Endocrine Aspects of Post-traumatic Stress Disorder and Implications for Diagnosis and Treatment

Yehuda, 2002, Post-traumatic stress disorder, N Engl J Med, 346, 108, 10.1056/NEJMra012941

American Psychiatric Association, 2000

Kessler, 1995, Posttraumatic stress disorder in the National Comorbidity Survey, Arch Gen Psychiatry, 52, 1048, 10.1001/archpsyc.1995.03950240066012

Creamer, 2001, Post-traumatic stress disorder: findings from the Australian National Survey of Mental Health and Well-being, Psychol Med, 31, 1237, 10.1017/S0033291701004287

Perkonigg, 2000, Traumatic events and post-traumatic stress disorder in the community: prevalence, risk factors and comorbidity, Acta Psychiatr Scand, 101, 46, 10.1034/j.1600-0447.2000.101001046.x

Kessler, 2005, Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication, Arch Gen Psychiatry, 62, 617, 10.1001/archpsyc.62.6.617

Breslau, 1998, Trauma and posttraumatic stress disorder in the community: the 1996 Detroit Area Survey of Trauma, Arch Gen Psychiatry, 55, 626, 10.1001/archpsyc.55.7.626

Greenberg, 1999, The economic burden of anxiety disorders in the 1990s, J Clin Psychiatry, 60, 427, 10.4088/JCP.v60n0702

Solomon, 1997, Trauma: prevalence, impairment, service use, and cost, J Clin Psychiatry, 58, 5

Marciniak, 2005, The cost of treating anxiety: the medical and demographic correlates that impact total medical costs, Depress Anxiety, 21, 178, 10.1002/da.20074

Ouimette, 2004, Posttraumatic stress disorder and health status among female and male medical patients, J Trauma Stress, 17, 1, 10.1023/B:JOTS.0000014670.68240.38

Schnurr, 2000, Physician-diagnosed medical disorders in relation to PTSD symptoms in older male military veterans, Health Psychol, 19, 91, 10.1037/0278-6133.19.1.91

Sareen, 2007, Physical and mental comorbidity, disability, and suicidal behavior associated with posttraumatic stress disorder in a large community sample, Psychosom Med, 69, 242, 10.1097/PSY.0b013e31803146d8

Heppner, 2009, The association of posttraumatic stress disorder and metabolic syndrome: a study of increased health risk in veterans, BMC Med, 7, 1, 10.1186/1741-7015-7-1

Boscarino, 2004, Posttraumatic stress disorder and physical illness: results from clinical and epidemiologic studies, Ann N Y Acad Sci, 1032, 141, 10.1196/annals.1314.011

Ahmadi, 2011, Post-traumatic stress disorder, coronary atherosclerosis, and mortality, Am J Cardiol, 108, 29, 10.1016/j.amjcard.2011.02.340

McEwen, 1998, Protective and damaging effects of stress mediators, N Engl J Med, 338, 171, 10.1056/NEJM199801153380307

Cannon, 1929, Organization for physiological homeostasis, Physiol Rev, 9, 399, 10.1152/physrev.1929.9.3.399

de Kloet, 2005, Stress and the brain: from adaptation to disease, Nat Rev Neurosci, 6, 463, 10.1038/nrn1683

Joels, 2012, Unraveling the time domains of corticosteroid hormone influences on brain activity: rapid, slow, and chronic modes, Pharmacol Rev, 64, 901, 10.1124/pr.112.005892

de Kloet, 2009, Glucocorticoid signaling and stress-related limbic susceptibility pathway: about receptors, transcription machinery and microRNA, Brain Res, 1293, 129, 10.1016/j.brainres.2009.03.039

Mayer, 2000, The neurobiology of stress and gastrointestinal disease, Gut, 47, 861, 10.1136/gut.47.6.861

Roozendaal, 2009, Stress, memory and the amygdala, Nat Rev Neurosci, 10, 423, 10.1038/nrn2651

Mason, 1986, Urinary free-cortisol levels in posttraumatic stress disorder patients, J Nerv Ment Dis, 174, 145, 10.1097/00005053-198603000-00003

