Endocannabinoids in the retina: From marijuana to neuroprotection

Adams, 1975, Alcohol prolongs time course of glare recovery, Nature, 257, 481, 10.1038/257481a0 Adams, 1975, Alcohol and marijuana effects on static visual acuity, Am. J. Optom. Physiol. Opt., 52, 729, 10.1097/00006324-197511000-00001 Adams, 1978, Marijuana, alcohol, and combined drug effects on the time course of glare recovery, Psychopharmacology (Berl), 56, 81, 10.1007/BF00571413 Aguado, 2007, The CB1 cannabinoid receptor mediates excitotoxicity-induced neural progenitor proliferation and neurogenesis, J. Biol. Chem., 282, 23892, 10.1074/jbc.M700678200 Ahmad, 2006, Stimulation of prostaglandin EP2 receptors prevents NMDA-induced excitotoxicity, J. Neurotrauma, 23, 1895, 10.1089/neu.2006.23.1895 Akopian, 2000, Somatostatin modulates voltage-gated K+ and Ca2+ currents in rod and cone photoreceptors of the salamander retina, J. Neurosci., 20, 929, 10.1523/JNEUROSCI.20-03-00929.2000 Baker, 2006, In silico patent searching reveals a new cannabinoid receptor, Trends Pharmacol. Sci., 27, 1, 10.1016/j.tips.2005.11.003 Balse, 2006, Glycine receptors in a population of adult mammalian cones, J. Physiol., 571, 391, 10.1113/jphysiol.2005.100891 Barnes, 1991, Modulation of calcium-activated chloride current via pH-induced changes of calcium channel properties in cone photoreceptors, J. Neurosci., 11, 4015, 10.1523/JNEUROSCI.11-12-04015.1991 Barnett-Norris, 2005, Lipids, lipid rafts and caveolae: their importance for GPCR signaling and their centrality to the endocannabinoid system, Life Sci., 77, 1629, 10.1016/j.lfs.2005.05.040 Begbie, 2004, Cannabinoid receptor, CB1, expression follows neuronal differentiation in the early chick embryo, J. Anat., 205, 213, 10.1111/j.0021-8782.2004.00325.x Begg, 2005, Evidence for novel cannabinoid receptors, Pharmacol. Ther., 106, 133, 10.1016/j.pharmthera.2004.11.005 Beinfeld, 2001, Activation of CB1 cannabinoid receptors in rat hippocampal slices inhibits potassium-evoked cholecystokinin release, a possible mechanism contributing to spatial memory defects produced by cannabinoids, Neurosci. Lett., 301, 69, 10.1016/S0304-3940(01)01591-9 Bisogno, 1999, Biosynthesis and inactivation of N-arachidonoylethanolamine (anandamide) and N-docosahexaenoylethanolamine in bovine retina, Arch. Biochem. Biophys., 370, 300, 10.1006/abbi.1999.1410 Bisogno, 2005, The endocannabinoid signalling system: biochemical aspects, Pharmacol. Biochem. Behav., 81, 224, 10.1016/j.pbb.2005.01.027 Bisogno, 2000, N-Acyl-dopamines: novel synthetic CB(1) cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo, Biochem. J., 351, 817, 10.1042/0264-6021:3510817 Biswas, 2004, Prostaglandin E2 receptor subtypes, EP1, EP2, EP3 and EP4 in human and mouse ocular tissues–a comparative immunohistochemical study, Prostaglandins Leukot. Essent. Fatty Acids, 71, 277, 10.1016/j.plefa.2004.03.021 Bojesen, 2003, Binding of anandamide to bovine serum albumin, J. Lipid Res., 46, 1790, 10.1194/jlr.M300170-JLR200 Bonhaus, 1998, Dual activation and inhibition of adenylyl cyclase by cannabinoid receptor agonists: evidence for agonist-specific trafficking of intracellular responses, J. Pharmacol. Exp. Ther., 287, 884 Bortolato, 2007, Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress, Biol. Psychiatry, 62, 1103, 10.1016/j.biopsych.2006.12.001 Bradshaw, 2005, The expanding field of cannabimimetic and related lipid mediators, Br. J. Pharmacol., 144, 459, 10.1038/sj.bjp.0706093 Brandon, 1983, l-Glutamic acid: a neurotransmitter candidate for cone photoreceptors in human and rat retinas, Proc. Natl. Acad. Sci. U S A, 80, 5117, 10.1073/pnas.80.16.5117 Breivogel, 2001, Evidence for a new G protein-coupled cannabinoid receptor in mouse brain, Mol. Pharmacol., 60, 155, 10.1124/mol.60.1.155 Buckley, 1998, Expression of the CB1 and CB2 receptor messenger RNAs during embryonic development in the rat, Neuroscience, 82, 1131, 10.1016/S0306-4522(97)00348-5 Burnstein, 2005, PPAR-γ: a nuclear receptor with affinity for cannabinoids, Life Sci., 77, 1674, 10.1016/j.lfs.2005.05.039 Cabral, 2008, CB2 receptors in the brain: role in central immune function, Br. J. Pharmacol., 153, 240, 10.1038/sj.bjp.0707584 Calandra, 1999, Dual intracellular signaling pathways mediated by the human cannabinoid CB1 receptor, Eur. J. Pharmacol., 374, 445, 10.1016/S0014-2999(99)00349-0 Carlin, 1972, Social facilitation of marijuana intoxication: impact of social set and pharmacological activity, J. Abnorm. Psychol., 80, 132, 10.1037/h0033317 Chaperon, 1999, Behavioral effects of cannabinoid agents in animals, Crit. Rev. Neurobiol., 13, 243, 10.1615/CritRevNeurobiol.v13.i3.20 Chen, 2005, Finding of endocannabinoids in human eye tissues: implications for glaucoma, Biochem. Biophys. Res. Commun., 330, 1062, 10.1016/j.bbrc.2005.03.095 Chien, 2003, Effect of WIN 55212-2, a cannabinoid receptor agonist, on aqueous humor dynamics in monkeys, Arch. Ophthalmol., 121, 87, 10.1001/archopht.121.1.87 Chin, 2001, Cyclooxygenase-2 gene expression and regulation in human retinal pigment epithelial cells, Invest. Ophthalmol. Vis. Sci., 42, 2338 Consroe, 1997, The perceived effects of smoked cannabis on patients with multiple sclerosis, Eur. Neurol., 38, 44, 10.1159/000112901 Crandall, 2007, Neuroprotective and intraocular pressure-lowering effects of (−)Delta9-tetrahydrocannabinol in