Electrophysiology of the pancreatic β-cell

Progress in Biophysics and Molecular Biology - Tập 54 Số 2 - Trang 87-143 - 1989
Frances M. Ashcroft1, Patrik Rorsman2
1University Laboratory of Physiology, Parks Road, Oxford OX1 3PT U.K.
2‡ Department of Medical Physics, University of Gothenburg, Box 33031, S-400 33 Gothenburg, Sweden

Tóm tắt

Từ khóa


Tài liệu tham khảo

Aguilar-Bryan, 1990, Photoaffinity labelling and partial purification of the β-cell sulphonylurea receptor using a novel, biologically active glyburide analogue, J. biol. Chem., 265, 8218, 10.1016/S0021-9258(19)39060-X

Ahrén, 1986, Galanin inhibits glucose-stimulated insulin release by a mechanism involving hyperpolarization and lowering of cytoplasmic free Ca2+ concentration, Biochem. biophys. Res. Commun., 140, 1059, 10.1016/0006-291X(86)90742-4

Ahrén, 1989, Does galanin inhibit insulin secretion by opening of the ATP-regulated K+ channel in the β-cell?, Peptides, 10, 453, 10.1016/0196-9781(89)90058-2

Arkhammar, 1986, Direct evidence for opposite effects of d-glucose and d-glyceraldehyde on cytoplasmic pH in mouse pancreatic β-cells, Biosci. Rep., 6, 355, 10.1007/BF01116422

Arkhammar, 1987, Inhibition of ATP-regulated K+-channels precedes depolarization-induced increase in cytoplasmic free Ca2+-concentration in pancreatic β-cells, J. biol. Chem., 262, 5448, 10.1016/S0021-9258(18)45593-7

Arkhammar, 1989, Effects of protein kinase C activation on the regulation of the stimulus-secretion coupling in pancreatic β-cells, Biochem. J., 264, 207, 10.1042/bj2640207

Armstrong, 1987, Voltage-activated calcium channel that must be phosphorylated to respond to membrane depolarisation, 84, 2518

Ashcroft, 1988, Adenosine-triphosphate sensitive K+-channels, A. Rev. Neurosci., 11, 97, 10.1146/annurev.ne.11.030188.000525

Ashcroft, 1989, ATP-sensitive K+-channels in rat pancreatic β-cells: modulation by ATP and Mg2+ ions, J. Physiol., 416, 349, 10.1113/jphysiol.1989.sp017765

Ashcroft, 1989, ATP-sensitive K+-channels: a link between β-cell metabolism and insulin secretion, Biochem. Trans., 18, 109, 10.1042/bst0180109

Ashcroft, 1982, Calcium inactivation in skeletal muscle fibres of the stick insect Carausius morosus, J. Physiol., 330, 349, 10.1113/jphysiol.1982.sp014345

Ashcroft, 1984, Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells, Nature, 312, 446, 10.1038/312446a0

Ashcroft, 1985, The glucose-sensitive potassium channel in rat pancreatic β-cells is inhibited by ATP, J. Physiol., 369, 101P

Ashcroft, 1987, Effects of 2-ketoisocaproic acid on insulin secretion and single potassium activity in dispersed rat pancreatic β-cells, J. Physiol., 385, 517, 10.1113/jphysiol.1987.sp016505

Ashcroft, 1988, Properties of single potassium channels modulated by glucose in rat pancreatic β-cells, J. Physiol., 400, 501, 10.1113/jphysiol.1988.sp017134

Ashcroft, 1988, Expression of K-channels in Xenopus laevis oocytes injected with poly(A+)mRNA from the insulin-secreting β-cell line, HIT T15, FEBS Lett., 239, 185, 10.1016/0014-5793(88)80913-X

Ashcroft, 1989, The ATP-sensitive K-channel from human pancreatic β-cells, Diabetologia, 32, 591, 10.1007/BF00285333

Ashcroft, 1989, Rubidium and sodium permeability of the ATP-sensitive K+-channel in single rat pancreatic β-cells, J. Physiol., 408, 413, 10.1113/jphysiol.1989.sp017467

Ashcroft, 1989, Single calcium channel activity in mouse pancreatic β-cells, Ann. N.Y. Acad. Sci., 650, 410, 10.1111/j.1749-6632.1989.tb24123.x

Ashcroft, 1990, Perforated patch recordings of ATP-regulated K-currents and electrical activity in murine pancreatic β-cells, Diabetologia, 33, A78

Ashcroft, 1990, Two types of Ca channel in rat pancreatic β-cells, Pflügers Arch., 415, 504, 10.1007/BF00373633

Ashcroft, 1980, Glucoreceptor mechanisms and the control of insulin release and biosynthesis, Diabetologia, 18, 5, 10.1007/BF01228295

Ashcroft, 1989, The role of the ATP-sensitive K-channel in stimulus-secretion coupling in the pancreatic β-cell, Horm. Cell Regulation, 14, 99

Ashcroft, 1990, ATP-regulated K-channels, Cellular Signalling, 2, 197, 10.1016/0898-6568(90)90048-F

Ashcroft, 1973, Interrelationship of islet metabolism, adenosine triphosphate content and insulin release, Biochem. J., 132, 223, 10.1042/bj1320223

Ashcroft, 1986, Insulin secretory response of a clonal cell line of simian virus 40-transformed β-cells, Diabetologia, 29, 727, 10.1007/BF00870283

Ashford, 1990, Potassium channels and modulation of insulin secretion, 300

Atwater, 1978, Cyclic changes in membrane potential and resistance of the β cell membrane induced by glucose in islets of Langerhans from mouse, J. Physiol., 278, 117, 10.1113/jphysiol.1978.sp012296

Atwater, 1979, Potassium permeability activated by intracellular calcium ion concentration in the pancreatic β-cell, J. Physiol., 288, 579, 10.1113/jphysiol.1979.sp012714

