Endocannabinoid Signaling and Synaptic Function

Neuron - Tập 76 Số 1 - Trang 70-81 - 2012
Pablo E. Castillo1, Thomas J. Younts1, Andrés E. Chávez1, Yuki Hashimotodani1
1Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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Ade, 2007, Anandamide regulates postnatal development of long-term synaptic plasticity in the rat dorsolateral striatum, J. Neurosci., 27, 2403, 10.1523/JNEUROSCI.2916-06.2007

Ahn, 2008, Enzymatic pathways that regulate endocannabinoid signaling in the nervous system, Chem. Rev., 108, 1687, 10.1021/cr0782067

Alger, 2002, Retrograde signaling in the regulation of synaptic transmission: focus on endocannabinoids, Prog. Neurobiol., 68, 247, 10.1016/S0301-0082(02)00080-1

Alger, 2012, Endocannabinoids at the synapse a decade after the dies mirabilis (29 March 2001): what we still do not know, J. Physiol., 590, 2203, 10.1113/jphysiol.2011.220855

Auclair, 2000, Cannabinoids modulate synaptic strength and plasticity at glutamatergic synapses of rat prefrontal cortex pyramidal neurons, J. Neurophysiol., 83, 3287, 10.1152/jn.2000.83.6.3287

Bacci, 2004, Long-lasting self-inhibition of neocortical interneurons mediated by endocannabinoids, Nature, 431, 312, 10.1038/nature02913

Banni, 2010, Effect of dietary fat on endocannabinoids and related mediators: consequences on energy homeostasis, inflammation and mood, Mol. Nutr. Food Res., 54, 82, 10.1002/mnfr.200900516

Beltramo, 1997, Functional role of high-affinity anandamide transport, as revealed by selective inhibition, Science, 277, 1094, 10.1126/science.277.5329.1094

Bender, 2006, Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex, J. Neurosci., 26, 4166, 10.1523/JNEUROSCI.0176-06.2006

Blankman, 2007, A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol, Chem. Biol., 14, 1347, 10.1016/j.chembiol.2007.11.006

Brenowitz, 2005, Associative short-term synaptic plasticity mediated by endocannabinoids, Neuron, 45, 419, 10.1016/j.neuron.2004.12.045

Brown, 2003, Brief presynaptic bursts evoke synapse-specific retrograde inhibition mediated by endogenous cannabinoids, Nat. Neurosci., 6, 1048, 10.1038/nn1126

Caiati, 2012, Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses, Sci. Rep., 2, 285, 10.1038/srep00285

Carriba, 2008, Detection of heteromerization of more than two proteins by sequential BRET-FRET, Nat. Methods, 5, 727, 10.1038/nmeth.1229

Caterina, 2001, The vanilloid receptor: a molecular gateway to the pain pathway, Annu. Rev. Neurosci., 24, 487, 10.1146/annurev.neuro.24.1.487

Caterina, 1997, The capsaicin receptor: a heat-activated ion channel in the pain pathway, Nature, 389, 816, 10.1038/39807

Cavanaugh, 2011, Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells, J. Neurosci., 31, 5067, 10.1523/JNEUROSCI.6451-10.2011

Chanda, 2010, Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system, Mol. Pharmacol., 78, 996, 10.1124/mol.110.068304

Chávez, 2010, TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus, Nat. Neurosci., 13, 1511, 10.1038/nn.2684

Chen, 2003, Long-term plasticity of endocannabinoid signaling induced by developmental febrile seizures, Neuron, 39, 599, 10.1016/S0896-6273(03)00499-9

Chen, 2007, Prevention of plasticity of endocannabinoid signaling inhibits persistent limbic hyperexcitability caused by developmental seizures, J. Neurosci., 27, 46, 10.1523/JNEUROSCI.3966-06.2007

Chen, 2011, Sapap3 deletion anomalously activates short-term endocannabinoid-mediated synaptic plasticity, J. Neurosci., 31, 9563, 10.1523/JNEUROSCI.1701-11.2011

Chevaleyre, 2003, Heterosynaptic LTD of hippocampal GABAergic synapses: a novel role of endocannabinoids in regulating excitability, Neuron, 38, 461, 10.1016/S0896-6273(03)00235-6