a rat model of glaucoma, Ophthalmic. Res., 39, 69, 10.1159/000099240 Cravatt, 2001, Supersensitivity to anandamide and enhanced cannabinoid signaling in mice lacking fatty acid amide hydrolase, Proc. Natl. Acad. Sci. U S A, 98, 9371, 10.1073/pnas.161191698 Cravatt, 2004, Functional dissociation of the central and peripheral fatty acid amide signaling systems, Proc. Natl. Acad. Sci. U S A, 101, 10821, 10.1073/pnas.0401292101 Cristino, 2008, Immunohistochemical localization of anabolic and catabolic enzymes for anandamide and other putative endovanilloids in the hippocampus and cerebellar cortex of the mouse brain, Neuroscience, 151, 955, 10.1016/j.neuroscience.2007.11.047 Dacey, 1985, Wide-spreading terminal axons in the inner plexiform layer of the cat's retina: evidence for intrinsic axon collaterals of ganglion cells, J. Comp. Neurol., 242, 247, 10.1002/cne.902420207 Dainese, 2007, Modulation of the endocannabinoid system by lipid rafts, Curr. Med. Chem., 14, 2702, 10.2174/092986707782023235 Dawson, 1977, Marijuana and vision – after ten years' use in Costa Rica, Invest. Ophthalmol. Vis. Sci., 16, 689 De Petrocellis, 2001, The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism, J. Biol. Chem., 276, 12856, 10.1074/jbc.M008555200 Dearry, 1986, Dopaminergic regulation of cone retinomotor movement in isolated teleost retinas: I. Induction of cone contraction is mediated by D2 receptors, J. Neurochem., 46, 1006, 10.1111/j.1471-4159.1986.tb00612.x Deutsch, 1993, Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist, Biochem. Pharmacol., 46, 791, 10.1016/0006-2952(93)90486-G Deutsch, 1997, Methyl arachidonyl fluorophosphonate: a potent irreversibe inhibitor of anandamide amidase, Biochem. Pharmacol., 53, 255, 10.1016/S0006-2952(96)00830-1 Devane, 1988, Determination and characterization of a cannabinoid receptor in rat brain, Mol. Pharmacol., 34, 605 Devane, 1992, Isolation and structure of a brain constituent that binds to the cannabinoid receptor, Science, 258, 1946, 10.1126/science.1470919 Diana, 2004, Endocannabinoid-mediated short-term synaptic plasticity: depolarization-induced suppression of inhibition (DSI) and depolarization-induced suppression of excitation (DSE), Br. J. Pharmacol., 142, 9, 10.1038/sj.bjp.0705726 Diaz-Laviada, 2005, Signal transduction activated by cannabinoid receptors, Mini Rev. Med. Chem., 5, 619, 10.2174/1389557054368808 Di Marzo, 1994, Formation and inactivation of endogenous cannabinoid anandamide in central neurons, Nature, 6501, 686, 10.1038/372686a0 Dinh, 2002, Brain monoglyceride lipase participating in endocannabinoid inactivation, Proc. Nat. Acad. Sci. U S A, 99, 10819, 10.1073/pnas.152334899 Egertová, 2003, Comparative analysis of fatty acid amide hydrolase and cb(1) cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling, Neuroscience, 119, 481, 10.1016/S0306-4522(03)00145-3 Egertová, 2000, Localisation of cannabinoid receptors in the rat brain using antibodies to the intracellular C-terminal tail of CB1, J. Comp. Neurol., 422, 159, 10.1002/(SICI)1096-9861(20000626)422:2<159::AID-CNE1>3.0.CO;2-1 Egertová, 1998, A new perspective on cannabinoid signalling: complementary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain, Proc. R. Soc. London B: Biol Sci., 265, 2081, 10.1098/rspb.1998.0543 Ehinger, 1981, [3H]-d-aspartate accumulation in the retina of pigeon, guinea pig and rabbit, Exp. Eye Res., 33, 381, 10.1016/S0014-4835(81)80090-5 El Remessy, 2003, Neuroprotective effect of delta(9)-tetrahydrocannabinol and cannabidiol in N-methyl-d-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite, Am. J. Pathol., 163, 1997, 10.1016/S0002-9440(10)63558-4 Emrich, 1991, Reduced binocular depth inversion as an indicator of cannabis-induced censorship impairment, Pharmacol. Biochem. Behav., 40, 689, 10.1016/0091-3057(91)90383-D Fan, 1999, Modulation of voltage-gated K+ currents (IK(v)) in retinal bipolar cells by ascorbate is mediated by dopamine D1 receptors, Vis. Neurosci., 16, 928, 10.1017/S095252389916512X Fan, 2003, Biphasic modulation of voltage-dependent currents of retinal cones by cannabinoid CB1 agonist, WIN 55212-2, Vis. Neurosci., 20, 177, 10.1017/S095252380320208X Fan, 2004, Inhibitory interaction of cannabinoid CB1 receptor and dopamine D2 receptor agonists on voltage-gated currents of goldfish cones, Vis. Neurosci., 21, 69, 10.1017/S0952523804041070 Fan, 2005, Reciprocal inhibition of voltage-gated potassium currents (I K(V)) by activation of cannabinoid CB1 and dopamine D1 receptors in ON bipolar cells of goldfish retina, Vis. Neurosci., 22, 55, 10.1017/S0952523805221089 Fan, 2007, Retrograde endocannabinoid inhibition of goldfish retinal cones in mediated by 2-arachidonoyl glycerol, Vis. Neurosci., 24, 257, 10.1017/S095252380707006X Fernández-Ruiz, 2004, Cannabinoids and gene expression during brain development, Neurotox. Res., 6, 389, 10.1007/BF03033314 Fernández-Ruiz, 1999, Role of endocannabinoids in brain development, Life Sci., 65, 725, 10.1016/S0024-3205(99)00295-7 Flom, 1976, Alcohol and marijuana effects on ocular tracking, Am. J. Optom. Physiol. Opt., 53, 764, 10.1097/00006324-197612000-00003 Fowler, 2007, The contribution of cyclooxgenase-2 to endocannabinoid metabolism and action, Br. J. Pharmacol., 152, 594, 10.1038/sj.bjp.0707379 Fowler, 2005, The endocannabinoid signaling system: pharmacological and