Enhancing Cognitive Functioning in Healthly Older Adults: a Systematic Review of the Clinical Significance of Commercially Available Computerized Cognitive Training in Preventing Cognitive Decline

AccessEconomics (2004). Delaying the onset of Alzheimer’s disease: projections and issues. Anand, R., Chapman, S. B., Rackley, A., Keebler, M., Zientz, J., & Hart, J. (2011). Gist reasoning training in cognitively normal seniors. International Journal of Geriatric Psychiatry, 26(9), 961–968. Anderson, S., White-Schwoch, T., Parbery-Clark, A., & Kraus, N. (2013). Reversal of age-related neural timing delays with training. Proceedings of the National Academy of Sciences, 110(11), 4357–4362. Anderson, S., White-Schwoch, T., Choi, H. J., & Kraus, N. (2014). Partial maintenance of auditory-based cognitive training benefits in older adults. Neuropsychologia, 62, 286–296. Anderson-Hanley, C., Arciero, P. J., Brickman, A. M., Nimon, J. P., Okuma, N., Westen, S. C., et al. (2012). Exergaming and older adult cognition: A cluster randomized clinical trial. American Journal of Preventive Medicine, 42(2), 109–119. Bahar-Fuchs, A., Clare, L., & Woods, B. (2013). Cognitive training and cognitive rehabilitation for mild to moderate Alzheimer’s disease and vascular dementia. Cochrane Database of Systematic Reviews. doi:10.1002/14651858. Ball, K., & Owsley, C. (1993). The useful field of view test: a new technique for evaluating age-related declines in visual function. Journal of the American Optometric Association, 64(1), 71–79. Ball, K. K., Beard, B. L., Roenker, D. L., Miller, R. L., & Griggs, D. S. (1988). Age and visual search: Expanding the useful field of view. Journal of the Optical Society of America A, 5(12), 2210–2219. Ball, K., Berch, D. B., Helmers, K. F., Jobe, J. B., Leveck, M. D., Marsiske, M., et al. (2002a). Effects of cognitive training interventions with older adults: a randomized controlled trial. The Journal of the American Medical Association, 288(18), 2271–2281. Ball, K. K., Wadley, V. G., & Edwards, J. D. (2002b). Advances in technology used to assess and retrain older drivers. Gerontechnology, 1(4), 251–261. Ball, K. K., Ross, L. A., Roth, D. L., & Edwards, J. D. (2013). Speed of Processing Training in the ACTIVE Study How Much Is Needed and Who Benefits? Journal of Aging and Health, 25(8 suppl), 65S–84S. Ballesteros, S., Prieto, A., Mayas, J., Toril, P., Pita, C., Ponce de León, L., et al. (2014). Brain training with non-action video games enhances aspects of cognition in older adults: a randomized controlled trial. Frontiers in Aging Neuroscience, 6, 277. doi:10.3389/fnagi.2014.00277. Ballesteros, S., Mayas, J., Prieto, A., Toril, P., Pita, C., Laura, P. D. L., et al. (2015a). A randomized controlled trial of brain training with non-action video games in older adults: results of the 3-month follow-up. Frontiers in Aging Neuroscience, 7, 45. doi:10.3389/fnagi.2015.00045. Ballesteros, S., Prieto, A., Mayas, J., & Waterworth, J. A. (2015b). Corrigendum: Brain training with non-action video games enhances aspects of cognition in older adults: a randomized controlled trial. Frontiers in Aging Neuroscience, 7, 82. Baltes, P. B., & Lindenberger, U. (1988). On the range of cognitive plasticity in old age as a function of experience: 15 years of intervention research. Behavior Therapy, 19(3), 283–300. Baltes, P. B., Kliegl, R., & Dittmann-Kohli, F. (1988). On the locus of training gains in research on the plasticity of fluid intelligence in old age. Journal of Educational Psychology, 80(3), 