Elucidating the role of microbes in celiac disease through gnotobiotic modeling

Abadie, 2014, IL-15: A central regulator of celiac disease immunopathology, Immunological Reviews, 260, 221, 10.1111/imr.12191 Abadie, 2020, IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease, Nature, 578, 600, 10.1038/s41586-020-2003-8 Arrieta, 2016, Human microbiota-associated mice: A model with challenges, Cell Host & Microbe, 19, 575, 10.1016/j.chom.2016.04.014 Arvidsson, 2012, Generating and analyzing germ-free mice, Current Protocols in Mouse Biology, 2, 307 Black, 2002, HLA-DQ determines the response to exogenous wheat proteins: A model of gluten sensitivity in transgenic knockout mice, Journal of Immunology, 169, 5595, 10.4049/jimmunol.169.10.5595 Caminero, 2016, Duodenal bacteria from patients with celiac disease and healthy subjects distinctly affect gluten breakdown and immunogenicity, Gastroenterology, 151, 670, 10.1053/j.gastro.2016.06.041 Caminero, 2019, Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2, Nature Communications, 10, 1198, 10.1038/s41467-019-09037-9 Caminero, 2019, Lactobacilli degrade wheat amylase trypsin inhibitors to reduce intestinal dysfunction induced by immunogenic wheat proteins, Gastroenterology, 156, 2266, 10.1053/j.gastro.2019.02.028 Caminero, 2019, Mechanisms by which gut microorganisms influence food sensitivities, Nature Reviews. Gastroenterology & Hepatology, 16, 7, 10.1038/s41575-018-0064-z Catassi, 2022, Coeliac disease, Lancet, 399, 2413, 10.1016/S0140-6736(22)00794-2 Constante, 2022, Biogeographic variation and functional pathways of the gut microbiota in celiac disease, Gastroenterology, 163, 1351, 10.1053/j.gastro.2022.06.088 de Kauwe, 2009, Resistance to celiac disease in humanized HLA-DR3-DQ2-transgenic mice expressing specific anti-gliadin CD4+ T cells, Journal of Immunology, 182, 7440, 10.4049/jimmunol.0900233 De Palma, 2017, Transplantation of fecal microbiota from patients with irritable bowel syndrome alters gut function and behavior in recipient mice, Science Translational Medicine, 9, 10.1126/scitranslmed.aaf6397 DePaolo, 2011, Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens, Nature, 471, 220, 10.1038/nature09849 Dewan, 2021, Generation of an HLA-DQ2.5 knock-in mouse, Immunohorizons, 5, 25, 10.4049/immunohorizons.2000107 Di Sabatino, 2006, Epithelium derived interleukin 15 regulates intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in coeliac disease, Gut, 55, 469, 10.1136/gut.2005.068684 Faith, 2010, Creating and characterizing communities of human gut microbes in gnotobiotic mice, The ISME Journal, 4, 1094, 10.1038/ismej.2010.110 Freitag, 2014, Testing safety of germinated rye sourdough in a celiac disease model based on the adoptive transfer of prolamin-primed memory T cells into lymphopenic mice, American Journal of Physiology. Gastrointestinal and Liver Physiology, 306, G526, 10.1152/ajpgi.00136.2013 Freitag, 2020, Gliadin nanoparticles induce immune tolerance to gliadin in mouse models of celiac disease, Gastroenterology, 158, 1667, 10.1053/j.gastro.2020.01.045 Freitag, 2009, Gliadin-primed CD4+CD45RBlowCD25- T cells drive gluten-dependent small intestinal damage after adoptive transfer into lymphopenic mice, Gut, 58, 1597, 10.1136/gut.2009.186361 Galipeau, 2021, Novel fecal biomarkers that precede clinical diagnosis of ulcerative colitis, Gastroenterology, 160, 1532, 10.1053/j.gastro.2020.12.004 Galipeau, 2015, Intestinal microbiota modulates gluten-induced immunopathology in humanized mice, The American Journal of Pathology, 185, 2969, 10.1016/j.ajpath.2015.07.018 Galipeau, 2011, Sensitization to gliadin induces moderate enteropathy and insulitis in nonobese diabetic-DQ8 mice, Journal of Immunology, 187, 4338, 10.4049/jimmunol.1100854 Galipeau, 2022, The double-edged sword of gut bacteria in celiac disease and implications for therapeutic potential, Mucosal Immunology, 15, 235, 10.1038/s41385-021-00479-3 