therapeutic aspects, Pharmacol. Biochem. Behav., 81, 248, 10.1016/j.pbb.2005.01.023 Fride, 2008, Multiple roles for the endocannabinoid system during the earliest stages of life: pre- and postnatal development, J. Neuroendocrinol., 20, 75, 10.1111/j.1365-2826.2008.01670.x Fried, 1995, The Ottawa Prenatal Prospective Study (OPPS): methodological issues and findings – it's easy to throw the baby out with the bath, Life Sci., 56, 2159, 10.1016/0024-3205(95)00203-I Fukudome, 2004, Two distinct classes of muscarinic action on hippocampal inhibitory synapses: M2-mediated direct suppression and M1M3-mediated indirect suppression through endocannabinoid signaling, Eur. J. Neurosci., 19, 2682, 10.1111/j.0953-816X.2004.03384.x Funakoshi, 2005, Differential development of TRPV1-expressing sensory nerves in peripheral organs, Cell Tissue Res., 1 Galiegue, 1995, Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations, Eur. J. Biochem., 232, 54, 10.1111/j.1432-1033.1995.tb20780.x Gallego, 1965, Mammalian retina: associational nerve cells in ganglion cell layer, Science, 150, 1313, 10.1126/science.150.3701.1313 Galve-Roperh, 2006, Endocannabinoids: a new family of lipid mediators involved in the regulation of neural cell development, Curr. Pharm. Des., 12, 2319, 10.2174/138161206777585139 Gaoni, 1964, Isolation, structure and partial synthesis of an active constituent of hashish, J. Am. Chem. Soc., 86, 1646, 10.1021/ja01062a046 Gawienowski, 1982, Effect of delta 9-tetrahydrocannabinol on monoamine oxidase activity in bovine eye tissues, in vitro, Invest. Ophthalmol. Vis. Sci., 22, 482 Gilbert, 2007, Delta9-tetrahydrocannabinol protects hippocampal neurons from excitotoxicity, Brain Res., 1128, 61, 10.1016/j.brainres.2006.03.011 Glaser, 2005, Endocannabinoids in the intact retina: 3H-anandamide uptake, fatty acid amide hydrolase immunoreactivity and hydrolysis of anandamide, Vis. Neurosci., 22, 693, 10.1017/S0952523805226020 Glaser, 2005, Anadamide transport: a critical review, Life Sci., 77, 1584, 10.1016/j.lfs.2005.05.007 Glass, 1997, Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: evidence for a Gs linkage to the CB1 receptor, J. Neurosci., 17, 5327, 10.1523/JNEUROSCI.17-14-05327.1997 Goparaju, 1999, Enzymes of porcine brain hydrolyzing 2-arachidonoylglycerol, an endogenous ligand of cannabinoid receptors, Biochem. Pharmacol., 57, 417, 10.1016/S0006-2952(98)00314-1 Goparaju, 1998, Anandamide amidohydrolase reacting with 2-arachidonoylglycerol, another cannabinoid receptor ligand, FEBS Lett., 422, 69, 10.1016/S0014-5793(97)01603-7 Grant, 1996, On bipolar cell responses in the teleost retina are generated by two distinct mechanisms, J. Neurophysiol., 76, 3842, 10.1152/jn.1996.76.6.3842 Green, 1979, The ocular effects of cannabinoids, Curr. Top. Eye Res., 1, 175 Gulyas, 2004, Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala, Eur. J. Neurosci., 20, 441, 10.1111/j.1460-9568.2004.03428.x Harsanyi, 1993, Modulation of cone to horizontal cell transmission by calcium and pH in the fish retina, Vis. Neurosci., 10, 81, 10.1017/S0952523800003242 Hartwick, 2004, Adenosine A1-receptor modulation of glutamate-induced calcium influx in rat retinal ganglion cells, Invest. Ophthalmol. Vis. Sci., 45, 3740, 10.1167/iovs.04-0214 Heidelberger, 1994, Dopamine enhances Ca2+ responses in synaptic terminals of retinal bipolar neurons, Neuroreport, 5, 729, 10.1097/00001756-199402000-00018 Herkenham, 1991, Characterization and localization of cannabinoid receptors in rat brain: A quantitative in vitro autoradiographic study, J. Neurosci., 11, 563, 10.1523/JNEUROSCI.11-02-00563.1991 Hermann, 2006, 2-Arachidonoylglycerol (2-AG) membrane transport: history and outlook, AAPS J., 8, E409, 10.1208/aapsj080247 Hewett, 2000, Cyclooxygenase-2 contributes to N-methy-d-aspartate-mediated neuronal cell death in primary cortical cell culture, J. Pharmacol. Exp. Ther., 293, 417 Hill, 2007, Functional CB1 receptors are broadly expressed in neocortical GABAergic and glutamatergic neurons, J. Neurophysiol., 97, 2580, 10.1152/jn.00603.2006 Hillard, 2003, Cellular accumulation of anandamide: consensus and controversy, Br. J. Pharmacol., 140, 802, 10.1038/sj.bjp.0705468 Hohmann, 2006, Endocannabinoid mechanisms of pain modulation, AAPS J., 8, E693, 10.1208/aapsj080479 Hollister, 1971, Marihuana in man: three years later, Science, 172, 21, 10.1126/science.172.3978.21 Howlett, 2004, Cannabinoid physiology and pharmacology: 30 years of progress, Neuropharmacology, 47, 345, 10.1016/j.neuropharm.2004.07.030 Hwang, 2000, Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances, Proc. Natl. Acad. Sci. U S A, 97, 6155, 10.1073/pnas.97.11.6155 Iribane, 2008, Cannabinoid receptors in conjunctival epithelium: identification and functional properties, Invest. Ophthalmol. Vis. Sci., June 19 Iversen, 2003, Cannabis and the brain, Brain, 126, 1252, 10.1093/brain/awg143 Iversen, 2000 Järvinen, 2002, Cannabinoids in the treatment of glaucoma, Pharmacol. Ther., 95, 203, 10.1016/S0163-7258(02)00259-0 Jayamanne, 2006, Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models, Br. J. Pharmacol., 147, 281, 10.1038/sj.bjp.0706510 Ju, 2003, Increased activity of cyclooxygenase-2 signals early neurodegenerative events in the rat retina following transient ischemia, Exp. Eye Res., 77, 137, 10.1016/S0014-4835(03)00128-3 Jung, 1999, Capsaicin