Atwater, 1979, Mouse pancreatic β-cells: tetraethylammonium blockage of the potassium permeability increase induced by depolarization, J. Physiol., 288, 561, 10.1113/jphysiol.1979.sp012713

Atwater, 1981, Voltage noise measurements: calcium channel characteristics, J. Physiol., 314, 195, 10.1113/jphysiol.1981.sp013701

Atwater, 1983, Properties of the Ca-activated K+ channel in pancreatic β-cells, Cell Calcium, 4, 451, 10.1016/0143-4160(83)90021-0

Atwater, 1984, Cooling dissociates glucose-induced insulin release from electrical activity and cation fluxes in rodent pancreatic islets, J. Physiol., 348, 615, 10.1113/jphysiol.1984.sp015129

Atwater, 1990, Electrophysiology of the pancreatic β-cell, 49

Bangham, 1987, Nonconforming action potentials from isolated mouse islets of Langerhans, J. Physiol., 392, 15P

Bean, 1989, Classes of calcium channel in vertebrate cells, A. Rev. Physiol., 51, 367, 10.1146/annurev.ph.51.030189.002055

Betsholtz, 1990, Expression of voltage-gated K+-channels in insulin-producing cells: analysis by polymerase chain reaction, FEBS Lett., 263, 121, 10.1016/0014-5793(90)80719-Y

Bokvist, 1988, Evidence that ADP and ATP bind at different sites of the G-channel, Diabetologia, 31, 473A

Bokvist, 1990, Effects of external tetraethylammonium ions and quinine on delayed rectifying K+-channels in mouse pancreatic β-cells, J. Physiol., 423, 311, 10.1113/jphysiol.1990.sp018024

Bokvist, 1990, Block of ATP-regulated and Ca2+-activated K+-channels in mouse pancreatic β-cells by external tetraethylammonium and quinine, J. Physiol., 423, 327, 10.1113/jphysiol.1990.sp018025

Bokvist, 1991, Separate processes mediate nucleotide-induced inhibition and stimulation of ATP-regulated K+ -channels in mouse pancreatic β-cells and ATP

Boyd, 1988, Sulphonylurea receptors, ion channels and fruitflies, Diabetes, 37, 847, 10.2337/diab.37.7.847

Bozen, 1987, The ionic, electrical and secretory effects of protein kinase C activation in mouse pancreatic β-cells: studies with a phorbol ester, Endocrinology, 121, 1025, 10.1210/endo-121-3-1025

Brown, 1982, Electrophysiology of the sinoatrial node, Physiol. Rev., 62, 505, 10.1152/physrev.1982.62.2.505

Carpenter, 1986, Internalization of 3H glibenclamide in pancreatic islet cells, Diabetologia, 29, 259, 10.1007/BF00454887

Carrington, 1986, Five new insulin-producing cell lines with different secretory properties, J. Endocr., 109, 193, 10.1677/joe.0.1090193

Carroll, 1988, The ATP-sensitive potassium channel in pancreatic β-cells is inhibited in physiological bicarbonate buffer, FEBS Lett., 234, 208, 10.1016/0014-5793(88)81335-8

Chad, 1984, Calcium domains associated with individual channels can account for anomalous voltage relations of Ca-dependent responses, Biophys. J., 45, 993, 10.1016/S0006-3495(84)84244-7

Charles, 1982, A single mechanism for the stimulation of insulin release and 86Rb efflux from rat islets by cationic amino acids, Biochem. J., 208, 301, 10.1042/bj2080301

Chay, 1990, Effects of compartmentalized Ca2+ ions on electrical bursting activity of pancreatic β-cells, Am. J. Physiol., 258, C955, 10.1152/ajpcell.1990.258.5.C955

Ciani, 1988, Ion permeaion and rectification in ATP-sensitive channels from insulin-secreting cells (RINm5F): effects of K+, Na+ and Mg2+, J. Membr. Biol., 103, 171, 10.1007/BF01870947

Cohen, 1990, Ionic currents in rat pancreatic β-cells recorded with the perforated patch technique, Biophys. J., 57, 509a

Cook, 1984, Intracellular ATP directly blocks K+-channels in pancreatic B-cells, Nature, 311, 269, 10.1038/311269a0

Cook, 1982, Islet electrical pacemaker response to alpha adrenergic stimulation, Diabetes, 31, 985, 10.2337/diacare.31.11.985

Cook, 1980, Plateau potentials in pancreatic islet cells are voltage-dependent action potentials, Nature, 286, 404, 10.1038/286404a0

Cook, 1981, Glucose and acetylcholine have different effects on the pacemaker potential of pancreatic islet cells, Diabetes, 30, 558, 10.2337/diab.30.7.558

Cook, 1981, Voltage dependence of rhythmic plateau potentials of pancreatic islet cells, Am. J. Physiol., 240, E290

Cook, 1984, Lowering of pHi inhibits Ca2+-activated K+-channels in pancreatic β-cells, Nature, 311, 269, 10.1038/311269a0

Cook, 1988, ATP-sensitive K+ -channels in pancreatic beta-cells. Spare channel hypothesis, Diabetes, 37, 495, 10.2337/diab.37.5.495

Cook, 1990, Potassium channel pharmacology, 181

Dean, 1968, Electrical activity in pancreatic islet cells, Nature, 219, 389, 10.1038/219389a0

de Weille, 1988, ATP-sensitive K+-channels that are blocked by hypoglycaemia-inducing sulphonylureas in insulin-secreting cells are activated by galanin, a hyperglycemia-inducing hormone, 85, 1312

de Weille, 1989, Pharmacology and regulation of ATP-sensitive K+-channels, Pflügers Arch., 414, S80, 10.1007/BF00582253

de Weille, 1989, Regulation of ATP-sensitive K+-channels in insulinoma cells: Activation by somatostatin and protein kinase C and the role of cAM, 86, 2971

