Enhanced cellular cholesterol efflux by naringenin is mediated through inhibiting endoplasmic reticulum stress - ATF6 activity in macrophages

Phillips, 2014, Molecular mechanisms of cellular cholesterol efflux, J. Biol. Chem., 289, 24020, 10.1074/jbc.R114.583658

Zhao, 2010, Liver X receptor in cholesterol metabolism, J. Endocrinol., 204, 233, 10.1677/JOE-09-0271

Haze, 1999, Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress, Mol. Biol. Cell, 10, 3787, 10.1091/mbc.10.11.3787

Velho, 2017, Site-1 protease and lysosomal homeostasis, Biochim. Biophys. Acta, 1864, 2162, 10.1016/j.bbamcr.2017.06.023

Yoshida, 2000, ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response, Mol. Cell. Biol., 20, 6755, 10.1128/MCB.20.18.6755-6767.2000

Ye, 2000, ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs, Mol. Cell, 1355, 10.1016/S1097-2765(00)00133-7

Zeng, 2004, ATF6 modulates SREBP2-mediated lipogenesis, EMBO J., 23, 950, 10.1038/sj.emboj.7600106

Maruyama, 2013, ATF6α stimulates cholesterogenic gene expression and de novo cholesterol synthesis, Biosci. Biotechnol. Biochem., 77, 1734, 10.1271/bbb.130295

Yao, 2012, Minimally modified low-density lipoprotein induces macrophage endoplasmic reticulum stress via toll-like receptor 4, Biochim. Biophys. Acta, 1821, 954, 10.1016/j.bbalip.2012.03.003

Meex, 2009, The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels, Arterioscler. Thromb. Vasc. Biol., 29, 1322, 10.1161/ATVBAHA.108.180240

Mulvihill, 2010, Naringenin decreases progression of atherosclerosis by improving dyslipidemia in high-fat-fed low-density lipoprotein receptor-null mice, Arterioscler. Thromb. Vasc. Biol., 30, 742, 10.1161/ATVBAHA.109.201095

Goldwasser, 2010, Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPARalpha, PPARgamma and LXRalpha, PLoS One, 5, 10.1371/journal.pone.0012399

Shangguan, 2017, Naringin inhibits vascular endothelial cell apoptosis via endoplasmic reticulum stress- and mitochondrial-mediated pathways and promotes intraosseous angiogenesis in ovariectomized rats, Int. J. Mol. Med., 40, 1741

Tang, 2017, Naringenin ameliorates hypoxia/reoxygenation-induced endoplasmic reticulum stress-mediated apoptosis in H9c2 myocardial cells: involvement in ATF6, IRE1α and PERK signaling activation, Mol. Cell. Biochem., 424, 111, 10.1007/s11010-016-2848-1

Yao, 2012, Quercetin protects macrophages from oxidized low-density lipoprotein-induced apoptosis by inhibiting the endoplasmic reticulum stress-C/EBP homologous protein pathway, Exp. Biol. Med. (Maywood), 237, 822, 10.1258/ebm.2012.012027

Mostafa, 2019, Rutin hydrate inhibits apoptosis in the brains of cadmium chloride-treated rats via preserving the mitochondrial integrity and inhibiting endoplasmic reticulum stress, Neurol. Res., 1

Dong, 2014, Akt inhibition promotes ABCA1-mediated cholesterol efflux to ApoA-I through suppressing mTORC1, PLoS One, 9, 10.1371/journal.pone.0113789

Su, 2017, Inhibition of endoplasmic reticulum stress apoptosis by estrogen protects human umbilical vein endothelial cells through the PI3 kinase-akt signaling pathway, J. Cell. Biochem., 118, 4568, 10.1002/jcb.26120

Marcil, 2006, Oxidative stress influences cholesterol efflux in THP-1 macrophages: role of ATP-binding cassette A1 and nuclear factors, Cardiovasc. Res., 72, 473, 10.1016/j.cardiores.2006.08.024

Huang, 1997, Effects of genotype and diet on cholesterol efflux into plasma and lipoproteins of normal, apolipoprotein A-I-, and apolipoprotein E-deficient mice, Arterioscler. Thromb. Vasc. Biol., 17, 2010, 10.1161/01.ATV.17.10.2010

Mostafa, 2016, Effect of vildagliptin and pravastatin combination on cholesterol efflux in adipocytes, IUBMB Life, 68, 10.1002/iub.1510