392–400. Bamidis, P. D., Fissler, P., Papageorgiou, S. G., Zilidou, V., Konstantinidis, E. I., Billis, A. S., et al. (2015). Gains in cognition through combined cognitive and physical training: the role of training dosage and severity of neurocognitive disorder. Frontiers in Aging Neuroscience, 7, 152. Barnes, D. E., Yaffe, K., Belfor, N., Jagust, W. J., DeCarli, C., Reed, B. R., et al. (2009). Computer-based cognitive training for mild cognitive impairment: results from a pilot randomized, controlled trial. Alzheimer Disease and Associated Disorders, 23(3), 205–210. doi:10.1097/WAD.0b013e31819c6137. Barnes, D. E., Santos-Modesitt, W., Poelke, G., Kramer, A. F., Castro, C., Middleton, L. E., et al. (2013). The Mental Activity and eXercise (MAX) trial: a randomized controlled trial to enhance cognitive function in older adults. JAMA Internal Medicine, 173(9), 797–804. Berry, A. S., Zanto, T. P., Clapp, W. C., Hardy, J. L., Delahunt, P. B., Mahncke, H. W., et al. (2010). The influence of perceptual training on working memory in older adults. PloS One, 5(7), e11537. Brainage.com official site - brain age: concentration training for Nintendo 3DS. http://brainage.nintendo.com/. Accessed 16 Sept 2015. Brainhq.com. http://www.brainhq.com/#. Accessed 15 Sept 2015. Brayne, C. (2007). The elephant in the room—healthy brains in later life, epidemiology and public health. Nature Reviews Neuroscience, 8(3), 233–239. Brehmer, Y., Rieckmann, A., Bellander, M., Westerberg, H., Fischer, H., & Bäckman, L. (2011). Neural correlates of training-related working-memory gains in old age. NeuroImage, 58(4), 1110–1120. doi:10.1016/j.neuroimage.2011.06.079. Buonomano, D. V., & Merzenich, M. M. (1998). Cortical plasticity: from synapses to maps. Annual Review of Neuroscience, 21(1), 149–186. Buschert, V., Bokde, A. L., & Hampel, H. (2010). Cognitive intervention in Alzheimer disease. Nature Reviews Neurology, 6(9), 508–517. Cameirão, M. S., Badia, S. B. I., Oller, E. D., & Verschure, P. F. M. J. (2010). Neurorehabilitation using the virtual reality based Rehabilitation Gaming System: methodology, design, psychometrics, usability and validation. Journal of NeuroEngineering and Rehabilitation, 7, 48. doi:10.1186/1743-0003-7-48. Casey, D. A., Antimisiaris, D., & O’Brien, J. (2010). Drugs for Alzheimer’s disease: are they effective? Pharmacy and Therapeutics, 35(4), 208–211. Chapman, S. B., Aslan, S., Spence, J. S., Hart, J. J., Bartz, E. K., Didehbani, N., et al. (2013). Neural Mechanisms of Brain Plasticity with Complex Cognitive Training in Healthy Seniors. Cerebral Cortex. doi:10.1093/cercor/bht234. Cicerone, K. D., Langenbahn, D. M., Braden, C., Malec, J. F., Kalmar, K., Fraas, M., et al. (2011). Evidence-based cognitive rehabilitation: updated review of the literature from 2003 through 2008. Archives of Physical Medicine and Rehabilitation, 92(4), 519–530. Cogmed.com cogmed working memory training. http://www.cogmed.com/. Accessed 17 Sept 2015. Cohen, J. (1988). Statistical power analysis for the behavioral sciences. New York: Academic. Dakim.com Dakim brainfitness. https://www.dakim.com/. Accessed 17 Sept 2015. Edwards, J. D., Wadley, V. G., Myers, R. S., Roenker, D. L., Cissell, G. M., & Ball, K. K. (2002). Transfer of a Speed of Processing Intervention to Near and Far Cognitive Functions. Gerontology, 48(5), 329–340. Edwards, J. D., Vance, D. E., Wadley, V. G., Cissell, G. M., Roenker, D. L., & Ball, K. K. (2005). Reliability and validity of useful field of view test scores as administered by personal computer. Journal