Emergence of resistance to antibacterial agents: the role of quaternary ammonium compounds—a critical review

Cohen, 1997, Epidemiological factors influencing the emergence of antimicrobial resistance, Ciba Found Symp, 207, 223

Barza, 2002, Introduction, Clin Infect Dis, 34, S71, 10.1086/340241

Adcock, 1998, Methicillin-resistant Staphylococcus aureus in two child care centers, J Infect Dis, 178, 577, 10.1086/517478

Suggs, 1999, Methicillin-resistant and borderline methicillin-resistant asymptomatic Staphylococcus aureus colonization in children without identifiable risk factors, Pediatr Infect Dis J, 18, 410, 10.1097/00006454-199905000-00003

Hussain, 2001, Community-acquired methicillin-resistant Staphylococcus aureus colonization in healthy children attending an outpatient pediatric clinic, Pediatr Infect Dis J, 20, 763, 10.1097/00006454-200108000-00009

Charlebois, 2002, Population-based community prevalence of methicillin-resistant Staphylococcus aureus in the urban poor of San Francisco, Clin Infect Dis, 34, 425, 10.1086/338069

World Health Organization. Combating waterborne disease at the household level. Geneva, Switzerland: WHO; 2007. http://www.who.int/water_sanitation_health/publications/combating_diseasepart1lowres.pdf [accessed 13 February 2012].

McBain, 2002, Possible implications of biocide accumulation in the environment on the prevalence of bacterial antibiotic resistance, J Ind Microbiol Biotechnol, 29, 326, 10.1038/sj.jim.7000324

Poole, 2004, Bacterial resistance: acquired resistance, 170

Smith, 2008, The association between biocide tolerance and the presence or absence of qac genes among hospital-acquired and community-acquired MRSA isolates, J Antimicrob Chemother, 61, 78, 10.1093/jac/dkm395

Buffet-Bataillon, 2011, Effect of higher minimum inhibitory concentrations of quaternary ammonium compounds in clinical E. coli isolates on antibiotic susceptibilities and clinical outcomes, J Hosp Infect, 79, 141, 10.1016/j.jhin.2011.06.008

Merianos, 1991, Quaternary ammonium antimicrobial compounds, 225

Rahn, 1947, Quaternary ammonium compounds, Annu Rev Microbiol, 1, 173, 10.1146/annurev.mi.01.100147.001133

Walker, 2003, Quaternary ammonium compounds, 99

Xue, 2004, Kinetic characteristics and toxic effects of benzalkonium chloride following intravascular and oral administration in rats, J Chromatogr B Analyt Technol Biomed Life Sci, 811, 53, 10.1016/j.jchromb.2004.03.075

Merianos, 2001, Surface-active agents, 283

Gilbert, 2005, Cationic antiseptics: diversity of action under a common epithet, J Appl Microbiol, 99, 703, 10.1111/j.1365-2672.2005.02664.x

Fredell, 1994, Biological properties and applications of cationic surfactants, 31

Deo, 2010, Monocationic surfactant induced ultra-structural changes in antibiotic resistant Escherichia coli, Indian J Med Res, 131, 825

Ioannou, 2007, Action of disinfectant quaternary ammonium compounds against Staphylococcus aureus, Antimicrob Agents Chemother, 51, 296, 10.1128/AAC.00375-06

Gilbert, 1987, Inocula for antimicrobial sensitivity testing: a critical review, J Antimicrob Chemother, 20, 147, 10.1093/jac/20.2.147

Nicoletti, 1993, The antimicrobial activity in vitro of chlorhexidine, a mixture of isothiazolinones (‘Kathon’ CG) and cetyl trimethyl ammonium bromide (CTAB), J Hosp Infect, 23, 87, 10.1016/0195-6701(93)90014-Q

Bloomfield, 1995, Development of reproducible test inocula for disinfectant testing, Int Biodeterior Biodegrad, 36, 311, 10.1016/0964-8305(95)00100-X

Langsrud, 1998, Factors influencing a suspension test method for antimicrobial activity of disinfectants, J Appl Microbiol, 85, 1006, 10.1111/j.1365-2672.1998.tb05265.x