binds to the intracellular domain of the capsaicin-activated ion channel, J. Neurosci., 19, 529, 10.1523/JNEUROSCI.19-02-00529.1999 Jung, 2002, Agonist recognition sites in the cytosolic tails of vanilloid receptor 1, J. Biochem. (Tokyo), 46, 44448 Kamermans, 2001, Hemichannel-mediated inhibition in the outer retina, Science, 292, 1178, 10.1126/science.1060101 Kaplan-Messas, 2003, Ocular hypotensive effects of cholinergic and adrenergic drugs may be influenced by prostaglandins E2 in the human and rabbit eye, Eur. J. Ophthalmol., 13, 18, 10.1177/112067210301300103 Kárai, 2004, Vanilloid receptor 1 regulates multiple calcium compartments and contributes to Ca2+-induced Ca2+-release in sensory neurons, J. Biol. Chem., 279, 16377, 10.1074/jbc.M310891200 Karanian, 2005, Dual modulation of endocannabinoid transport and fatty acid amide hydrolase protects against excitotoxicity, J. Neurosci., 25, 7813, 10.1523/JNEUROSCI.2347-05.2005 Katona, 1999, Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons, J. Neurosci., 19, 4544, 10.1523/JNEUROSCI.19-11-04544.1999 Katona, 2006, Molecular composition of the endocannabinoid system at glutamatergic synapses, J. Neurosci., 26, 5628, 10.1523/JNEUROSCI.0309-06.2006 Kaufmann, 1996, COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex, Proc. Natl. Acad. Sci. U S A, 93, 2317, 10.1073/pnas.93.6.2317 Kim, 2004, Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampus, Nat. Neurosci., 7, 697, 10.1038/nn1262 Kiplinger, 1971, Dose-response analysis of the effects of tetrahydrocannabinol in man, Clin. Pharmacol. Ther., 12, 650, 10.1002/cpt1971124650 Klooster, 2001, Localization of the AMPA subunit GluR2 in the outer plexiform layer of goldfish retina, J. Comp. Neurol., 441, 155, 10.1002/cne.1404 Kogan, 2007, Cannabinoids in health and disease, Dialogues Clin. Neurosci., 9, 413, 10.31887/DCNS.2007.9.4/nkogan Kourennyi, 2004, Reciprocal modulation of calcium dynamics at rod and cone photoreceptor synapses by nitric oxide, J. Neurophysiol., 92, 477, 10.1152/jn.00606.2003 Kozak, 2000, Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2, J. Biol. Chem., 275, 33744, 10.1074/jbc.M007088200 Kreitzer, 2001, Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cells, Neuron, 29, 717, 10.1016/S0896-6273(01)00246-X Kurreny, 1994, Modulation of ion channels in rod photoreceptors by nitric oxide, Neuron, 13, 315, 10.1016/0896-6273(94)90349-2 Ladanyi, 1986, In-vivo labeling of (3H)d-aspartate uptake sites in monkey retina, Cell Tissue Res., 243, 59, 10.1007/BF00221852 de Lago, 2007, Cannabinoids and neuroprotection in motor-related disorders, CNS Neurol. Disord. Drug Targets, 6, 377, 10.2174/187152707783399210 Lambert, 2005, The endocannabinoid system: drug targets, lead compunds, and potential therapeutic applications, J. Med. Chem., 48, 5059, 10.1021/jm058183t Lalonde, 2006, Cannabinoid receptor-mediated inhibition of calcium signalling in rat retinal ganglion cells, Mol. Vis., 12, 1160 Lauckner, 2005, The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins, Proc. Natl. Acad. Sci. U S A, 102, 19149, 10.1073/pnas.0509588102 LaVail, 1974, C57BL/6J mice with inherited retinal degeneration, Arch. Ophthalmol., 91, 394, 10.1001/archopht.1974.03900060406015 Ledent, 1999, Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice, Science, 283, 401, 10.1126/science.283.5400.401 Leonelli, 2005, Developmental expression of cannabinoid receptors in the chick retinotectal system, Brain Res. Dev. Brain Res., 156, 176, 10.1016/j.devbrainres.2005.02.009 Leweke, 1999, Effects of synthetic 9-tetrahydrocannbinoi on binocular depth inversion in man, Psychopharmacology (Berl), 142, 230, 10.1007/s002130050884 Liang, 2004, Upregulation of orphan nuclear receptor Nur77 following PGF(2alpha), bimatoprost, and butaprost treatments. Essential role of a protein kinase C pathway involved in EP(2) receptor activated Nur77 gene transcription, Br. J. Pharmacol., 142, 737, 10.1038/sj.bjp.0705829 Liang, 2003, Comparison of prostaglandin F2alpha, bimatoprost (prostamide), and butaprost (EP2 agonist) on Cyr61 and connective tissue growth factor gene expression, J. Biol. Chem., 278, 27267, 10.1074/jbc.M301009200 Lichtman, 2004, Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia, Pain, 109, 319, 10.1016/j.pain.2004.01.022 Liu, 2005, Neuroprotection by the PGE2 EP2 receptor in permanent focal cerebral ischemia, Ann. Neurol., 57, 748, 10.1002/ana.20461 Liu, 2008, Multiple pathways involved in the biosynthesis of anadamide, Neuropharmacology, 54, 1, 10.1016/j.neuropharm.2007.05.020 Liu, 2003, Versatile regulation of cytosolic Ca2+ by vanilloid receptor I in rat dorsal root ganglion neurons, J. Cell Biol., 278, 5462 Lograno, 2004, Cannabinoid agonists induce contractile responses through Gi/o-dependent activation of phospholipase C in the bovine ciliary muscle, Eur. J. Pharmacol., 494, 55, 10.1016/j.ejphar.2004.04.039 Lu, 2000, Expression of CB2 cannabinoid receptor mRNA in adult rat retina, Vis. Neurosci., 17, 91, 10.1017/S0952523800171093 Mackie, 2006, Cannabinoid receptors as therapeutic targets, Annu. Rev. Pharmacol. Toxicol., 46, 101, 10.1146/annurev.pharmtox.46.120604.141254 Maejima, 2001, Presynaptic inhibition caused by retrograde signal from metabotropic glutamate to cannabinoid receptors, Neuron, 31, 463, 10.1016/S0896-6273(01)00375-0 Maejima, 2005, Synaptically driven