Endotoxin exposure and symptoms in asthmatic children

Pediatric Allergy and Immunology - Tập 8 Số 3 - Trang 121-126 - 1997
M C Rizzo1, Charles K. Naspitz1, Enrique Fernández‐Caldas2, Richard F. Lockey1,2, I Mimica1, Dirceu Solé1
11Federal University of Sap Paulo, Paulista School ot Medicine, Sao Paulo, Brazil
22University of South Florida, Tampa, FL, USA.

Tóm tắt

Endotoxins (ET) are pro‐innammatory substances present in hou.sc dust which may increase non‐specific bronchial reactivity in asthmatic patients. Endotoxins (EU/g) and Der p I levels were compared in the homes often asthmatic and ten control children, aged 6‐16 years, living in Sao Paulo, Brazil. The houses were visited once a month from February 1993 lo February 1994 and dust samples were collected from the bedding and floor of each subject's house. No significant differences were observed in ET and Derp 1 levels in the homes of asthmatics and controls. The highest ET levels were detected in January and November, whereas the lowest levels were detected in April and August (p < 0.05). demonstrating a distinct seasonal distribution. The highest Der p I levels in bedding were observed in July and the lowest in February (p < 0.05). while Derp I levels in floor did not show significant differences throughout the year. Symptom and medication scores were evaluated monthly in the group of asthmatic children. There was a significant correlation (p < 0.05. r = 0.63) between clinical symptom scores and ET exposure, however no significant correlation was found for mite exposure (p > 0.05. r = 0.19). The results suggest that ET exposure exacerbates asthmatic symptoms in mite allergic, asthmatic children.

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Pediatric Allergy and Immunology

Tập 8 Số 3

121-126

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