Encapsulated bacteriophages in alginate-nanohydroxyapatite hydrogel as a novel delivery system to prevent orthopedic implant-associated infections

Wang, 2017, Bone grafts and biomaterials substitutes for bone defect repair: A review, Bioact Mater, 2, 224, 10.1016/j.bioactmat.2017.05.007 Zimmerli, 2012, Pathogenesis and treatment concepts of orthopaedic biofilm infections, FEMS Immunol Med Microbiol, 65, 158, 10.1111/j.1574-695X.2012.00938.x Gimeno, 2015, A controlled antibiotic release system to prevent orthopedic-implant associated infections: An in vitro study, Eur J Pharm Biopharm, 96, 264, 10.1016/j.ejpb.2015.08.007 Street, 2017, others. Molecular diagnosis of orthopedic-device-related infection directly from sonication fluid by metagenomic sequencing, J Clin Microbiol, 55, 2334, 10.1128/JCM.00462-17 Junka, 2017, Bad to the bone: on in vitro and ex vivo microbial biofilm ability to directly destroy colonized bone surfaces without participation of host immunity or osteoclastogenesis, PLoS One, 12, 10.1371/journal.pone.0169565 Qiu, 2007, Biomaterial strategies to reduce implant-associated infections, Int J Artif Organs, 30, 828, 10.1177/039139880703000913 Silva, 2018, In vivo tissue response and antibacterial efficacy of minocycline delivery system based on polymethylmethacrylate bone cement, J Biomater Appl, 33, 380, 10.1177/0885328218795290 Francolini, 2017, Antifouling and antimicrobial biomaterials: an overview, APMIS, 125, 392, 10.1111/apm.12675 Kaur, 2014, Bacteriophage mediated killing of Staphylococcus aureus in vitro on orthopaedic K wires in presence of linezolid prevents implant colonization, PLoS One, 9, 10.1371/journal.pone.0090411 Loc-Carrillo, 2011, Pros and cons of phage therapy, Bacteriophage, 1, 111, 10.4161/bact.1.2.14590 Edgar, 2012, Reversing bacterial resistance to antibiotics by phage-mediated delivery of dominant sensitive genes, Appl Environ Microbiol, 78, 744, 10.1128/AEM.05741-11 Nobrega, 2015, Revisiting phage therapy: new applications for old resources, Trends Microbiol, 23, 185, 10.1016/j.tim.2015.01.006 Morris, 2019, Evaluation of bacteriophage anti-biofilm activity for potential control of orthopedic implant-related infections caused by Staphylococcus Aureus, Surg Infect, 20, 16, 10.1089/sur.2018.135 Yilmaz, 2013, Bacteriophage therapy in implant-related infections an experimental study, J Bone Jt Surg, 95a, 117, 10.2106/JBJS.K.01135 Trampuz A, Klatt A, Luca MD. Isolation of new lytic bacteriophages fro treatment of prosthetic joint infections. J Bone Joint Surg 2017;99-B(SUPP_22):36-36. Oliveira, 2015, Unexploited opportunities for phage therapy, Front Pharmacol, 6, 180, 10.3389/fphar.2015.00180 Gorski, 2018, Phage therapy: beyond antibacterial action, Front Med (Lausanne), 5, 146, 10.3389/fmed.2018.00146 Fish, 2018, Resolving digital staphylococcal osteomyelitis using bacteriophage – a case report, Antibiotics (Basel), 7 Kishor, 2016, Phage therapy of staphylococcal chronic osteomyelitis in experimental animal model, Indian J Med Res, 143, 87, 10.4103/0971-5916.178615 Dublanchet A. Patey O. Phage therapy for bone and joint infections: report of french cases. Orthopaedic Proceedings 2017;99-B(SUPP_22):35-35. Chan, 2018, Phage treatment of an aortic graft infected with Pseudomonas aeruginosa, Evol Med Public Health, 1, 60, 10.1093/emph/eoy005 Meurice, 2012, New antibacterial microporous CaP materials loaded with phages for prophylactic treatment in bone surgery, J Mater Sci Mater Med, 23, 2445, 10.1007/s10856-012-4711-6 Kaur, 2016, In vivo assessment of phage and linezolid based implant coatings for treatment of methicillin resistant S. aureus (MRSA) mediated orthopaedic device related infections, PLoS One, 11, 