Johnston, 2000, One explanation for the variability of the bacterial suspension test, J Appl Microbiol, 88, 237, 10.1046/j.1365-2672.2000.00951.x

Poole, 2002, Mechanisms of bacterial biocide and antibiotic resistance, J Appl Microbiol, 92, 55S, 10.1046/j.1365-2672.92.5s1.8.x

Jang, 2010, Clinical features, risk factors and outcomes of bacteremia due to enterococci with high-level gentamicin resistance: comparison with bacteremia due to enterococci without high-level gentamicin resistance, J Korean Med Sci, 25, 3, 10.3346/jkms.2010.25.1.3

British Pharmacopoeia Commission, 2000

United States Pharmacopeia, 2002

Russell, 2003, Challenge testing: principles and practice, Int J Cosmet Sci, 25, 147, 10.1046/j.1467-2494.2003.00179.x

Hegstad, 2010, Does the wide use of quaternary ammonium compounds enhance the selection and spread of antimicrobial resistance and thus threaten our health?, Microb Drug Resist, 16, 91, 10.1089/mdr.2009.0120

Chapman, 2003, Disinfectant resistance mechanisms, cross-resistance and co-resistance, Int Biodeter Biodegrad, 51, 271, 10.1016/S0964-8305(03)00044-1

Tabata, 2003, Correlation between resistance of Pseudomonas aeruginosa to quaternary ammonium compounds and expression of outer membrane protein OprR, Antimicrob Agents Chemother, 47, 2093, 10.1128/AAC.47.7.2093-2099.2003

Bore, 2007, Adapted tolerance to benzalkonium chloride in Escherichia coli K-12 studied by transcriptome and proteome analyses, Microbiology, 153, 935, 10.1099/mic.0.29288-0

Karatzas, 2008, Phenotypic and proteomic characterization of multiply antibiotic-resistant variants of Salmonella enterica serovar Typhimurium selected following exposure to disinfectants, Appl Environ Microbiol, 74, 1508, 10.1128/AEM.01931-07

Bjorland, 2003, Novel plasmid-borne gene qacJ mediates resistance to quaternary ammonium compounds in equine Staphylococcus aureus, Staphylococcus simulans, and Staphylococcus intermedius, Antimicrob Agents Chemother, 47, 3046, 10.1128/AAC.47.10.3046-3052.2003

Gillings, 2009, Gene cassettes encoding resistance to quaternary ammonium compounds: a role in the origin of clinical class 1 integrons?, ISME J, 3, 209, 10.1038/ismej.2008.98

Putman, 2000, Molecular properties of bacterial multidrug transporters, Microbiol Mol Biol Rev, 64, 672, 10.1128/MMBR.64.4.672-693.2000

Littlejohn, 1992, Substrate specificity and energetics of antiseptic and disinfectant resistance in Staphylococcus aureus, FEMS Microbiol Lett, 74, 259, 10.1111/j.1574-6968.1992.tb05376.x

Paulsen, 1996, Multidrug resistance proteins QacA and QacB from Staphylococcus aureus: membrane topology and identification of residues involved in substrate specificity, Proc Natl Acad Sci USA, 93, 3630, 10.1073/pnas.93.8.3630

Heir, 1999, Identification and characterization of quaternary ammonium compound resistant staphylococci from the food industry, Int J Food Microbiol, 48, 211, 10.1016/S0168-1605(99)00044-6

Heir, 1998, The Staphylococcus qacH gene product: a new member of the SMR family encoding multidrug resistance, FEMS Microbiol Lett, 163, 49, 10.1111/j.1574-6968.1998.tb13025.x

Kazama, 1998, Distribution of the antiseptic-resistance gene qacEΔ1 in Gram-positive bacteria, FEMS Microbiol Lett, 165, 295

Bischoff, 2012, First detection of the antiseptic resistance gene qacA/B in Enterococcus faecalis, Microb Drug Resist, 18, 7, 10.1089/mdr.2011.0092

Sasatsu, 1995, The origin of the antiseptic-resistance gene ebr in Staphylococcus aureus, Microbios, 84, 161

Moken, 1997, Selection of multiple-antibiotic-resistant (mar) mutants of Escherichia coli by using the disinfectant pine oil: roles of the mar and acrAB loci, Antimicrob Agents Chemother, 41, 2770, 10.1128/AAC.41.12.2770

