Emerging Roles of Hydrogen Sulfide in Inflammatory and Neoplastic Colonic Diseases

Abe, 1996, The possible role of hydrogen sulfide as an endogenous neuromodulator, J. Neurosci., 16, 1066, 10.1523/JNEUROSCI.16-03-01066.1996

Attene-Ramos, 2007, Hydrogen sulfide induces direct radical-associated DNA damage, Mol. Cancer Res., 5, 455, 10.1158/1541-7786.MCR-06-0439

Baskar, 2011, Hydrogen sulfide gas has cell growth regulatory role, Eur. J. Pharmacol., 656, 5, 10.1016/j.ejphar.2011.01.052

Bouillaud, 2011, Mitochondria and sulfide: a very old story of poisoning, feeding, and signaling?, Antioxid. Redox Signal., 15, 379, 10.1089/ars.2010.3678

Cai, 2010, Hydrogen sulfide induces human colon cancer cell proliferation: role of Akt, ERK and p21, Cell Biol. Int., 34, 565, 10.1042/CBI20090368

Cao, 2010, Butyrate-stimulated H2S production in colon cancer cells, Antioxid. Redox Signal., 12, 1101, 10.1089/ars.2009.2915

Chattopadhyay, 2013, Hydrogen sulfide-releasing aspirin inhibits the growth of leukemic Jurkat cells and modulates beta-catenin expression, Leuk. Res., 37, 1302, 10.1016/j.leukres.2013.07.004

Chiku, 2009, H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia, J. Biol. Chem., 284, 11601, 10.1074/jbc.M808026200

Cho, 2006, Critical role of the c-JunNH2-terminal kinase and p38 mitogen-activated protein kinase pathways on sodium butyrate-induced apoptosis in DU145 human prostate cancer cells, Eur. J. Cancer Prev., 15, 57, 10.1097/01.cej.0000195704.05246.fc

Coletta, 2012, Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation, Proc. Natl. Acad. Sci. U.S.A., 109, 9161, 10.1073/pnas.1202916109

Devkota, 2012, Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice, Nature, 487, 104, 10.1038/nature11225

Fan, 2014, Wnt/beta-catenin signaling induces the transcription of cystathionine-gamma-lyase, a stimulator of tumor in colon cancer, Cell. Signal., 26, 2801, 10.1016/j.cellsig.2014.08.023

Farrugia, 2014, Carbon monoxide, hydrogen sulfide, and nitric oxide as signaling molecules in the gastrointestinal tract, Gastroenterology, 147, 303, 10.1053/j.gastro.2014.04.041

Fite, 2004, Identification and quantitation of mucosal and faecal desulfovibrios using real time polymerase chain reaction, Gut, 53, 523, 10.1136/gut.2003.031245

Gallego, 2008, The gaseous mediator, hydrogen sulphide, inhibits in vitro motor patterns in the human, rat and mouse colon and jejunum, Neurogastroenterol. Motil., 20, 1306, 10.1111/j.1365-2982.2008.01201.x

Goubern, 2007, Sulfide, the first inorganic substrate for human cells, FASEB J., 21, 1699, 10.1096/fj.06-7407com

Gratzke, 2009, Transient receptor potential A1 (TRPA1) activity in the human urethra–evidence for a functional role for TRPA1 in the outflow region, Eur. Urol., 55, 696, 10.1016/j.eururo.2008.04.042

Hansen, 2011, Pan-genome of the dominant human gut-associated archaeon, Methanobrevibacter smithii, studied in twins, Proc. Natl. Acad. Sci. U.S.A., 108, 4599, 10.1073/pnas.1000071108

Hellmich, 2015, The therapeutic potential of cystathionine beta-synthetase/hydrogen sulfide inhibition in cancer, Antioxid. Redox Signal., 22, 424, 10.1089/ars.2014.5933

Hellmich, 2015, Hydrogen Sulfide and Cancer, Handb. Exp. Pharmacol., 230, 233, 10.1007/978-3-319-18144-8_12