endocannabinoid release requires Ca2+-assisted metabotropic glutamate receptor subtype 1 to phospholipase Cbeta4 signaling cascade in the cerebellum, J. Neurosci., 25, 6826, 10.1523/JNEUROSCI.0945-05.2005 Maihofner, 2001, Expression of cyclooxygenase-1 and -2 in normal and glaucomatous human eyes, Invest. Ophthalmol. Vis. Sci., 42, 2616 Mailleux, 1992, Distribution of neuronal cannabinoid receptor in the adult rat brain: A comparative receptor binding radioautography and in situ hybridization histochemistry, Neuroscience, 48, 655, 10.1016/0306-4522(92)90409-U Maneuf, 1997, Paradoxical action of the cannabinoid WIN 55,212-2 in stimulated and basal cyclic AMP accumulation in rat globus pallidus slices, Br. J. Pharmacol., 120, 1397, 10.1038/sj.bjp.0701101 Marc, 1981, Uptake of aspartic and glutamic acid by photoreceptors in goldfish retina, Proc. Natl. Acad. Sci. U S A, 78, 7185, 10.1073/pnas.78.11.7185 Marc, 1995, Pattern recognition of amino acid signatures in retinal neurons, J. Neurosci., 15, 5106, 10.1523/JNEUROSCI.15-07-05106.1995 Marsicano, 1999, Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain, Eur. J. Neurosci., 11, 4213, 10.1046/j.1460-9568.1999.00847.x Marsicano, 2002, Neuroprotective properties of cannabinoids against oxidative stress: role of the cannabinoid receptor CB1, J. Neurochem., 80, 448, 10.1046/j.0022-3042.2001.00716.x Martínez-Orgado, 2007, The seek of neuroprotection: introducing cannabinoids, Rec. Patents CNS Drug Discov, 2, 131, 10.2174/157488907780832724 Matias, 2006, Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration, Prostaglandins Leukot. Essent. Fatty Acids, 75, 413, 10.1016/j.plefa.2006.08.002 Matsuda, 1990, Structure of a cannabinoid receptor and functional expression of the cloned cDNA, Nature, 346, 561, 10.1038/346561a0 Matsuda, 1997, Metabolism of anandamide, an endogenous cannabinoid receptor ligand, in porcine ocular tissues, Exp. Eye Res., 64, 707, 10.1006/exer.1996.0265 2005, Visual Neurosci., 22, 553, 10.1017/S0952523805225026 McAllister, 2002, CB1 and CB2 receptor-mediated signalling: a focus on endocannabinoids, Prostaglandins Leukot. Essent. Fatty Acids, 66, 161, 10.1054/plef.2001.0344 McCullough, 2004, Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia, J. Neurosci., 24, 257, 10.1523/JNEUROSCI.4485-03.2004 McIntosh, 2007, Agonist-dependent cannabinoid signalling in human trabecular meshwork cells, Br. J. Pharmacol., 152, 1111, 10.1038/sj.bjp.0707495 McIntosh, 1998, CB1 cannabinoid receptor: cellular regulation and distribution in N18TG2 neuroblastoma cells, Mol. Brain Res., 53, 163, 10.1016/S0169-328X(97)00294-5 McKinney, 2005, Structure and function of fatty acid amide hydrolase, Annu. Rev. Biochem., 74, 411, 10.1146/annurev.biochem.74.082803.133450 Mechoulam, 2002, Discovery of endocannabinoids and some random thoughts on their possible roles in neuroprotection and aggression, Prostaglandins Leukot. Essent. Fatty Acids, 66, 93, 10.1054/plef.2001.0340 Mechoulam, 1995, Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors, Biochem. Pharmacol., 50, 83, 10.1016/0006-2952(95)00109-D Mechoulam, 1967, The absolute configuration of D1-tetrahydrocannabinol, the major active constituent of hashish, Tetrahedron Lett., 1109, 10.1016/S0040-4039(00)90646-4 Mechoulam, 2007, Endocannabinoids and traumatic brain injury, Mol. Neurobiol., 36, 68, 10.1007/s12035-007-8008-6 Micale, 2007, Endocannabinoids and neurodegenerative diseases, Pharmacol. Res., 56, 382, 10.1016/j.phrs.2007.09.008 Millns, 2006, Effects of inhibition of fatty acid amide hydrolase vs. the anandamide membrane transporter on TRPV1-mediated calcium responses in adult DRG neurons; the role of CB1 receptors, Eur. J. Neurosci., 24, 3489, 10.1111/j.1460-9568.2006.05236.x Mora-Ferrer, 1999, Dopamine D1-receptor immunolocalization in goldfish retina, J. Comp. Neurol., 411, 704, 10.1002/(SICI)1096-9861(19990906)411:4<705::AID-CNE14>3.0.CO;2-Y Munro, 1993, Molecular characterization of a peripheral receptor for cannabinoids, Nature, 365, 61, 10.1038/365061a0 Nagayama, 1999, Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures, J. Neurosci., 19, 2987, 10.1523/JNEUROSCI.19-08-02987.1999 Nakamichi, 2003, Effects of intraocular injection of a low concentration of zinc on the rat retina, Neuropharmacology, 45, 637, 10.1016/S0028-3908(03)00206-5 Navarrete, 2008, Endocannabinoids mediate neuron-astrocyte communication, Neuron, 57, 883, 10.1016/j.neuron.2008.01.029 Neal, 2001, Activation of nicotinic receptors on GABAergic amacrine cells in the rabbit retina indirectly stimulates dopamine release, Vis. Neurosci., 18, 55, 10.1017/S0952523801181058 Njie, Y.F., Qiao, Z., Xiao, Z., Wang, W., Song, Z.H., 2008. N-arachidonylethanolamide-induce increase in aqueous humor outflow facility. Invest. Ophthalmol. Vis. Sci. June 6 [Epub ahead of print]. Nogawa, 1997, Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage, J. Neurosci., 17, 2746, 10.1523/JNEUROSCI.17-08-02746.1997 Noyes, 1975, The analgesic properties of delta-9-tetrahydrocannabinol and codeine, Clin. Pharmacol. Ther., 18, 84, 10.1002/cpt197518184 Nucci, 2007, Involvement of the endocannabinoid system in retinal damage after high intracellular pressure-induced ischemia in rats, Invest. Ophthalmol. Vis. Sci., 48, 2997, 10.1167/iovs.06-1355 Ohno-Shosaku, 2005, Calcium signaling and synaptic modulation: regulation of