Donatsch, 1977, The functional significance of sodium channels in pancreatic beta-cell membranes, J. Physiol., 267, 357, 10.1113/jphysiol.1977.sp011817

Drews, 1990, Galanin and epinephrine act on distinct receptors to inhibit insulin release by the same mechanisms including an increase in K+ permeability of the β-cell membrane, Endocrinology, 126, 1646, 10.1210/endo-126-3-1646

Dunne, 1989, Protein phosphorylation is required for diazoxide to open ATP-sensitive potassium channels in insulin (RINm5F) secreting cells, FEBS Lett., 250, 262, 10.1016/0014-5793(89)80734-3

Dunne, 1990, Effects of pinacidil, RP 49356 and nicorandil on ATP-sensitive potassium channels in insulin-secreting cells, Br. J. Pharmac., 99, 487, 10.1111/j.1476-5381.1990.tb12955.x

Dunne, 1986, GTP and GDP activation of K+-channels that are inhibited by ATP, Pflügers Arch., 407, 564, 10.1007/BF00657518

Dunne, 1986, Intracellular ADP activates K+-channels that are inhibited by ADP in an insulin-secreting cell line, FEBS Lett., 208, 59, 10.1016/0014-5793(86)81532-0

Dunne, 1986, ATP-sensitive K+-channels in an insulin-secreting cell line are inhibited by glyceraldehyde and activated by membrane permeabilisation, J. Membr. Biol., 9, 271, 10.1007/BF01871181

Dunne, 1987, Interaction of diazoxide, tolbutamide and ATP4− on nucleotide-dependent K+-channels in an insulin-secreting cell line, J. Membr. Biol., 99, 215, 10.1007/BF01995702

Dunne, 1988, The effects of pyridine nucleotides on the gating of ATP-sensitive K+-channels in insulin-secreting cells, J. Membr. Biol., 102, 205, 10.1007/BF01925714

Dunne, 1988, The gating of nucleotide-sensitive K+-channels in insulin-secreting cells can be modulated by changes in the ratio ATP4−/ATP3− and by non-hydrolysable analogues derivatives of both ATP and ADP, J. Membr. Biol., 104, 165, 10.1007/BF01870928

Dunne, 1989, Galanin activates nucleotide-dependent K+ channels in insulin-secreting cells via a pertussis toxin-sensitive G-protein, EMBO J., 8, 413, 10.1002/j.1460-2075.1989.tb03392.x

Dunne, 1990, The effects of cromakalim on ATP-sensitive potassium channels in insulin-secreting cells, Br. J. Pharmac., 99, 165

Dunne, 1990, Activators of protein kinase C have novel effects on ATP-sensitive potassiu m channels in insulin-secreting cells, J. Physiol., 429, 93P

Dunne, 1990, The stimulant-evoked depolarization and increase in [Ca2+]i in insulin-secreting cells is dependent on external Na+, J. Membr. Biol., 113, 131, 10.1007/BF01872887

Eckert, 1984, Inactivation of Ca-channels, Prog. Biophys. molec. Biol., 44, 215, 10.1016/0079-6107(84)90009-9

Eddlestone, 1984, Electrical coupling between cells in islets of langerhans from mouse, J. Membr. Biol., 77, 1, 10.1007/BF01871095

Eddlestone, 1989, Comparative study of K channel behaviour on beta cell lines with different secretory responses to glucose, J. Membr. Biol., 109, 123, 10.1007/BF01870851

Efendic, 1985, Increased activity of the glucose cycle in the liver: early characteristic of type 2 diabetes, 82, 2965

Falke, 1989, ‘Perforated patch recording’ allows long-term monitoring of metabolite-induced electrical activity and voltage-dependent Ca2+-currents in pancreatic β-cells, FEBS Lett., 251, 167, 10.1016/0014-5793(89)81448-6

Fedulova, 1985, Two types of calcium channels in the somatic membrane of new-born dorsal root ganglion neurones, J. Physiol., 359, 431, 10.1113/jphysiol.1985.sp015594

Findlay, 1987, The effects of magnesium upon the adenosine triphosphate-sensitive potassium channels in a rat ATP-sensitive K+-channel in an insulin-secreting cell line, J. Physiol., 391, 611, 10.1113/jphysiol.1987.sp016759

Findlay, 1986, ATP maintains ATP-inhibited K+-channels in an operational state, Pflügers Arch., 407, 238, 10.1007/BF00580683

Findlay, 1985, High conductance K+ channel in pancreatic islet cells can be activated and inactivated by internal calcium, J. Membr. Biol., 83, 169, 10.1007/BF01868748

Findlay, 1985, Quinine inhibits Ca2+-independent K+ channels whereas tetrathylammonium inhibits Ca2+-activated K+ channels in insulin-secreting cells, FEBS Lett., 185, 4, 10.1016/0014-5793(85)80729-8

Findlay, 1989, Calcium currents in insulin-secreting β-cells, Ann. N.Y. Acad. Sci., 560, 403, 10.1111/j.1749-6632.1989.tb24122.x

Fosset, 1988, Somatostatin activates glibenclamide-sensitive and ATP-regulated K+-channels in insulinoma cells via G-protein, FEBS Lett., 242, 94, 10.1016/0014-5793(88)80992-X

Gagerman, 1978, Insulin release, cGMP, cAMP, and membrane potential in acetylcholine-stimulated islets, Am. J. Physiol., 235, E493

Gaines, 1988, Characterization of the sulphonylurea receptor on beta-cell membranes, J. biol. Chem., 263, 2589, 10.1016/S0021-9258(18)69106-9

Garrino, 1989, Effects of putative activators of K+ channels in mouse pancreatic β-cells, Br. J. Pharmac., 98, 957, 10.1111/j.1476-5381.1989.tb14626.x

Gillis, 1989, Effects of sulfonamides on a metabolite-regulated ATP-sensitive K+-channel in rat pancreatic β-cells, Am. J. Physiol., 257, C1119, 10.1152/ajpcell.1989.257.6.C1119

