Emodin attenuates silica-induced lung injury by inhibition of inflammation, apoptosis and epithelial-mesenchymal transition

International Immunopharmacology - Tập 91 - Trang 107277 - 2021
Xinru Pang1, Linlin Shao2, Xiaojuan Nie2, Haiyue Yan3, Chao Li1, Abrey J. Yeo1,4, Martin F. Lavin1,4, Qing Xia5, Hua Shao1, Gongchang Yu1, Qiang Jia1, Cheng Peng1,5
1Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong, China
2Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji’nan, Shandong, China
3Shandong Institute of Scientific and Technical Information
4University of Queensland Centre for Clinical Research (UQCCR), Brisbane, Queensland, Australia
5The University of Queensland, Queensland Alliance for Environmental Health Sciences (QAEHS), Brisbane, Queensland, Australia

Tóm tắt

Từ khóa


Tài liệu tham khảo

Bukovitz, 2019, Silicosis: Diagnosis and medicolegal implications, J. Forensic Sci., 64, 1389, 10.1111/1556-4029.14048

Wynn, 2011, Integrating mechanisms of pulmonary fibrosis, J. Exp. Med., 208, 1339, 10.1084/jem.20110551

Chanda, 2019, Developmental pathways in the pathogenesis of lung fibrosis, Mol. Aspects Med., 65, 56, 10.1016/j.mam.2018.08.004

Lei, 2019, Cell-surface translocation of annexin A2 contributes to bleomycin-induced pulmonary fibrosis by mediating inflammatory response in mice, Clin. Sci. (Lond.), 133, 789, 10.1042/CS20180687

Wang, 2016, MCPIP1 regulates alveolar macrophage apoptosis and pulmonary fibroblast activation after in vitro exposure to silica, Toxicol. Sci., 151, 126, 10.1093/toxsci/kfw029

Hosseinzadeh, 2018, Idiopathic pulmonary fibrosis (IPF) signaling pathways and protective roles of melatonin, Life Sci., 201, 17, 10.1016/j.lfs.2018.03.032

Du, 2019, Dioscin alleviates crystalline silica-induced pulmonary inflammation and fibrosis through promoting alveolar macrophage autophagy, Theranostics., 9, 1878, 10.7150/thno.29682

Wynn, 2010, Macrophages: master regulators of inflammation and fibrosis, Semin. Liver Dis., 30, 245, 10.1055/s-0030-1255354

Stone, 2016, Epithelial-mesenchymal transition in tissue repair and fibrosis, Cell Tissue Res., 365, 495, 10.1007/s00441-016-2464-0

Xie, 2019, Emodin weakens liver inflammatory injury triggered by lipopolysaccharide through elevating microRNA-145 in vitro and in vivo, Artif. Cells Nanomed. Biotechnol., 47, 1877, 10.1080/21691401.2019.1614015

Chen, 2019, Emodin enhances antitumor effect of paclitaxel on human non-small-cell lung cancer cells in vitro and in vivo, Drug Des. Devel. Ther., 13, 1145, 10.2147/DDDT.S196319

Hwang, 2013, Emodin suppresses inflammatory responses and joint destruction in collagen-induced arthritic mice, Rheumatology (Oxford), 52, 1583, 10.1093/rheumatology/ket178

Dong, 2009, Emodin protects rat liver from CCl(4)-induced fibrogenesis via inhibition of hepatic stellate cells activation, World J. Gastroenterol., 15, 4753, 10.3748/wjg.15.4753

Thacker, 2015, Curcumin and emodin down-regulate TGF-beta signaling pathway in human cervical cancer cells, PLoS ONE, 10, e0120045, 10.1371/journal.pone.0120045

Su, 2005, Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway, Biochem. Pharmacol., 70, 229, 10.1016/j.bcp.2005.04.026

Qu, 2013, Emodin induces human T cell apoptosis in vitro by ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction, Acta Pharmacol. Sin., 34, 1217, 10.1038/aps.2013.58

Wang, 2015, Protective effect of emodin against airway inflammation in the ovalbumin-induced mouse model, Chin. J. Integr. Med., 21, 431, 10.1007/s11655-014-1898-z