Chevaleyre, 2004, Endocannabinoid-mediated metaplasticity in the hippocampus, Neuron, 43, 871, 10.1016/j.neuron.2004.08.036

Chevaleyre, 2006, Endocannabinoid-mediated synaptic plasticity in the CNS, Annu. Rev. Neurosci., 29, 37, 10.1146/annurev.neuro.29.051605.112834

Chevaleyre, 2007, Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1alpha, Neuron, 54, 801, 10.1016/j.neuron.2007.05.020

Chiu, 2010, Dopaminergic modulation of endocannabinoid-mediated plasticity at GABAergic synapses in the prefrontal cortex, J. Neurosci., 30, 7236, 10.1523/JNEUROSCI.0736-10.2010

Coutts, 2001, Agonist-induced internalization and trafficking of cannabinoid CB1 receptors in hippocampal neurons, J. Neurosci., 21, 2425, 10.1523/JNEUROSCI.21-07-02425.2001

Cristino, 2006, Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain, Neuroscience, 139, 1405, 10.1016/j.neuroscience.2006.02.074

Cristino, 2008, Immunohistochemical localization of anabolic and catabolic enzymes for anandamide and other putative endovanilloids in the hippocampus and cerebellar cortex of the mouse brain, Neuroscience, 151, 955, 10.1016/j.neuroscience.2007.11.047

Crosby, 2011, Endocannabinoids gate state-dependent plasticity of synaptic inhibition in feeding circuits, Neuron, 71, 529, 10.1016/j.neuron.2011.06.006

De Chiara, 2010, Brain-derived neurotrophic factor controls cannabinoid CB1 receptor function in the striatum, J. Neurosci., 30, 8127, 10.1523/JNEUROSCI.1683-10.2010

De Petrocellis, 2010, Non-CB1, non-CB2 receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: focus on G-protein-coupled receptors and transient receptor potential channels, J. Neuroimmune Pharmacol., 5, 103, 10.1007/s11481-009-9177-z

den Boon, 2012, Excitability of prefrontal cortical pyramidal neurons is modulated by activation of intracellular type-2 cannabinoid receptors, Proc. Natl. Acad. Sci. USA, 109, 3534, 10.1073/pnas.1118167109

Di Marzo, 2009, The endocannabinoid system: its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation, Pharmacol. Res., 60, 77, 10.1016/j.phrs.2009.02.010

Di Marzo, 2011, Endocannabinoid signaling in the brain: biosynthetic mechanisms in the limelight, Nat. Neurosci., 14, 9, 10.1038/nn.2720

Di Marzo, 2002, Anandamide receptors, Prostaglandins Leukot. Essent. Fatty Acids, 66, 377, 10.1054/plef.2001.0349

DiPatrizio, 2012, The thrifty lipids: endocannabinoids and the neural control of energy conservation, Trends Neurosci., 35, 403, 10.1016/j.tins.2012.04.006

Domenici, 2006, Cannabinoid receptor type 1 located on presynaptic terminals of principal neurons in the forebrain controls glutamatergic synaptic transmission, J. Neurosci., 26, 5794, 10.1523/JNEUROSCI.0372-06.2006

Dong, 2010, TRP channels of intracellular membranes, J. Neurochem., 113, 313, 10.1111/j.1471-4159.2010.06626.x

Edwards, 2008, Metaplastic control of the endocannabinoid system at inhibitory synapses in hippocampus, Proc. Natl. Acad. Sci. USA, 105, 8142, 10.1073/pnas.0803558105

Egertová, 2008, Localization of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) expression in mouse brain: A new perspective on N-acylethanolamines as neural signaling molecules, J. Comp. Neurol., 506, 604, 10.1002/cne.21568

Freund, 2003, Role of endogenous cannabinoids in synaptic signaling, Physiol. Rev., 83, 1017, 10.1152/physrev.00004.2003

Fu, 2012, A catalytically silent FAAH-1 variant drives anandamide transport in neurons, Nat. Neurosci., 15, 64, 10.1038/nn.2986

Gao, 2010, Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice, J. Neurosci., 30, 2017, 10.1523/JNEUROSCI.5693-09.2010