McMurry, 1998, Overexpression of marA, soxS, or acrAB produces resistance to triclosan in laboratory and clinical strains of Escherichia coli, FEMS Microbiol Lett, 166, 305, 10.1111/j.1574-6968.1998.tb13905.x

Yerushalmi, 1995, EmrE, an Escherichia coli 12-kDa multidrug transporter, exchanges toxic cations and H+ and is soluble in organic solvents, J Biol Chem, 270, 6856, 10.1074/jbc.270.12.6856

Morita, 1998, NorM, a putative multidrug efflux protein, of Vibrio parahaemolyticus and its homolog in Escherichia coli, Antimicrob Agents Chemother, 42, 1778, 10.1128/AAC.42.7.1778

Edgar, 1997, MdfA, an Escherichia coli multidrug resistance protein with an extraordinarily broad spectrum of drug recognition, J Bacteriol, 179, 2274, 10.1128/jb.179.7.2274-2280.1997

Turner, 1997, Expression of Escherichia coli TehA gives resistance to antiseptics and disinfectants similar to that conferred by multidrug resistance efflux pumps, Antimicrob Agents Chemother, 41, 440, 10.1128/AAC.41.2.440

Pages, 2011, An original deal for new molecule: reversal of efflux pump activity, a rational strategy to combat Gram-negative resistant bacteria, Curr Med Chem, 18, 2969, 10.2174/092986711796150469

Archer, 1986, Plasmid-encoded trimethoprim resistance in staphylococci, Antimicrob Agents Chemother, 29, 733, 10.1128/AAC.29.5.733

Sidhu, 2001, Genetic linkage between resistance to quaternary ammonium compounds and β-lactam antibiotics in food-related Staphylococcus spp., Microb Drug Resist, 7, 363, 10.1089/10766290152773374

Anthonisen, 2002, Organization of the antiseptic resistance gene qacA and Tn552-related β-lactamase genes in multidrug-resistant Staphylococcus haemolyticus strains of animal and human origins, Antimicrob Agents Chemother, 46, 3606, 10.1128/AAC.46.11.3606-3612.2002

Sidhu, 2002, Frequency of disinfectant resistance genes and genetic linkage with β-lactamase transposon Tn552 among clinical staphylococci, Antimicrob Agents Chemother, 46, 2797, 10.1128/AAC.46.9.2797-2803.2002

Bjorland, 2005, Widespread distribution of disinfectant resistance genes among staphylococci of bovine and caprine origin in Norway, J Clin Microbiol, 43, 4363, 10.1128/JCM.43.9.4363-4368.2005

Cookson, 2005, Clinical significance of emergence of bacterial antimicrobial resistance in the hospital environment, J Appl Microbiol, 99, 989, 10.1111/j.1365-2672.2005.02693.x

Ciric, 2011, Antibiotic and antiseptic resistance genes are linked on a novel mobile genetic element: Tn6087, J Antimicrob Chemother, 66, 2235, 10.1093/jac/dkr311

Yum, 2002, A new integron carrying VIM-2 metallo-β-lactamase gene cassette in a Serratia marcescens isolate, Diagn Microbiol Infect Dis, 42, 217, 10.1016/S0732-8893(01)00352-2

Chang, 2007, Increased incidence of class 1 integrons in trimethoprim/sulfamethoxazole-resistant clinical isolates of Stenotrophomonas maltophilia, J Antimicrob Chemother, 59, 1038, 10.1093/jac/dkm034

Paulsen, 1993, The 3′ conserved segment of integrons contains a gene associated with multidrug resistance to antiseptics and disinfectants, Antimicrob Agents Chemother, 37, 761, 10.1128/AAC.37.4.761

Ploy, 1998, Characterization of In40 of Enterobacter aerogenes BM2688, a class 1 integron with two new gene cassettes, cmlA2 and qacF, Antimicrob Agents Chemother, 42, 2557, 10.1128/AAC.42.10.2557

Laraki, 1999, Structure of In31, a blaIMP-containing Pseudomonas aeruginosa integron phyletically related to In5, which carries an unusual array of gene cassettes, Antimicrob Agents Chemother, 43, 890, 10.1128/AAC.43.4.890