Grapengiesser, 1989, Regulation of pH in individual pancreatic β-cells as evaluated by fluorescence ratio microscopy, Biochim. biophys. Acta, 1014, 219, 10.1016/0167-4889(89)90215-2

Gylfe, 1988, Nutrient secretagogues induce bimodal early changes in cytoplasmic calcium of insulin-releasing ob/ob mouse β-cells, J. biol. Chem., 263, 13750, 10.1016/S0021-9258(18)68305-X

Gylfe, 1983, Depolarization-independent net uptake of calcium into clonal insulin-releasing cells exposed to glucose, Biosci. Rep., 3, 927, 10.1007/BF01140662

Gylfe, 1984, Interaction of sulfonylureas with the pancreatic β-cell, Experientia, 40, 1126, 10.1007/BF01971460

Hamill, 1981, Improved patch-clamp techniques for high resolution recording from cells and cell-free membrane patches, Pflügers Arch., 391, 85, 10.1007/BF00656997

Heder, 1986, Calcium channel blockers: spectrum of side effects and drug interactions, Acta pharmac. tox. (Copenh.), 58, 119, 10.1111/j.1600-0773.1986.tb02527.x

Hellman, 1986, Calcium and the control of insulin secretion, Vol. VI, 253

Henquin, 1985, The interplay between cyclic AMP and ions in the stimulus-secretion coupling in pancreatic β-cells, Archs. int. Physiol. Biochim., 93, 37

Henquin, 1988, ATP-sensitive K+ channels may control glucose-induced electrical activity in pancreatic β-cells, Biochem. biophys. Res. Commun., 156, 769, 10.1016/S0006-291X(88)80910-0

Henquin, 1990, Role of voltage-and Ca2+-dependent K+ channels in the control of glucose-induced electrical activity in pancreatic β-cells, Pflügers Arch., 416, 568, 10.1007/BF00382691

Henquin, 1981, Effects of amino acids on membrane potential and 86Rb fluxes in pancreatic β-cells, Am. J. Physiol., 240, E245

Henquin, 1982, The electrogenic sodium-potassium pump of mouse pancreatic β-cells, J. Physiol., 332, 529, 10.1113/jphysiol.1982.sp014429

Henquin, 1982, Opposite effects of tolbutamide and diazoxide on 86Rb+ fluxes and membrane potential in pancreatic β-cells, Biochem. Pharmac., 31, 1407, 10.1016/0006-2952(82)90036-3

Henquin, 1983, Dibutryl cyclic AMP triggers Ca2+ influx and Ca2+-dependent electrical activity in pancreatic β-cells, Biochem. biophys. Res. Commun., 112, 614, 10.1016/0006-291X(83)91508-5

Henquin, 1984, Significance of ionic fluxes and changes in membrane potential for stimulus-secretion coupling in pancreatic β-cells, Experientia, 40, 1043, 10.1007/BF01971450

Henquin, 1986, Cyclic adenosine monophosphate differently affects the response of mouse pancreatic β-cells to various amino acids, J. Physiol., 381, 77, 10.1113/jphysiol.1986.sp016314

Henquin, 1983, Forskolin, an activator of adenylate cyclase, increases Ca2+-dependent electrical activity induced by glucose in mouse pancreatic β-cells, Endocrinology, 112, 2218, 10.1210/endo-112-6-2218

Henquin, 1988, Muscarinic control of pancreatic β-cell function involves sodium-dependent depolarization and calcium-influx, Endocrinology, 122, 2134, 10.1210/endo-122-5-2134

Henquin, 1989, Does protein kinase C link glucose metabolism to β-cell membrane depolarization?, Diabetologia, 32, 496A

Henquin, 1990, Les méchanisms cellulaires du controle de la sécretion d'insuline, Archs int. Physiol. Biochim., 98, A61

Hill, 1985, Perfusion of a clonal cell line of simian virus 40-transformed beta cells. Insulin secretory dynamics in response to glucose, 3-iso-butyl- methylxanthine and potassium, Diabetes, 43, 115, 10.2337/diab.34.2.115

Hiriart, 1988, Na channels and two types of Ca-channels in rat pancreatic β-cells identified with the reverse hemolytic plaque assay, J. gen. Physiol., 91, 617, 10.1085/jgp.91.5.617

Hockberger, 1989, A diacylglycerol analogue reduces neuronal calcium currents independently of protein kinase C activation, Nature, 338, 340, 10.1038/338340a0

Hoenig, 1989, Characterization of calcium channels of a glucose-responsive rat insulinoma, Am. J. Physiol., 256, E488

Hole, 1988, Development of the biphasic response to glucose in fetal and neonatal rat pancreas, Am. J. Physiol., 254, E166

Horn, 1988, Muscarinic activation of ionic currents measured by a new whole-cell recording method, J. gen. Physiol., 92, 145, 10.1085/jgp.92.2.145

Hsu, 1989, Somatostatin decreases insulin secretion by inhibiting Ca2+-iflux through voltage-dependent Ca2+-channel in an insulin secreting cell line (HIT-cells), J. cell. Biol., 129, 335A

Isenberg, 1988, Kinetics of ATP-dependent K+-channels in the membrane of murine pancreatic β-cells, Pflügers Arch., 411, R111

Jones, 1986, Effects of Ca2+ and a phorbol ester on insulin secretion from islets of Langerhans permeabilized by high voltage discharge, FEBS Lett., 191, 102, 10.1016/0014-5793(85)81002-4

Kakei, 1986, The ATP-sensitivity of K+-channels in rat pancreatic β-cells is modulated by ADP, FEBS Lett., 208, 63, 10.1016/0014-5793(86)81533-2

Kalman, 1988, Calcium dependent inactivation of dihydropyridine sensitive calcium channels in GH3 cells, J. gen. Physiol., 92, 531, 10.1085/jgp.92.4.531

Keahey, 1989, Characterization of voltage-dependent calcium channels in a β-cell line, Diabetes, 38, 188, 10.2337/diab.38.2.188

Keahey, 1989, Catecholamine modulation of calcium currents in clonal pancreatic β-cells, Am. J. Physiol., 257, C1171, 10.1152/ajpcell.1989.257.6.C1171

Keizer, 1989, ATP-sensitive potassium channels and bursting in the pancreatic beta cell. A theoretical study, Biophys. J., 56, 229, 10.1016/S0006-3495(89)82669-4

Kelly, 1990, Voltage-activated calcium and potassium currents in human pancreatic β-cells, J. Physiol.

