Elevated VEGF-D Modulates Tumor Inflammation and Reduces the Growth of Carcinogen-Induced Skin Tumors

Neoplasia - Tập 18 - Trang 436-446 - 2016
Hanne-Kaisa Honkanen1, Valerio Izzi1, Tiina Petäistö1, Tanja Holopainen2, Vanessa Harjunen1,2, Taina Pihlajaniemi1, Kari Alitalo2, Ritva Heljasvaara1
1Oulu Center for Cell-Matrix Research, Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, FIN-90014, University of Oulu, Oulu, Finland
2Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, FIN-00290, Helsinki, Finland

Tài liệu tham khảo

Alam, 2001, Cutaneous squamous-cell carcinoma, N Engl J Med, 344, 975, 10.1056/NEJM200103293441306 Kivisaari, 2013, Squamous cell carcinoma of the skin: emerging need for novel biomarkers, World J Clin Oncol, 4, 85, 10.5306/wjco.v4.i4.85 Madan, 2010, Non-melanoma skin cancer, Lancet, 375, 673, 10.1016/S0140-6736(09)61196-X Fu, 2013, Enhanced UV-induced skin carcinogenesis in transgenic mice overexpressing proprotein convertases, Neoplasia, 15, 169, 10.1593/neo.121846 Weinberg, 2007, Metastatic cutaneous squamous cell carcinoma: an update, Dermatol Surg, 33, 885 Edge, 2010, The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM, Ann Surg Oncol, 17, 1471, 10.1245/s10434-010-0985-4 Moussai, 2011, The human cutaneous squamous cell carcinoma microenv ironment is characterized by increased lymphatic density and enhanced expression of macrophage-derived VEGF-C, J Invest Dermatol, 131, 229, 10.1038/jid.2010.266 Tobler, 2006, Tumor and lymph node lymphangiogenesis - impact on cancer metastasis, J Leukoc Biol, 80, 691, 10.1189/jlb.1105653 Ruddell, 2011, B lymphocytes promote lymphogenous metastasis of lymphoma and melanoma, Neoplasia, 13, 748, 10.1593/neo.11756 Joukov, 1996, A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases, EMBO J, 15, 290, 10.1002/j.1460-2075.1996.tb00359.x Achen, 1998, Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4), Proc Natl Acad Sci U S A, 95, 548, 10.1073/pnas.95.2.548 Mäkinen, 2001, Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3, EMBO J, 20, 4762, 10.1093/emboj/20.17.4762 Tammela, 2008, Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation, Nature, 454, 656, 10.1038/nature07083 Kärkkäinen, 2004, Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins, Nat Immunol, 5, 74, 10.1038/ni1013 Baldwin, 2005, Vascular endothelial growth factor D is dispensable for development of the lymphatic system, Mol Cell Biol, 25, 2441, 10.1128/MCB.25.6.2441-2449.2005 Koch, 2009, VEGF-D deficiency in mice does not affect embryonic or postnatal lymphangiogenesis but reduces lymphatic metastasis, J Pathol, 219, 356, 10.1002/path.2605 Paquet-Fifield, 2013, Vascular endothelial growth factor-d modulates caliber and function of initial lymphatics in the dermis, J Invest Dermatol, 133, 2074, 10.1038/jid.2013.83 Alitalo, 2011, The lymphatic vasculature in disease, Nat Med, 17, 1371, 10.1038/nm.2545 Baldwin, 2001, The specificity of receptor binding by vascular endothelial growth factor-d is different in mouse and man, J Biol Chem, 276, 19166, 10.1074/jbc.M100097200 Mandriota, 2001, Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis, EMBO J, 20, 672, 10.1093/emboj/20.4.672 Skobe, 2001, Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis, Nat Med, 7, 192, 10.1038/84643 Stacker, 2001, VEGF-D promotes the metastatic spread of tumor cells via the lymphatics, Nat Med, 7, 186, 10.1038/84635 Kopfstein, 2007, Distinct roles of vascular endothelial growth factor-D in lymphangiogenesis and metastasis, Am J Pathol, 170, 1348, 10.2353/ajpath.2007.060835 Harris, 2011, Proteolytic processing of vascular endothelial growth factor-D is essential for its capacity to promote the growth and spread of cancer, FASEB J, 25, 2615, 10.1096/fj.10-179788 He, 2002, Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling, J Natl Cancer Inst, 94, 819, 10.1093/jnci/94.11.819 Stacker, 2004, Lymphangiogenic growth factors as markers of tumor metastasis, APMIS, 112, 539, 10.1111/j.1600-0463.2004.apm11207-0812.x Achen, 2005, Focus on lymphangiogenesis in tumor metastasis, Cancer Cell, 7, 121, 10.1016/j.ccr.2005.01.017 Haiko, 2008, Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos, Mol Cell Biol, 28, 4843, 10.1128/MCB.02214-07 