Han, 2009, Interleukin-10 facilitates both cholesterol uptake and efflux in macrophages, J. Biol. Chem., 284, 32950, 10.1074/jbc.M109.040899

Chellan, 2014, IL-22 is induced by S100/calgranulin and impairs cholesterol efflux in macrophages by downregulating ABCG1, J. Lipid Res., 55, 443, 10.1194/jlr.M044305

Fu, 2014, Interleukin-27 inhibits foam cell formation by promoting macrophage ABCA1 expression through JAK2/STAT3 pathway, Biochem. Biophys. Res. Commun., 452, 881, 10.1016/j.bbrc.2014.08.120

Hotamisligil, 2010, Endoplasmic reticulum stress and atherosclerosis, Nat. Med., 16, 396, 10.1038/nm0410-396

Tabas, 2010, The role of endoplasmic reticulum stress in the progression of atherosclerosis, Circ. Res., 107, 839, 10.1161/CIRCRESAHA.110.224766

Ivanova, 2016, The role of endoplasmic reticulum stress and unfolded protein response in atherosclerosis, Int. J. Mol. Sci., 17, 193, 10.3390/ijms17020193

Han, 2016, The role of ER stress in lipid metabolism and lipotoxicity, J. Lipid Res., 57, 1329, 10.1194/jlr.R067595

Sekiya, 2014, Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages, J. Lipid Res., 55, 2082, 10.1194/jlr.M050864

Luchetti, 2017, Endothelial cells, endoplasmic reticulum stress and oxysterols, Redox Biol., 13, 581, 10.1016/j.redox.2017.07.014

Myoishi, 2007, Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndrome, Circulation., 116, 1226, 10.1161/CIRCULATIONAHA.106.682054

Park, 2014, Purple perilla extracts allay ER stress in lipid-laden macrophages, PLoS One, 9, 10.1371/journal.pone.0110581

Chanet, 2012, Naringin, the major grapefruit flavonoid, specifically affects atherosclerosis development in diet-induced hypercholesterolemia in mice, J. Nutr. Biochem., 469, 10.1016/j.jnutbio.2011.02.001

Feng, 2003, The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages, Nat. Cell Biol., 5, 781, 10.1038/ncb1035

Devries-Seimon, 2005, Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor, J. Cell Biol., 171, 61, 10.1083/jcb.200502078

Haghpassand, 2001, Monocyte/macrophage expression of ABCA1 has minimal contribution to plasma HDL levels, J. Clin. Invest., 108, 1315, 10.1172/JCI200112810

Basso, 2003, Role of the hepatic ABCA1 transporter in modulating intrahepatic cholesterol and plasma HDLcholesterolconcentrations, J. Lipid Res., 44, 296, 10.1194/jlr.M200414-JLR200

Brunham, 2006, Intestinal ABCA1 directly contributes to HDL biogenesis in vivo, J. Clin. Invest., 116, 1052, 10.1172/JCI27352

Linsel-Nitschke, 2009, Macrophage cholesterol efflux correlates with lipoprotein subclass distribution and risk of obstructive coronary artery disease in patients undergoing coronary angiography, Lipids Health Dis., 8, 14, 10.1186/1476-511X-8-14

Oh, 2012, Endoplasmic reticulum stress controls M2 macrophage differentiation and foam cell formation, J. Biol. Chem., 287, 11629, 10.1074/jbc.M111.338673

Oh, 2015, Deletion of macrophage vitamin D receptor promotes insulin resistance and monocyte cholesterol transport to accelerate atherosclerosis in mice, Cell Rep., 10, 1872, 10.1016/j.celrep.2015.02.043

Zhong, 2015, Inflammatory stress exacerbated mesangial foam cell formation and rRenalinjury via disrupting cellular cholesterol homeostasis, Inflammation., 38, 959, 10.1007/s10753-014-0058-0

Clément, 2016, Necrotic cell sensor Clec4e promotes a proatherogenic macrophage phenotype through activation of the unfolded protein response, Circulation., 134, 1039, 10.1161/CIRCULATIONAHA.116.022668

Saenz, 2018, Grapefruit flavonoid naringenin regulates the expression of LXRα in THP-1 macrophages by modulating AMP-activated protein kinase, Mol. Pharm., 15, 1735, 10.1021/acs.molpharmaceut.7b00797

Wang, 2014, The inhibition of RANKL-induced osteoclastogenesis through the suppression of p38 signaling pathway by naringenin and attenuation of titanium-particle-induced osteolysis, Int. J. Mol. Sci., 15, 21913, 10.3390/ijms151221913