Khan, 1989, Evidence for the presence of glucose cycling in pancreatic islets of the ob/ob mouse, J. biol. Chem., 264, 9732, 10.1016/S0021-9258(18)81716-1

Kozlowski, 1990, Pharmacological modulation of ATP-sensitive potassium channels in an insulin-secreting cell line

Kozlowski, 1990, ATP-sensitive K-channel rundown is Mg-dependent, 240, 397

Kozlowski, 1989, Dual effects of diazoxide on ATP-K+-currents recorded from an insulin-secreting cell line, Br. J. Pharmac., 97, 1039, 10.1111/j.1476-5381.1989.tb12560.x

Kozlowski, 1989, The ATP-K+ channel; a novel site of action for the barbiturates, Diabetologia, 23, 506A

Kramer, 1988, Direct photo-affinity labelling of putative sulphonylurea receptor in rat β-cell tumor membranes by [3H] glibenclamide, FEBS Lett., 229, 355, 10.1016/0014-5793(88)81155-4

Lansman, 1986, Blockade of currents through single calcium channels by Cd2+, Mg2+ and Ca2+, J. gen. Physiol., 88, 321, 10.1085/jgp.88.3.321

Malaisse, 1987, Glucose induced changes in cytosolic ATP content in pancreatic islets, Biochim. biophys. Acta, 97, 190, 10.1016/0167-4889(87)90134-0

Malaisse, 1979, The stimulus secretion coupling of glucose induced insulin release: the links between metabolism and cationic events, Diabetologia, 16, 321, 10.1007/BF01223623

Mancilla, 1990, Quinine blocks the high conductance, calcium-activated potassium channel in rat pancreatic β-cells, FEBS Lett., 260, 105, 10.1016/0014-5793(90)80078-W

Martin, 1989, Vasopressin directly closes ATP-sensitive potassium channels evoking membrane depolarisation and an increase in the free intracellular Ca2+- concentration in insulin-secreting cells, EMBO J., 8, 3595, 10.1002/j.1460-2075.1989.tb08532.x

Meda, 1986, Direct identification of electrophysiologically monitored cells within intact mouse islets of Langerhans, Diabetes, 35, 232, 10.2337/diab.35.2.232

Meglasson, 1989, Bioenergetic response of pancreatic islets to stimulation by fuel molecules, Metabolism, 38, 1188, 10.1016/0026-0495(89)90158-3

Meissner, 1976, Electrophysiological evidence for coupling between beta cells of pancreatic islets, Nature, 262, 502, 10.1038/262502a0

Meissner, 1983, Comparison of the effects of glucose, amino acids and sulphonamides on the membrane potential of pancreatic β cells, 353

Meissner, 1979, Glucose-induced changes in membrane potential of pancreatic β-cells: their significance for the regulation of insulin release, 97

Meissner, 1980, Ionic mechanisms of the glucose-induced membrane potential changes in β-cells, Horm. Metab. Res. Suppl., 10, 91

Meissner, 1974, Membrane potential of β-cells in pancreatic islets, Pflügers Arch., 351, 195, 10.1007/BF00586918

Meissner, 1978, Potassium dependence of the membrane potential of pancreatic β-cells, FEBS Lett., 94, 87, 10.1016/0014-5793(78)80912-0

Meissner, 1980, Possible ionic mechanisms of the electical activity induced by glucose and tolbutamide in pancreatic β-cells, 166

Miller, 1985, Charybdotoxin, a protein inhibitor of single Ca2+-activated K+-channels from mammalian skeletal muscle, Nature, 313, 316, 10.1038/313316a0

Misler, 1986, A metabolite regulated potassium channel in rat pancreatic β-cells, 83, 7119

Misler, 1988, Voltage-gated single K+ and Ca2+ channel currents in pancreatic islet β-cells, J. gen. Physiol., 92, 7a

Misler, 1989, Modulation of gating of a metabolically regulated ATP-dependent K+ channel intracellular pH of the pancreatic islet, J. Membr. Biol., 109, 135, 10.1007/BF01870852

Misler, 1989, A metabolite regulated potassium channel in human pancreatic islet cells, Diabetes, 38, 422, 10.2337/diab.38.4.422

Monaco, 1988, Synergism between vasopressin and phorbol esters in stimulation of insulin secretion and phosphatidylcholine metabolism in RIN insulinoma cells, Biochem. biophys. Res. Commun., 151, 717, 10.1016/S0006-291X(88)80339-5

Neer, 1988, Roles of G protein subunits in transmembrane signalling, Nature, 333, 129, 10.1038/333129a0

Niki, 1989, The dependence on intracellular ATP concentration of ATP-sensitive K-channels and of Na, K-ATPase in intact HIT T15 β-cells, FEBS Lett., 257, 361, 10.1016/0014-5793(89)81572-8

Niki, 1989, ATP-sensitive K-channels in HIT T15 β-cells studied by patch-clamp methods, 86Rb efflux and glibenclamide binding, Pflügers Arch., 408, 133

Niki, 1990, The β-cell glibenclamide receptor is an ADP-binding protein, Biochem. J., 268, 713, 10.1042/bj2680713

