Empowering Electrochemical Biosensing through Nanostructured or Multifunctional Nucleic Acid or Peptide Biomaterials

Advanced Materials Technologies - Tập 7 Số 10 - 2022
Susana Campuzano1, Marı́a Pedrero1, Rodrigo Barderas2, José M. Pingarrón1
1Department of Analytical Chemistry, Faculty of Chemistry, Complutense University of Madrid, Madrid, 28040 Spain
2Chronic Disease Programme, UFIEC, Institute of Health Carlos III, Majadahonda, Madrid, 28220 Spain

Tóm tắt

AbstractElectrochemical biosensors continue to evolve at an astonishing pace, consolidating as competitive tools for determining a wide range of targets and relentlessly strengthening their attributes in terms of sensitivity, selectivity, simplicity, response time, and antifouling ability, making them suitable for getting a foothold in real‐world applications. The design and exploitation of nanostructured or multifunctional nucleic acid or peptide biomaterials are playing a determinant role in these achievements. With the aim of highlighting the potential and opportunities of these biomaterials, this perspective article critically discusses and overviews the electrochemical biosensors reported since 2019 involving nanostructured and multifunctional DNA biomaterials, multifunctional aptamers, modern peptides, and CRISPR/Cas systems. The use of these biomaterials as recognition elements, electrode modifiers (acting as linkers or creating scaffolds with antifouling properties), enzyme substrates, and labeling/carrier agents for signal amplification is discussed through rationally and strategically selected examples, concluding with a personal perspective about the challenges to be faced and future lines of action.

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Advanced Materials Technologies

Tập 7 Số 10

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