Engineering drought tolerance in plants: discovering and tailoring genes to unlock the future

Boyer, 1982, Plant productivity and environment, Science, 218, 443, 10.1126/science.218.4571.443

Ramachandra-Reddy, 2004, Drought-induced responses of photosynthesis and antioxidant metabolism in higher plants, J Plant Physiol, 161, 1189, 10.1016/j.jplph.2004.01.013

Flowers, 2004, Improving crop salt tolerance, J Exp Bot, 55, 307, 10.1093/jxb/erh003

Vinocur, 2005, Recent advances in engineering plant tolerance to abiotic stress: achievements and limitations, Curr Opin Biotechnol, 16, 123, 10.1016/j.copbio.2005.02.001

Chaves, 2004, Mechanisms underlying plant resistance to water deficits: prospects for water-saving agriculture, J Exp Bot, 55, 2365, 10.1093/jxb/erh269

Chen, 2002, Enhancement of tolerance of abiotic stress by metabolic engineering of betaines and other compatible solutes, Curr Opin Plant Biol, 5, 250, 10.1016/S1369-5266(02)00255-8

Nyyssola, 2000, Extreme halophiles synthesize betaine from glycine by methylation, J Biol Chem, 275, 22196, 10.1074/jbc.M910111199

Waditee, 2003, Isolation and functional characterization of N-methyltransferases that catalyze betaine synthesis from glycine in a halotolerant photosynthetic organism Aphanothece halophytica, J Biol Chem, 278, 4932, 10.1074/jbc.M210970200

Waditee, 2005, Genes for direct methylation of glycine provide high levels of glycinebetaine and abiotic-stress tolerance in Synechococcus and Arabidopsis, Proc Natl Acad Sci USA, 102, 1318, 10.1073/pnas.0409017102

Bartels, 2005, Drought and salt tolerance in plants, Crit Rev Plant Sci, 24, 23, 10.1080/07352680590910410

Iuchi, 2001, Regulation of drought tolerance by gene manipulation of 9-cis-epoxycarotenoid dioxygenase, a key enzyme in abscisic acid biosynthesis in Arabidopsis, Plant J, 27, 325, 10.1046/j.1365-313x.2001.01096.x

Saito, 2004, Arabidopsis CYP707As encode (+)-abscisic acid 8′-hydroxylase, a key enzyme in the oxidative catabolism of abscisic acid, Plant Physiol, 134, 1439, 10.1104/pp.103.037614

Kushiro, 2004, The Arabidopsis cytochrome P450 CYP707A encodes ABA 8′-hydroxylases: key enzymes in ABA catabolism, EMBO J, 23, 1647, 10.1038/sj.emboj.7600121

Umezawa T, Okamoto M, Kushiro T, Nambara E, Oono Y, Seki M, Kobayashi M, Koshiba T, Kamiya Y, Shinozaki K: CYP707A3, a major ABA 8′-hydroxylase involved in dehydration and rehydration response in Arabidopsis thaliana. Plant J 2006: in press.

Goyal, 2005, LEA proteins prevent protein aggregation due to water stress, Biochem J, 388, 151, 10.1042/BJ20041931

Wise, 2003, LEAping to conclusions: a computational reanalysis of late embryogenesis abundant proteins and their possible roles, BMC Bioinformatics, 4, 52, 10.1186/1471-2105-4-52

Wise, 2004, POPP the question: what do LEA proteins do?, Trends Plant Sci, 9, 13, 10.1016/j.tplants.2003.10.012

Oksman-Caldentey, 2005, Integrating genomics and metabolomics for engineering plant metabolic pathways, Curr Opin Biotechnol, 16, 174, 10.1016/j.copbio.2005.02.007

Seki, 2001, Monitoring the expression pattern of 1300 Arabidopsis genes under drought and cold stresses by using a full-length cDNA microarray, Plant Cell, 13, 61, 10.1105/tpc.13.1.61

Fowler, 2002, Arabidopsis transcriptome profiling indicates that multiple regulatory pathways are activated during cold acclimation in addition to the CBF cold response pathway, Plant Cell, 14, 1675, 10.1105/tpc.003483

Maruyama, 2004, Identification of cold-inducible downstream genes of the Arabidopsis DREB1A/CBF3 transcriptional factor using two microarray systems, Plant J, 38, 982, 10.1111/j.1365-313X.2004.02100.x

