Enhancement in liver SREBP-1c/PPAR-α ratio and steatosis in obese patients: Correlations with insulin resistance and n-3 long-chain polyunsaturated fatty acid depletion

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Tập 1792 Số 11 - Trang 1080-1086 - 2009
Paulina Pettinelli1, Talía del Pozo2, Julia Araya3, Ramón Rodrigo1, A. Verónica Araya4, G Smok5, Attila Csendes6, Luís Gutiérrez6, Jorge Rojas6, Owen Korn6, Fernando Maluenda6, Juan Carlos Díaz6, G. Rencoret6, Italo Braghetto6, Jaime Castillo6, Jaime Poníachik7, Luis A. Videla1
1Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
2Laboratory of Bioinformatics and Gene Expression, Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile
3Department of Nutrition, Faculty of Medicine, University of Chile, Santiago, Chile
4Department of Endocrinology, University of Chile Clinical Hospital, Santiago, Chile
5Department of Pathological Anatomy, University of Chile Clinical Hospital, Santiago, Chile
6Department of Surgery, University of Chile Clinical Hospital, Santiago, Chile
7Department of Medicine, University of Chile, Clinical Hospital, Santiago, Chile

Tóm tắt

Từ khóa


Tài liệu tham khảo

Angulo, 2002, Nonalcoholic fatty liver disease, New Engl. J. Med., 346, 1221, 10.1056/NEJMra011775

George, 2008, Nonalcoholic fatty liver disease: pathogenesis and potential for nuclear receptors as therapeutic targets, Mol. Pharm., 5, 49, 10.1021/mp700110z

Videla, 2006, Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease, Trends Mol. Med., 12, 555, 10.1016/j.molmed.2006.10.001

Nielsen, 2004, Splanchnic lipolysis in human obesity, J. Clin. Invest., 113, 1582, 10.1172/JCI21047

Fabbrini, 2008, Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease, Gastroenterology, 134, 424, 10.1053/j.gastro.2007.11.038

Araya, 2004, Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease, Clin. Sci., 106, 635, 10.1042/CS20030326

Elizondo, 2007, Polyunsaturated fatty acid pattern in liver and erythrocyte phospholipids from obese patients, Obesity, 15, 24, 10.1038/oby.2007.518

Videla, 2004, Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients, Clin. Sci., 106, 261, 10.1042/CS20030285

Borkman, 1993, The relationship between insulin sensitivity and the fatty acid composition of phospholipids of skeletal muscle, N. Engl. J. Med., 328, 238, 10.1056/NEJM199301283280404

Lombardo, 2006, Effects of dietary polyunsaturated n-3 fatty acids on dyslipidemia and insulin resistance in rodents and humans. A review, J. Nutr. Biochem., 17, 1, 10.1016/j.jnutbio.2005.08.002

Jump, 2005, Fatty acid regulation of hepatic gene transcription, J. Nutr., 135, 2503, 10.1093/jn/135.11.2503

Sampath, 2005, Polyunsaturated fatty acid regulation of genes of lipid metabolism, Annu. Rev. Nutr., 25, 317, 10.1146/annurev.nutr.25.051804.101917

Lindén, 2002, Influence of peroxisome proliferator-activated receptor α agonists on the intracellular turnover and secretion of apolipoprotein (apo) B-100 and apoB48, J. Biol. Chem., 277, 23044, 10.1074/jbc.M110416200

Kadowaki, 2005, Adiponectin and adiponectin receptors, Endocr. Rev., 26, 439, 10.1210/er.2005-0005

Matthews, 1985, Homeostasis model assessment: insulin resistance and β-cell function from fasting glucose and insulin concentration in man, Diabetologia, 28, 412, 10.1007/BF00280883

Chomczynski, 1987, Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction, Anal. Biochem., 162, 156, 10.1016/0003-2697(87)90021-2

Ramakers, 2003, Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data, Neurosci. Lett., 339, 62, 10.1016/S0304-3940(02)01423-4

Dheda, 2004, Validation of housekeeping genes for normalizing RNA expression in real-time PCR, Biotechniques, 37, 112, 10.2144/04371RR03

Bligh, 1959, A rapid method of total lipid extraction, Can. J. Biochem. Physiol., 37, 911, 10.1139/o59-099

Schwarz, 2003, Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets, Am. J. Clin. Nutr., 77, 43, 10.1093/ajcn/77.1.43

Timlin, 2005, Temporal pattern of de novo lipogenesis in the postprandial state in health men, Am. J. Clin. Nutr., 81, 35, 10.1093/ajcn/81.1.35

Donnelly, 2005, Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease, J. Clin. Invest., 115, 1343, 10.1172/JCI23621

Tamura, 2005, Contribution of adipose tissue and de novo lipogenesis to nonalcoholic fatty liver disease, J. Clin. Invest., 115, 1139, 10.1172/JCI24930

Sato, 2009, SREBPs: protein interaction and SREBPs, FEBS J., 276, 622, 10.1111/j.1742-4658.2008.06807.x

Palmer, 1998, Peroxisome proliferator activated receptor-α expression in human liver, Mol. Pharmacol., 53, 14, 10.1124/mol.53.1.14

Mukherjee, 1994, Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators, J. Steroid Biochem. Mol. Biol., 51, 157, 10.1016/0960-0760(94)90089-2

Reddy, 2004, Peroxisome proliferators and peroxisome proliferator-activated receptor α. Biotic and xenobiotic sensing, Am. J. Pathol., 164, 2305, 10.1016/S0002-9440(10)63787-X

Gervois, 1999, A truncated human peroxisome proliferator-activated receptor α splice variant with dominant negative activity, Mol. Endocrinol., 13, 1535

Ye, 2008, Regulation of PPARγ function by TNF-α, Biochem. Biophys. Res. Commun., 374, 405, 10.1016/j.bbrc.2008.07.068

Poniachik, 2006, Increased production of IL-1α and TNF-α in lipopolysaccharide-stimulated blood from obese patients with non-alcoholic fatty liver disease, Cytokine, 33, 252, 10.1016/j.cyto.2006.02.006

Murakami, 1999, Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha, Biochem. Biophys. Res. Commun., 260, 609, 10.1006/bbrc.1999.0951

Elizondo, 2008, Effects of weight loss on liver and erythrocyte polyunsaturated fatty acid pattern and oxidative stress status in obese patients with non-alcoholic fatty liver disease, Biol. Res., 41, 59, 10.4067/S0716-97602008000100008

Yamauchi, 2001, The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity, Nat. Med., 7, 941, 10.1038/90984

Kohjima, 2007, Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease, Int. J. Mol. Med., 20, 351

Nakamuta, 2008, The significance of differences in fatty acid metabolism between obese and non-obese patients with non-alcoholic fatty liver disease, Int. J. Mol. Med., 22, 663

Clarke, 2001, Polyunsaturated fatty acid regulation of gene transcription: a molecular mechanism to improve the metabolic syndrome, J. Nutr., 131, 1129, 10.1093/jn/131.4.1129

Capanni, 2006, Prolonged n-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease: a pilot study, Aliment. Pharmacol. Ther., 23, 1143, 10.1111/j.1365-2036.2006.02885.x

Videla, 2008, Oxidative stress and insulin resistance as interdependent pathogenic mechanisms in non-alcoholic fatty liver disease associated with obesity, 369

Ferré, 2007, SREBP-1c transcription factor and lipid homeostasis: clinical perspective, Horm. Res., 68, 72, 10.1159/000100426

Videla, 2009, Liver NF-κB and AP-1 DNA binding in obese patients, Obesity, 17, 973, 10.1038/oby.2008.601