of Clinical and Experimental Neuropsychology, 27(5), 529–543. Edwards, J. D., Ross, L. A., Wadley, V. G., Clay, O. J., Crowe, M., Roenker, D. L., et al. (2006). The useful field of view test: normative data for older adults. Archives of Clinical Neuropsychology, 21(4), 275–286. Edwards, J. D., Valdés, E. G., Peronto, C., Castora-Binkley, M., Alwerdt, J., Andel, R., et al. (2013). The efficacy of InSight cognitive training to improve useful field of view performance: A brief report. The Journals of Gerontology Series B: Psychological Sciences and Social Sciences, 70(3), 417–422. doi:10.1093/geronb/gbt113. Engvig, A., Fjell, A. M., Westlye, L. T., Moberget, T., Sundseth, Ø., Larsen, V. A., et al. (2010). Effects of memory training on cortical thickness in the elderly. NeuroImage, 52(4), 1667–1676. Engvig, A., Fjell, A. M., Westlye, L. T., Moberget, T., Sundseth, Ø., Larsen, V. A., et al. (2012). Memory training impacts short-term changes in aging white matter: A longitudinal diffusion tensor imaging study. Human Brain Mapping, 33(10), 2390–2406. Fernandez, A. (2010). Transforming brain health with digital tools to assess, enhance and treat cognition across the lifespan: the state of the brain health market. <http://www.sharpbrains.com/executive-summary/>. Accessed 9 Feb 2011. Frantzidis, C. A., Ladas, A.-K. I., Vivas, A. B., Tsolaki, M., & Bamidis, P. D. (2014). Cognitive and physical training for the elderly: Evaluating outcome efficacy by means of neurophysiological synchronization. International Journal of Psychophysiology, 93(1), 1–11. doi:10.1016/j.ijpsycho.2014.01.007. Fratiglioni, L., Paillard-Borg, S., & Winblad, B. (2004). An active and socially integrated lifestyle in late life might protect against dementia. The Lancet Neurology, 3(6), 343–353. Galante, E., Venturini, G., & Fiaccadori, C. (2007). Computer-based cognitive intervention for dementia: Preliminary results of a randomized clinical trial. The Italian Journal of Occupational Medicine and Ergonomics, 29(3 suppl B), B26–B32. Gates, N., Sachdev, P., Singh, M. F., & Valenzuela, M. (2011). Cognitive and memory training in adults at risk of dementia: A systematic review. BMC Geriatrics, 11(1), 55. doi:10.1186/1471-2318-11-55. Geyer, J., Insel, P., Farzin, F., Sternberg, D., Hardy, J. L., Scanlon, M., et al. (2015). Evidence for age-associated cognitive decline from internet game scores. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 1(2), 260–267. Günther, V. K., Schäfer, P., Holzner, B., & Kemmler, G. (2003). Long-term improvements in cognitive performance through computer-assisted cognitive training: A pilot study in a residential home for older people. Aging & Mental Health, 7(3), 200–206. Haier, R. J., Siegel, B. V., Jr., MacLachlan, A., Soderling, E., Lottenberg, S., & Buchsbaum, M. S. (1992). Regional glucose metabolic changes after learning a complex visuospatial/motor task: A positron emission tomographic study. Brain Research, 570(1), 134–143. Haimov, I., Hanuka, E., & Horowitz, Y. (2008). Chronic insomnia and cognitive functioning among older adults. Behavioral Sleep Medicine, 6(1), 32–54. Hardy, J., & Scanlon, M. (2009). The science behind lumosity. Hardy, J. L., Nelson, R. A., Thomason, M. E., Sternberg, D. A., Katovich, K., Farzin, F., et al. (2015). Enhancing cognitive abilities with comprehensive training: A large, online, randomized, active-controlled trial. PloS One, 10(9), e0134467. Jobe, J. B., Smith, D. M., Ball, K., Tennstedt, S. L., Marsiske, M., Willis, S. L., et al. (2001). ACTIVE: A cognitive