Yang, 2016, Emodin suppresses silica-induced lung fibrosis by promoting Sirt1 signaling via direct contact, Mol. Med. Rep., 14, 4643, 10.3892/mmr.2016.5838

O'Brien, 2018, Prolonged treatment with open-label pirfenidone in Hermansky-Pudlak syndrome pulmonary fibrosis, Mol. Genet. Metab., 125, 168, 10.1016/j.ymgme.2018.07.012

Guo, 2019, Pirfenidone inhibits epithelial-mesenchymal transition and pulmonary fibrosis in the rat silicosis model, Toxicol. Lett., 300, 59, 10.1016/j.toxlet.2018.10.019

Stahnke, 2017, Suppression of TGF-β pathway by pirfenidone decreases extracellular matrix deposition in ocular fibroblasts in vitro, PLoS ONE, 12, e0172592, 10.1371/journal.pone.0172592

Alisi, 2012, Emodin prevents intrahepatic fat accumulation, inflammation and redox status imbalance during diet-induced hepatosteatosis in rats, Int. J. Mol. Sci., 13, 2276, 10.3390/ijms13022276

Vancheri, 2018, Nintedanib with add-on pirfenidone in idiopathic pulmonary fibrosis results of the injourney trial, Am. J. Respir. Crit. Care Med., 197, 356, 10.1164/rccm.201706-1301OC

Szapiel, 1979, Bleomycin-induced interstitial pulmonary disease in the nude, athymic mouse, Am. Rev. Respir. Dis., 120, 893

Ashcroft, 1988, Simple method of estimating severity of pulmonary fibrosis on a numerical scale, J. Clin. Pathol., 41, 467, 10.1136/jcp.41.4.467

Xu, 2019, Effect of dermatan sulphate on a C57-mouse model of pulmonary fibrosis, J. Int. Med. Res., 47, 2655, 10.1177/0300060519842048

Dong, 2016, Emodin: A review of its pharmacology, toxicity and pharmacokinetics, Phytother. Res., 30, 1207, 10.1002/ptr.5631

Gao, 2017, Emodin suppresses TGF-β1-induced epithelial-mesenchymal transition in alveolar epithelial cells through Notch signaling pathway, Toxicol. Appl. Pharmacol., 318, 1, 10.1016/j.taap.2016.12.009

Haston, 2002, Bleomycin hydrolase and a genetic locus within the MHC affect risk for pulmonary fibrosis in mice, Hum. Mol. Genet., 11, 1855, 10.1093/hmg/11.16.1855

Voltz, 2008, Male sex hormones exacerbate lung function impairment after bleomycin-induced pulmonary fibrosis, Am. J. Respir. Cell Mol. Biol., 39, 45, 10.1165/rcmb.2007-0340OC

Hoy, 2020, Silica-related diseases in the modern world, Allergy, 75, 2805, 10.1111/all.14202

Liu, 2017, The antiangiogenesis effect of pirfenidone in wound healing in vitro, J. Ocul. Pharmacol. Ther., 33, 693, 10.1089/jop.2017.0007

Zhang, 2018, N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) attenuates silicotic fibrosis by suppressing apoptosis of alveolar type II epithelial cells via mediation of endoplasmic reticulum stress, Toxicol. Appl. Pharmacol., 350, 1, 10.1016/j.taap.2018.04.025

Joshi, 2013, Silica phagocytosis causes apoptosis and necrosis by different temporal and molecular pathways in alveolar macrophages, Apoptosis, 18, 271, 10.1007/s10495-012-0798-y

Karmakar, 2016, Regulation of apoptosis through bcl-2/bax proteins expression and DNA damage by Zanthoxylum alatum, Pharm. Biol., 54, 503, 10.3109/13880209.2015.1050675

Wu, 2019, Antifibrotic effects of Fraxetin on carbon tetrachloride-induced liver fibrosis by targeting NF-kappaB/IkappaBalpha, MAPKs and Bcl-2/Bax pathways, Pharmacol. Rep., 71, 409, 10.1016/j.pharep.2019.01.008

Korsmeyer, 1993, Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death, Semin. Cancer Biol., 4, 327

Chen, 2018, Transplantation of adipose-derived mesenchymal stem cells attenuates pulmonary fibrosis of silicosis via anti-inflammatory and anti-apoptosis effects in rats, Stem Cell Res. Ther., 9, 110, 10.1186/s13287-018-0846-9