Kasuga, 1999, Improving plant drought, salt, and freezing tolerance by gene transfer of a single stress-inducible transcription factor, Nat Biotechnol, 17, 287, 10.1038/7036

Aharoni, 2004, The SHINE clade of AP2 domain transcription factors activates wax biosynthesis, alters cuticle properties, and confers drought tolerance when overexpressed in Arabidopsis, Plant Cell, 16, 2463, 10.1105/tpc.104.022897

Zhang, 2005, Overexpression of WXP1, a putative Medicago truncatula AP2 domain-containing transcription factor gene, increases cuticular wax accumulation and enhances drought tolerance in transgenic alfalfa (Medicago sativa), Plant J, 42, 689, 10.1111/j.1365-313X.2005.02405.x

Zhang, 2004, From laboratory to field. Using information from Arabidopsis to engineer salt, cold, and drought tolerance in crops, Plant Physiol, 135, 615, 10.1104/pp.104.040295

Liu, 1998, Two transcription factors, DREB1 and DREB2, with an EREBP/AP2 DNA binding domain separate two cellular signal transduction pathways in drought- and low-temperature-responsive gene expression, respectively, in Arabidopsis, Plant Cell, 10, 1391, 10.1105/tpc.10.8.1391

Fujita Y, Fujita M, Satoh R, Maruyama K, Parvez MM, Seki M, Hiratsu K, Ohme-Takagi M, Shinozaki K, Yamaguchi-Shinozaki K: AREB1 is a transcription activator of novel ABRE-dependent ABA-signaling that enhances drought stress tolerance in Arabidopsis, Plant Cell 2005, in press.

Devaux, 2001, An artificial transcription activator mimics the genome-wide properties of the yeast Pdr1 transcription factor, EMBO Rep, 2, 493, 10.1093/embo-reports/kve114

Kagaya, 2002, Abscisic acid-induced transcription is mediated by phosphorylation of an abscisic acid response element binding factor, TRAB1, Plant Cell, 14, 3177, 10.1105/tpc.005272

Furihata, 2006, Abscisic acid-dependent multisite phosphorylation regulates the activity of a transcription activator AREB1, Proc Natl Acad Sci USA, 103, 1988, 10.1073/pnas.0505667103

Zhang, 2003, Overexpression analysis of plant transcription factors, Curr Opin Plant Biol, 6, 430, 10.1016/S1369-5266(03)00081-5

Cominelli, 2005, A guard-cell-specific MYB transcription factor regulates stomatal movements and plant drought tolerance, Curr Biol, 15, 1196, 10.1016/j.cub.2005.05.048

Kasuga, 2004, A combination of the Arabidopsis DREB1A gene and stress-inducible rd29A promoter improved drought- and low-temperature stress tolerance in tobacco by gene transfer, Plant Cell Physiol, 45, 346, 10.1093/pcp/pch037

Schroeder, 2001, Guard cell abscisic acid signalling and engineering drought hardiness in plants, Nature, 410, 327, 10.1038/35066500

Hiratsu, 2003, Dominant repression of target genes by chimeric repressors that include the EAR motif, a repression domain, in Arabidopsis, Plant J, 34, 733, 10.1046/j.1365-313X.2003.01759.x

Fujita, 2004, A dehydration-induced NAC protein, RD26, is involved in a novel ABA-dependent stress-signaling pathway, Plant J, 39, 863, 10.1111/j.1365-313X.2004.02171.x

Kubo, 2005, Transcription switches for protoxylem and metaxylem vessel formation, Genes Dev, 19, 1855, 10.1101/gad.1331305

Sakamoto, 2004, Arabidopsis Cys2/His2-type zinc-finger proteins function as transcription repressors under drought, cold, and high-salinity stress conditions, Plant Physiol, 136, 2734, 10.1104/pp.104.046599

Kim, 2004, CAZFP1, Cys2/His2-type zinc-finger transcription factor gene functions as a pathogen-induced early-defense gene in Capsicum annuum, Plant Mol Biol, 55, 883, 10.1007/s11103-005-2151-0

Boudsocq, 2005, Osmotic signaling in plants: multiple pathways mediated by emerging kinase families, Plant Physiol, 138, 1185, 10.1104/pp.105.061275

Shinozaki, 2003, Regulatory network of gene expression in the drought and cold stress responses, Curr Opin Plant Biol, 6, 410, 10.1016/S1369-5266(03)00092-X