Gerdeman, 2002, Postsynaptic endocannabinoid release is critical to long-term depression in the striatum, Nat. Neurosci., 5, 446, 10.1038/nn832

Gibson, 2008, TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons, Neuron, 57, 746, 10.1016/j.neuron.2007.12.027

Gomez, 2010, The constitutive production of the endocannabinoid 2-arachidonoylglycerol participates in oligodendrocyte differentiation, Glia, 58, 1913, 10.1002/glia.21061

Grueter, 2010, Postsynaptic TRPV1 triggers cell type-specific long-term depression in the nucleus accumbens, Nat. Neurosci., 13, 1519, 10.1038/nn.2685

Gulyas, 2004, Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala, Eur. J. Neurosci., 20, 441, 10.1111/j.1460-9568.2004.03428.x

Han, 2012, Acute cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD, Cell, 148, 1039, 10.1016/j.cell.2012.01.037

Harkany, 2008, Wiring and firing neuronal networks: endocannabinoids take center stage, Curr. Opin. Neurobiol., 18, 338, 10.1016/j.conb.2008.08.007

Hashimotodani, 2005, Phospholipase Cbeta serves as a coincidence detector through its Ca2+ dependency for triggering retrograde endocannabinoid signal, Neuron, 45, 257, 10.1016/j.neuron.2005.01.004

Hashimotodani, 2007, Ca(2+)-assisted receptor-driven endocannabinoid release: mechanisms that associate presynaptic and postsynaptic activities, Curr. Opin. Neurobiol., 17, 360, 10.1016/j.conb.2007.03.012

Hashimotodani, 2007, Presynaptic monoacylglycerol lipase activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus, J. Neurosci., 27, 1211, 10.1523/JNEUROSCI.4159-06.2007

Hegyi, 2012, Differential distribution of diacylglycerol lipase-alpha and N-acylphosphatidylethanolamine-specific phospholipase d immunoreactivity in the superficial spinal dorsal horn of rats, Glia, 60, 1316, 10.1002/glia.22351

Heifets, 2009, Endocannabinoid signaling and long-term synaptic plasticity, Annu. Rev. Physiol., 71, 283, 10.1146/annurev.physiol.010908.163149

Heifets, 2008, Interneuron activity controls endocannabinoid-mediated presynaptic plasticity through calcineurin, Proc. Natl. Acad. Sci. USA, 105, 10250, 10.1073/pnas.0711880105

Hentges, 2005, Differential regulation of synaptic inputs by constitutively released endocannabinoids and exogenous cannabinoids, J. Neurosci., 25, 9746, 10.1523/JNEUROSCI.2769-05.2005

Herkenham, 1990, Cannabinoid receptor localization in brain, Proc. Natl. Acad. Sci. USA, 87, 1932, 10.1073/pnas.87.5.1932

Hill, 2007, Functional CB1 receptors are broadly expressed in neocortical GABAergic and glutamatergic neurons, J. Neurophysiol., 97, 2580, 10.1152/jn.00603.2006

Hillard, 1997, Accumulation of N-arachidonoylethanolamine (anandamide) into cerebellar granule cells occurs via facilitated diffusion, J. Neurochem., 69, 631, 10.1046/j.1471-4159.1997.69020631.x

Hillard, 2012, Contributions of endocannabinoid signaling to psychiatric disorders in humans: genetic and biochemical evidence, Neuroscience, 204, 207, 10.1016/j.neuroscience.2011.11.020

Hoffman, 2010, Control of cannabinoid CB1 receptor function on glutamate axon terminals by endogenous adenosine acting at A1 receptors, J. Neurosci., 30, 545, 10.1523/JNEUROSCI.4920-09.2010

Howlett, 2005, Cannabinoid receptor signaling, Handb. Exp. Pharmacol., 168, 53, 10.1007/3-540-26573-2_2

Howlett, 2002, International Union of Pharmacology. XXVII. Classification of cannabinoid receptors, Pharmacol. Rev., 54, 161, 10.1124/pr.54.2.161

Huang, 2008, Roles of endocannabinoids in heterosynaptic long-term depression of excitatory synaptic transmission in visual cortex of young mice, J. Neurosci., 28, 7074, 10.1523/JNEUROSCI.0899-08.2008