Naas, 2001, Characterization of In53, a class 1 plasmid- and composite transposon-located integron of Escherichia coli which carries an unusual array of gene cassettes, J Bacteriol, 183, 235, 10.1128/JB.183.1.235-249.2001

Plante, 2003, Direct sequencing and PCR mapping of integrons reveals multiple class 1 integrons in the multiresistant strain Enterobacter cloacae SCH88040794, FEMS Microbiol Lett, 221, 59, 10.1016/S0378-1097(03)00163-0

Ceccarelli, 2006, New cluster of plasmid-located class 1 integrons in Vibrio cholerae O1 and a dfrA15 cassette-containing integron in Vibrio parahaemolyticus isolated in Angola, Antimicrob Agents Chemother, 50, 2493, 10.1128/AAC.01310-05

Schluter, 2007, Genomics of IncP-1 antibiotic resistance plasmids isolated from wastewater treatment plants provides evidence for a widely accessible drug resistance gene pool, FEMS Microbiol Rev, 31, 449, 10.1111/j.1574-6976.2007.00074.x

Norman, 2008, Nucleotide sequence of pOLA52: a conjugative IncX1 plasmid from Escherichia coli which enables biofilm formation and multidrug efflux, Plasmid, 60, 59, 10.1016/j.plasmid.2008.03.003

Kaatz, 1995, Inducible NorA-mediated multidrug resistance in Staphylococcus aureus, Antimicrob Agents Chemother, 39, 2650, 10.1128/AAC.39.12.2650

Okusu, 1996, AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants, J Bacteriol, 178, 306, 10.1128/jb.178.1.306-308.1996

Masuda, 2000, Substrate specificities of MexAB–OprM, MexCD–OprJ, and MexXY–OprM efflux pumps in Pseudomonas aeruginosa, Antimicrob Agents Chemother, 44, 3322, 10.1128/AAC.44.12.3322-3327.2000

Levy, 2002, Active efflux, a common mechanism for biocide and antibiotic resistance, J Appl Microbiol, 92, 65S, 10.1046/j.1365-2672.92.5s1.4.x

Chen, 2003, An RND-type multidrug efflux pump SdeXY from Serratia marcescens, J Antimicrob Chemother, 52, 176, 10.1093/jac/dkg308

Morita, 2003, Induction of mexCD–oprJ operon for a multidrug efflux pump by disinfectants in wild-type Pseudomonas aeruginosa PAO1, J Antimicrob Chemother, 51, 991, 10.1093/jac/dkg173

He, 2004, An H+-coupled multidrug efflux pump, PmpM, a member of the MATE family of transporters, from Pseudomonas aeruginosa, J Bacteriol, 186, 262, 10.1128/JB.186.1.262-265.2004

Huang, 2004, Novel chromosomally encoded multidrug efflux transporter MdeA in Staphylococcus aureus, Antimicrob Agents Chemother, 48, 909, 10.1128/AAC.48.3.909-917.2004

Langsrud, 2004, Cross-resistance to antibiotics of Escherichia coli adapted to benzalkonium chloride or exposed to stress-inducers, J Appl Microbiol, 96, 201, 10.1046/j.1365-2672.2003.02140.x

Kaatz, 2005, Multidrug resistance in Staphylococcus aureus due to overexpression of a novel multidrug and toxin extrusion (MATE) transport protein, Antimicrob Agents Chemother, 49, 1857, 10.1128/AAC.49.5.1857-1864.2005

Piddock, 2006, Multidrug-resistance efflux pumps—not just for resistance, Nat Rev Microbiol, 4, 629, 10.1038/nrmicro1464

Romanova, 2006, Role of efflux pumps in adaptation and resistance of Listeria monocytogenes to benzalkonium chloride, Appl Environ Microbiol, 72, 3498, 10.1128/AEM.72.5.3498-3503.2006

Hansen, 2007, Substrate specificity of the OqxAB multidrug resistance pump in Escherichia coli and selected enteric bacteria, J Antimicrob Chemother, 60, 145, 10.1093/jac/dkm167

Huet, 2008, Multidrug efflux pump overexpression in Staphylococcus aureus after single and multiple in vitro exposures to biocides and dyes, Microbiology, 154, 3144, 10.1099/mic.0.2008/021188-0

