Endothelial Dysfunction in Chronic Obstructive Pulmonary Disease

Angiology - Tập 59 Số 3 - Trang 357-364 - 2008
Leo Moro1, Claudio Pedone1, Simone Scarlata1, Vincenzo Malafarina1, Filippo Luca Fimognari2, Raffaele Antonelli Incalzi1
1Area di Geriatria, Università Campus Biomedico, Rome, Italy,
2Respiratory Unit, Division of Internal Medicine, ASL Roma G-Leopoldo Parodi Delfino Hospital, Colleferro, Rome, Italy

Tóm tắt

Background: Cardiovascular diseases are prevalent in people with chronic obstructive pulmonary disease (COPD). We hypothesized that endothelial dysfunction could be a marker of the proatherogen status in COPD. Methods and results: We measured endothelial dysfunction by flow-mediated dilation (FMD) and after sublingual administration of nitroglycerin (nitrate-mediated dilation: NMD) in 44 COPD patients and 48 controls. Compared with controls COPD patients had worse mean FMD (5.4% vs 8.2%, P < .001) and NMD (12.0% vs 13.9%, P = .007). FMD was inversely related to FEV1/VC ratio ( r = −0.327, P = .030). The negative association between COPD and FMD was confirmed after correction for potential confounders in a multiple linear regression model (β = −0.019, P = .002). In the same model NMD (β = 0.396, P < .001) was positively associated with FMD. Conclusions: Endothelial-dependent and, to a lesser extent, endothelial-independent dilations are significantly impaired in COPD, and the impairment is proportional to the severity of bronchial obstruction.

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Angiology

Tập 59 Số 3

357-364

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