Engineering disulfide-linked single-chain Fv dimers [(sFv')<sub>2</sub>] with improved solution and targeting properties: anti-digoxin 26–10 (sFv')<sub>2</sub> and anti-c-erbB-2 741F8 (sFv')<sub>2</sub> made by protein folding and bonded through C-terminal cysteinyl peptides

Protein Engineering, Design and Selection - Tập 8 Số 3 - Trang 301-314 - 1995
John E. McCartney1, Mei-Sheng Tai1, Robert M. Hudziak1, Gregory P. Adams2, Louis M. Weiner2, Donald Jin1, Walter F. Stafford3, Sen Liu3, Michael A. Bookman2, Axel A. Laminet4, I. Fand5, L. L. Houston4, Hermann Oppermann1, James S. Huston1
1Creative BioMolecules Inc.45 South Street, Hopkinton, MA 01748
2Department of Medical Oncology, Fox Chase Cancer CenterPhiladelphia, PA 19111
3Boston Biomedical Research Institute20 Staniford Street, Boston, MA 02114
4Cetus Oncology Corporation4560 Horton Street, Emeryville, CA 94608
5Garden State Cancer Center at the Center for Molecular Medicine and ImmunologyNewark, NJ 07103, USA

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Protein Engineering, Design and Selection

Tập 8 Số 3

301-314

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