Gehrig, 2019, Effects of microbiota-directed foods in gnotobiotic animals and undernourished children, Science, 365, 10.1126/science.aau4732 Gopalakrishnan, 2012, Larazotide acetate regulates epithelial tight junctions in vitro and in vivo, Peptides, 35, 86, 10.1016/j.peptides.2012.02.015 Gordon, 1965, Germ-free animals in research: An extension of the pure culture concept, Triangle, 7, 108 Gustafsson, 1959, Lightweight stainless steel systems for rearing germfree animals, Annals of the New York Academy of Sciences, 78, 17, 10.1111/j.1749-6632.1959.tb53092.x Gustafsson, 1957, Biogenesis of histamine studied by its distribution and urinary excretion in germ free reared and not germ free rats fed a histamine free diet, Acta Physiologica Scandinavica, 41, 217, 10.1111/j.1748-1716.1957.tb01522.x Heinecke, 1990, The origins of the gnotobiotic technic—Kuster/Nuttall/Schottelius/Thierfelder, Zeitschrift für Versuchstierkunde, 33, 19 Herrán, 2017, Gluten-degrading bacteria are present in the human small intestine of healthy volunteers and celiac patients, Research in Microbiology, 168, 673, 10.1016/j.resmic.2017.04.008 Husby, 2020, European society paediatric gastroenterology, hepatology and nutrition guidelines for diagnosing coeliac disease 2020, Journal of Pediatric Gastroenterology and Nutrition, 70, 141, 10.1097/MPG.0000000000002497 Kennedy, 2018, Mouse microbiota models: Comparing germ-free mice and antibiotics treatment as tools for modifying gut bacteria, Frontiers in Physiology, 9, 1534, 10.3389/fphys.2018.01534 Kreznar, 2017, Host genotype and gut microbiome modulate insulin secretion and diet-induced metabolic phenotypes, Cell Reports, 18, 1739, 10.1016/j.celrep.2017.01.062 Kubelkova, 2016, Gnotobiotic mouse model's contribution to understanding host-pathogen interactions, Cellular and Molecular Life Sciences, 73, 3961, 10.1007/s00018-016-2341-8 Lamas, 2020, Aryl hydrocarbon receptor ligand production by the gut microbiota is decreased in celiac disease leading to intestinal inflammation, Science Translational Medicine, 12, 10.1126/scitranslmed.aba0624 Leonard, 2021, Microbiome signatures of progression toward celiac disease onset in at-risk children in a longitudinal prospective cohort study, Proceedings of the National Academy of Sciences of the United States of America, 118 Lindfors, 2019, Coeliac disease, Nature Reviews. Disease Primers, 5, 3, 10.1038/s41572-018-0054-z Luczynski, 2016, Growing up in a bubble: Using germ-free animals to assess the influence of the gut microbiota on brain and behavior, The International Journal of Neuropsychopharmacology, 19, pyw020, 10.1093/ijnp/pyw020 Lundberg, 2016, Antibiotic-treated versus germ-free rodents for microbiota transplantation studies, Gut Microbes, 7, 68, 10.1080/19490976.2015.1127463 Macpherson, 2004, Interactions between commensal intestinal bacteria and the immune system, Nature Reviews. Immunology, 4, 478, 10.1038/nri1373 Mallett, 1987, The use of rats associated with a human faecal flora as a model for studying the effects of diet on the human gut microflora, The Journal of Applied Bacteriology, 63, 39, 10.1111/j.1365-2672.1987.tb02415.x Marietta, 2004, A new model for dermatitis herpetiformis that uses HLA-DQ8 transgenic NOD mice, The Journal of Clinical Investigation, 114, 1090, 10.1172/JCI200421055 Martin, 2016, Gnotobiotic rodents: An in vivo model for the study of microbe-microbe interactions, Frontiers in Microbiology, 7, 409, 10.3389/fmicb.2016.00409 Mention, 2003, Interleukin 15: A key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease, Gastroenterology, 125, 730, 10.1016/S0016-5085(03)01047-3 Miyakawa, 1959, The Miyakawa remote-control germfree rearing unit, Annals of the New York Academy of Sciences, 78, 37, 10.1111/j.1749-6632.1959.tb53094.x Molberg, 1998, Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease, Nature Medicine, 4, 713, 10.1038/nm0698-713 Nabozny, 1996, HLA-DQ8 