Chinnusamy, 2004, Molecular genetic perspectives on cross-talk and specificity in abiotic stress signalling in plants, J Exp Bot, 55, 225, 10.1093/jxb/erh005

Kovtun, 2000, Functional analysis of oxidative stress-activated mitogen-activated protein kinase cascade in plants, Proc Natl Acad Sci USA, 97, 2940, 10.1073/pnas.97.6.2940

Shou, 2004, Expression of the Nicotiana protein kinase (NPK1) enhanced drought tolerance in transgenic maize, J Exp Bot, 55, 1013, 10.1093/jxb/erh129

Cutler, 1996, A protein farnesyl transferase involved in abscisic acid signal transduction in Arabidopsis, Science, 273, 1239, 10.1126/science.273.5279.1239

Pei, 1998, Role of farnesyltransferase in ABA regulation of guard cell anion channels and plant water loss, Science, 282, 287, 10.1126/science.282.5387.287

Wang, 2005, Molecular tailoring of farnesylation for plant drought tolerance and yield protection, Plant J, 43, 413, 10.1111/j.1365-313X.2005.02463.x

Davies, 1999, Sac3, an Snf1-like serine/threonine kinase that positively and negatively regulates the responses of Chlamydomonas to sulfur limitation, Plant Cell, 11, 1179, 10.1105/tpc.11.6.1179

Mikolajczyk, 2000, Osmotic stress induces rapid activation of a salicylic acid-induced protein kinase and a homolog of protein kinase ASK1 in tobacco cells, Plant Cell, 12, 165

Li, 2000, Regulation of abscisic acid-induced stomatal closure and anion channels by guard cell AAPK kinase, Science, 287, 300, 10.1126/science.287.5451.300

Monks, 2001, Hyperosmotic stress induces the rapid phosphorylation of a soybean phosphatidylinositol transfer protein homolog through activation of the protein kinases SPK1 and SPK2, Plant Cell, 13, 1205, 10.1105/tpc.13.5.1205

Kobayashi, 2004, Differential activation of the rice sucrose nonfermenting 1-related protein kinase 2 family by hyperosmotic stress and abscisic acid, Plant Cell, 16, 1163, 10.1105/tpc.019943

Boudsocq, 2004, Identification of nine SNF1-related protein kinases 2 activated by hyperosmotic and saline stresses in Arabidopsis thaliana, J Biol Chem, 279, 41758, 10.1074/jbc.M405259200

Mustilli, 2002, Arabidopsis OST1 protein kinase mediates the regulation of stomatal aperture by abscisic acid and acts upstream of reactive oxygen species production, Plant Cell, 14, 3089, 10.1105/tpc.007906

Yoshida, 2002, ABA-activated SnRK2 protein kinase is required for dehydration stress signaling in Arabidopsis, Plant Cell Physiol, 43, 1473, 10.1093/pcp/pcf188

Yoshida R, Umezawa T, Mizoguchi T, Takahashi F, Takahashi S, Shinozaki K: The regulatory domain of SRK2E/OST1/SnRK2.6 interacts with ABI1 and integrates ABA and osmotic stress signals controlling stomatal closure in Arabidopsis. J Biol Chem 2006: in press.

Umezawa, 2004, SRK2C, a SNF1-related protein kinase 2, improves drought tolerance by controlling stress-responsive gene expression in Arabidopsis thaliana, Proc Natl Acad Sci USA, 101, 17306, 10.1073/pnas.0407758101

Albrecht, 2003, The calcium sensor CBL1 integrates plant responses to abiotic stresses, Plant J, 36, 457, 10.1046/j.1365-313X.2003.01892.x

Cheong, 2003, CBL1, a calcium sensor that differentially regulates salt, drought, and cold responses in Arabidopsis, Plant Cell, 15, 1833, 10.1105/tpc.012393

Gong, 2004, The SOS3 family of calcium sensors and SOS2 family of protein kinases in Arabidopsis, Plant Physiol, 134, 919, 10.1104/pp.103.037440

Batistic, 2004, Integration and channeling of calcium signaling through the CBL calcium sensor/CIPK protein kinase network, Planta, 219, 915, 10.1007/s00425-004-1333-3

Kolukisaoglu, 2004, Calcium sensors and their interacting protein kinases: genomics of the Arabidopsis and rice CBL-CIPK signaling networks, Plant Physiol, 134, 43, 10.1104/pp.103.033068