Hudson, 2010, Ligand- and heterodimer-directed signaling of the CB(1) cannabinoid receptor, Mol. Pharmacol., 77, 1, 10.1124/mol.109.060251

Jin, 1999, Distinct domains of the CB1 cannabinoid receptor mediate desensitization and internalization, J. Neurosci., 19, 3773, 10.1523/JNEUROSCI.19-10-03773.1999

Kang-Park, 2007, Differential sensitivity of GABA A receptor-mediated IPSCs to cannabinoids in hippocampal slices from adolescent and adult rats, J. Neurophysiol., 98, 1223, 10.1152/jn.00091.2007

Kano, 2009, Endocannabinoid-mediated control of synaptic transmission, Physiol. Rev., 89, 309, 10.1152/physrev.00019.2008

Katona, 2012, Multiple functions of endocannabinoid signaling in the brain, Annu. Rev. Neurosci., 35, 529, 10.1146/annurev-neuro-062111-150420

Katona, 1999, Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons, J. Neurosci., 19, 4544, 10.1523/JNEUROSCI.19-11-04544.1999

Katona, 2006, Molecular composition of the endocannabinoid system at glutamatergic synapses, J. Neurosci., 26, 5628, 10.1523/JNEUROSCI.0309-06.2006

Kawamura, 2006, The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory presynaptic sites in the hippocampus and cerebellum, J. Neurosci., 26, 2991, 10.1523/JNEUROSCI.4872-05.2006

Kim, 2010, Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses, Nat. Neurosci., 13, 592, 10.1038/nn.2517

Kreitzer, 2001, Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cells, Neuron, 29, 717, 10.1016/S0896-6273(01)00246-X

Lafourcade, 2007, Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex, PLoS ONE, 2, e709, 10.1371/journal.pone.0000709

Lafourcade, 2011, Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions, Nat. Neurosci., 14, 345, 10.1038/nn.2736

Lerner, 2012, RGS4 is required for dopaminergic control of striatal LTD and susceptibility to parkinsonian motor deficits, Neuron, 73, 347, 10.1016/j.neuron.2011.11.015

Ligresti, 2009, From endocannabinoid profiling to ‘endocannabinoid therapeutics’, Curr. Opin. Chem. Biol., 13, 321, 10.1016/j.cbpa.2009.04.615

Liu, 2008, Multiple pathways involved in the biosynthesis of anandamide, Neuropharmacology, 54, 1, 10.1016/j.neuropharm.2007.05.020

Losonczy, 2004, Persistently active cannabinoid receptors mute a subpopulation of hippocampal interneurons, Proc. Natl. Acad. Sci. USA, 101, 1362, 10.1073/pnas.0304752101

Lourenço, 2010, Synaptic activation of kainate receptors gates presynaptic CB(1) signaling at GABAergic synapses, Nat. Neurosci., 13, 197, 10.1038/nn.2481

Ludányi, 2008, Downregulation of the CB1 cannabinoid receptor and related molecular elements of the endocannabinoid system in epileptic human hippocampus, J. Neurosci., 28, 2976, 10.1523/JNEUROSCI.4465-07.2008

Ludányi, 2011, Complementary synaptic distribution of enzymes responsible for synthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in the human hippocampus, Neuroscience, 174, 50, 10.1016/j.neuroscience.2010.10.062

Maccarrone, 2008, Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum, Nat. Neurosci., 11, 152, 10.1038/nn2042

Mackie, 2005, Cannabinoid receptor homo- and heterodimerization, Life Sci., 77, 1667, 10.1016/j.lfs.2005.05.011

Maejima, 2001, Presynaptic inhibition caused by retrograde signal from metabotropic glutamate to cannabinoid receptors, Neuron, 31, 463, 10.1016/S0896-6273(01)00375-0

Maejima, 2005, Synaptically driven endocannabinoid release requires Ca2+-assisted metabotropic glutamate receptor subtype 1 to phospholipase Cbeta4 signaling cascade in the cerebellum, J. Neurosci., 25, 6826, 10.1523/JNEUROSCI.0945-05.2005