endocannabinoid-mediated synaptic modulation by calcium, Cell Calcium, 38, 369, 10.1016/j.ceca.2005.06.014 Ohno-Shosaku, 2001, Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals, Neuron, 29, 729, 10.1016/S0896-6273(01)00247-1 Ohno-Shosaku, 2002, Presynaptic cannabinoid sensitivity is a major determinant of depolarization-induced retrograde suppression at hippocampal synapses, J. Neurosci., 22, 3864, 10.1523/JNEUROSCI.22-10-03864.2002 Oku, 2004, Adenosine protects cultured retinal neurons against NMDA-induced cell death through A1 receptors, Curr. Eye Res., 29, 449, 10.1080/02713680490522443 Olah, 2001, Ligand-induced dynamic membrane changes and cell deletion conferred by vanilloid receptor 1, J. Biol. Chem., 276, 11021, 10.1074/jbc.M008392200 2006 Opere, 2006, Inhibition of potassium- and ischemia-evoked [3H] d-aspartate release from isolated bovine retina by cannabinoids, Curr. Eye Res., 31, 645, 10.1080/02713680600762747 Osborne, 2004, Retinal ischemia: mechanisms of damage and potential therapeutic strategies, Prog. Retin. Eye Res., 23, 91, 10.1016/j.preteyeres.2003.12.001 Patrick, 1995, Auditory and visual P300 event related potentials are not altered in medically and psychiatrically normal chronic marihuana users, Life Sci., 56, 2135, 10.1016/0024-3205(95)00199-G Pazos, 2005, Functional neuroanatomy of the endocannabinoid system, Pharmacol. Biochem. Behav., 81, 239, 10.1016/j.pbb.2005.01.030 Pertwee, 2005, The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids, AAPS J., 7, E625, 10.1208/aapsj070364 Pertwee, 2006, Cannabinoid pharmacology: the first 66 years, Br. J. Pharmacol., 147, S163, 10.1038/sj.bjp.0706406 Pertwee, 2002, Cannabinoid receptors and their ligands, Prostaglandins Leukot. Essent. Fatty Acids, 66, 101, 10.1054/plef.2001.0341 Pettit, 1998, Immunohistochemical localization of the neural cannabinoid receptor in rat brain, J. Neurosci. Res., 51, 391, 10.1002/(SICI)1097-4547(19980201)51:3<391::AID-JNR12>3.0.CO;2-A Picaud, 1998, GABAA and GABAC receptors in adult porcine cones: evidence from a photoreceptor-glia co-culture model, J. Physiol., 513, 33, 10.1111/j.1469-7793.1998.033by.x Piomelli, 2003, The molecular logic of endocannabinoid signalling, Nat. Rev. Neurosci., 4, 873, 10.1038/nrn1247 Porcella, 1998, Cannabinoid receptor CB1 mRNA is highly expressed in the rat ciliary body: implications for the antiglaucoma properties of marihuana, Mol. Brain Res., 58, 240, 10.1016/S0169-328X(98)00105-3 Porcella, 2000, The human eye expresses high levels of CB1 cannabinoid receptor mRNA and protein, Eur. J. Neurosci., 12, 1123, 10.1046/j.1460-9568.2000.01027.x Porcella, 2001, The synthetic cannabinoid WIN55212-2 decreases the intraocular pressure in human glaucoma resistant to conventional therapies, Eur. J. Neurosci., 13, 409, 10.1046/j.0953-816X.2000.01401.x Quigley, 1999, Neuronal death in glaucoma, Prog. Retin. Eye Res., 18, 39, 10.1016/S1350-9462(98)00014-7 Ramos, 2005, Effects on development, Handb. Exp. Pharmacol., 168, 643, 10.1007/3-540-26573-2_22 Reese, 1991, Cannabis seems to improve night vision of fisherman, Chem. Eng. News, 69, 44, 10.1021/cen-v069n031.p044 Rosch, 2005, Prostaglandin E(2) induces cyclooxygenase-2 expression in human non-pigmented ciliary epithelial cells through activation of p38 and p42/44 mitogen-activated pritein kinases, Biochem. Biophys. Res. Commun., 338, 1171, 10.1016/j.bbrc.2005.10.051 Rosch, 2006, R(+)-Methanandamide and other cannabinoids induce the expression of cyclooxygenase-2 and matrix metalloproteinases in human non-pigmented ciliary epithelial cells, J. Pharmacol. Exp. Ther., 316, 1219, 10.1124/jpet.105.092858 Ross, 2003, Anandamide and vanilloid TRPV1 receptors, Br. J. Pharmacol., 140, 790, 10.1038/sj.bjp.0705467 Russo, 2004, Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?, Neuroendocrinol. Lett., 25, 31 Russo, 2004, Cannabis improves night vision: a case study of dark adaptometry and scotopic sensitivity in kif smokers of the Rif mountains of northern Morocco, J. Ethnopharmacol., 93, 99, 10.1016/j.jep.2004.03.029 Saario, 2004, Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes, Biochem. Pharmacol., 67, 1381, 10.1016/j.bcp.2003.12.003 Sagar, 1988, Somatostatin-like immunoreactive material in associational ganglion cells of human retina, Neuroscience, 27, 507, 10.1016/0306-4522(88)90284-9 Sang, 2007, COX-2 oxidative metabolite of endocannabinoid 2-AG enhances excitatory glutamatergic synaptic transmission and induces neurotoxicity, J. Neurochem., 102, 1966, 10.1111/j.1471-4159.2007.04668.x Sang, 2005, Postsynaptically synthesized prostaglandin E2 (PGE2) modulates hippocampal synaptic transmission via a presynaptic PGE2 EP2 receptor, J. Neurosci., 25, 9858, 10.1523/JNEUROSCI.2392-05.2005 Sarker, 2003, Anandamide induces cell death independently of cannabinoid receptors or vanilloid receptor 1: possible involvement of lipid rafts, Cell. Mol. Life Sci., 60, 1200, 10.1007/s00018-003-3055-2 Savinainen, 2004, Detection of cannabinoid CB1, adenosine A1, muscarinic acetylcholine, and GABA(B) receptor-dependent G protein activity in transducin-deactivated membranes and autoradiography sections of rat retina, Cell Mol. Neurobiol., 24, 243, 10.1023/B:CEMN.0000018619.18631.53 Schlicker, 1996, Cannabinoid receptor-mediated inhibition of dopamine release in the retina, Naunyn Schmiedebergs Arch. Pharmacol., 354, 