Electroresponsive Pulsatile Depot Delivery of Insulin from Poly(dimethylaminopropylacrylamide) Gel in Rats

Clark, 1988, Growth hormone (GH) secretion in the conscious rat: negative feedback of GH on its own release, J. Endocrinol., 119, 201, 10.1677/joe.0.1190201 Clark, 1985, Intravenous growth hormone: growth responses to patterned infusions, J. Endocrinol., 104, 53, 10.1677/joe.0.1040053 Tarquini, 1988, Prominent circadian absorption of intranasal salmon calcitonin (SCT) in healthy subjects, Chronobiol. Int., 5, 149, 10.3109/07420528809079555 Avgerinos, 1986, Pulsatile administration of human corticotropin-releasing hormone in patients with secondary adrenal insufficiency: restoration of the normal corticol secretory pattern, J. Clin. Endocrinol. Metab., 62, 816, 10.1210/jcem-62-5-816 Chien, 1990, Facilitated Transdermal Delivery of Therapeutic Peptides and Proteins by Iontophoretic Delivery Devices, J. Controlled Release, 13, 263, 10.1016/0168-3659(90)90017-N Green, 1992, In vitro and in vivo iontophoresis of a tripeptide across nude rat skin, J. Controlled Release, 20, 209, 10.1016/0168-3659(92)90123-9 Knoblauch, 1993, In vitro pulsatile and continuous transdermal delivery of buserelin by iontophoresis, J. Controlled Release, 26, 203, 10.1016/0168-3659(93)90187-A Banga, 1993, Characterization of in vitro transdermal iontophoretic delivery of insulin, Drug. Dev. Industr. Pharm., 19, 2069, 10.3109/03639049309069342 Heit, 1994, Transdermal iontophoretic delivery of luteinizing hormone releasing hormone (LHRH): effect of repeated administration, Pharm. Res., 11, 1000, 10.1023/A:1018983303842 Riviere, 1995, Pulsatile transdermal delivery using electroporation: drug delivery and skin toxicology, J. Controlled Release, 36, 229, 10.1016/0168-3659(95)00036-8 Prausnitz, 1994, Rapid temporal control of transdermal drug delivery by electroporation, Pharm. Res., 11, 1834, 10.1023/A:1018944223290 Mitragotri, 1996, Transdermal drug delivery using low-frequency sonophoresis, Pharm. Res., 13, 411, 10.1023/A:1016096626810 Shiino, 1994, Controlled release of insulin from boronic acid gel under physiological conditions, J. Controlled Release, 28, 317, 10.1016/0168-3659(94)90196-1 Siegel, 1988, pH-controlled release from hydrophobic/polyelectrolyte copolymer gels, J. Controlled Release, 8, 179, 10.1016/0168-3659(88)90044-2 Gutowska, 1992, Heparin release from thermosensitive hydrogels, J. Controlled Release, 22, 95, 10.1016/0168-3659(92)90194-V Hoffman, 1987, Applications of thermally reversible polymers and gels in therapeutics and diagnostics, J. Controlled Release, 6, 297, 10.1016/0168-3659(87)90083-6 Supersaxo, 1993, Performed porous microspheres for controlled and pulsed release of macromolecules, J. Controlled Release, 23, 157, 10.1016/0168-3659(93)90041-3 Kost, 1987, Magnetically enhanced insulin release in diabetic rats, J. Biomed. Mater. Res., 21, 1367, 10.1002/jbm.820211202 Kwon, 1994, Heparin release from polymer complex, J. Controlled Release, 30, 155, 10.1016/0168-3659(94)90262-3 Kwon, 1991, Drug release from electric current sensitive polymers, J. Controlled Release, 17, 149, 10.1016/0168-3659(91)90054-H Sawahata, 1990, Electrically controlled drug delivery system using polyelectrolyte gels, J. Controlled Release, 14, 253, 10.1016/0168-3659(90)90165-P Tomer, 1995, Electrically controlled release of macromolecules from cross-linked hyaluronic acid gels, J. Controlled Release, 33, 405, 10.1016/0168-3659(94)00115-B Hirai, 1981, Effect of surfactants on the nasal absorption of insulin in rats, Int. J. Pharm., 9, 165, 10.1016/0378-5173(81)90009-0 Kishi, 1989, Reversible volume change of microparticles in an electric field, J. Chem. Soc., Faraday Trans. 1., 85, 655, 10.1039/f19898500655 Kishi, 1990, Mechanism and process of chemomechanical contraction of polyelectrolyte gels under electric field, Polym. Adv. Technol., 1, 19, 10.1002/pat.1990.220010104 Gong, 1994, P.; Nitta, T.; Osada, Y. Electrokinetic modeling of the contractile phenomena of polyelectrolyte gels. One-dimensional capillary model, J. Phys. Chem, 98, 9583, 10.1021/j100089a036 1989, The Merck Index, 790 Jeffrey, 1966, An equilibrium ultracentrifuge study of the effect of ionic strength on the self-association of bovine insulin, Biochemistry, 12, 3820, 10.1021/bi00876a012 Pekar, 1972, Conformation of proinsulin, A comparison of insulin and proinsulin self-association at neutral pH. Biochemistry, 11, 4013 Abramson, 1941, Skin reactions, J. Allergy, 12, 169, 10.1016/S0021-8707(41)90162-4 Malanga, 1985, Pharmacologic Choice in Drug Iono- phoresis, Boll. Soc. Ital. Farm. Osp., 31, 263