Hirata, 2011, Endogenous hydrogen sulfide is an anti-inflammatory molecule in dextran sodium sulfate-induced colitis in mice, Dig. Dis. Sci., 56, 1379, 10.1007/s10620-010-1461-5

Huycke, 2004, Commensal bacteria, redox stress, and colorectal cancer: mechanisms and models, Exp. Biol. Med. (Maywood)., 229, 586, 10.1177/153537020422900702

Kashfi, 2014, Anti-cancer activity of new designer hydrogen sulfide-donating hybrids, Antioxid. Redox Signal., 20, 831, 10.1089/ars.2013.5308

Kashfi, 2013, Biology and therapeutic potential of hydrogen sulfide and hydrogen sulfide-releasing chimeras, Biochem. Pharmacol., 85, 689, 10.1016/j.bcp.2012.10.019

Kimura, 2011, Hydrogen sulfide: its production, release and functions, Amino Acids, 41, 113, 10.1007/s00726-010-0510-x

Kimura, 2010, Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria, Antioxid. Redox Signal., 12, 1, 10.1089/ars.2008.2282

Kleessen, 2002, Mucosal and invading bacteria in patients with inflammatory bowel disease compared with controls, Scand. J. Gastroenterol., 37, 1034, 10.1080/003655202320378220

Leschelle, 2005, Adaptative metabolic response of human colonic epithelial cells to the adverse effects of the luminal compound sulfide, Biochim. Biophys. Acta, 1725, 201, 10.1016/j.bbagen.2005.06.002

Levitt, 2002, Physiology of sulfide in the rat colon: use of bismuth to assess colonic sulfide production, J. Appl. Physiol. (1985), 92, 1655, 10.1152/japplphysiol.00907.2001

Li, 2007, Anti-inflammatory and gastrointestinal effects of a novel diclofenac derivative, Free Radic. Biol. Med., 42, 706, 10.1016/j.freeradbiomed.2006.12.011

Linden, 2008, Production of the gaseous signal molecule hydrogen sulfide in mouse tissues, J. Neurochem., 106, 1577, 10.1111/j.1471-4159.2008.05502.x

Liu, 2009, Hydrogen sulfide protects from intestinal ischaemia-reperfusion injury in rats, J. Pharm. Pharmacol., 61, 207, 10.1211/jpp.61.02.0010

Loubinoux, 2002, Sulfate-reducing bacteria in human feces and their association with inflammatory bowel diseases, FEMS Microbiol. Ecol., 40, 107, 10.1111/j.1574-6941.2002.tb00942.x

Ma, 2011, H2S donor, S-propargyl-cysteine, increases CSE in SGC-7901 and cancer-induced mice: evidence for a novel anti-cancer effect of endogenous H2S?, PLoS ONE, 6, e20525, 10.1371/journal.pone.0020525

Matsunami, 2009, Luminal hydrogen sulfide plays a pronociceptive role in mouse colon, Gut, 58, 751, 10.1136/gut.2007.144543

Medani, 2011, Emerging role of hydrogen sulfide in colonic physiology and pathophysiology, Inflamm. Bowel Dis., 17, 1620, 10.1002/ibd.21528

Modis, 2013a, Oxidative stress suppresses the cellular bioenergetic effect of the 3-mercaptopyruvate sulfurtransferase/hydrogen sulfide pathway, Biochem. Biophys. Res. Commun., 433, 401, 10.1016/j.bbrc.2013.02.131

Modis, 2014, Effect of S-adenosyl-L-methionine (SAM), an allosteric activator of cystathionine-beta-synthase (CBS) on colorectal cancer cell proliferation and bioenergetics in vitro, Nitric Oxide, 41, 146, 10.1016/j.niox.2014.03.001

Modis, 2013b, Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics, FASEB J., 27, 601, 10.1096/fj.12-216507