Maseda, 2009, Mutational upregulation of a resistance–nodulation–cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens, Antimicrob Agents Chemother, 53, 5230, 10.1128/AAC.00631-09

Wootton, 2009, Evaluation of the effectiveness of common hospital hand disinfectants against methicillin-resistant Staphylococcus aureus, glycopeptide-intermediate S. aureus, and heterogeneous glycopeptide-intermediate S. aureus, Infect Control Hosp Epidemiol, 30, 226, 10.1086/595691

Gaze, 2005, Incidence of class 1 integrons in a quaternary ammonium compound-polluted environment, Antimicrob Agents Chemother, 49, 1802, 10.1128/AAC.49.5.1802-1807.2005

Zhang, 2011, Prevalence of antiseptic-resistance genes in Staphylococcus aureus and coagulase-negative staphylococci colonising nurses and the general population in Hong Kong, J Hosp Infect, 78, 113, 10.1016/j.jhin.2011.02.018

Gajadhar, 2003, Microbial contamination of disinfectants and antiseptics in four major hospitals in Trinidad, Rev Panam Salud Publica, 14, 193, 10.1590/S1020-49892003000800006

Heuer, 2004, The complete sequences of plasmids pB2 and pB3 provide evidence for a recent ancestor of the IncP-1β group without any accessory genes, Microbiology, 150, 3591, 10.1099/mic.0.27304-0

Johnson, 2005, DNA sequence and comparative genomics of pAPEC-O2-R, an avian pathogenic Escherichia coli transmissible R plasmid, Antimicrob Agents Chemother, 49, 4681, 10.1128/AAC.49.11.4681-4688.2005

Crowley, 2008, First detection of a class 2 integron among clinical isolates of Serratia marcescens, Br J Biomed Sci, 65, 86, 10.1080/09674845.2008.11732803

Jeong, 2009, Analysis of a novel class 1 integron containing metallo-β-lactamase gene VIM-2 in Pseudomonas aeruginosa, J Microbiol, 47, 753, 10.1007/s12275-008-0272-2

Yong, 2009, Characterization of a new metallo-β-lactamase gene, blaNDM-1, and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India, Antimicrob Agents Chemother, 53, 5046, 10.1128/AAC.00774-09

Romao, 2011, Presence of qacEΔ1 gene and susceptibility to a hospital biocide in clinical isolates of Pseudomonas aeruginosa resistant to antibiotics, Curr Microbiol, 63, 16, 10.1007/s00284-011-9934-0

Thorsteinsson, 2003, Soft antibacterial agents, Curr Med Chem, 10, 1129, 10.2174/0929867033457520

Linton, 1982

Lina, 2003, Bacterial competition for human nasal cavity colonization: role of staphylococcal agr alleles, Appl Environ Microbiol, 69, 18, 10.1128/AEM.69.1.18-23.2003

Akimitsu, 1999, Increase in resistance of methicillin-resistant Staphylococcus aureus to β-lactams caused by mutations conferring resistance to benzalkonium chloride, a disinfectant widely used in hospitals, Antimicrob Agents Chemother, 43, 3042, 10.1128/AAC.43.12.3042

Levy, 2000, Antibiotic and antiseptic resistance: impact on public health, Pediatr Infect Dis J, 19, S120, 10.1097/00006454-200010001-00008

Gillespie, 1986, Plasmid-encoded resistance to acriflavine and quaternary ammonium compounds in methicillin-resistant Staphylococcus aureus, FEMS Microbiol Lett, 34, 47, 10.1111/j.1574-6968.1986.tb01346.x

Noguchi, 1999, Antiseptic susceptibility and distribution of antiseptic-resistance genes in methicillin-resistant Staphylococcus aureus, FEMS Microbiol Lett, 172, 247, 10.1111/j.1574-6968.1999.tb13475.x

Mayer, 2001, Distribution of the antiseptic resistance genes qacA, qacB and qacC in 497 methicillin-resistant and -susceptible European isolates of Staphylococcus aureus, J Antimicrob Chemother, 47, 896, 10.1093/jac/47.6.896