Abel, 2009, Multi-stage chemical carcinogenesis in mouse skin: fundamentals and applications, Nat Protoc, 4, 1350, 10.1038/nprot.2009.120 Brideau, 2007, Endostatin overexpression inhibits lymphangiogenesis and lymph node metastasis in mice, Cancer Res, 67, 11528, 10.1158/0008-5472.CAN-07-1458 Leder, 1979, The chloroacetate esterase reaction. A useful means of histological diagnosis of hematological disorders from paraffin sections of skin, Am J Dermatopathol, 1, 39, 10.1097/00000372-197901010-00005 Garaczi, 2004, Negative regulatory effect of histamine in DNFB-induced contact hypersensitivity, Int Immunol, 16, 1781, 10.1093/intimm/dxh179 Kar Mahapatra, 2011, Alteration of immune functions and Th1/Th2 cytokine balance in nicotine-induced murine macrophages: immunomodulatory role of eugenol and N-acetylcysteine, Int Immunopharmacol, 11, 485, 10.1016/j.intimp.2010.12.020 Stober, 2005, IL-10 from regulatory T cells determines vaccine efficacy in murine Leishmania major infection, J Immunol, 175, 2517, 10.4049/jimmunol.175.4.2517 Udalov, 2010, Effects of phosphodiesterase 4 inhibition on bleomycin-induced pulmonary fibrosis in mice, BMC Pulm Med, 10, 26, 10.1186/1471-2466-10-26 Yang, 2008, Regulation of inflammatory responses by IL-17 F, J Exp Med, 205, 1063, 10.1084/jem.20071978 Smith, 2008, IL-17A inhibits the expansion of IL-17A-producing T cells in mice through “short-loop” inhibition via IL-17 receptor, J Immunol, 181, 1357, 10.4049/jimmunol.181.2.1357 Kapil, 2009, Interleukin-12 (IL-12), but not IL-23, deficiency ameliorates viral encephalitis without affecting viral control, J Virol, 83, 5978, 10.1128/JVI.00315-09 Livak, 2001, Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method, Methods, 25, 402, 10.1006/meth.2001.1262 Sica, 2008, Macrophage polarization in tumour progression, Semin Cancer Biol, 18, 349, 10.1016/j.semcancer.2008.03.004 Zhu, 2010, Differentiation of effector CD4 T cell populations, Annu Rev Immunol, 28, 445, 10.1146/annurev-immunol-030409-101212 Bailey, 2014, Th17 cells in cancer: the ultimate identity crisis, Front Immunol, 5, 276, 10.3389/fimmu.2014.00276 Alitalo, 2013, VEGF-C and VEGF-D Blockade Inhibits Inflammatory Skin Carcinogenesis, Cancer Res, 73, 4212, 10.1158/0008-5472.CAN-12-4539 Yusuf, 2008, Antagonistic roles of CD4+ and CD8+ T-cells in 7,12-dimethylbenz[a]anthracene cutaneous carcinogenesis, Cancer Res, 68, 3924, 10.1158/0008-5472.CAN-07-3059 Daniel, 2003, Immune enhancement of skin carcinogenesis by CD4+ T cells, J Exp Med, 197, 1017, 10.1084/jem.20021047 Zancope, 2010, Differential infiltration of CD8+ and NK cells in lip and oral cavity squamous cell carcinoma, J Oral Pathol Med, 39, 162, 10.1111/j.1600-0714.2009.00792.x Pettersen, 2011, Lowes MA, Carucci JA. Tumor-associated macrophages in the cutaneous SCC microenvironment are heterogeneously activated, J Invest Dermatol, 131, 1322, 10.1038/jid.2011.9 Gabrilovich, 2012, Coordinated regulation of myeloid cells by tumours, Nat Rev Immunol, 12, 253, 10.1038/nri3175 Wang, 2010, Alternative activation of tumor-associated macrophages by IL-4, Cell Cycle, 9, 4824, 10.4161/cc.9.24.14322 Udagawa, 2013, Vascular endothelial growth factor-D-mediated blockade of regulatory T cells within tumors is induced by hematopoietic stem cell transplantation, J Immunol, 191, 3440, 10.4049/jimmunol.1201454 Huggenberger, 2010, Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation, J Exp Med, 207, 2255, 10.1084/jem.20100559 Rinderknecht, 2008, Tumor lymphangiogenesis and melanoma metastasis, J Cell Physiol, 216, 347, 10.1002/jcp.21494 Chauhan, 2011, A novel pro-lymphangiogenic function for Th17/IL-17, Blood, 118, 4630, 10.1182/blood-2011-01-332049 Kozlowski, 2010, Serum vascular endothelial growth factors C and D in patients with oesophageal cancer, Eur J Cardiothorac Surg, 38, 260, 10.1016/j.ejcts.2010.01.061 Sotiropoulou, 2010, Tumour expression of lymphangiogenic growth factors but not lymphatic vessel density is implicated in human cervical cancer progression, Pathology, 42, 629, 10.3109/00313025.2010.522174 Szajewski, 2014, VEGF-C and VEGF-D overexpression is more common in left-sided and well-differentiated colon adenocarcinoma, Oncol Rep, 31, 125, 10.3892/or.2013.2821