Marinelli, 2008, The endocannabinoid 2-arachidonoylglycerol is responsible for the slow self-inhibition in neocortical interneurons, J. Neurosci., 28, 13532, 10.1523/JNEUROSCI.0847-08.2008

Marinelli, 2009, Self-modulation of neocortical pyramidal neurons by endocannabinoids, Nat. Neurosci., 12, 1488, 10.1038/nn.2430

Marrs, 2010, The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors, Nat. Neurosci., 13, 951, 10.1038/nn.2601

Marsicano, 2002, The endogenous cannabinoid system controls extinction of aversive memories, Nature, 418, 530, 10.1038/nature00839

Massa, 2010, Alterations in the hippocampal endocannabinoid system in diet-induced obese mice, J. Neurosci., 30, 6273, 10.1523/JNEUROSCI.2648-09.2010

Mato, 2004, A single in-vivo exposure to delta 9THC blocks endocannabinoid-mediated synaptic plasticity, Nat. Neurosci., 7, 585, 10.1038/nn1251

Mato, 2008, Role of the cyclic-AMP/PKA cascade and of P/Q-type Ca++ channels in endocannabinoid-mediated long-term depression in the nucleus accumbens, Neuropharmacology, 54, 87, 10.1016/j.neuropharm.2007.04.014

Mechoulam, 2012, The endocannabinoid system and the brain, Annu Rev Psychol.

Mezey, 2000, Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human, Proc. Natl. Acad. Sci. USA, 97, 3655, 10.1073/pnas.97.7.3655

Mikasova, 2008, Altered surface trafficking of presynaptic cannabinoid type 1 receptor in and out synaptic terminals parallels receptor desensitization, Proc. Natl. Acad. Sci. USA, 105, 18596, 10.1073/pnas.0805959105

Min, 2012, Astrocyte signaling controls spike timing-dependent depression at neocortical synapses, Nat. Neurosci., 15, 746, 10.1038/nn.3075

Navarrete, 2008, Endocannabinoids mediate neuron-astrocyte communication, Neuron, 57, 883, 10.1016/j.neuron.2008.01.029

Navarrete, 2010, Endocannabinoids potentiate synaptic transmission through stimulation of astrocytes, Neuron, 68, 113, 10.1016/j.neuron.2010.08.043

Neu, 2007, Postsynaptic origin of CB1-dependent tonic inhibition of GABA release at cholecystokinin-positive basket cell to pyramidal cell synapses in the CA1 region of the rat hippocampus, J. Physiol., 578, 233, 10.1113/jphysiol.2006.115691

Nevian, 2006, Spine Ca2+ signaling in spike-timing-dependent plasticity, J. Neurosci., 26, 11001, 10.1523/JNEUROSCI.1749-06.2006

Nomura, 2007, Phospholipase Cbeta3 is distributed in both somatodendritic and axonal compartments and localized around perisynapse and smooth endoplasmic reticulum in mouse Purkinje cell subsets, Eur. J. Neurosci., 25, 659, 10.1111/j.1460-9568.2007.05334.x

Nomura, 2011, Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation, Science, 334, 809, 10.1126/science.1209200

Nyilas, 2008, Enzymatic machinery for endocannabinoid biosynthesis associated with calcium stores in glutamatergic axon terminals, J. Neurosci., 28, 1058, 10.1523/JNEUROSCI.5102-07.2008

Ohno-Shosaku, 2001, Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals, Neuron, 29, 729, 10.1016/S0896-6273(01)00247-1

Okamoto, 2007, Biosynthetic pathways of the endocannabinoid anandamide, Chem. Biodivers., 4, 1842, 10.1002/cbdv.200790155

Oliet, 2007, Retrograde regulation of GABA transmission by the tonic release of oxytocin and endocannabinoids governs postsynaptic firing, J. Neurosci., 27, 1325, 10.1523/JNEUROSCI.2676-06.2007

Pan, 2008, D2 dopamine receptor activation facilitates endocannabinoid-mediated long-term synaptic depression of GABAergic synaptic transmission in midbrain dopamine neurons via cAMP-protein kinase A signaling, J. Neurosci., 28, 14018, 10.1523/JNEUROSCI.4035-08.2008