10.1371/journal.pone.0157626 Barros, 2019, Lytic bacteriophages against multidrug-resistant Staphylococcus aureus, Enterococcus faecalis and Escherichia coli isolates from orthopaedic implant-associated infections, Int J Antimicrob Agents, 54, 329, 10.1016/j.ijantimicag.2019.06.007 Melo, 2014, Characterization of Staphylococcus epidermidis phage vB_SepS_SEP9-a unique member of the Siphoviridae family, Res Microbiol, 165, 679, 10.1016/j.resmic.2014.09.012 Ma, 2008, Microencapsulation of bacteriophage felix O1 into chitosan-alginate microspheres for oral delivery, Appl Environ Microbiol, 74, 4799, 10.1128/AEM.00246-08 Mohammed, 2015, Cellulose nanocrystal-alginate hydrogel beads as novel adsorbents for organic dyes in aqueous solutions, Cellulose, 22, 3725, 10.1007/s10570-015-0747-3 Gomes, 2007, Effect of therapeutic levels of doxycycline and minocycline in the proliferation and differentiation of human bone marrow osteoblastic cells, Arch Oral Biol, 52, 251, 10.1016/j.archoralbio.2006.10.005 Orapiriyakul, 2018, Antibacterial surface modification of titanium implants in orthopaedics, J Tissue Eng, 9, 10.1177/2041731418789838 Siljander, 2018, Multidrug-resistant organisms in the setting of periprosthetic joint infectiond-diagnosis, prevention, and treatment, J Arthroplast, 33, 185, 10.1016/j.arth.2017.07.045 Colom, 2017, Microencapsulation with alginate/CaCO3: A strategy for improved phage therapy, Sci Rep, 7, 10.1038/srep41441 Tønnesen, 2002, Alginate in drug delivery systems, Drug Dev Ind Pharm, 28, 621, 10.1081/DDC-120003853 Jain, 2014, Alginate drug delivery systems: application in context of pharmaceutical and biomedical research, Drug Dev Ind Pharm, 40, 1576, 10.3109/03639045.2014.917657 Vinner, 2017, Microencapsulation of Clostridium difficile specific bacteriophages using microfluidic glass capillary devices for colon delivery using pH triggered release, PLoS One, 12, 10.1371/journal.pone.0186239 Kinnari, 2009, Influence of surface porosity and pH on bacterial adherence to hydroxyapatite and biphasic calcium phosphate bloceramics, J Med Microbiol, 58, 132, 10.1099/jmm.0.002758-0 ter Boo, 2015, Antimicrobial delivery systems for local infection prophylaxis in orthopedic- and trauma surgery, Biomaterials, 52, 113, 10.1016/j.biomaterials.2015.02.020 Cisek, 2017, Phage therapy in bacterial infections treatment: one hundred years after the discovery of bacteriophages, Curr Microbiol, 74, 277, 10.1007/s00284-016-1166-x Kazmierczak, 2015, Facing antibiotic resistance: Staphylococcus aureus phages as a medical tool, Viruses-Basel, 7, 1667 Zimecki, 2009, Effects of prophylactic administration of bacteriophages to immunosuppressed mice infected with Staphylococcus aureus, BMC Microbiol, 9, 169, 10.1186/1471-2180-9-169 Chung, 2010, Fabrication of engineered M13 bacteriophages into liquid crystalline films and fibers for directional growth and encapsulation of fibroblasts, Soft Matter, 6, 4454, 10.1039/c0sm00199f Teotia, 2017, Nano-hydroxyapatite bone substitute functionalized with bone active molecules for enhanced cranial bone regeneration, ACS Appl Mater Interfaces, 9, 6816, 10.1021/acsami.6b14782 Cunniffe, 2016, Content-dependent osteogenic response of nanohydroxyapatite: an in vitro and in vivo assessment within collagen-based scaffolds, ACS Appl Mater Interfaces, 8, 23477, 10.1021/acsami.6b06596 Martinelli NM, Ribeiro MJG, Ricci R, Marques MA, Lobo AO, Marciano FR. In Vitro Osteogenesis stimulation via nano-hydroxyapatite/carbon nanotube thin films on biomedical stainless steel. Materials 2018;11(9). Melo LDR, Brandao A, Akturk E, Santos SB, Azeredo J. Characterization of a new Staphylococcus aureus kayvirus harboring a lysin active against biofilms. Viruses-Basel 2018;10(4).