791, 10.1007/BF00166907 Schlotzer-Schrehardt, 2002, Expression and localization of FP and EP prostanoid receptor subtypes in human ocular tissues, Invest. Ophthalmol. Vis. Sci., 43, 1475 Semple, 2003, Reduced binocular depth inversion in regular cannabis users, Pharmacol. Biochem. Behav., 75, 789, 10.1016/S0091-3057(03)00140-0 Sharif, 2004, Molecular pharmacology of the DP/EP2 class prostaglandin AL-6598 and quantitative autoradiographic visualization of DP and EP2 receptor sites in human eyes, J. Ocul. Pharmacol. Ther., 20, 489, 10.1089/jop.2004.20.489 Shivachar, 2007, Cannabinoids inhibit sodium-dependent, high affinity excitatory amino acid transport in cultured rat cortical astrocytes, Biochem. Pharmacol., 73, 2004, 10.1016/j.bcp.2007.03.018 Skosnik, 2006, The effect of cannabis use and gender on the visual steady state evoked potential, Clin. Neurophysiol., 117, 144, 10.1016/j.clinph.2005.09.024 Slanina, 2005, Inhibition of cyclooxygenase-2 elicits a CB1-mediated decrease of excitatory transmission in rat CA1 hippocampus, Neuropharmacology, 49, 653, 10.1016/j.neuropharm.2005.04.019 Sommer, 2006, Neuroprotective cannabinoid receptor antagonist SR141716A prevents downregulation of excitotoxic NMDA receptors in the ischemic penumbra, Acta Neuropathol., 112, 277, 10.1007/s00401-006-0110-8 Song, 2000, Involvement of cannabinoid receptors in the intraocular pressure-lowering effects of WIN55212-2, J. Pharmacol. Exp. Ther., 292, 136 Stamer, 2001, Cannabinoid CB(1) receptor expression, activation and detection of endogenous ligand in trabecular meshwork and ciliary process tissues, Eur. J. Pharmacol., 431, 277, 10.1016/S0014-2999(01)01438-8 Stella, 1997, A second endogenous cannabinoid that modulates long-term potentiation, Nature, 388, 773, 10.1038/42015 Stella, 2003, Endogenous adenosine reduces glutamatergic output from rods through activation of A(2)-like adenosine receptors, J. Neurophysiol., 90, 165, 10.1152/jn.00671.2002 Stella, 2002, A(2) adenosine receptors inhibit calcium influx through L-type calcium channels in rod photoreceptors of the salamander retina, J. Neurophysiol., 87, 351, 10.1152/jn.00010.2001 Straiker, 2006, Cannabinoids, electrophysiology, and retrograde messengers: challenges for the next 5 years, AAPS J., 8, E272, 10.1007/BF02854897 Straiker, 2003, Cannabinoid receptor activation differentially modulates ion channels in photoreceptors of the tiger salamander, J. Neurophysiol., 89, 2647, 10.1152/jn.00268.2002 Straiker, 1999, Localization of cannabinoid CB1 receptors in the human anterior eye and retina, Invest. Ophthalmol. Vis. Sci., 40, 2442 Struik, 2006, Cannabinoid agonist WIN 55212-2 speeds up the cone light offset response in goldfish, Vis. Neurosci., 23, 285, 10.1017/S0952523806232127 Stumpff, 2005, Stimulation of cannabinoid (CB1) and prostanoid (EP2) receptors opens BKCa channels and relaxes ocular trabecular meshwork, Exp. Eye Res., 80, 697, 10.1016/j.exer.2004.12.003 Sugiura, 1995, 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain, Biochem. Biophys. Res. Commun., 215, 89, 10.1006/bbrc.1995.2437 Sulcova, 1998, Biphasic effects of anandamide, Pharmacol. Biochem. Behav., 59, 347, 10.1016/S0091-3057(97)00422-X Sun, 2004, Biosynthesis of anandamide and N-palmitoylethanolamne by sequential actions of phospolipase A2 and phospholipase D, Biochem. J., 380, 749, 10.1042/bj20040031 Sawzdargo, 1999, Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain, Brain Res. Mol. Brain Res., 64, 193, 10.1016/S0169-328X(98)00277-0 Szabo, 1998, Inhibition of gabaergic inhibitory postsynaptic currents by cannabinoids in rat corpus striatum, Neuroscience, 85, 395, 10.1016/S0306-4522(97)00597-6 Szabo, 2006, Depolarization-induced retrograde synaptic inhibition in the cerebellar cortex is mediated by 2-arachidonoylglycerol, J. Physiol., 577, 262, 10.1113/jphysiol.2006.119362 Szallasi, 1993, Vanilloid receptors in the urinary bladder: regional distribution, localization on sensory nerves, and species-related differences, Naunyn Schmiedebergs Arch. Pharmacol., 347, 624, 10.1007/BF00166945 Tachibana, 1984, g-Aminobutyric acid acts at axon terminals of turtle photoreceptors: difference in sensitivity among cell types, Proc. Natl. Acad. Sci. U S A, 81, 7961, 10.1073/pnas.81.24.7961 Takadera, 2006, Prostaglandin E2 deteriorates N-methyl-d-aspartate receptor-mediated cytotoxicity possible by activating EP2 receptors in cultured cortical neurons, Life Sci., 78, 1878, 10.1016/j.lfs.2005.08.026 Takadera, 2002, Prostaglandin E(2) induces caspase-dependent apoptosis in rat cortical cells, Neurosci. Lett., 317, 61, 10.1016/S0304-3940(01)02449-1 Thomas, 1997, Fatty acid amide hydrolase, the degradative enzyme for anandamide and oleamide, has selective distribution in neurons within the rat central nervous system, J. Neurosci. Res., 50, 1047, 10.1002/(SICI)1097-4547(19971215)50:6<1047::AID-JNR16>3.0.CO;2-1 Tomida, 2004, Cannabinoids and glaucoma, Br. J. Ophthalmol., 88, 708, 10.1136/bjo.2003.032250 Toth, 2005, Expression and distribution of vanilloid receptor 1 (TRPV1) in the adult rat brain, Brain Res. Mol. Brain Res., 135, 162, 10.1016/j.molbrainres.2004.12.003 Tsou, 1998, Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system, Neuroscience, 83, 393, 10.1016/S0306-4522(97)00436-3 Tsou, 1998, Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistry, Neurosci. Lett., 