Nội dung được dịch bởi AI, chỉ mang tính chất tham khảo
Ra mắt tế bào gốc phôi để điều trị động kinh thùy thái dương
Tóm tắt
Động kinh cục bộ phức tạp phát sinh từ các cấu trúc thùy thái dương trung gian là một đặc điểm xác định của động kinh thùy thái dương (TLE). Đối với nhiều bệnh nhân TLE, đã có một chấn thương đầu ban đầu mà chính nó là nguyên nhân khởi phát động kinh. TLE nặng có thể liên quan đến những thay đổi về sinh lý thần kinh, bao gồm xơ hóa hippocampus, thoái hóa thần kinh ở rãnh dentate, và tái tổ chức rộng rãi các mạch nhầy của hippocampus. Khuyết tật học tập và các tình trạng tâm thần cũng có thể xảy ra ở những bệnh nhân TLE nặng, đối với người mà các loại thuốc chống động kinh thông thường không hiệu quả. Cần có những phương pháp điều trị mới để hạn chế hoặc phục hồi thiệt hại tế bào thần kinh, đặc biệt là ở hippocampus và các vùng limbic liên quan trong TLE nặng, và để làm giảm cơn động kinh thùy thái dương. Một chiến lược điều trị hứa hẹn có thể là phục hồi sự ức chế của các nơ-ron hạt của rãnh dentate thông qua các cấy ghép tế bào của các tiền thân nơ-ron GABAergic từ tế bào gốc phôi. Các nghiên cứu
Từ khóa
#động kinh thùy thái dương #tế bào gốc phôi #nơ-ron GABAergic #cấy ghép tế bào #thiệt hại tế bào thần kinhTài liệu tham khảo
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