Nilsson, 1988, Inhibition of glucose-stimulated insulin release by alpha 2 adrenoreceptor activation is paralleled by both a repolarisation and a reduction of cytoplasmic free Ca2+-concentration, J. biol. Chem., 263, 1855, 10.1016/S0021-9258(19)77955-1

Nilsson, 1989, Suppression of insulin release by galanin and somatostatin is mediated by G-protein. An effect involving repolarisation and reduction in cytoplasmic free Ca2+-concentration, J. biol. Chem., 264, 973, 10.1016/S0021-9258(19)85039-1

Nowycky, 1985, Three types of neuronal calcium channel with different calcium agonist sensitivity, Nature, 316, 440, 10.1038/316440a0

Ohno-Shosaku, 1987, Dual effects of ATP on K+-currents of mouse pancreatic β-cells, Pflügers Arch., 408, 133, 10.1007/BF00581342

Oosawa, 1990, Ca2+ -activated K+ -channels from HIT T15 β-cells incorporated into planar lipid bilavers, Diabetologia, 33, A105

Pace, 1985, Action of a phorbol ester on β-cells: Potentiation of stimulant-induced electrical activity, Am. J. Physiol., 248, C527, 10.1152/ajpcell.1985.248.5.C527

Pace, 1977, Somatostatin inhibition of glucose-induced electrical activity in cultured rat islet cells, Am. J. Physiol., 233, C164, 10.1152/ajpcell.1977.233.5.C164

Panten, 1987, Rapid control of insulin secretion from pancreatic islets, 307

Panten, 1974, Studies on the mechanisms of L-leucine and alpha ketoisocaproic acid induced insulin release from perifused isolated pancreatic islets, Diabetologia, 10, 149, 10.1007/BF01219672

Panten, 1989, Control of insulin secretion by sulfonylureas, meglitinide and diazoxide in relation to their binding to the sulfonylurea receptor in pancreatic islets, Biochem. Pharmac., 38, 1217, 10.1016/0006-2952(89)90327-4

Panten, 1989, Activity of ATP-sensitive K+ -channels in β-cells is regulated by ATP utilization in the vicinity of the plasma membrane, Diabetologia, 32, 527A

Peers, 1990, Ligustrazine selectively blocks ATP-sensitive K+ channels in mouse β-cells, FEBS Lett., 261, 5, 10.1016/0014-5793(90)80622-P

Perez-Armendariz, 1986, Glucose-evoked changes in [K+] and [Ca2+] in the intercellular spaces of the mouse islet of Langerhans, Adv. exp. med. Biol., 211, 31, 10.1007/978-1-4684-5314-0_3

Perez-Armendariz, 1986, Glucose-induced oscillatory changes in exracellular ionized potassium concentration in mouse islets of Langerhans, Biophys. J., 48, 741, 10.1016/S0006-3495(85)83832-7

Petersen, 1987, Electrophysiology of the pancreas, Physiol. Rev., 67, 1054, 10.1152/physrev.1987.67.3.1054

Pipeleers, 1987, The biosociology of pancreatic β cells, Diabetologia, 30, 277, 10.1007/BF00299019

Plant, 1988, Na+ currents in cultured mouse pancreatic β-cells, Pflügers Arch., 411, 429, 10.1007/BF00587723

Plant, 1988, Properties of calcium-dependent inactivation of calcium channels in cultured mouse pancreatic β-cells, J. Physiol., 404, 731, 10.1113/jphysiol.1988.sp017316

Plant, 1989, Effects of 1,2-dioctanoyl-sn-glycerol (DiC8) on ionic currents in cultured mouse pancreatic β-cells, J. Physiol., 418, 21P

Pongs, 1989, Molecular basis of potassium channel diversity, Pflügers Arch., 414, S71, 10.1007/BF00582251

Portha, 1988, Insulin production and glucose metabolism in isolated pancreatic islets of rats with NIDDM, Diabetes, 37, 1226, 10.2337/diab.37.9.1226

Pralong, 1990, Single islet β-cell stimulation by nutrients: relationship between pyridine nucleotides, cytosolic Ca2+ and secretion, EMBO J., 9, 53, 10.1002/j.1460-2075.1990.tb08079.x

Praz, 1983, Regulation of immunoreactive-insulin release from a rat cell line (RINm5F), Biochem. J., 210, 345, 10.1042/bj2100345

Prentki, 1987, Ca2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion, Physiol. Rev., 67, 1185, 10.1152/physrev.1987.67.4.1185

Pressel, 1990, Sodium channels contribute to action potential generation in canine and human β-cells, J. Membr. Biol., 116, 10.1007/BF01868466

Rajan, 1990, Ion channels and insulin secretion, Diabetes Care, 13, 340, 10.2337/diacare.13.3.340

Reuter, 1983, Calcium channel modulation by neurotransmitters, enzymes and drugs, Nature, 301, 569, 10.1038/301569a0

Ribalet, 1980, Calcium action potentials and potassium permeability activation in pancreatic β-cells, Am. J. Physiol., 239, C124, 10.1152/ajpcell.1980.239.3.C124

Ribalet, 1982, Effects of sodium on β-cell electrical activity, Am. J. Physiol., 242, C296, 10.1152/ajpcell.1982.242.5.C296

Ribalet, 1987, Regulation by cell metabolism and adenine nucleotides of a K channel in insulin-secreting β-cells (RINm5F), 84, 1721

Ribalet, 1988, Metabolic regulation of the K(ATP) and a maxi-K(V) channel in the insulin-secreting RINm5F-cell, J. gen. Physiol., 92, 219, 10.1085/jgp.92.2.219

Ribalet, 1989, ATP mediates both activation and inhibition of K(ATP) channel via cyclic-AMP dependent protein kinase in insulin secreting cell lines, J. gen. Physiol., 94, 693, 10.1085/jgp.94.4.693