Pan, 2011, Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice, J. Neurosci., 31, 13420, 10.1523/JNEUROSCI.2075-11.2011

Patel, 2009, Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdala, Neuropsychopharmacology, 34, 2699, 10.1038/npp.2009.101

Pertwee, 2010, International union of basic and clinical pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB1 and CB2, Pharmacol. Rev., 62, 588, 10.1124/pr.110.003004

Piomelli, 2003, The molecular logic of endocannabinoid signalling, Nat. Rev. Neurosci., 4, 873, 10.1038/nrn1247

Piomelli, 2005, The endocannabinoid system: a drug discovery perspective, Curr. Opin. Investig. Drugs, 6, 672

Puente, 2011, Polymodal activation of the endocannabinoid system in the extended amygdala, Nat. Neurosci., 14, 1542, 10.1038/nn.2974

Regehr, 2009, Activity-dependent regulation of synapses by retrograde messengers, Neuron, 63, 154, 10.1016/j.neuron.2009.06.021

Riebe, 2011, Endocannabinoids and stress, Stress, 14, 384, 10.3109/10253890.2011.586753

Robbe, 2002, Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens, Proc. Natl. Acad. Sci. USA, 99, 8384, 10.1073/pnas.122149199

Roberts, 2004, [3H]Resiniferatoxin autoradiography in the CNS of wild-type and TRPV1 null mice defines TRPV1 (VR-1) protein distribution, Brain Res., 995, 176, 10.1016/j.brainres.2003.10.001

Roloff, 2010, Homer 1a gates the induction mechanism for endocannabinoid-mediated synaptic plasticity, J. Neurosci., 30, 3072, 10.1523/JNEUROSCI.4603-09.2010

Rossi, 2008, Chronic psychoemotional stress impairs cannabinoid-receptor-mediated control of GABA transmission in the striatum, J. Neurosci., 28, 7284, 10.1523/JNEUROSCI.5346-07.2008

Schlicker, 2001, Modulation of transmitter release via presynaptic cannabinoid receptors, Trends Pharmacol. Sci., 22, 565, 10.1016/S0165-6147(00)01805-8

Schlosburg, 2010, Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system, Nat. Neurosci., 13, 1113, 10.1038/nn.2616

Singla, 2007, Mechanisms for synapse specificity during striatal long-term depression, J. Neurosci., 27, 5260, 10.1523/JNEUROSCI.0018-07.2007

Sjöström, 2003, Neocortical LTD via coincident activation of presynaptic NMDA and cannabinoid receptors, Neuron, 39, 641, 10.1016/S0896-6273(03)00476-8

Slanina, 2005, Inhibition of cyclooxygenase-2 elicits a CB1-mediated decrease of excitatory transmission in rat CA1 hippocampus, Neuropharmacology, 49, 653, 10.1016/j.neuropharm.2005.04.019

Smart, 2000, The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1), Br. J. Pharmacol., 129, 227, 10.1038/sj.bjp.0703050

Stella, 2009, Endocannabinoid signaling in microglial cells, Neuropharmacology, 56, 244, 10.1016/j.neuropharm.2008.07.037

Stella, 2010, Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas, Glia, 58, 1017, 10.1002/glia.20983

Szabo, 2006, Depolarization-induced retrograde synaptic inhibition in the mouse cerebellar cortex is mediated by 2-arachidonoylglycerol, J. Physiol., 577, 263, 10.1113/jphysiol.2006.119362

Takahashi, 2006, The CB1 cannabinoid receptor mediates glutamatergic synaptic suppression in the hippocampus, Neuroscience, 139, 795, 10.1016/j.neuroscience.2006.01.024

Tanimura, 2010, The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission, Neuron, 65, 320, 10.1016/j.neuron.2010.01.021

Tanimura, 2012, Synapse type-independent degradation of the endocannabinoid 2-arachidonoylglycerol after retrograde synaptic suppression, Proc. Natl. Acad. Sci. USA, 109, 12195, 10.1073/pnas.1204404109

Tóth, 2005, Expression and distribution of vanilloid receptor 1 (TRPV1) in the adult rat brain, Brain Res. Mol. Brain Res., 135, 162, 10.1016/j.molbrainres.2004.12.003

