Endosome to trans-Golgi network transport of Proprotein Convertase 7 is mediated by a cluster of basic amino acids and palmitoylated cysteines

Baumann, 1990, Investigations on GABAB receptor-mediated autoinhibition of GABA release, Naunyn-Schmiedeberg's Archiv. Pharmacol., 341, 88 Bruzzaniti, 1996, PC8 [corrected], a new member of the convertase family, Biochem. J., 314, 727, 10.1042/bj3140727 Chia, 2011, Rab9-dependent retrograde transport and endosomal sorting of the endopeptidase furin, J. Cell Sci., 124, 2401, 10.1242/jcs.083782 Constam, 1996, SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis, J. Cell Biol., 134, 181, 10.1083/jcb.134.1.181 Constam, 2000, SPC4/PACE4 regulates a TGFbeta signaling network during axis formation, Genes Dev., 14, 1146, 10.1101/gad.14.9.1146 Creemers, 2008, Knock-out mouse models of proprotein convertases: unique functions or redundancy?, Front. Biosci., 13, 4960, 10.2741/3055 Creemers, 2000, Binding of BiP to the processing enzyme lymphoma proprotein convertase prevents aggregation, but slows down maturation, J. Biol. Chem., 275, 38842, 10.1074/jbc.M006758200 De Bie, 1996, The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments, J. Cell Biol., 135, 1261, 10.1083/jcb.135.5.1261 Declercq, 2012, Internalization of proprotein convertase PC7 from plasma membrane is mediated by a novel motif, J. Biol. Chem., 287, 9052, 10.1074/jbc.M111.306407 Delgui, 2013, The endosomal pathway and the Golgi complex are involved in the infectious bursal disease virus life cycle, J. Virol., 87, 8993, 10.1128/JVI.03152-12 Essalmani, 2008, In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate, Proc. Natl. Acad. Sci. U.S.A., 105, 5750, 10.1073/pnas.0709428105 Funaki, 2011, Localization of SMAP2 to the TGN and its function in the regulation of TGN protein transport, Cell Struct. Funct., 36, 83, 10.1247/csf.10022 Gruenberg, 1989, Characterization of the early endosome and putative endocytic carrier vesicles in vivo and with an assay of vesicle fusion in vitro, J. Cell Biol., 108, 1301, 10.1083/jcb.108.4.1301 Guillemot, 2013, Implication of the proprotein convertases in iron homeostasis: proprotein convertase 7 sheds human transferrin receptor 1 and furin activates hepcidin, Hepatology, 57, 2514, 10.1002/hep.26297 Heldwein, 2004, Crystal structure of the clathrin adaptor protein 1 core, Proc. Natl. Acad. Sci. U.S.A., 101, 14108, 10.1073/pnas.0406102101 Leonhardt, 2010, Post-endoplasmic reticulum rescue of unstable MHC class I requires proprotein convertase PC7, J. Immunol., 184, 2985, 10.4049/jimmunol.0900308 Lieu, 2010, Identification of different itineraries and retromer components for endosome-to-Golgi transport of TGN38 and Shiga toxin, Eur. J. Cell Biol., 89, 379, 10.1016/j.ejcb.2009.10.021 Meerabux, 1996, A new member of the proprotein convertase gene family (LPC) is located at a chromosome translocation breakpoint in lymphomas, Cancer Res., 56, 448 Molloy, 1994, Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface, EMBO J., 13, 18, 10.1002/j.1460-2075.1994.tb06231.x Pfeffer, 2009, Multiple routes of protein transport from endosomes to the trans Golgi network, FEBS Lett., 583, 3811, 10.1016/j.febslet.2009.10.075 Roebroek, 1998, Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin, Development, 125, 4863, 10.1242/dev.125.24.4863 Rousselet, 2011, The proprotein convertase PC7: unique zymogen activation and trafficking pathways, J. Biol. Chem., 286, 2728, 10.1074/jbc.M110.192344 Sakai, 1991, Microtubule-disrupting drugs blocked delivery of endocytosed transferrin to the cytocenter, but did not affect return of transferrin to plasma membrane, J. Biochem., 109, 528, 10.1093/oxfordjournals.jbchem.a123415 Scheglmann, 2002, Role of paired basic residues of protein C-termini in phospholipid binding, Protein Eng., 15, 521, 10.1093/protein/15.6.521 Seidah, 1996, cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases, Proc. Natl. Acad. Sci. U.S.A., 93, 3388, 10.1073/pnas.93.8.3388 Seidah, 2012, The biology and therapeutic targeting of the proprotein convertases, Nat. Rev. Drug Discov., 11, 367, 10.1038/nrd3699 Taylor, 2003, Curbing activation: proprotein convertases in homeostasis and pathology, FASEB J., 17, 1215, 10.1096/fj.02-0831rev Teuchert, 1999, Recycling of furin from the plasma membrane. Functional importance of the cytoplasmic tail sorting signals and interaction with the AP-2 adaptor medium chain subunit, J. Biol. Chem., 274, 36781, 10.1074/jbc.274.51.36781 Teuchert, 1999, Sorting of furin at the trans-Golgi network. Interaction of the cytoplasmic tail sorting signals with AP-1 Golgi-specific assembly proteins, J. Biol. Chem., 274, 8199, 10.1074/jbc.274.12.8199 van de Loo, 1997, Biosynthesis, distinct post-translational modifications, and functional characterization of lymphoma proprotein convertase, J. Biol. Chem., 272, 27116, 10.1074/jbc.272.43.27116 van de Loo, 2000, Dynamic palmitoylation of lymphoma proprotein convertase prolongs its half-life, but is not essential for trans-Golgi network localization, Biochem. J., 352 Pt, 827, 10.1042/bj3520827 Villeneuve, 2002, Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study, J. Neurochem., 82, 783, 10.1046/j.1471-4159.2002.00988.x Wan, 1998, PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization, Cell, 94, 205, 10.1016/S0092-8674(00)81420-8 Wang, 2007, PI4P promotes the recruitment of the GGA adaptor proteins to the trans-Golgi network and regulates their recognition of the ubiquitin sorting signal, Mol. Biol. Cell, 18, 2646, 10.1091/mbc.e06-10-0897 Wang, 2003, Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi, Cell, 114, 299, 10.1016/S0092-8674(03)00603-2 Wetsel, 2013, Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice, Proc. Natl. Acad. Sci. U.S.A., 110, 17362, 10.1073/pnas.1314698110 Wouters, 1998, Furin and proprotein convertase 7 (PC7)/lymphoma PC endogenously expressed in rat liver can be resolved into distinct post-Golgi compartments, Biochem. J., 336, 311, 10.1042/bj3360311 Xiang, 2000, The PC6B cytoplasmic domain contains two acidic clusters that direct sorting to distinct trans-Golgi network/endosomal compartments, Mol. Biol. Cell, 11, 1257, 10.1091/mbc.11.4.1257