254, 1, 10.1016/S0304-3940(98)00700-9 Twitchell, 1997, Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons, J. Neurophysiol., 78, 43, 10.1152/jn.1997.78.1.43 Valenti, 2005, The endocannabinoid system in the brain of Carassius auratus and its possible role in the control of food intake, J. Neurochem., 95, 662, 10.1111/j.1471-4159.2005.03406.x Valenti, 2004, Differential diurnal variations of anandamide and 2-arachidonoyl-glycerol levels in rat brain, Cell. Mol. Life Sci., 61, 945, 10.1007/s00018-003-3453-5 Van der Stelt, 2004, Endovanilloids, Eur. J. Biochem., 271, 1827, 10.1111/j.1432-1033.2004.04081.x Van der Stelt, 2005, Cannabinoid receptors and their role in neuroprotection, Neuromolecular Med., 7, 37, 10.1385/NMM:7:1-2:037 Varvel, 2006, Fatty acid amide hydrolase (−/−) mice exhibit an increased sensitivity to the disruptive effects of anandamide or oleamide in a working memory water maze task, J. Pharmacol. Exp. Ther., 317, 251, 10.1124/jpet.105.095059 Veldhuis, 2003, Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat: role of vanilloid receptors and lipoxygenases, J. Neurosci., 23, 4127, 10.1523/JNEUROSCI.23-10-04127.2003 Vellani, 2000, Modulation of the synaptic Ca2+ current in salamander photoreceptors by polyunsaturated fatty acids and retinoids, J. Physiol. (London), 529, 333, 10.1111/j.1469-7793.2000.00333.x Wagner, 1993, Microanatomy of the dopaminergic system in the rainbow trout retina, Vision Res., 33, 1345, 10.1016/0042-6989(93)90042-U Warrier, 2007, Endocannabinoid signaling regulates spontaneous transmitter release from embryonic retinal amacrine cells, Vis. Neurosci., 24, 25, 10.1017/S0952523807230160 Watanabe, 2005, Immunohistochemical localization of vanilloid receptor subtype 1 (TRPV1) in the guinea pig respiratory system, Pulm. Pharmacol. Ther., 18, 187, 10.1016/j.pupt.2004.12.002 Weber, 2001, Modulation of dopamine release in the guinea-pig retina by G(i)- but not by G(s)- or G(q)-protein-coupled receptors, Fundam. Clin. Pharmacol., 15, 393, 10.1046/j.1472-8206.2001.00056.x Weil, 1968, Clinical and psychological effects of marihuana in man, Science, 162, 1234, 10.1126/science.162.3859.1234 West, 1991, Cannabis and night vision, Nature, 351, 703, 10.1038/351703b0 Westlake, 1994, Cannabinoid receptor binding and messenger RNA expression in human brain: an in vitro receptor autoradiography and in situ hybridization histochemistry study of normal aged and Alzheimer's brains, Neuroscience, 63, 637, 10.1016/0306-4522(94)90511-8 Wilson, 2001, Endogenous cannabinoids mediate retrograde signaling at hippocampal synapses, Nature, 410, 588, 10.1038/35069076 Wise, 2007, Assessment of anandamide's pharmacological effects in mice deficient of both fatty acid amide hydrolase and cannabinoid CB1 receptors, Eur. J. Pharmacol., 557, 44, 10.1016/j.ejphar.2006.11.002 Wong, 2004, Retinal bipolar cell input mechanisms in giant danio: II. Patch-clamp analysis of ON bipolar cells, J. Neurophysiol., 93, 94, 10.1152/jn.00270.2004 2004, Vision Res., 44, 3233, 10.1016/j.visres.2004.09.012 Yazulla, 1995, Differential effects of dopamine depletion on the distribution of 3H-SCH23390 and 3H-spiperone binding sites in the goldfish retina, Vision Res., 35, 2509, 10.1016/0042-6989(95)00010-0 Yazulla, 1997, Light adaptation affects synaptic vesicle density but not the distribution of GABAA receptors in goldfish photoreceptor terminals, Microsc. Res. Tech., 36, 43, 10.1002/(SICI)1097-0029(19970101)36:1<43::AID-JEMT4>3.0.CO;2-# Yazulla, 2004, Vanilloid receptor like 1 (VRL1) immunoreactivity in mammalian retina: colocalization with somatostatin and purinergic P2X1 receptors, J. Comp. Neurol., 474, 407, 10.1002/cne.20144 Yazulla, 2001, Neurochemical anatomy of the zebrafish retina as determined by immunocytochemistry, J. Neurocytol., 30, 551, 10.1023/A:1016512617484 Yazulla, 1999, Immunocytochemical localization of cannabinoid CB1 receptor and fatty acid amide hydrolase in rat retina, J. Comp. Neurol., 415, 80, 10.1002/(SICI)1096-9861(19991206)415:1<80::AID-CNE6>3.0.CO;2-H Yazulla, 2000, Cannabinoid receptors on goldfish retinal bipolar cells: electron-microscope immunocytochemistry and whole-cell recordings, Vis. Neurosci., 17, 391, 10.1017/S0952523800173079 Yazulla, 1989, Immunocytochemical localization of GABAA receptors in goldfish and chicken retinas, J. Comp. Neurol., 280, 15, 10.1002/cne.902800103 Yu, 1997, Synthesis of prostaglandin E2 ethanolamide from anandamide by cyclooxygenase-2, J. Biol. Chem., 272, 21181, 10.1074/jbc.272.34.21181 Zhang, 2008, Endocannabinoid 2-AG protects neurons by limiting COX-2 elevation, J. Biol. Chem., 282, 22601, 10.1074/jbc.M800524200 Zheng, 2007, Retinal ischemia and reperfusion causes capillary degeneration: similarities to diabetes, Invest. Ophthalmol. Vis. Sci., 48, 361, 10.1167/iovs.06-0510 Zhu, 2005, Heterogeneous expression and regulation of PGE2 receptors in the hippocampus, J. Neurosci. Res., 81, 817, 10.1002/jnr.20597 Zimmer, 1999, Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice, Proc. Natl. Acad. Sci. U S A, 96, 5780, 10.1073/pnas.96.10.5780 Zimov, 2007, Vanilloid receptor 1 (TRPV1/VR1) co-localizes with fatty acid amide hydrolase (FAAH) in retinal amacrine cells, Vis. Neurosci., 24, 581, 10.1017/S095252380707054X Zygmunt, 1999, Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide, Nature, 400, 452, 10.1038/22761