Noguchi, 2005, Susceptibilities to antiseptic agents and distribution of antiseptic-resistance genes qacA/B and smr of methicillin-resistant Staphylococcus aureus isolated in Asia during 1998 and 1999, J Med Microbiol, 54, 557, 10.1099/jmm.0.45902-0

Guarner, 2006, Enteric flora in health and disease, Digestion, 73, 5, 10.1159/000089775

Dawson, 2011, Hypervirulent Clostridium difficile PCR-ribotypes exhibit resistance to widely used disinfectants, PLoS One, 6, e25754, 10.1371/journal.pone.0025754

Gibson, 1995

Hood, 1997, Isolation and identification of adherent Gram-negative microorganisms from four meat-processing facilities, J Food Prot, 60, 1135, 10.4315/0362-028X-60.9.1135

Mettler, 1998, Variations over time of microbial load and physicochemical properties of floor materials after cleaning in food industry premises, J Food Prot, 61, 57, 10.4315/0362-028X-61.1.57

Bagge-Ravn, 2003, The microbial ecology of processing equipment in different fish industries—analysis of the microflora during processing and following cleaning and disinfection, Int J Food Microbiol, 87, 239, 10.1016/S0168-1605(03)00067-9

Langsrud, 2003, Bacterial disinfectant resistance—a challenge for the food industry, Int Biodeter Biodegrad, 51, 283, 10.1016/S0964-8305(03)00039-8

Gudbjörnsdottir, 2005, Microbial adhesion to processing lines for fish fillets and cooked shrimp: influence of stainless steel surface finish and presence of Gram-negative bacteria on the attachment of Listeria monocytogenes, Food Technol Biotechnol, 43, 55

Brightwell, 2006, Identifying the bacterial community on the surface of Intralox belting in a meat boning room by culture-dependent and culture-independent 16S rDNA sequence analysis, Int J Food Microbiol, 109, 47, 10.1016/j.ijfoodmicro.2006.01.008

Langsrud, 2006, Characterization of the microbial flora in disinfecting footbaths with hypochlorite, J Food Prot, 69, 2193, 10.4315/0362-028X-69.9.2193

Moretro, 2006, Evaluation of the antibacterial effect of a triclosan-containing floor used in the food industry, J Food Prot, 69, 627, 10.4315/0362-028X-69.3.627

Van de Weyer, 1993, Bactericidal activity of disinfectants on Listeria, J Appl Bacteriol, 74, 480, 10.1111/j.1365-2672.1993.tb05157.x

Jacquet, 1994, Differences in the sensitivity to eight disinfectants of Listeria monocytogenes strains as related to their origin (short note), Int J Food Microbiol, 22, 79, 10.1016/0168-1605(94)90010-8

Gronhölm, 1999, Screening of antimicrobial activities of disinfectants and cleaning agents against foodborne spoilage microbes, Z Lebensm Unters Forsch, 208, 289, 10.1007/s002170050419

Gonzales-Fandos, 2005, Effectiveness of disinfectants used in the food industry on microorganisms of sanitary interest, Acta Aliment, 34, 253, 10.1556/AAlim.34.2005.3.7

Heir, 1995, Resistance to quaternary ammonium compounds in Staphylococcus spp. isolated from the food industry and nucleotide sequence of the resistance plasmid pST827, J Appl Bacteriol, 79, 149, 10.1111/j.1365-2672.1995.tb00928.x

Aase, 2000, Occurrence of and a possible mechanism for resistance to a quaternary ammonium compound in Listeria monocytogenes, Int J Food Microbiol, 62, 57, 10.1016/S0168-1605(00)00357-3

Aarestrup, 2007, Antimicrobial susceptibility of Listeria monocytogenes from food products, Foodborne Pathog Dis, 4, 216, 10.1089/fpd.2006.0078

Best, 1990, Efficacy of a variety of disinfectants against Listeria spp., Appl Environ Microbiol, 56, 377, 10.1128/AEM.56.2.377-380.1990

Aarnisalo, 2003, Typing of Listeria monocytogenes isolates originating from the food processing industry with automated ribotyping and pulsed-field gel electrophoresis, J Food Prot, 66, 249, 10.4315/0362-028X-66.2.249

Willinghan, 1996, Investigation of bacterial resistance to hatchery disinfectants, Avian Dis, 40, 510, 10.2307/1592258