intervention trial to promote independence in older adults. Controlled Clinical Trials, 22(4), 453–479. Johansson, B. B. (2004). Brain plasticity in health and disease. The Keio Journal of Medicine, 53(4), 231–246. Koepp, M., Gunn, R., Lawrence, A., Cunningham, V., Dagher, A., Jones, T., et al. (1998). Evidence for striatal dopamine release during a video game. Nature, 393(6682), 266–267. Kueider, A. M., Parisi, J. M., Gross, A. L., & Rebok, G. W. (2012). Computerized cognitive training with older adults: A systematic review. PloS One, 7(7), e40588. Lampit, A., Hallock, H., & Valenzuela, M. (2014). Computerized cognitive training in cognitively healthy older adults: A systematic review and meta-analysis of effect modifiers. PLoS Medicine, 11(11), e1001756. Landau, S. M., Marks, S. M., Mormino, E. C., Rabinovici, G. D., Oh, H., O’Neil, J. P., et al. (2012). Association of lifetime cognitive engagement and low beta-amyloid deposition. Archives of Neurology, 69(5), 623–629. Leung, N. T., Tam, H. M., Chu, L. W., Kwok, T. C., Chan, F., Lam, L. C., et al. (2015). Neural plastic effects of cognitive training on aging brain. Neural Plasticity, 501, 535618. doi:10.1155/2015/535618. Lewis, M. S., & Miller, L. S. (2007). Executive control functioning and functional ability in older adults. The Clinical Neuropsychologist, 21(2), 274–285. Lumosity.com brain games & brain training - lumosity. http://www.lumosity.com/. Accessed 17 Sept 2015. Maher, C. G., Sherrington, C., Herbert, R. D., Moseley, A. M., & Elkins, M. (2003). Reliability of the PEDro scale for rating quality of randomized controlled trials. Physical Therapy, 83(8), 713–721. Mahncke, H. W., Connor, B. B., Appelman, J., Ahsanuddin, O. N., Hardy, J. L., Wood, R. A., et al. (2006). Memory enhancement in healthy older adults using a brain plasticity-based training program: A randomized, controlled study. Proceedings of the National Academy of Sciences, 103(33), 12523–12528. Mayas, J., Parmentier, F. B., Andrés, P., & Ballesteros, S. (2014). Plasticity of attentional functions in older adults after non-action video game training: a randomized controlled trial. PloS One, 9(3), e92269. Merzenich, M. M. & Jenkins, W. M. (1993). Cortical representation of learned behaviors. In P. Andersen (Ed.), Memory Concepts (pp. 437-453). Amsterdam: Elsevier. Merzenich, M. M. & Jenkins, W. M. (1999). In S. Levy-Reiner (Ed.), The adaptable brain (Vol. II, pp 37-50). Washington, DC: Library of Congress. Miller, K. J., Dye, R. V., Kim, J., Jennings, J. L., O’Toole, E., Wong, J., et al. (2013). Effect of a computerized brain exercise program on cognitive performance in older adults. American Journal of Geriatric Psychiatry, 21(7), 655–663. doi:10.1016/j.jagp.2013.01.077. Mowszowski, L., Batchelor, J., & Naismith, S. L. (2010). Early intervention for cognitive decline: can cognitive training be used as a selective prevention technique? International Psychogeriatrics, 22(04), 537–548. Mybraintrainer.com brain exercises, brain age test and cognitive exercises by MyBrainTrainer. http://www.mybraintrainer.com/. Accessed 17 Sept 2015. Ngandu, T., Lehtisalo, J., Solomon, A., Levälahti, E., Ahtiluoto, S., Antikainen, R., et al. (2015). A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): A randomised controlled trial. The Lancet, 385(9984), 2255–2263. Nouchi, R., Taki, Y., Takeuchi, H., Hashizume, H., Akitsuki, Y., Shigemune, Y., et al. (2012). Brain training game improves executive functions and processing speed in the elderly: A randomized controlled trial. PLoS One, 