Enhanced vascular endothelial growth factor signaling in islets contributes to β cell injury and consequential diabetes in spontaneously diabetic Torii rats

Ismail-Beigi, 2012, Clinical practice. Glycemic management of type 2 diabetes mellitus, New Engl J Med, 153, 44 King, 2012, The use of animal models in diabetes research, Br J Pharmacol, 166, 877, 10.1111/j.1476-5381.2012.01911.x Katsuda, 2014, Diabetic complications in obese type 2 diabetic rat models, Exp Anim, 64, 121, 10.1538/expanim.63.121 Shinohara, 2000, A new spontaneously diabetic non-obese Torii rat strain with severe ocular complications, Int J Exp Diabetes Res, 1, 89, 10.1155/EDR.2000.89 Ohta, 2007, Effect of insulin therapy on renal changes in spontaneously diabetic Torii rats, Exp Anim, 56, 355, 10.1538/expanim.56.355 Masuyama, 2004, Chronological characterization of diabetes development in male spontaneously diabetic Torii rats, Biochem Biophys Res Commun, 314, 870, 10.1016/j.bbrc.2003.12.180 Miki, 1997, Abnormalities of pancreatic islets by targeted expression of a dominant-negative KATP channel, Proc Natl Acad Sci USA, 94, 11969, 10.1073/pnas.94.22.11969 Mukai, 2011, Exendin-4 suppresses SRC activation and reactive oxygen species production in diabetic Goto-Kakizaki rat islets in an Epac-dependent manner, Diabetes, 60, 218, 10.2337/db10-0021 Kawamura, 2008, Vascular endothelial growth factor (VEGF)-A165b is a weak in vitro agonist for VEGF receptor-2 due to lack of coreceptor binding and deficient regulation of kinase activity, Cancer Res, 68, 4683, 10.1158/0008-5472.CAN-07-6577 Masuda, 2001, Vascular endothelial growth factor enhances glomerular capillary repair and accelerates resolution of experimentally induced glomerulonephritis, Am J Pathol, 159, 599, 10.1016/S0002-9440(10)61731-2 Takahashi, 2004, A novel snake venom vascular endothelial growth factor (VEGF) predominantly induces vascular permeability through preferential signaling via VEGF receptor-1, J Biol Chem, 279, 46304, 10.1074/jbc.M403687200 Shibuya, 2006, Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis, Exp Cell Res, 312, 549, 10.1016/j.yexcr.2005.11.012 Kuroda, 1995, Colocalization of vascular endothelial growth factor (vascular permeability factor) and insulin in pancreatic islet cells, J Clin Endocrinol Metab, 80, 3196 Li, 2006, Islet microvasculature in islet hyperplasia and failure in a model of type 2 diabetes, Diabetes, 55, 2965, 10.2337/db06-0733 Brissova, 2006, Pancreatic islet production of vascular endothelial growth factor-a is essential for islet vascularization, revascularization, and function, Diabetes, 55, 2974, 10.2337/db06-0690 Donath, 2010, Cytokine production by islets in health and diabetes: cellular origin, regulation and function, Trends Endocrinol Metab, 21, 261, 10.1016/j.tem.2009.12.010 Donath, 2011, Type 2 diabetes as an inflammatory disease, Nat Rev Immunol, 11, 98, 10.1038/nri2925 Inokuchi, 2009, Role of macrophages in the development of pancreatic islet injury in spontaneously diabetic torii rats, Exp Anim, 58, 383, 10.1538/expanim.58.383 Faivre, 2007, Molecular basis for sunitinib efficacy and future clinical development, Nat Rev Drug Discovery, 6, 734, 10.1038/nrd2380 Eberhard, 2010, ‘Giving and taking’: endothelial and beta-cells in the islets of Langerhans, Trends Endocrinol Metab, 21, 457, 10.1016/j.tem.2010.03.003 Lammert, 2003, Role of VEGF-A in vascularization of pancreatic islets, Curr Biol, 13, 1070, 10.1016/S0960-9822(03)00378-6 Iwashita, 2007, Impaired insulin secretion in vivo but enhanced insulin secretion from isolated islets in pancreatic beta cell-specific vascular endothelial growth factor-A knock-out mice, Diabetologia, 50, 380, 10.1007/s00125-006-0512-0 Claesson-Welsh, 2013, VEGFA and tumour angiogenesis, J Intern Med, 273, 114, 10.1111/joim.12019 Vasir, 1998, Hypoxia induces vascular endothelial growth factor gene and protein expression in cultured rat islet cells, Diabetes, 47, 1894, 10.2337/diabetes.47.12.1894 Westwell-Roper, 2014, Resident macrophages mediate islet amyloid polypeptide-induced islet IL-1β production and β-cell dysfunction, Diabetes, 63, 1698, 10.2337/db13-0863 Fuse, 2008, Identification of a major locus for islet inflammation and fibrosis in the spontaneously diabetic Torii rat, Physiol Genomics, 35, 96, 10.1152/physiolgenomics.90214.2008 Mokhtari, 2009, Potential utility of small tyrosine kinase inhibitors in the treatment of diabetes, Clin Sci (Lond), 118, 241, 10.1042/CS20090348 Billemont, 2008, Blood glucose levels in patients with metastatic renal cell carcinoma treated with sunitinib, Br J Cancer, 99, 1380, 10.1038/sj.bjc.6604709 Louvet, 2008, Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice, Proc Natl Acad Sci USA, 105, 18895, 10.1073/pnas.0810246105 Hagerkvist, 2007, Amelioration of diabetes by imatinib mesylate (Gleevec): role of beta-cell NF-kappaB activation and anti-apoptotic preconditioning, FASEB J, 21, 618, 10.1096/fj.06-6910com Han, 2009, Imatinib mesylate reduces endoplasmic reticulum stress and induces remission of diabetes in db/db mice, Diabetes, 58, 329, 10.2337/db08-0080 Portha, 2009, The GK rat beta-cell: a prototype for the diseased human beta-cell in type 2 diabetes, Mol Cell Endocrinol, 297, 73, 10.1016/j.mce.2008.06.013