Endobronchial mucosal nodules and actinomycosis in a child with activated phosphatidylinositol 3-kinase delta syndrome (APDS)

Martinez-Balzano, 2015, 66-Year-Old man with a past history of relapsing polychondritis presented with right upper lobe consolidation, nodular airway lesions, and a corticosteroid-responsive chronic cough, Chest, 148, e142, 10.1378/chest.15-0498 Zhao, 2019, A case with nodular airway lesions misdiagnosed as difficult-to-treat asthma, Ann. Allergy Asthma Immunol., 123, 217, 10.1016/j.anai.2019.05.005 Matsushima, 2006, Multiple tracheobronchial mucosal lesions in two cases of Churg-Strauss syndrome, Respirology, 11, 109, 10.1111/j.1440-1843.2006.00795.x Wakamaya, 1994, A case of hypereosinophilic syndrome presenting endobronchial lesion with multiple nodules and pulmonary lesion at onset, J. Jpn. Soc. Bronchol., 16, 397 Gurminder, 2016, Endobronchial nodules: a rare manifestation of non-Hodgkin’s lymphoma, Chest, 150 Hara, 2017, Macroscopic inflammatory tracheal and endobronchial nodules in Sjogren's syndrome, Thorax, 72, 864, 10.1136/thoraxjnl-2016-209390 Cho, 2013, A case of pulmonary sarcoidosis with endobronchial nodular involvement, Tuberc. Respir. Dis., 74, 274, 10.4046/trd.2013.74.6.274 Pascoe, 2019, McCusker MW Rare manifestation of Neurofibromatosis type 1: a plexiform neurofibroma involving the mediastinum and lungs with endobronchial neurofibromata, J. Med. Imag. Radiat. Oncol., 63, 76, 10.1111/1754-9485.12802 Decalmer, 2007, Smith J Airway abnormalities at flexible bronchoscopy in patients with chronic cough, Eur. Respir. J., 30, 1138, 10.1183/09031936.00034807 Dave MH, Gerber A, Bailey M, et al. Prevalence and characteristics of tracheal cobblestoning in children. Pediatr. Pulmonol.; 50(10):995–999. Coulter TI, Chandra A, Bacon CM, et al Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: a large patient cohort study. J. Allergy Clin. Immunol., 139 (2). 597-606.e4. Kimberlin, 2021 Kalai, 2015, A 35-year-old woman with productive cough and breathlessness, Lung India, 32, 651, 10.4103/0970-2113.168106 Yilin, 2022, Pediatric pulmonary actinomycosis: a misdiagnosed case report, Front. Pediatr., 10, 10.3389/fped.2022.955554 Condliffe, 2018, Respiratory manifestations of the activated phosphoinositide 3-kinase delta syndrome, Front. Immunol., 9, 338, 10.3389/fimmu.2018.00338 Michalovich D, Nejentsev S Activated PI3 kinase delta syndrome: from genetics to therapy. Front. Immunol. 9:369. doi: 10.3389/fimmu.2018.00369.