Hrabak, 2003, The Arabidopsis CDPK-SnRK superfamily of protein kinases, Plant Physiol, 132, 666, 10.1104/pp.102.011999

Gong, 2002, Constitutive activation and transgenic evaluation of the function of an Arabidopsis PKS protein kinase, J Biol Chem, 277, 42088, 10.1074/jbc.M205504200

Posas, 1997, Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role of Pbs2p MAPKK, Science, 276, 1702, 10.1126/science.276.5319.1702

Park, 2003, Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms, Science, 299, 1061, 10.1126/science.1076979

Nakagami, 2005, Emerging MAP kinase pathways in plant stress signaling, Trends Plant Sci, 10, 339, 10.1016/j.tplants.2005.05.009

Yamaguchi-Shinozaki, 2005, Organization of cis-acting regulatory elements in osmotic- and cold-stress-responsive promoters, Trends Plant Sci, 10, 88, 10.1016/j.tplants.2004.12.012

Capell, 2004, Modulation of the polyamine biosynthetic pathway in transgenic rice confers tolerance to drought stress, Proc Natl Acad Sci USA, 101, 9909, 10.1073/pnas.0306974101

Kasukabe, 2004, Overexpression of spermidine synthase enhances tolerance to multiple environmental stresses and up-regulates the expression of various stress-regulated genes in transgenic Arabidopsis thaliana, Plant Cell Physiol, 45, 712, 10.1093/pcp/pch083

Yamada, 2005, Effects of free proline accumulation in petunias under drought stress, J Exp Bot, 56, 1975, 10.1093/jxb/eri195

Cortina, 2005, Tomato abiotic stress enhanced tolerance by trehalose biosynthesis, Plant Sci, 169, 75, 10.1016/j.plantsci.2005.02.026

Chandra Babu, 2004, HVA1, a LEA gene from barley confers dehydration tolerance in transgenic rice (Oryza sativa L.) via cell membrane protection, Plant Sci, 166, 855, 10.1016/j.plantsci.2003.11.023

Park, 2005, Genetic improvement of chinese cabbage for salt and drought tolerance by constitutive expression of a B. napus LEA gene, Plant Sci, 169, 553, 10.1016/j.plantsci.2005.05.008

De Block, 2005, Poly(ADP-ribose) polymerase in plants affects energy homeostasis, cell death and stress tolerance, Plant J, 41, 95, 10.1111/j.1365-313X.2004.02277.x

Laporte, 2002, Engineering for drought avoidance: expression of maize NADP-malic enzyme in tobacco results in altered stomatal function, J Exp Bot, 53, 699, 10.1093/jexbot/53.369.699

Wang, 2003, Plant responses to drought, salinity and extreme temperatures: towards genetic engineering for stress tolerance, Planta, 218, 1, 10.1007/s00425-003-1105-5

Qin, 2004, Cloning and functional analysis of a novel DREB1/CBF transcription factor involved in cold-responsive gene expression in Zea mays L, Plant Cell Physiol, 45, 1042, 10.1093/pcp/pch118

Novillo, 2004, CBF2/DREB1C is a negative regulator of CBF1/DREB1B and CBF3/DREB1A expression and plays a central role in stress tolerance in Arabidopsis, Proc Natl Acad Sci USA, 101, 3985, 10.1073/pnas.0303029101

Pellegrineschi, 2004, Stress-induced expression in wheat of the Arabidopsis thaliana DREB1A gene delays water stress symptoms under greenhouse conditions, Genome, 47, 493, 10.1139/g03-140

Oh, 2005, Arabidopsis CBF3/DREB1A and ABF3 in transgenic rice increased tolerance to abiotic stress without stunting growth, Plant Physiol, 138, 341, 10.1104/pp.104.059147

Kim, 2004, ABF2, an ABRE-binding bZIP factor, is an essential component of glucose signaling and its overexpression affects multiple stress tolerance, Plant J, 40, 75, 10.1111/j.1365-313X.2004.02192.x

Tran, 2004, Isolation and functional analysis of Arabidopsis stress-inducible NAC transcription factors that bind to a drought-responsive cis-element in the early responsive to dehydration stress 1 promoter, Plant Cell, 16, 2481, 10.1105/tpc.104.022699

Yan, 2004, Overexpression of the Arabidopsis 14-3-3 protein GF14λ in cotton leads to a ‘stay-green’ phenotype and improves stress tolerance under moderate drought conditions, Plant Cell Physiol, 45, 1007, 10.1093/pcp/pch115