Encapsulation of Acyclovir in new carboxylated cyclodextrin-based nanosponges improves the agent's antiviral efficacy

International Journal of Pharmaceutics - Tập 443 Số 1-2 - Trang 262-272 - 2013
David Lembo1, Shankar Swaminathan2,3,4, Manuela Donalisio1, Andrea Civra1, Linda Pastero5, Dino Aquilano5, Pradeep R. Vavia2, Francesco Trotta2, Roberta Cavalli4
1Dipartimento di Scienze Cliniche e Biologiche, Università degli Studi di Torino Ospedale S. Luigi Gonzaga, 10043 Orbassano, Torino, Italy
2Dep. of Pharmaceutical Sciences and Technology, University Institute of Chemical Technology, Mumbai, 400019, India
3Dipartimento di Chimica, Università degli Studi di Torino, via P. Giuria 7, 10125 Torino, Italy
4Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Via P. Giuria 9, 10125 Torino, Italy
5Dipartimento di Mineralogia e Petrologia, Università degli Studi di Torino, via V. Caluso 35, 10125 Torino, Italy

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Amidon, 1995, A theoretical basis for a biopharmaceutic drug classification – the correlation of in vitro drug dissolution and in vivo bioavailability, Pharm. Res., 12, 413, 10.1023/A:1016212804288

Ansari, 2010, Paclitaxel loaded nanosponges: in vivo characterization and cytotoxycity study on MCF-7 cell line culture, Curr. Drug Deliv., 8, 192

Ansari, 2011, Cyclodextrin-based nanosponges for delivery of resveratrol: in vitro characterisation, stability, cytotoxicity and permeation study, AAPS PharmSciTech, 11, 279, 10.1208/s12249-011-9584-3

Attia, 2007, Influence of a niosomal formulation on the oral bioavailability of Acyclovir in rabbits, AAPS PharmSciTech, 8, E1, 10.1208/pt0804106

Bencini, 2008, Preparation and in vitro evaluation of the antiviral activity of the Acyclovir complex of a beta-cyclodextrin/poly(amidoamine) copolymer, J. Control. Release, 126, 17, 10.1016/j.jconrel.2007.11.004

Bertino Ghera, 2009, Novel nanoparticles made from amphiphilic perfluoroalkyl α-cyclodextrin derivatives: preparation, characterization and application to the transport of Acyclovir, Int. J. Pharm., 375, 155, 10.1016/j.ijpharm.2009.04.004

Cavalli, 2009, Enhanced antiviral activity of Acyclovir loaded into β-cyclodextrin-poly(4-acryloylmorpholine) conjugate nanoparticles, J. Control. Release, 137, 116, 10.1016/j.jconrel.2009.04.004

Cavalli, 2006, Cyclodestrin-based nanosponges for drug delivery, J. Incl. Phenom. Macrocycl. Chem., 56, 209, 10.1007/s10847-006-9085-2

Chetoni, 2004, Comparison of liposome encapsulated Acyclovir with Acyclovir ointment: ocular pharmacokinetics in rabbits, J. Ocul. Pharmacol. Ther., 20, 169, 10.1089/108076804773710849

Del Valle, 2004, Cyclodextrins and their uses: a review, Process Biochem., 39, 1033, 10.1016/S0032-9592(03)00258-9

Dubes, 2003, Synthesis and characterisation of sulfated amphiphilic α-, β- and γ cyclodextrins: application to the complexation of Acyclovir, Carbohydr. Res., 338, 2185, 10.1016/S0008-6215(03)00356-2

Elshafeeya, 2010, Ammonium methacrylate units polymer content and their effect on Acyclovir colloidal nanoparticles properties and bioavailability in human volunteers, Colloids Surf. B Biointerfaces, 75, 398, 10.1016/j.colsurfb.2009.08.050

Ghosh, 2006, Design and development of microemulsion drug delivery system of Acyclovir for improvement of oral bioavailability, AAPS PharmSciTech, 7, E1, 10.1208/pt070377

Giannavola, 2003, Influence of preparation conditions on Acyclovir-loaded poly-d,l-lactic acid nanospheres and effect of PEG coating on ocular drug bioavailability, Pharm. Res., 20, 584, 10.1023/A:1023290514575

Jin, 2006, Self-assembled drug delivery systems 1. Properties and in vitro/in vivo behavior of Acyclovir self-assembled nanoparticles (SAN), Int. J. Pharm., 309, 199, 10.1016/j.ijpharm.2005.11.025

Kamel, 2009, Preparation of intravenous stealthy Acyclovir nanoparticles with increased mean residence time, AAPS PharmSciTech, 10, 1427, 10.1208/s12249-009-9342-y

Lembo, 2010, Nanoparticulate delivery systems for antiviral drugs, Antivir. Chem. Chemother., 21, 53, 10.3851/IMP1684

Loftsson, 2010, Pharmaceutical applications of cyclodextrins: basic science and Product development, J. Pharm. Pharmacol., 62, 1119, 10.1111/j.2042-7158.2010.01030.x

Mognetti, 2012, In vitro enhancement of anticancer activity of paclitaxel by a Cremophor free cyclodextrin-based nanosponge formulation, J. Incl. Phenom. Macrocycl. Chem., 74, 201, 10.1007/s10847-011-0101-9

Mukherjee, 2007, Sustained release of Acyclovir from nano-liposomes and nano-niosomes: an in vitro study, Int. J. Nanomedicine, 2, 213

O’Brien, 1989, Acyclovir. An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy, Drugs, 37, 233

Pauwels, 1988, Rapid and automated tetrazolium-based colorimetric assay for the detection of anti HIV compounds, J. Virol. Methods, 20, 309, 10.1016/0166-0934(88)90134-6

Pavelic, 2005, Development and in vitro evaluation of a liposomal vaginal delivery system for Acyclovir, J. Control. Release, 106, 34, 10.1016/j.jconrel.2005.03.032

Shishu, 2009, Development of novel microemulsion-based topical formulations of Acyclovir for the treatment of cutaneous herpetic infections, AAPS PharmSciTech, 10, 560, 10.1208/s12249-009-9242-1

Swaminathan, 2007, Formulation of cyclodextrin-based nanosponges of itraconazole, J. Incl. Phenom. Macrocycl. Chem., 57, 89, 10.1007/s10847-006-9216-9

Swaminathan, 2010, Cyclodextrin-based nanosponges encapsulating camptothecin: physicochemical characterization, stability and cytotoxicity, Eur. J. Pharm. Biopharm., 74, 193, 10.1016/j.ejpb.2009.11.003

Torne, 2010, Enhanced oral paclitaxel bioavailability after administration of paclitaxel-loaded nanosponges, Drug Deliv., 17, 419, 10.3109/10717541003777233

Torne, 2013, Cyclodextrin-based nanosponges: effective nanocarrier for Tamoxifen delivery, Pharm. Dev. Technol., 10.3109/10837450.2011.649855

Trotta, 2009, Characterization and applications of new hyper-cross-linked cyclodextrins, Compos. Interfaces, 16, 39, 10.1163/156855408X379388

Trotta, 2012, Cyclodextrin-based nanosponges as drug carriers, Belstein J. Org. Chem., 8, 2091, 10.3762/bjoc.8.235

Van de Manakker, 2009, Cyclodextrin-based polymeric materials: synthesis, properties and pharmaceutical/biomedical applications, Biomacromolecules, 10, 3157, 10.1021/bm901065f

Wojdyr, 2010, Fityk: a general purpose peak fitting program, J. Appl. Cryst., 43, 1126, 10.1107/S0021889810030499