7(1), e29676. Nouchi, R., Taki, Y., Takeuchi, H., Hashizume, H., Nozawa, T., Kambara, T., et al. (2013). Brain training game boosts executive functions, working memory and processing speed in the young adults: A randomized controlled trial. PloS One, 8(2), e55518. Nyberg, L., Sandblom, J., Jones, S., Neely, A. S., Petersson, K. M., Ingvar, M., et al. (2003). Neural correlates of training-related memory improvement in adulthood and aging. Proceedings of the National Academy of Sciences, 100(23), 13728–13733. O’Brien, J. L., Edwards, J. D., Maxfield, N. D., Peronto, C. L., Williams, V. A., & Lister, J. J. (2013). Cognitive training and selective attention in the aging brain: An electrophysiological study. Clinical Neurophysiology, 124(11), 2198–2208. Olesen, P. J., Westerberg, H., & Klingberg, T. (2003). Increased prefrontal and parietal activity after training of working memory. Nature Neuroscience, 7(1), 75–79. Owen, A. M., Hampshire, A., Grahn, J. A., Stenton, R., Dajani, S., Burns, A. S., et al. (2010). Putting brain training to the test. Nature, 465(7299), 775–778. Owsley, C., Ball, K., McGwin, G., Sloane, M. E., Roenker, D. L., White, M. F., et al. (1998). Visual processing impairment and risk of motor vehicle crash among older adults. The Journal of the American Medical Association, 279(14), 1083–1088. Pascual-Leone, A., Amedi, A., Fregni, F., & Merabet, L. B. (2005). The plastic human brain cortex. Neuroscience, 28(1), 377–401. Peretz, C., Korczyn, A. D., Shatil, E., Aharonson, V., Birnboim, S., & Giladi, N. (2011). Computer-based, personalized cognitive training versus classical computer games: A randomized double-blind prospective trial of cognitive stimulation. Neuroepidemiology, 36(2), 91–99. Petersen, R. C., Doody, R., Kurz, A., Mohs, R. C., Morris, J. C., Rabins, P. V., et al. (2001). Current concepts in mild cognitive impairment. Archives of Neurology, 58(12), 1985–1992. Rebok, G. W., Ball, K., Guey, L. T., Jones, R. N., Kim, H. Y., King, J. W., et al. (2014). Ten-year effects of the advanced cognitive training for independent and vital elderly cognitive training trial on cognition and everyday functioning in older adults. Journal of the American Geriatrics Society, 62(1), 16–24. Recanzone, G. H., Merzenich, M. M., Jenkins, W. M., Grajski, K. A., & Dinse, H. R. (1992). Topographic reorganization of the hand representation in cortical area 3b owl monkeys trained in a frequency-discrimination task. Journal of Neurophysiology, 67(5), 1031–1056. Recanzone, G. H., Schreiner, C. E., & Merzenich, M. M. (1993). Plasticity in the frequency representation of primary auditory cortex following discrimination training in adult owl monkeys. Journal of Neuroscience, 13(1), 87–103. Reitz, C., Brayne, C., & Mayeux, R. (2011). Epidemiology of Alzheimer disease. Nature Reviews Neurology, 7(3), 137–152. Rosen, A. C., Sugiura, L., Kramer, J. H., Whitfield-Gabrieli, S., & Gabrieli, J. D. (2011). Cognitive training changes hippocampal function in mild cognitive impairment: A pilot study. Journal of Alzheimer’s Disease, 3, 349–357. Ruthirakuhan, M., Luedke, A. C., Tam, A., Goel, A., Kurji, A., & Garcia, A. (2012). Use of physical and intellectual activities and socialization in the management of cognitive decline of aging and in dementia: A review. Journal of Aging Research, 2012, 384875. doi:10.1155/2012/384875. Sanders, A. F. (1970). Some aspects of the selective process in the functional visual field. Ergonomics, 13(1), 101–117. Scanlon, M., Drescher, D., & Sarkar, K. (2007). Improvement of visual attention