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Hormone giới tính nội sinh và mối liên hệ với các yếu tố nguy cơ bệnh tim mạch ở phụ nữ sau mãn kinh
Tóm tắt
Mục tiêu: Mục tiêu của chúng tôi là hiểu mối quan hệ giữa hormone giới tính nội sinh và các yếu tố nguy cơ bệnh tim mạch ở phụ nữ sau mãn kinh. Vật liệu và phương pháp: Chúng tôi đã bao gồm 83 phụ nữ sau mãn kinh từ một nghiên cứu được thiết kế tiên tiến trước đó. Chúng tôi đã phân tích các hormone giới tính nội sinh và các tham số sinh hóa. Kết quả: Mức estradiol và testosterone tự do cao hơn ở những bệnh nhân mắc hội chứng chuyển hóa. Estradiol có mối liên hệ tích cực với interleukin-6 (IL-6), trọng lượng cơ thể, chỉ số khối cơ thể (BMI), insulin, homocysteine và chỉ số độ nhạy insulin (HOMA-IR). Testosterone tự do có mối liên hệ tích cực với trọng lượng, vòng bụng (WC), BMI, insulin, HOMA-IR và mối quan hệ tiêu cực với HDL và SHBG. DHEAS chỉ có mối liên hệ với HDL. FSH có mối quan hệ tiêu cực với tuổi tác, trọng lượng, WC, vòng hông, BMI, huyết áp tâm thu, huyết áp tâm trương, thời gian mãn kinh, glucose lúc đói, HDL, protein phản ứng C và insulin. LH có mối quan hệ tiêu cực với IL-6, tuổi, WC, thời gian mãn kinh và SHBG. Kết luận: Chúng tôi đã xác định estradiol nội sinh và testosterone tự do là những liên kết mạnh nhất với nguy cơ bệnh tim mạch. Chúng có thể được sử dụng như các dấu ấn sinh học để ước lượng nguy cơ bệnh tim mạch.
Từ khóa
#hormone giới tính nội sinh #bệnh tim mạch #phụ nữ sau mãn kinh #yếu tố nguy cơ #estradiol #testosterone tự doTài liệu tham khảo
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