Richardson, 1980, Correlations between channelled Na+ entry, Ca2+ fluxes and insulin release in pancreatic β-cells, Horm. Metab. Res., 10, 81

Rojas, 1990, A new class of calcium channels activated by glucose in human pancreatic β-cells, FEBS Lett., 261, 265, 10.1016/0014-5793(90)80568-4

Rorsman, 1986, Patch-clamp studies on pancreatic glucagon and insulin-secreting cells, Acta Universitatis Upsaliensis, (Ph.D. Thesis), 70, 1

Rorsman, 1985, Cyclic AMP potentiates glucose-induced insulin release from mouse pancreatic islets without increasing cytosolic free Ca2+, Acta. physiol. scand., 125, 639, 10.1111/j.1748-1716.1985.tb07766.x

Rorsman, 1988, Voltage-activated currents in guinea-pig pancreatic α2-cells, J. gen. physiol., 91, 223, 10.1085/jgp.91.2.223

Rorsman, 1985, Glucose dependent K+-channels in pancreatic β-cells are regulated by intracellular ATP, Pflügers Arch., 405, 305, 10.1007/BF00595682

Rorsman, 1986, Calcium and delayed potassium currents in mouse pancreatic β-cells under voltage-clamp conditions, J. Physiol., 374, 531, 10.1113/jphysiol.1986.sp016096

Rorsman, 1990, Biophysics and physiology of ATP-regulated K+ -channels (KATP), 96

Rorsman, 1986, Voltage-activated Na+ -currents and their suppression by phorbol ester in the clonal insulin-producing RINm5F-cells, Am. J. Physiol., 251, C912, 10.1152/ajpcell.1986.251.6.C912

Rorsman, 1988, Single Ca channel currents in mouse pancreatic β-cells, Pflügers Arch., 412, 597, 10.1007/BF00583760

Rorsman, 1989, Failure of glucose to elicit a normal response in fetal pancreatic β-cells results from glucose-insensitivity of the ATP-regulated K+ -channels, 86, 4505

Rorsman, 1990, ATP-regulated K+ -channels and diabetes mellitus, News Physiol. Sci., 5, 143

Rorsman, 1991, Activation by adrenaline of a low conductance G-protein-dependent K+ -channel in mouse pancreatic β-cells, Nature, 349, 77, 10.1038/349077a0

Rosenberg, 1988, Cardiac calcium channels in planar lipid bilayers, J. gen. Physiol., 92, 27, 10.1085/jgp.92.1.27

Sala, 1990, Single channel recordings of calcium channels in pancreatic β-cells, Biophys. J., 57, 525A

Salomon, 1986, Heterogeneity and contact-dependent regulation of hormone secretion by individual β-cells, Exp. cell. Res., 162, 507, 10.1016/0014-4827(86)90354-X

Sánchez-Andrés, 1988, Evidence that muscarinic potentiation of insulin release is initiated by an early transient calcium entry, FEBS Lett., 231, 143, 10.1016/0014-5793(88)80719-1

Sandström, 1988, Furosemide-induced glucose intolerance in mice is associated with reduced insulin secretion, Eur. J. Pharmac., 147, 403, 10.1016/0014-2999(88)90175-6

Santos, 1989, Muscarinic receptor modulation of glucose-induced electrical activity in mouse pancreatic β-cells, FEBS Lett., 249, 411, 10.1016/0014-5793(89)80669-6

Santos, 1990

Satin, 1985, Voltage-gated inward currents in pancreatic islet β-cells, Pflügers Arch., 404, 385, 10.1007/BF00585354

Satin, 1988, Evidence for two calcium currents in insulin-secreting cells, Pflügers Arch., 411, 401, 10.1007/BF00587719

Satin, 1989, Calcium current inactivation in insulin-secreting cells mediated by calcium influx and membrane depolarization, Pflügers Arch., 414, 1, 10.1007/BF00585619

Satin, 1989, Expression of a rapid, low-voltage threshold K+ current in insulin-secreting cells is dependent on intracellular calcium buffering, J. Membr. Biol., 112, 213, 10.1007/BF01870952

Schmid-Antomarchi, 1987, The receptor for antidiabetic sulphonylureas controls the activity of the ATP-modulated K+-channel in insulin-secreting cells, J. biol. Chem., 262, 15840, 10.1016/S0021-9258(18)47664-8

Scott, 1981, A method for the simultaneous measurement of insulin release and β cell membrane potential in single mouse islets of Langerhans, Diabetologia, 21, 470, 10.1007/BF00257788

Sener, 1987, Stimulation by D-glucose of mitochondrial oxidative events in islet cells, Biochem. J., 246, 89, 10.1042/bj2460089

Sharp, 1989, Galanin can inhibit insulin release by a mechanism other than membrane hyperpolarization or inhibition of adenylate cyclase, J. biol. Chem., 264, 7302, 10.1016/S0021-9258(18)83234-3

Sherman, 1990, Domain model for Ca2+ inactivation of Ca2+ -channels at low channel density, Biophys. J., 58, 985, 10.1016/S0006-3495(90)82443-7

Smith, 1988, Electrophysiology of β-cells from pancreatic islets of Langerhans

Smith, 1989, Demonstration of A-currents in pancreatic islet cells, Pflügers Arch., 413, 441, 10.1007/BF00584497

Smith, 1989, Modulation of dihydropyridine-sensitive Ca2+ -channels by glucose metabolism in pancreatic β-cells, Nature, 342, 550, 10.1038/342550a0

Smith, 1990, Simultaneous recording of glucose-dependent electrical activity and ATP-regulated K+ -currents in isolated mouse pancreatic β-cells, FEBS Lett., 261, 187, 10.1016/0014-5793(90)80667-8

Smith, 1990, Delayed rectifying and calcium-activated K+ -channels and their significance for action potential repolarization in mouse pancreatic β-cells, J. gen. Physiol., 95, 1041, 10.1085/jgp.95.6.1041

Smith, 1991, Ba-currents through L-type Ca channels in mouse pancreatic β-cells, J. Physiol.