and working memory through a web-based cognitive training program. A Lumos Labs White Paper. Scarmeas, N., Levy, G., Tang, M. X., Manly, J., & Stern, Y. (2001). Influence of leisure activity on the incidence of Alzheimer’s disease. Neurology, 57(12), 2236–2242. Schaie, K. W., & Willis, S. L. (1986). Can decline in adult intellectual functioning be reversed. Developmental Psychology, 22(2), 223–232. Schonknecht, P., Pantel, J., Kruse, A., & Schroder, J. (2005). Prevalence and natural course of aging-associated cognitive decline in a population-based sample of young-old subjects. American Journal of Psychiatry, 162(11), 2071–2077. doi:10.1176/appi.ajp.162.11.2071. Shah, T., Verdile, G., Sohrabi, H., Campbell, A., Putland, E., Cheetham, C., et al. (2014). A combination of physical activity and computerized brain training improves verbal memory and increases cerebral glucose metabolism in the elderly. Translational Psychiatry, 4(12), e487. Shao, Y.-K., Mang, J., Li, P.-L., Wang, J., Deng, T., & Xu, Z.-X. (2015). Computer-based cognitive programs for improvement of memory, processing speed and executive function during age-related cognitive decline: a meta-analysis. PloS One, 10(6), e0130831. Shatil, E. (2013). Does combined cognitive training and physical activity training enhance cognitive abilities more than either alone? a four-condition randomized controlled trial among healthy older adults. Frontiers in Aging Neuroscience, 5, 8. doi:10.3389/fnagi.2013.00008. Shatil, E., Mikulecká, J., Bellotti, F., & Bureš, V. (2014). Novel television-based cognitive training improves working memory and executive function. PloS One, 9(7), e101472. doi:10.1371/journal.pone.0101472. Simpson, T., Camfield, D., Pipingas, A., Macpherson, H., & Stough, C. (2012). Improved processing speed: Online computer-based cognitive training in older adults. Educational Gerontology, 38(7), 445–458. Slegers, K., van Boxtel, M., & Jolles, J. (2009). Effects of computer training and internet usage on cognitive abilities in older adults: A randomized controlled study. Aging Clinical and Experimental Research, 21(1), 43–54. Small, G. W., Silverman, D. H. S., Siddarth, P., Ercoli, L. M., Miller, K. J., Lavretsky, H., et al. (2006). Effects of a 14-day healthy longevity lifestyle program on cognition and brain function. American Journal of Geriatric Psychiatry, 14(6), 538–545. Smith, G. E., Housen, P., Yaffe, K., Ruff, R., Kennison, R. F., Mahncke, H. W., et al. (2009). A cognitive training program based on principles of brain plasticity: Results from the improvement in memory with plasticity-based adaptive cognitive training (IMPACT) study. Journal of the American Geriatrics Society, 57(4), 594–603. Stern, Y. (2006). Cognitive reserve and Alzheimer disease. Alzheimer Disease & Associated Disorders, 20, S69. Stern, Y. (2012). Cognitive reserve in ageing and Alzheimer’s disease. The Lancet Neurology, 11(11), 1006–1012. Strenziok, M., Parasuraman, R., Clarke, E., Cisler, D. S., Thompson, J. C., & Greenwood, P. M. (2014). Neurocognitive enhancement in older adults: Comparison of three cognitive training tasks to test a hypothesis of training transfer in brain connectivity. NeuroImage, 85, 1027–1039. doi:10.1016/j.neuroimage.2013.07.069. Tárraga, L., Boada, M., Modinos, G., Espinosa, A., Diego, S., Morera, A., et al. (2006). A randomised pilot study to assess the efficacy of an interactive, multimedia tool of cognitive stimulation in Alzheimer’s disease. Journal of Neurology, Neurosurgery & Psychiatry, 77(10), 