transdermal delivery of insulin to alloxan-diabetic rabbits by ultrasound exposure., Pharm. Res., 9, 952, 10.1023/A:1015869420159

Takeuchi, 2017, Skin permeability and transdermal delivery route of 50-nm indomethacin-loaded PLGA nanoparticles., Colloids Surf., 159, 312, 10.1016/j.colsurfb.2017.08.003

Tavano, 2017, Tetracycline-niosomes versus tetracycline hydrochlo-ride-niosomes: how to modulate encapsulation and percutaneous permeation properties., J. Drug., 1, 1, 10.24218/jod.2017.6

Taveira, 2014, Effect of iontophoresis on topical delivery of doxorubicin-loaded solid lipid nanoparticles., J. Biomed. Nanotechnol., 10, 1382, 10.1166/jbn.2014.1834

Teong, 2017, Liposomal encapsulation for systemic delivery of propranolol via transdermal iontophoresis improves bone microarchitecture in ovariectomized rats., Int. J. Mol. Sci., 18, 10.3390/ijms18040822

Tomoda, 2011, Enhanced transdermal delivery of indomethacin-loaded PLGA nanoparticles by iontophoresis., Colloids Surf. B, 88, 706, 10.1016/j.colsurfb.2011.08.004

Tomoda, 2012, Enhanced transdermal delivery of indomethacin using combination of PLGA nanoparticles and iontophoresis in vivo., Colloids Surf. B, 92, 50, 10.1016/j.colsurfb.2011.11.016

Tsong, 1989, Electroporation of cell membranes, Electroporation and Electrofusion in Cell Biology, 149, 10.1007/978-1-4899-2528-2_9

Tyle, 1989, Drug delivery by phonophoresis., Pharm. Res., 6, 355, 10.1023/A:1015967012253

Vickers, 2017, Animal communication: when i’m calling you, will you answer too?, Curr. Biol., 27, R713, 10.1016/j.cub.2017.05.064

Waghule, 2019, Microneedles: a smart approach and increasing potential for transdermal drug delivery system., Biomed. Pharmacother., 109, 1249, 10.1016/j.biopha.2018.10.078

Walters, 1993, Pharmaceutical skin Penetration Enhancement.

Wang, 1998, Transdermal delivery of cyclosporin-A using electroporation., J. Control. Release, 50, 61, 10.1016/S0168-3659(97)00117-X

Watanabe, 2009, Enhanced transdermal drug penetration by the simultaneous application of iontophoresis and sonophoresis., J. Drug Deliv. Sci. Technol., 19, 185, 10.1016/S1773-2247(09)50034-2

Weiss, 2012, Transcutaneous vaccination via laser microporation., J. Control. Release, 162, 391, 10.1016/j.jconrel.2012.06.031

Wichayapreechar, 2020, Dermal targeting of Centella asiatica extract using hyaluronic acid surface modified niosomes., J. Liposome Res., 30, 197, 10.1080/08982104.2019.1614952

Williams, 1987, The extracellular matrix of stratum corneum: role of lipids in normal and pathological function., Crit. Rev. Ther. Drug Carrier Syst., 3, 95

Wu, 2020, Self-powered Iontophoretic transdermal drug delivery system driven and regulated by biomechanical motions., Adv. Funct. Mater., 30

Wu, 2017, Formulation and characterization of hydroquinone nanostructured lipid carriers by homogenization emulsification method., J. Nanomater., 2017, 10.1155/2017/3282693

Zaib, 2019, Nanotechnology: applications, techniques, approaches, & the advancement in toxicology and environmental impact of engineered nanomaterials., Importance Appl. Nanotechnol., 8, 1

Zaytsev, 2020, Optimized skin optical clearing for optical coherence tomography monitoring of encapsulated drug delivery through the hair follicles., J. Biophotonics, 13, 10.1002/jbio.201960020