Endocrine disruptive action of cypermethrin in male mice
Tóm tắt
Administration (intubation) of cypermethrin to adult male mice for 6 and 12 weeks on alternate day in 3 dose levels,1.38, 2.76 and 5.52 mg/kg body weight (bw) corresponding to 1/476, 1/238 and 1/119 of LD50 dose respectively, caused degeneration of germinal epithelium, vacuolization of seminiferous tubules and a significant decrease in i) weight of the body, testes and epididymis, ii) diameter of the seminiferous tubules and epididymal ducts and iii) serum levels of testosterone these parameters were restored to control levels, six weeks after cessation of 1.38 mg/kg bw treatment (both durations) but not after 5.52 mg/kg bw treatment within the same period. The results reveal for the first time that chronic exposure even to 5.52 mg/kg bw i.e. up to 1/119 of LD50 induces histopathological alterations and impairment in spermatogenic and steroidogenic activities of the testis which are not reversible within a period of 6 weeks.
Tài liệu tham khảo
United State environmental Protection Agency. Pesticide Fact Sheet Number 199: Cypermethrin. US EPA, Office of pesticide Programs, Registration Div., Washington, DC, USA pp. 2–9 (1989).
Oheme, W. & Mannala S. Pesticide use in veterinary medicine. In: Handbook of Pesticide. Toxicology 2nd Ed. Academic Press, New York, USA pp. 235 (2001).
Elbetieha, A., Da’as S. I., Khamas, W. & Darmani, H. Evaluation of the toxic potentials of cypermethrin pesticide on some reproductive and fertility parameters in the male rats. Arch. Environ. Contam. Toxicol. 41, 522–528 (2001).
Yousef, M., El-Demerdash, F. & Al-Salhen, K. Protective role of isoflavones against the toxic effect of cypermethrin on semen quality and testosterone levels of rabbits. J. Environ. Sci. Health B 38, 463–478 (2003).
Ullah, M. S., Ahmad, M., Ahmad, N., Khan, M. Z. & Ahmad, I. Toxic effects of cypermethrin in female rabbits. Pa. Vet. J. 26, 193–196 (2006).
Assayed, M. E., Salem, H. A. & Khalaf, A. A. Protective effects of garlic extract and vitamine C against cypermethrin reproductive toxicity in male rats. Res. J. Vet. Sci. 1, 1–15 (2008).
Ahmad, M., Hussain, I., Khan, A. & Rehman, N. Deleterious effects of cypermethrin on semen characteristics and testes of dwarf goats (Capra hircus). Exp. Toxicol. Pathol. 61, 339–346 (2009).
Rodrigeuz, H. et al. Cypermethrin effects on the adult mice seminal gland. Ecotoxicol. Environ. Saf. 72, 658–662 (2009).
Wang, X. Z. et al. Beta-cypermethrin impairs reproductive function in male mice by iducing oxidative stress. Theriogenology 72, 599–611 (2009).
Wang, H. et al. Cypermethrin exposure during puberty disrupts testosterone synthesis via downregulating StAR in mouse testes. Arch. Toxicol. 84, 53–61 (2010).
Liu, L. et al. Effects of Beta-cypermethrin on male rat reproductive system. Environ. Toxicol. Pharmacol. 30, 251–256 (2010).
Elzeinova, F., Novakova, V., Buckiova, D., Kubatova, A. & Peknicova, J. Effect of low dose of vinclozolin on reproductive tract development and sperm parameters in CD1 outbred mice. Reprod. Toxicol. 26, 231–238 (2008).
Al-Hamdani, M. H. N. & Yajurvedi, H. N. Cypermethrin reversibly alters sperm count without altering fertility in mice. Ecotoxicol. Environ. Saf. 73, 1092–1097 (2010).
El-Demerdash, F. M., Yousef, M. I., Kedwanyand, F. S. & Baghdadi, H. H. Role of α-tcopherol and betacarotene in ameliorating the fenvalerate-induced changes in oxidative stress, hematcbiochemical parameter and semen quality of male rats. J. Environ. Sci. Health. B 39, 443–459 (2004).
Sharpe, R. M. Testosterone and spermatogenesis. Endocrinology 113, 1–20 (1987).
Zizmann, M. Effect of testosterone replacement and its pharmacogenetics on physical performance and metabolism. Asia (2008).
Zhang, J., Zhu, W., Zheng, Y. F., Yang, J. & Zhu, X. O. The antiandrogenic activity of pyrethroids pesticides cyflythrin and beta-cyflythrin. Reprod. Toxicol. 25, 491–496 (2008).
Bunya, S. P. & Pati, P. C. Genotoxic effects of a synthetic pyrthroid insecticide, cypermethrin, in mice in vivo. Toxicol. Lett. 41, 223–230 (1988).
Kumar, S., Gautam, A. K., Agarwal, K. R., Shah, B. A. & Saiyad, H. N. Demonstration of sperm head shape abnormality and clastogenic potential of cypermethrin. J. Environ. Biol. 25, 187–190 (2004).
Rose, G. P. Toxicology of pyrethroids: the acute oral and percutaneous toxicity of WL 85871 (cis-2-Ripcord) in comparison with Ripcord. Unpublished Report No. SBGR.82.130 from Shell Research Limited, Sittingbourne Research Centre, Submitted to the WHO by Cyanamid, Wayne, NJ, USA (1982).
World Health Organization. Environmental Health Criteria. Cypermethrin, vol. 82. United Nations Environmental Programme, the International Labour Organization, and the World Health Organization, Geneva (1989).
Clermont, Y. Kinetics of spermatogenesis in mammals: seminiferous epithelium cycle and spermatogonial renewal. Physiol. Rev. 52, 198–236 (1972).