1116–1121. Valenzuela, M. J., & Sachdev, P. (2006). Brain reserve and dementia: A systematic review. Psychological Medicine, 36(04), 441–454. Valenzuela, M. J., Jones, M., Wen, W., Rae, C., Graham, S., Shnier, R., et al. (2003). Memory training alters hippocampal neurochemistry in healthy elderly. Neuroreport, 14(10), 1333–1337. Verghese, J., Lipton, R. B., Katz, M. J., Hall, C. B., Derby, C. A., Kuslansky, G., et al. (2003). Leisure activities and the risk of dementia in the elderly. New England Journal of Medicine, 348(25), 2508–2516. Verghese, J., Mahoney, J., Ambrose, A. F., Wang, C., & Holtzer, R. (2010). Effect of cognitive remediation on gait in sedentary seniors. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 65(12), 1338–1343. doi:10.1093/gerona/glq127. Vinogradov, S., Fisher, M., Holland, C., Shelly, W., Wolkowitz, O., & Mellon, S. H. (2009). Is serum brain-derived neurotrophic factor a biomarker for cognitive enhancement in schizophrenia? Biological Psychiatry, 66(6), 549–553. Walser, R. F., Meserve, B. B., & Boucher, T. R. (2009). The effectiveness of thoracic spine manipulation for the management of musculoskeletal conditions: A systematic review and meta-analysis of randomized clinical trials. The Journal of Manual & Manipulative Therapy, 17(4), 237–246. doi:10.1179/106698109791352085. Willis, S. L. (1987). Cognitive training and everyday competence. Annual Review of Gerontology & Geriatrics, 7, 159–188. Willis, S. L., Tennstedt, S. L., Marsiske, M., Ball, K., Elias, J., Koepke, K. M., et al. (2006). Long-term effects of cognitive training on everyday functional outcomes in older adults. The Journal of the American Medical Association, 296(23), 2805–2814. Wilson, R., Scherr, P., Schneider, J., Tang, Y., & Bennett, D. (2007). Relation of cognitive activity to risk of developing Alzheimer disease. Neurology, 69(20), 1911–1920. Wolinsky, F. D., Unverzagt, F. W., Smith, D. M., Jones, R., Stoddard, A., & Tennstedt, S. L. (2006a). The ACTIVE cognitive training trial and health-related quality of life: protection that lasts for 5 years. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 61(12), 1324–1329. Wolinsky, F. D., Unverzagt, F. W., Smith, D. M., Jones, R., Wright, E., & Tennstedt, S. L. (2006b). The effects of the ACTIVE cognitive training trial on clinically relevant declines in health-related quality of life. The Journals of Gerontology: Series B, 61(5), S281–S287. Wolinsky, F. D., Vander Weg, M. W., Howren, M. B., Jones, M. P., & Dotson, M. M. (2013). A randomized controlled trial of cognitive training using a visual speed of processing intervention in middle aged and older adults. PloS One, 8, (5), e61624. doi:10.1371/journal.pone.0061624. Woods, S. P., Weinborn, M., Velnoweth, A., Rooney, A., & Bucks, R. S. (2012). Memory for intentions is uniquely associated with instrumental activities of daily living in healthy older adults. Journal of the International Neuropsychological Society, 18(1), 134–138. doi:10.1017/S1355617711001263. Woodward, M., & Brodaty, H. (2007). Dementia risk reduction: the evidence: Alzheimer’s Australia. Xerri, C., Merzenich, M. M., Jenkins, W., & Santucci, S. (1999). Representational plasticity in cortical area 3b paralleling tactual-motor skill acquisition in adult monkeys. Cerebral Cortex, 9(3), 264–276. Zelinski, E. M., Spina, L. M., Yaffe, K., Ruff, R., Kennison, R. F., Mahncke, H. W., et al. (2011). Improvement in memory with plasticity-based adaptive cognitive training: Results of the 3-month follow-up. Journal of the American Geriatrics Society, 59(2), 258–265.