Tsetsenis, 2011, Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning, Proc. Natl. Acad. Sci. USA, 108, 14300, 10.1073/pnas.1112237108

Uchigashima, 2011, Molecular and morphological configuration for 2-arachidonoylglycerol-mediated retrograde signaling at mossy cell-granule cell synapses in the dentate gyrus, J. Neurosci., 31, 7700, 10.1523/JNEUROSCI.5665-10.2011

van Beugen, 2006, Climbing fiber-evoked endocannabinoid signaling heterosynaptically suppresses presynaptic cerebellar long-term potentiation, J. Neurosci., 26, 8289, 10.1523/JNEUROSCI.0805-06.2006

van der Stelt, 2005, Anandamide as an intracellular messenger regulating ion channel activity, Prostaglandins Other Lipid Mediat., 77, 111, 10.1016/j.prostaglandins.2004.09.007

Van Sickle, 2005, Identification and functional characterization of brainstem cannabinoid CB2 receptors, Science, 310, 329, 10.1126/science.1115740

Vandevoorde, 2007, The multiple pathways of endocannabinoid metabolism: a zoom out, Chem. Biodivers., 4, 1858, 10.1002/cbdv.200790156

Varma, 2001, Metabotropic glutamate receptors drive the endocannabinoid system in hippocampus, J. Neurosci., 21, RC188, 10.1523/JNEUROSCI.21-24-j0003.2001

Wamsteeker, 2010, Repeated stress impairs endocannabinoid signaling in the paraventricular nucleus of the hypothalamus, J. Neurosci., 30, 11188, 10.1523/JNEUROSCI.1046-10.2010

Wang, 2010, Deficiency in endocannabinoid signaling in the nucleus accumbens induced by chronic unpredictable stress, Neuropsychopharmacology, 35, 2249, 10.1038/npp.2010.99

Wang, 2012, Acute restraint stress enhances hippocampal endocannabinoid function via glucocorticoid receptor activation, J. Psychopharmacol. (Oxford), 26, 56, 10.1177/0269881111409606

Wilson, 2001, Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses, Nature, 410, 588, 10.1038/35069076

Wilson, 2001, Presynaptic specificity of endocannabinoid signaling in the hippocampus, Neuron, 31, 453, 10.1016/S0896-6273(01)00372-5

Wu, 2008, Role of receptor internalization in the agonist-induced desensitization of cannabinoid type 1 receptors, J. Neurochem., 104, 1132, 10.1111/j.1471-4159.2007.05063.x

Xi, 2011, Brain cannabinoid CB2 receptors modulate cocaine’s actions in mice, Nat. Neurosci., 14, 1160, 10.1038/nn.2874

Yasuda, 2008, Regulation of excitability and plasticity by endocannabinoids and PKA in developing hippocampus, Proc. Natl. Acad. Sci. USA, 105, 3106, 10.1073/pnas.0708349105

Yoshida, 2006, Localization of diacylglycerol lipase-alpha around postsynaptic spine suggests close proximity between production site of an endocannabinoid, 2-arachidonoyl-glycerol, and presynaptic cannabinoid CB1 receptor, J. Neurosci., 26, 4740, 10.1523/JNEUROSCI.0054-06.2006

Yoshida, 2011, Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleus, Proc. Natl. Acad. Sci. USA, 108, 3059, 10.1073/pnas.1012875108

Yoshino, 2011, Postsynaptic diacylglycerol lipase mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex, J. Physiol., 589, 4857, 10.1113/jphysiol.2011.212225

Zhang, 2010, Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome, J. Neurosci., 30, 5724, 10.1523/JNEUROSCI.0795-10.2010

Zhong, 2011, Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum, J. Physiol., 589, 4847, 10.1113/jphysiol.2011.215509

Zhu, 2007, Persistent synaptic activity produces long-lasting enhancement of endocannabinoid modulation and alters long-term synaptic plasticity, J. Neurophysiol., 97, 4386, 10.1152/jn.01228.2006

Zhu, 2010, Developmental alteration of endocannabinoid retrograde signaling in the hippocampus, J. Neurophysiol., 103, 1123, 10.1152/jn.00327.2009

Zygmunt, 1999, Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide, Nature, 400, 452, 10.1038/22761