Guan, 2016, Emodin ameliorates bleomycin-induced pulmonary fibrosis in rats by suppressing epithelial-mesenchymal transition and fibroblast activation, Sci. Rep., 6, 35696, 10.1038/srep35696

Huang, 2013, Characterization of apoptosis induced by emodin and related regulatory mechanisms in human neuroblastoma cells, Int. J. Mol. Sci., 14, 20139, 10.3390/ijms141020139

Yaoxian, 2013, Emodin induces apoptosis of human cervical cancer hela cells via intrinsic mitochondrial and extrinsic death receptor pathway, Cancer Cell Int., 13, 71, 10.1186/1475-2867-13-71

Pollard, 2016, Silica, Silicosis, and Autoimmunity, Front. Immunol., 7, 97, 10.3389/fimmu.2016.00097

Li, 2018, Pirfenidone ameliorates lipopolysaccharide-induced pulmonary inflammation and fibrosis by blocking NLRP3 inflammasome activation, Mol. Immunol., 99, 134, 10.1016/j.molimm.2018.05.003

Di Giuseppe, 2009, Systemic inhibition of NF-kappaB activation protects from silicosis, PLoS ONE, 4, e5689, 10.1371/journal.pone.0005689

Hubbard, 2002, Activation of NF-kappaB-dependent gene expression by silica in lungs of luciferase reporter mice, Am. J. Physiol. Lung Cell. Mol. Physiol., 282, L968, 10.1152/ajplung.00327.2001

Li, 2018, NLRP3 inflammasome inhibition attenuates silica-induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells, Exp. Cell Res., 362, 489, 10.1016/j.yexcr.2017.12.013

Tian, 2017, NLRP3 participates in the regulation of EMT in bleomycin-induced pulmonary fibrosis, Exp. Cell Res., 357, 328, 10.1016/j.yexcr.2017.05.028

Liu, 2016, Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy, Part. Fibre Toxicol., 13, 55, 10.1186/s12989-016-0167-z

Mack, 2018, Inflammation and fibrosis, Matrix Biol., 68–69, 106, 10.1016/j.matbio.2017.11.010

Saito, 2018, The role of TGF-beta signaling in lung cancer associated with idiopathic pulmonary fibrosis, Int. J. Mol. Sci., 19, 10.3390/ijms19113611

Gao, 2019, MiR-34c-5p plays a protective role in chronic obstructive pulmonary disease via targeting CCL22, Exp. Lung Res., 45, 1, 10.1080/01902148.2018.1563925

Chen, 2017, TGF-beta1 induces EMT in bovine mammary epithelial cells through the TGFbeta1/Smad signaling pathway, Cell. Physiol. Biochem., 43, 82, 10.1159/000480321

Ma, 2018, Emodin ameliorates renal fibrosis in rats via TGF-β1/Smad signaling pathway and function study of Smurf 2, Int. Urol. Nephrol., 50, 373, 10.1007/s11255-017-1757-x

Kyung, 2018, Sulforaphane attenuates pulmonary fibrosis by inhibiting the epithelial-mesenchymal transition, BMC Pharmacol. Toxicol., 19, 13, 10.1186/s40360-018-0204-7

Hu, 2018, New insights into TGF-beta/Smad signaling in tissue fibrosis, Chem. Biol. Interact., 292, 76, 10.1016/j.cbi.2018.07.008

Wang, 2017, Structure activity relationships of engineered nanomaterials in inducing NLRP3 inflammasome activation and chronic lung fibrosis, NanoImpact, 6, 99, 10.1016/j.impact.2016.08.002

Perez, 2017, Endothelial-to-mesenchymal transition: Cytokine-mediated pathways that determine endothelial fibrosis under inflammatory conditions, Cytokine Growth Factor Rev., 33, 41, 10.1016/j.cytogfr.2016.09.002

Zhou, 2019, Bortezomib attenuates renal interstitial fibrosis in kidney transplantation via regulating the EMT induced by TNF-α-Smurf1-Akt-mTOR-P70S6K pathway, J. Cell Mol. Med., 23, 5390, 10.1111/jcmm.14420