Sự kết hợp giữa xúc tác enamine và kim loại chuyển tiếp: Các biến đổi xúc tác liên quan đến các trung gian điện thế hữu cơ

Springer Science and Business Media LLC - Tập 377 - Trang 1-27 - 2019
Samson Afewerki1, Armando Córdova1
1Department of Natural Sciences, Mid Sweden University, Sundsvall, Sweden

Tóm tắt

Khái niệm kết hợp xúc tác kích hoạt enamine với xúc tác kim loại chuyển tiếp là một chiến lược quan trọng, cho phép thực hiện các biến đổi hóa học chọn lọc mà không thể tiếp cận nếu không có sự kết hợp này. Chất xúc tác amine kích hoạt các hợp chất carbonyl thông qua việc hình thành trung gian enamine nucleophilic phản ứng còn kim loại chuyển tiếp thì kích hoạt một loạt các chức năng như các cơ chất allylic thông qua sự hình thành phức hợp π-allyl-kim loại điện thế phản ứng. Kể từ báo cáo đầu tiên về chiến lược này vào năm 2006, một nỗ lực đáng kể đã được dành cho việc phát triển thành công công nghệ này. Trong chương này, những phát hiện này sẽ được nhấn mạnh và thảo luận.

Từ khóa

#xúc tác enamine #kim loại chuyển tiếp #biến đổi hóa học #hợp chất carbonyl #trung gian điện thế hữu cơ

Tài liệu tham khảo

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