Standen, 1989, Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscle, Science, 245, 177, 10.1126/science.2501869

Struthers, 1985, Glucose tolerance during antihypertensive therapy in patients with diabetes mellitus, Hypertension (part II), 7, 95

Stühmer, 1989, Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain, EMBO J., 8, 3235, 10.1002/j.1460-2075.1989.tb08483.x

Sturgess, 1985, The sulphonylurea receptor may be an ATP-sensitive potassium channel, Lancet, 8453, 474, 10.1016/S0140-6736(85)90403-9

Sturgess, 1986, Single channel recordings of potassium currents in an insulin-secreting cell line, J. Endocrin., 109, 201, 10.1677/joe.0.1090201

Sturgess, 1986, Inhibition of a calcium-activated non-selective cation channel, in a rat insulinoma cell line, by adenine derivatives, FEBS Lett., 208, 397, 10.1016/0014-5793(86)81056-0

Sturgess, 1987, Nucleotide-sensitive ion channels in human insulin producing tumor cells, Pflügers Arch., 410, 169, 10.1007/BF00581911

Sturgess, 1987, Calcium and ATP regukate the activity of a non-selective cation channel in a rat insulinoma cell line, Pflügers Arch., 409, 607, 10.1007/BF00584661

Sturgess, 1988, Effects of sulphonylureas and diazoxide on insulin secretion and nucleotide-sensitive channels in an insulin-secreting cell line, Br. J. Pharmac., 95, 83, 10.1111/j.1476-5381.1988.tb16551.x

Tabcharani, 1989, Ca2+-activated K+-channel in rat pancreatic β-cells: permeation, gating and block by cations, Biochim. biophys. Acta, 982, 67

Tamagawa, 1983, Epinephrine modifications of insulin release and of 86Rb and 45Ca fluxes in rat islets, Am. J. Physiol., 244, E245

Trube, 1987, Calcium and potassium currents recorded from pancreatic β-cells under voltage clamp control, Adv. exp. med. Biol., 211, 167, 10.1007/978-1-4684-5314-0_14

Trube, 1986, Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+-channel in pancreatic β-cells, Pflügers Arch., 407, 493, 10.1007/BF00657506

Trube, 1989, Regulation and function of ATP-dependent K+-channels in pancreatic β-cells, Vol. 44, 84

Ullrich, 1988, GTP-dependent inhibition of insulin secretion by epinephrine in permeabilized RINm5F cells. Lack of correlation between insulin and cyclic AMP levels, J. biol. Chem., 263, 8615, 10.1016/S0021-9258(18)68349-8

Ullrich, 1989, Galanin inhibits insulin secretion by direct interference with exocytosis, FEBS Lett., 247, 401, 10.1016/0014-5793(89)81379-1

Vague, 1982, The defective glucose-sensitivity of the β-cell in non-insulin-dependent1diabetes. Improvement after twenty hours of normoglycaemia, Metabolism, 31, 139, 10.1016/0026-0495(82)90125-1

Valdeolmillos, 1989, Glucose-induced oscillations of intracellular Ca2+-concentration matching bursting electrical activity in single mouse islets of Langerhans, FEBS Lett., 259, 19, 10.1016/0014-5793(89)81484-X

Velasco, 1987, Calcium channels in insulin-secreting RINm5F cell line, J. Physiol., 398, 15P

Velasco, 1987, Voltage-activation of high conductance K+-channel in the insulin-secreting cell line RINm5F is dependent on local extracellular Ca2+ concentration, Biochim. biophys. Acta, 896, 305, 10.1016/0005-2736(87)90191-X

Velasco, 1989, The effects of a cell-permeable diacylglycerol analogue on single Ca2+ (Ba2+) channel currents in insulin-secreting cell line RINm5F, Q. J. exp. Physiol., 74, 367, 10.1113/expphysiol.1989.sp003280

Velasco, 1988, Single channel Ba2+ currents in insulin secreting cells are activated by glyceraldehyde stimulation, FEBS Lett., 213, 366, 10.1016/0014-5793(88)80851-2

Wåhlander, 1991, Galanin inhibits β-cell electrical activity by a G-protein-regulated sulphonylurea-insensitive mechanism

Weston, 1989, Smooth muscle K+ channel openers; their pharmacology and clinical potential, Pflügers Arch., 411, S99, 10.1007/BF00582256

White, 1983, Severe hypoglycaemia and hyperinsulinaemia in falciparum malaria, New Engl. J. Med., 309, 60, 10.1056/NEJM198307143090201

Wollheim, 1980, Dependency of acetylcholine-induced insulin release on Ca++ uptake by rat pancreatic islets, Endocrinology, 107, 924, 10.1210/endo-107-4-924

Wollheim, 1988, Activators of protein kinase C depolarise insulin-secreting cells by closing K+-channels, EMBO J., 7, 2443, 10.1002/j.1460-2075.1988.tb03090.x

Zünkler, 1988, Concentration-dependent effects of tolbutamide, meglitinide, glipizide, glibenclamide and diazoxide on ATP-regulated K+-currents in pancreatic β-cells, Archs Pharmac., 337, 225, 10.1007/BF00169252

Zünkler, 1988, Cytosolic ADP enhances the sensitivity to tolbutamide of ATP-dependent K+ channels from pancreatic β-cells, FEBS Lett., 239, 241, 10.1016/0014-5793(88)80925-6

Zünkler, 1988, Forskolin-induced block of delayed rectifying K+-channels in pancreatic β-cells is not mediated by cAMP, Pflügers Arch., 411, 613, 10.1007/BF00580856

Zünkler, 1989, How do sulfonylureas approach their receptor in the β-cell membrane?, Naunyn-Schmiedebergs Arch. exp. Path. Pharmak., 340, 328, 10.1007/BF00168518