Modis, 2013c, Hydrogen sulfide-mediated stimulation of mitochondrial electron transport involves inhibition of the mitochondrial phosphodiesterase 2A, elevation of cAMP and activation of protein kinase A, Biochem Pharmacol., 86, 1311, 10.1016/j.bcp.2013.08.064

Murata, 2014, Differential susceptibility to hydrogen sulfide-induced apoptosis between PHLDA1-overexpressing oral cancer cell lines and oral keratinocytes: role of PHLDA1 as an apoptosis suppressor, Exp. Cell Res., 320, 247, 10.1016/j.yexcr.2013.10.023

Mustafa, 2009, H2S signals through protein S-sulfhydration, Sci. Signal, 2, ra72, 10.1126/scisignal.2000464

Nagai, 2004, Hydrogen sulfide induces calcium waves in astrocytes, FASEB J., 18, 557, 10.1096/fj.03-1052fje

Ning, 2014, Dysregulation of hydrogen sulphide metabolism impairs oviductal transport of embryos, Nat. Commun., 5, 4107, 10.1038/ncomms5107

Oh, 2006, Hydrogen sulfide inhibits nitric oxide production and nuclear factor-kappaB via heme oxygenase-1 expression in RAW264.7 macrophages stimulated with lipopolysaccharide, Free Radic. Biol. Med., 41, 106, 10.1016/j.freeradbiomed.2006.03.021

Patacchini, 2005, Pharmacological investigation of hydrogen sulfide (H2S) contractile activity in rat detrusor muscle, Eur. J. Pharmacol., 509, 171, 10.1016/j.ejphar.2005.01.005

Picton, 2007, Impaired detoxication of hydrogen sulfide in ulcerative colitis?, Dig. Dis. Sci., 52, 373, 10.1007/s10620-006-9529-y

Pitcher, 2000, The contribution of sulphate reducing bacteria and 5-aminosalicylic acid to faecal sulphide in patients with ulcerative colitis, Gut, 46, 64, 10.1136/gut.46.1.64

Pupo, 2011, Hydrogen sulfide promotes calcium signals and migration in tumor-derived endothelial cells, Free Radic. Biol. Med., 51, 1765, 10.1016/j.freeradbiomed.2011.08.007

Ramasamy, 2006, Sulfide-detoxifying enzymes in the human colon are decreased in cancer and upregulated in differentiation, Am. J. Physiol. Gastrointest. Liver Physiol., 291, G288, 10.1152/ajpgi.00324.2005

Rey, 2013, Metabolic niche of a prominent sulfate-reducing human gut bacterium, Proc. Natl. Acad. Sci. U.S.A., 110, 13582, 10.1073/pnas.1312524110

Roediger, 1997, Colonic sulfide in pathogenesis and treatment of ulcerative colitis, Dig. Dis. Sci., 42, 1571, 10.1023/A:1018851723920

Rose, 2005, Hydrogen sulfide protects colon cancer cells from chemopreventative agent beta-phenylethyl isothiocyanate induced apoptosis, World J. Gastroenterol., 11, 3990, 10.3748/wjg.v11.i26.3990

Roudsari, 2015, Studying the influence of angiogenesis in in vitro cancer model systems, Adv. Drug Deliv. Rev, 97, 250, 10.1016/j.addr.2015.11.004

Rowan, 2009, Sulphate-reducing bacteria and hydrogen sulphide in the aetiology of ulcerative colitis, Br. J. Surg., 96, 151, 10.1002/bjs.6454

Scanlan, 2009, Culture-independent analysis of desulfovibrios in the human distal colon of healthy, colorectal cancer and polypectomized individuals, FEMS Microbiol. Ecol., 69, 213, 10.1111/j.1574-6941.2009.00709.x

Sen, 2012, Hydrogen sulfide-linked sulfhydration of NF-kappaB mediates its antiapoptotic actions, Mol. Cell, 45, 13, 10.1016/j.molcel.2011.10.021

