Endothelial Cells Are Essential for the Self-Renewal and Repopulation of Notch-Dependent Hematopoietic Stem Cells

Cell Stem Cell - Tập 6 Số 3 - Trang 251-264 - 2010
Jason M. Butler1, Daniel J. Nolan1, Eva Vertes1, Barbara Varnum‐Finney2, Hideki Kobayashi1, Andrea T. Hooper1, Marco Seandel3,1, Koji Shido1, Ian White1, Mariko Kobayashi1, Luc de Witte4, Chad May4, Carrie J. Shawber5, Yuki Kimura1, Jan Kitajewski5,6, Zev Rosenwaks2, Irwin D. Bernstein7, Shahin Rafii1
1Howard Hughes Medical Institute, Department of Genetic Medicine and Ansary Stem Cell Institute, Weill Cornell Medical College, New York, NY 10065, USA
2ImClone Systems Incorporated, 180 Varrick Street, New York, NY 10014, USA
3Department of Surgery, Weill Cornell Medical College, New York, NY, 10065 USA
4Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, New York, NY 10065, USA
5Department of Ob/Gyn, Columbia University Medical Center, New York, NY 10032, USA
6Department of Pathology, Columbia University Medical Center, New York, NY 10032, USA
7Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA

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Tài liệu tham khảo

Antonchuk, 2002, HOXB4-induced expansion of adult hematopoietic stem cells ex vivo, Cell, 109, 39, 10.1016/S0092-8674(02)00697-9

Arai, 2004, Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche, Cell, 118, 149, 10.1016/j.cell.2004.07.004

Avecilla, 2004, Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis, Nat. Med., 10, 64, 10.1038/nm973

Butler, 2010, Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors, Nat. Rev. Cancer, 10, 138, 10.1038/nrc2791

Calvi, 2003, Osteoblastic cells regulate the haematopoietic stem cell niche, Nature, 425, 841, 10.1038/nature02040

Carmeliet, 1999, Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis, Cell, 98, 147, 10.1016/S0092-8674(00)81010-7

Duncan, 2005, Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance, Nat. Immunol., 6, 314, 10.1038/ni1164

Fernandez, 2008, Tumor necrosis factor-alpha and endothelial cells modulate Notch signaling in the bone marrow microenvironment during inflammation, Exp. Hematol., 36, 545, 10.1016/j.exphem.2007.12.012

Funahashi, 2008, A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesis, Cancer Res., 68, 4727, 10.1158/0008-5472.CAN-07-6499

Gerber, 2002, VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism, Nature, 417, 954, 10.1038/nature00821

Hadland, 2004, A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development, Blood, 104, 3097, 10.1182/blood-2004-03-1224

Heissig, 2002, Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand, Cell, 109, 625, 10.1016/S0092-8674(02)00754-7

Hooper, 2009, Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells, Cell Stem Cell, 4, 263, 10.1016/j.stem.2009.01.006

Karanu, 2000, The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells, J. Exp. Med., 192, 1365, 10.1084/jem.192.9.1365

Kiel, 2005, SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells, Cell, 121, 1109, 10.1016/j.cell.2005.05.026

Kollet, 2006, Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells, Nat. Med., 12, 657, 10.1038/nm1417

Kopp, 2006, Thrombospondins deployed by thrombopoietic cells determine angiogenic switch and extent of revascularization, J. Clin. Invest., 116, 3277, 10.1172/JCI29314

Krosl, 2003, In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein, Nat. Med., 9, 1428, 10.1038/nm951

Maillard, 2008, Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells, Cell Stem Cell, 2, 356, 10.1016/j.stem.2008.02.011

Mancini, 2005, Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation, Blood, 105, 2340, 10.1182/blood-2004-08-3207

Miller, 1997, Expansion in vitro of adult murine hematopoietic stem cells with transplantable lympho-myeloid reconstituting ability, Proc. Natl. Acad. Sci. USA, 94, 13648, 10.1073/pnas.94.25.13648

Mizutani, 2007, Differential Notch signalling distinguishes neural stem cells from intermediate progenitors, Nature, 449, 351, 10.1038/nature06090

Rafii, 1995, Human bone marrow microvascular endothelial cells support long-term proliferation and differentiation of myeloid and megakaryocytic progenitors, Blood, 86, 3353, 10.1182/blood.V86.9.3353.bloodjournal8693353

Ramalingam, 1999, E1(-)E4(+) adenoviral gene transfer vectors function as a “pro-life” signal to promote survival of primary human endothelial cells, Blood, 93, 2936, 10.1182/blood.V93.9.2936

Seandel, 2008, Generation of a functional and durable vascular niche by the adenoviral E4ORF1 gene, Proc. Natl. Acad. Sci. USA, 105, 19288, 10.1073/pnas.0805980105

Till, 1964, A stochastic model of stem cell proliferation, based on the growth of spleen colony-forming cells, Proc. Natl. Acad. Sci. USA, 51, 29, 10.1073/pnas.51.1.29

Varnum-Finney, 2000, Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling, Nat. Med., 6, 1278, 10.1038/81390

Willert, 2003, Wnt proteins are lipid-modified and can act as stem cell growth factors, Nature, 423, 448, 10.1038/nature01611

Wolfe, 1999, Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease, Biochemistry, 38, 4720, 10.1021/bi982562p

Wu, 2007, Imaging hematopoietic precursor division in real time, Cell Stem Cell, 1, 541, 10.1016/j.stem.2007.08.009

Zhang, 2003, Identification of the haematopoietic stem cell niche and control of the niche size, Nature, 425, 836, 10.1038/nature02041

Zhang, 2004, Adenovirus E4 gene promotes selective endothelial cell survival and angiogenesis via activation of the vascular endothelial-cadherin/Akt signaling pathway, J. Biol. Chem., 279, 11760, 10.1074/jbc.M312221200

Zhang, 2005, Adenovirus vector E4 gene regulates connexin 40 and 43 expression in endothelial cells via PKA and PI3K signal pathways, Circ. Res., 96, 950, 10.1161/01.RES.0000165867.95291.7b

Zhang, 2006, Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells, Nat. Med., 12, 240, 10.1038/nm1342