Encapsulation and Release Mechanisms in Coordination Polymer Nanoparticles

Chemistry - A European Journal - Tập 19 Số 51 - Trang 17508-17516 - 2013
Laura Amorín‐Ferré1, Félíx Busqué1, J.L. Bourdelande1, Daniel Ruiz‐Molina2,3, Jordi Hernando1,4,5, Fernando Novio2,4,3,5
1Departament de Química, Universitat Autònoma de Barcelona, Edifici C/n, Campus UAB, Cerdanyola del Vallès, 08193 (Spain), Fax: (+34) 935811265
2Consejo Superior de Investigaciones, Científicas (CSIC), Edificio ICN2, Campus UAB, Cerdanyola del Vallès, 08193(Spain)
3Institut Català de Nanociència i Nanotecnologia (ICN2), Edifici ICN2, Campus UAB Cerdanyola del Vallès, 08193 (Spain), Fax: (+ 34) 937372648
4Fernando Novio, Institut Català de Nanociència i Nanotecnologia (ICN2), Edifici ICN2, Campus UAB Cerdanyola del Vallès, 08193 (Spain), Fax: (+ 34) 937372648===
5Jordi Hernando, Departament de Química, Universitat Autònoma de Barcelona, Edifici C/n, Campus UAB, Cerdanyola del Vallès, 08193 (Spain), Fax: (+34) 935811265===

Tóm tắt

AbstractThe interplay of guest encapsulation and release mechanisms in nanoscale metal–organic vehicles and its effect on the drug‐delivery kinetics of these materials were investigated through a new multidisciplinary approach. Two rationally‐designed molecular guests were synthesized, which consist of a red‐fluorescent benzophenoxazine dye covalently tethered to a coordinating catechol group and a protected, non‐coordinating catechol moiety. This allowed loading of the guests into compositionally and structurally equivalent coordination polymer particles through distinct encapsulation mechanisms: coordination and mechanical entrapment. The two types of particles delivered their fluorescent cargo with remarkably different kinetic profiles, which could be satisfactorily modeled considering degradation‐ and diffusion‐controlled release processes. This demonstrates that careful selection of the method of guest incorporation into coordination polymer nanoparticles allows selective tuning of the rate of drug delivery from these materials and, therefore, of the time window of action of the encapsulated therapeutic agents.

Từ khóa


Tài liệu tham khảo

10.1038/nature04191

10.1021/ja0534809

10.1039/b807085g

10.1021/ar200028a

10.1016/j.ccr.2011.01.031

10.1016/j.ccr.2013.04.022

10.1016/S0169-409X(01)00116-8

10.1016/j.addr.2006.09.007

10.1016/j.ijpharm.2010.12.020

10.1021/ja803383k

10.1016/j.biomaterials.2011.08.022

10.1039/c2cc30877k

10.1039/C1SC00499A

10.1021/cg3006162

10.1002/ange.200804255

10.1002/anie.200804255

10.1039/c003084h

10.1002/chem.201101634

10.1002/ange.200705263

10.1002/anie.200705263

 

10.1002/ejic.200500323

10.1007/b95413

10.1002/ange.19971092406

10.1002/anie.199727341

10.1016/j.tet.2006.03.111

10.1021/cm9907155

10.1016/S0040-4020(97)10362-3

10.1002/ange.200700169

10.1002/anie.200700169

10.1021/ac0491511

10.1016/j.jphotochem.2006.06.013

 

10.1021/ic9611812

10.1021/ja9619566

10.1039/c2pp05378k

 

Crank J., 1975, The Mathematics of Diffusion

10.1016/j.ijpharm.2011.07.015

 

10.1021/bk-1976-0033.ch003

10.3109/02652049209040480

10.1021/bc060327a

10.1016/0022-2313(81)90075-2

Thông tin
Thông tin xuất bản

Chemistry - A European Journal

Tập 19 Số 51

17508-17516

Thông tin tác giả