Gill, 2008, Low cortisol, high DHEA, and high levels of stimulated TNF-alpha, and IL-6 in women with PTSD, J Trauma Stress, 21, 530, 10.1002/jts.20372

Thaller, 1999, The potential role of hypocortisolism in the pathophysiology of PTSD and psoriasis, Coll Antropol, 23, 611

Bremner, 2007, Cortisol, dehydroepiandrosterone, and estradiol measured over 24 hours in women with childhood sexual abuse-related posttraumatic stress disorder, J Nerv Ment Dis, 195, 919, 10.1097/NMD.0b013e3181594ca0

Yehuda, 1990, Low urinary cortisol excretion in patients with posttraumatic stress disorder, J Nerv Ment Dis, 178, 366, 10.1097/00005053-199006000-00004

Baker, 1999, Serial CSF corticotropin-releasing hormone levels and adrenocortical activity in combat veterans with posttraumatic stress disorder, Am J Psychiatry, 156, 585, 10.1176/ajp.156.4.585

Geracioti, 2001, CSF norepinephrine concentrations in posttraumatic stress disorder, Am J Psychiatry, 158, 1227, 10.1176/appi.ajp.158.8.1227

Baker, 2001, Plasma and cerebrospinal fluid interleukin-6 concentrations in posttraumatic stress disorder, Neuroimmunomodulation, 9, 209, 10.1159/000049028

de Kloet, 2008, Elevated plasma corticotrophin-releasing hormone levels in veterans with posttraumatic stress disorder, Prog Brain Res, 167, 287, 10.1016/S0079-6123(07)67025-3

Spivak, 1997, Elevated levels of serum interleukin-1 beta in combat-related posttraumatic stress disorder, Biol Psychiatry, 42, 345, 10.1016/S0006-3223(96)00375-7

Morris, 2012, Relations among posttraumatic stress disorder, comorbid major depression, and HPA function: a systematic review and meta-analysis, Clin Psychol Rev, 32, 301, 10.1016/j.cpr.2012.02.002

Meewisse, 2007, Cortisol and post-traumatic stress disorder in adults: systematic review and meta-analysis, Br J Psychiatry, 191, 387, 10.1192/bjp.bp.106.024877

Yehuda, 2002, The cortisol and glucocorticoid receptor response to low dose dexamethasone administration in aging combat veterans and holocaust survivors with and without posttraumatic stress disorder, Biol Psychiatry, 52, 393, 10.1016/S0006-3223(02)01357-4

McFarlane, 2000, Posttraumatic stress disorder: a model of the longitudinal course and the role of risk factors, J Clin Psychiatry, 61, 15

Brewin, 2000, Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults, J Consult Clin Psychol, 68, 748, 10.1037/0022-006X.68.5.748

van Zuiden, 2013, Predicting PTSD: Pre-existing vulnerabilities in glucocorticoid-signaling and implications for preventive interventions, Brain Behav Immun, 30, 12, 10.1016/j.bbi.2012.08.015

Raison, 2003, When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders, Am J Psychiatry, 160, 1554, 10.1176/appi.ajp.160.9.1554

Yehuda, 1995, Dose-response changes in plasma cortisol and lymphocyte glucocorticoid receptors following dexamethasone administration in combat veterans with and without posttraumatic stress disorder, Arch Gen Psychiatry, 52, 583, 10.1001/archpsyc.1995.03950190065010

Yehuda, 2004, Effects of trauma exposure on the cortisol response to dexamethasone administration in PTSD and major depressive disorder, Psychoneuroendocrinology, 29, 389, 10.1016/S0306-4530(03)00052-0

Yehuda, 2004, Enhanced sensitivity to glucocorticoids in peripheral mononuclear leukocytes in posttraumatic stress disorder, Biol Psychiatry, 55, 1110, 10.1016/j.biopsych.2004.02.010

Sarapas, 2011, Genetic markers for PTSD risk and resilience among survivors of the World Trade Center attacks, Dis Markers, 30, 101, 10.1155/2011/328054

Matic, 2013, Lymphocyte glucocorticoid receptor expression level and hormone-binding properties differ between war trauma-exposed men with and without PTSD, Prog Neuropsychopharmacol Biol Psychiatry, 43, 238, 10.1016/j.pnpbp.2013.01.005