Langsrud, 1997, Factors contributing to the survival of poultry associated Pseudomonas spp. exposed to a quaternary ammonium compound, J Appl Microbiol, 82, 705, 10.1046/j.1365-2672.1997.00186.x

Sidhu, 2002, Resistance to quaternary ammonium compounds in food-related bacteria, Microb Drug Resist, 8, 393, 10.1089/10766290260469679

Langsrud, 2003, Characterization of Serratia marcescens surviving in disinfecting footbaths, J Appl Microbiol, 95, 186, 10.1046/j.1365-2672.2003.01968.x

Bundgaard-Nielsen, 1996, Fungicidal effect of 15 disinfectants against 25 fungal contaminants commonly found in bread and cheese manufacturing, J Food Prot, 59, 268, 10.4315/0362-028X-59.3.268

Korukuoglu, 2006, The fungicidal efficacy of various commercial disinfectants used in the food industry, Ann Microbiol, 56, 325, 10.1007/BF03175025

Dean-Raymond, 1977, Bacterial metabolism of quaternary ammonium compounds, Appl Environ Microbiol, 33, 1037, 10.1128/AEM.33.5.1037-1041.1977

Sullivan, 1983, Biodegradation of a cationic surfactant in activated sludge, Water Res, 17, 1145, 10.1016/0043-1354(83)90055-6

Kümmerer, 2004, Emission from medical care units, 27

Clara, 2007, Occurrence of selected surfactants in untreated and treated sewage, Water Res, 41, 4339, 10.1016/j.watres.2007.06.027

Sutterlin, 2008, Mixtures of quaternary ammonium compounds and anionic organic compounds in the aquatic environment: elimination and biodegradability in the closed bottle test monitored by LC–MS/MS, Chemosphere, 72, 479, 10.1016/j.chemosphere.2008.03.008

McBain, 2004, Effects of quaternary-ammonium-based formulations on bacterial community dynamics and antimicrobial susceptibility, Appl Environ Microbiol, 70, 3449, 10.1128/AEM.70.6.3449-3456.2004

Sutterlin, 2008, The toxicity of the quaternary ammonium compound benzalkonium chloride alone and in mixtures with other anionic compounds to bacteria in test systems with Vibrio fischeri and Pseudomonas putida, Ecotoxicol Environ Saf, 71, 498, 10.1016/j.ecoenv.2007.12.015

Gillings, 2009, Evidence for dynamic exchange of qac gene cassettes between class 1 integrons and other integrons in freshwater biofilms, FEMS Microbiol Lett, 296, 282, 10.1111/j.1574-6968.2009.01646.x

Tan, 2002, Use of antimicrobial agents in consumer products, Arch Dermatol, 138, 1082, 10.1001/archderm.138.8.1082

Kahlmeter, 2003, European harmonization of MIC breakpoints for antimicrobial susceptibility testing of bacteria, J Antimicrob Chemother, 52, 145, 10.1093/jac/dkg312

Kahlmeter, 2004, Harmonization of antimicrobial breakpoints in Europe—can it be achieved?, Clin Microbiol Newsl, 26, 187, 10.1016/S0196-4399(04)80015-1

Aiello, 2002, What is the evidence for a causal link between hygiene and infections?, Lancet Infect Dis, 2, 103, 10.1016/S1473-3099(02)00184-6

Joynson, 2002, Adaptive resistance to benzalkonium chloride, amikacin and tobramycin: the effect on susceptibility to other antimicrobials, J Appl Microbiol, 93, 96, 10.1046/j.1365-2672.2002.01667.x

Penna, 2001, The efficacy of chemical agents in cleaning and disinfection programs, BMC Infect Dis, 1, 16, 10.1186/1471-2334-1-16

Walsh, 2003, Development of bacterial resistance to several biocides and effects on antibiotic susceptibility, J Hosp Infect, 55, 98, 10.1016/S0195-6701(03)00240-8

Lambert, 2000, Susceptibility testing: accurate and reproducible minimum inhibitory concentration (MIC) and non-inhibitory concentration (NIC) values, J Appl Microbiol, 88, 784, 10.1046/j.1365-2672.2000.01017.x