Shatalin, 2011, H2S: a universal defense against antibiotics in bacteria, Science, 334, 986, 10.1126/science.1209855

Shibuya, 2009a, Vascular endothelium expresses 3-mercaptopyruvate sulfurtransferase and produces hydrogen sulfide, J. Biochem., 146, 623, 10.1093/jb/mvp111

Shibuya, 2009b, 3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain, Antioxid. Redox Signal., 11, 703, 10.1089/ars.2008.2253

Singh, 2009, Relative contributions of cystathionine beta-synthase and gamma-cystathionase to H2S biogenesis via alternative trans-sulfuration reactions, J. Biol. Chem., 284, 22457, 10.1074/jbc.M109.010868

Stewart, 2006, Carriage, quantification, and predominance of methanogens and sulfate-reducing bacteria in faecal samples, Lett. Appl. Microbiol., 43, 58, 10.1111/j.1472-765X.2006.01906.x

Suarez, 1998, Production and elimination of sulfur-containing gases in the rat colon, Am. J. Physiol., 274, G727

Szabo, 2013, Tumor-derived hydrogen sulfide, produced by cystathionine-beta-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer, Proc. Natl. Acad. Sci. U.S.A., 110, 12474, 10.1073/pnas.1306241110

Szabo, 2013, Endogenously produced hydrogen sulfide supports tumor cell growth and proliferation, Cell Cycle, 12, 2915, 10.4161/cc.26064

Szabo, 2011, Hydrogen sulphide and angiogenesis: mechanisms and applications, Br. J. Pharmacol., 164, 853, 10.1111/j.1476-5381.2010.01191.x

Szabo, 2014, Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part I. Biochemical and physiological mechanisms, Br. J. Pharmacol., 171, 2099, 10.1111/bph.12369

Tao, 2013, VEGFR2 functions as an H2S-targeting receptor protein kinase with its novel Cys1045-Cys1024 disulfide bond serving as a specific molecular switch for hydrogen sulfide actions in vascular endothelial cells, Antioxid. Redox Signal., 19, 448, 10.1089/ars.2012.4565

Wallace, 2007a, Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulfide-releasing diclofenac derivative in the rat, Gastroenterology, 132, 261, 10.1053/j.gastro.2006.11.042

Wallace, 2007b, Hydrogen sulfide enhances ulcer healing in rats, FASEB J., 21, 4070, 10.1096/fj.07-8669com

Wallace, 2009, Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats, Gastroenterology, 137, 569, 10.1053/j.gastro.2009.04.012

Wang, 2012, Effect of precursor and preparation method on manganese based activated carbon sorbents for removing H2S from hot coal gas, J. Hazard. Mater., 213, 10.1016/j.jhazmat.2012.01.080

Wang, 2009, Hydrogen sulfide: a new EDRF, Kidney Int., 76, 700, 10.1038/ki.2009.221

Wang, 2012, Physiological implications of hydrogen sulfide: a whiff exploration that blossomed, Physiol. Rev., 92, 791, 10.1152/physrev.00017.2011

Whiteman, 2011, Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools, Clin. Sci., 121, 459, 10.1042/CS20110267

Whiteman, 2010, The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages, Antioxid. Redox Signal., 12, 1147, 10.1089/ars.2009.2899

Wu, 2015, Hydrogen sulfide in cancer: friend or foe?, Nitric Oxide, 50, 38, 10.1016/j.niox.2015.08.004

Wu, 2012, Hydrogen sulfide lowers proliferation and induces protective autophagy in colon epithelial cells, PLoS ONE, 7, e37572, 10.1371/journal.pone.0037572

Yamagishi, 2012, Generation of gaseous sulfur-containing compounds in tumour tissue and suppression of gas diffusion as an antitumour treatment, Gut, 61, 554, 10.1136/gutjnl-2011-300721

Yang, 2008, H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase, Science, 322, 587, 10.1126/science.1162667