Yehuda, 2009, Gene expression patterns associated with posttraumatic stress disorder following exposure to the World Trade Center attacks, Biol Psychiatry, 66, 708, 10.1016/j.biopsych.2009.02.034

Binder, 2008, Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults, JAMA, 299, 1291, 10.1001/jama.299.11.1291

Klengel, 2013, Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions, Nat Neurosci, 16, 33, 10.1038/nn.3275

Koenen, 2005, Polymorphisms in FKBP5 are associated with peritraumatic dissociation in medically injured children, Mol Psychiatry, 10, 1058, 10.1038/sj.mp.4001727

Lightman, 2010, The crucial role of pulsatile activity of the HPA axis for continuous dynamic equilibration, Nat Rev Neurosci, 11, 710, 10.1038/nrn2914

Yehuda, 1996, Cortisol regulation in posttraumatic stress disorder and major depression: a chronobiological analysis, Biol Psychiatry, 40, 79, 10.1016/0006-3223(95)00451-3

Yehuda, 2007, Parental posttraumatic stress disorder as a vulnerability factor for low cortisol trait in offspring of holocaust survivors, Arch Gen Psychiatry, 64, 1040, 10.1001/archpsyc.64.9.1040

Yehuda, 2009, Cortisol metabolic predictors of response to psychotherapy for symptoms of PTSD in survivors of the World Trade Center attacks on September 11, 2001, Psychoneuroendocrinology, 34, 1304, 10.1016/j.psyneuen.2009.03.018

Yehuda, 2009, Enduring effects of severe developmental adversity, including nutritional deprivation, on cortisol metabolism in aging Holocaust survivors, J Psychiatr Res, 43, 877, 10.1016/j.jpsychires.2008.12.003

Vickers, 2012, Strategies for reversing the effects of metabolic disorders induced as a consequence of developmental programming, Front Physiol, 3, 242, 10.3389/fphys.2012.00242

Yehuda, 2011, Minireview: stress-related psychiatric disorders with low cortisol levels: a metabolic hypothesis, Endocrinology, 152, 4496, 10.1210/en.2011-1218

Aerni, 2004, Low-dose cortisol for symptoms of posttraumatic stress disorder, Am J Psychiatry, 161, 1488, 10.1176/appi.ajp.161.8.1488

Pratchett, 2011, New approaches to combining pharmacotherapy and psychotherapy for posttraumatic stress disorder, Expert Opin Pharmacother, 12, 2339, 10.1517/14656566.2011.604030

Yehuda, 2010, Hydrocortisone responsiveness in Gulf War veterans with PTSD: effects on ACTH, declarative memory hippocampal [18F] FDG uptake on PET, Psychiatry Res, 184, 117, 10.1016/j.pscychresns.2010.06.010

Cohen, 2006, Blunted HPA axis response to stress influences susceptibility to posttraumatic stress response in rats, Biol Psychiatry, 59, 1208, 10.1016/j.biopsych.2005.12.003

Zalachoras, 2013, Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator, Proc Natl Acad Sci U S A, 110, 7910, 10.1073/pnas.1219411110

Cohen, 2008, Early post-stressor intervention with high-dose corticosterone attenuates posttraumatic stress response in an animal model of posttraumatic stress disorder, Biol Psychiatry, 64, 708, 10.1016/j.biopsych.2008.05.025

Zohar, 2011, High dose hydrocortisone immediately after trauma may alter the trajectory of PTSD: interplay between clinical and animal studies, Eur Neuropsychopharmacol, 21, 796, 10.1016/j.euroneuro.2011.06.001

Cohen, 2004, An animal model of posttraumatic stress disorder: the use of cut-off behavioral criteria, Ann N Y Acad Sci, 1032, 167, 10.1196/annals.1314.014

Dong, 1988, Regulation of glucocorticoid receptor expression: evidence for transcriptional and posttranslational mechanisms, Mol Endocrinol, 2, 1256, 10.1210/mend-2-12-1256

Foa, 2009

National Research Council, 2008

Bradley, 2005, A multidimensional meta-analysis of psychotherapy for PTSD, Am J Psychiatry, 162, 214, 10.1176/appi.ajp.162.2.214