transgenic mice are highly susceptible to collagen-induced arthritis: A novel model for human polyarthritis, The Journal of Experimental Medicine, 183, 27, 10.1084/jem.183.1.27 Natividad, 2009, Host responses to intestinal microbial antigens in gluten-sensitive mice, PLoS One, 4, 10.1371/journal.pone.0006472 Natividad, 2015, Ecobiotherapy rich in firmicutes decreases susceptibility to colitis in a humanized gnotobiotic mouse model, Inflammatory Bowel Diseases, 21, 1883, 10.1097/MIB.0000000000000422 Ng, 2020, Recovery of the gut microbiota after antibiotics depends on host diet, community context, and environmental reservoirs, Cell Host & Microbe, 28, 628, 10.1016/j.chom.2020.09.001 Oberhuber, 2000, Histopathology of celiac disease, Biomedicine & Pharmacotherapy, 54, 368, 10.1016/S0753-3322(01)80003-2 Papista, 2012, Gluten induces coeliac-like disease in sensitised mice involving IgA, CD71 and transglutaminase 2 interactions that are prevented by probiotics, Laboratory Investigation, 92, 625, 10.1038/labinvest.2012.13 Park, 2020, Of men in mice: The development and application of a humanized gnotobiotic mouse model for microbiome therapeutics, Experimental & Molecular Medicine, 52, 1383, 10.1038/s12276-020-0473-2 Penny, 2021, Accuracy of a no-biopsy approach for the diagnosis of coeliac disease across different adult cohorts, Gut, 70, 876, 10.1136/gutjnl-2020-320913 Raibaud, 1980, Implantation of bacteria from the digestive tract of man and various animals into gnotobiotic mice, The American Journal of Clinical Nutrition, 33, 2440, 10.1093/ajcn/33.11.2440 Reyniers, 1946, Rearing germ-free albino rats, Lobund Reports, 1-84 Ridaura, 2013, Gut microbiota from twins discordant for obesity modulate metabolism in mice, Science, 341, 1241214, 10.1126/science.1241214 Round, 2009, The gut microbiota shapes intestinal immune responses during health and disease, Nature Reviews. Immunology, 9, 313, 10.1038/nri2515 Shan, 2002, Structural basis for gluten intolerance in celiac sprue, Science, 297, 2275, 10.1126/science.1074129 Smith, 2007, Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota, Seminars in Immunology, 19, 59, 10.1016/j.smim.2006.10.002 Syage, 2019, Latiglutenase treatment for celiac disease: Symptom and quality of life improvement for seropositive patients on a gluten-free diet, GastroHep, 1, 293, 10.1002/ygh2.371 Tack, 2013, Consumption of gluten with gluten-degrading enzyme by celiac patients: A pilot-study, World Journal of Gastroenterology, 19, 5837, 10.3748/wjg.v19.i35.5837 Taneja, 2010, Role of HLA class II genes in susceptibility/resistance to inflammatory arthritis: Studies with humanized mice, Immunological Reviews, 233, 62, 10.1111/j.0105-2896.2009.00858.x Troncone, 1991, Animal model of gluten induced enteropathy in mice, Gut, 32, 871, 10.1136/gut.32.8.871 Uzbay, 2019, Germ-free animal experiments in the gut microbiota studies, Current Opinion in Pharmacology, 49, 6, 10.1016/j.coph.2019.03.016 van de Wal, 1998, Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity, Journal of Immunology, 161, 1585, 10.4049/jimmunol.161.4.1585 Verdu, 2006, Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice, Gut, 55, 182, 10.1136/gut.2005.066100 Verdu, 2008, Gliadin-dependent neuromuscular and epithelial secretory responses in gluten-sensitive HLA-DQ8 transgenic mice, American Journal of Physiology. Gastrointestinal and Liver Physiology, 294, G217, 10.1152/ajpgi.00225.2007 Verdu, 2021, Co-factors, microbes, and immunogenetics in celiac disease to guide novel approaches for diagnosis and treatment, Gastroenterology, 10.1053/j.gastro.2021.08.016 Whelan, 2014, The loss of topography in the microbial communities of the upper respiratory tract in the elderly, Annals of the American Thoracic Society, 11, 513, 10.1513/AnnalsATS.201310-351OC Zucoloto, 2021, Generation, maintenance, and monitoring of gnotobiotic mice, STAR Protocols, 2, 10.1016/j.xpro.2021.100536