Electroconvulsive therapy in children and adolescents: results from a population‑based study utilising the Swedish National Quality Register

European Child & Adolescent Psychiatry - Tập 32 Số 12 - Trang 2649-2656 - 2023
Olof Rask1, Axel Nordenskjöld2, Björn Johansson1, Pouya Movahed3
1Division of Child and Adolescent Psychiatry, Department of Clinical Sciences, Lund University, Lund, Sweden
2Faculty of Medicine and Health, University Health Care Research Center, Örebro University, Örebro, Sweden
3Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden

Tóm tắt

AbstractElectroconvulsive therapy (ECT) is effective and safe for adults with severe depression, but less studied in adolescents. Here, we examined the indications, prevalence, practice, response and remission rates, and side effects in young people treated with ECT in Sweden. We also examined the usage of ECT in the transition to adult psychiatry. Using data from national patient registers and the Swedish National Quality Register for ECT (Q-ECT), we identified patients aged up to 19 years treated with ECT over a 5-year study period. Response and remission rates were analysed using the Clinical Global Impression (7-point scale)-Improvement (CGI-I) and Severity (CGI-S). A total of 118 individuals were identified, of which 105 were also enrolled in the Q-ECT. The most common indication for ECT was depression (68%; n = 80). Adolescents aged < 18 years were more severely ill before treatment than those aged 18 years (P < 0.01). Three of the hospitals in Sweden treated the majority of adolescents < 18 years old. The median number of sessions in each ECT series was seven. Unilateral placement of the electrodes was the most common (88%; n = 99). Fifty-seven percent (n = 54) of the patients responded (CGI-I, 1–2) to the treatment; remission (CGI-S, 1–2) was achieved by 32% (n = 30). Psychotic symptoms were associated with a higher response rate in patients with depression (P = 0.038). A deterioration of memory compared to pre-treatment was reported in six patients. ECT was associated with high response and remission rates in adolescents with severe psychiatric disorders after non-response to medication.

Từ khóa


Tài liệu tham khảo

WHO (2022) Adolescent and young adult health. https://www.who.int/news-room/fact-sheets/detail/adolescents-health-risks-and-solutions. Accessed 10 Aug 2022

Substance Abuse and Mental Health Services Administration (2019) National survey on drug use and health. https://www.nimh.nih.gov/health/statistics/major-depression#part_2565. Accessed 10 Aug 2022

Lewinsohn PM, Hops H, Roberts RE et al (1993) Adolescent psychopathology: I. Prevalence and incidence of depression and other DSM-III-R disorders in high school students. J Abnorm Psychol 102:133–144. https://doi.org/10.1037//0021-843x.102.1.133

Swedish National Board of Health and Welfare (2019) Statistics on pharmaceuticals 2018. https://www.socialstyrelsen.se/en/publications. Accessed 10 Aug 2022

Feeney A, Hock RS, Fava M et al (2022) Antidepressants in children and adolescents with major depressive disorder and the influence of placebo response: a meta-analysis. J Affect Disord 305:55–64. https://doi.org/10.1016/j.jad.2022.02.074

Hetrick S, Merry S, McKenzie J et al (2007) Selective serotonin reuptake inhibitors (SSRIs) for depressive disorders in children and adolescents. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD004851.pub2

Emslie GJ, Ventura D, Korotzer A et al (2009) Escitalopram in the treatment of adolescent depression: a randomized placebo-controlled multisite trial. J Am Acad Child Adolesc Psychiatry 48:721–729. https://doi.org/10.1097/CHI.0b013e3181a2b304

Findling RL, Robb A, Bose A (2013) Escitalopram in the treatment of adolescent depression: a randomized, double-blind, placebo-controlled extension trial. J Child Adolesc Psychopharmacol 23:468–480. https://doi.org/10.1089/cap.2012.0023

Hetrick SE, McKenzie JE, Bailey AP et al (2021) New generation antidepressants for depression in children and adolescents: a network meta-analysis. Cochrane Database Syst Rev 5:CD013674. https://doi.org/10.1002/14651858.CD013674.pub2

Miller L, Campo JV (2021) Depression in adolescents. N Engl J Med 385:445–449. https://doi.org/10.1056/NEJMra2033475

Zhou X, Michael KD, Liu Y et al (2014) Systematic review of management for treatment-resistant depression in adolescents. BMC Psychiatry 14:340. https://doi.org/10.1186/s12888-014-0340-6

Carvalho AF, Sharma MS, Brunoni AR et al (2016) The safety, tolerability and risks associated with the use of newer generation antidepressant drugs: a critical review of the literature. Psychother Psychosom 85:270–288. https://doi.org/10.1159/000447034

Castaneda-Ramirez S, Becker TD, Bruges-Boude A et al (2022) Systematic review: electroconvulsive therapy for treatment-resistant mood disorders in children and adolescents. Eur Child Adolesc Psychiatry. https://doi.org/10.1007/s00787-022-01942-7

Ferrier I, Waite J (2019) The ECT handbook. Cambridge University Press, Cambridge

Bender L (1947) One hundred cases of childhood schizophrenia treated with electric shock. Trans Am Neurol Soc 72:165–169

Heuyer G, Bour LR (1943) L’électrochoc chez les enfants. Ann Med Psychol (Paris) 2:402–407

Ghaziuddin N, Kutcher SP, Knapp P et al (2004) Practice parameter for use of electroconvulsive therapy with adolescents. J Am Acad Child Adolesc Psychiatry 43:1521–1539. https://doi.org/10.1097/01.chi.0000142280.87429.68

Thompson JW, Blaine JD (1987) Use of ECT in the United States in 1975 and 1980. Am J Psychiatry 144:557–562. https://doi.org/10.1176/ajp.144.5.557

Pippard J, Ellam L (1981) Electroconvulsive treatment in Great Britain. Br J Psychiatry 139:563–568. https://doi.org/10.1192/bjp.139.6.563

Elvin T, Nordenskjöld A (2016) Swedish National Quality register for ECT—annual report, vol 2017. https://ect.registercentrum.se/om-registret/kvalitetsregister-ect/p/HyUWjuR7W. Accessed 10 Aug 2022

Socialstyrelsen (2018) Läkemedelsregistret [Prescribed drug register] https://www.socialstyrelsen.se/statistik-och-data/register/lakemedelsregistret. Accessed 10 Oct 2022

Leucht S, Fennema H, Engel R et al (2013) What does the HAMD mean? J Affect Disord 148:243–248. https://doi.org/10.1016/j.jad.2012.12.001

Berk M, Ng F, Dodd S et al (2008) The validity of the CGI severity and improvement scales as measures of clinical effectiveness suitable for routine clinical use. J Eval Clin Pract 14:979–983. https://doi.org/10.1111/j.1365-2753.2007.00921.x

Guy W (1976) ECDEU assessment manual for psychopharmacology. United States Department of Health, Education and Welfare, Rockville

Montgomery SA, Asberg M (1979) A new depression scale designed to be sensitive to change. Br J Psychiatry 134:382–389. https://doi.org/10.1192/bjp.134.4.382

Hanley JA, Lippman-Hand A (1983) If nothing goes wrong, is everything all right? Interpreting zero numerators. JAMA 249:1743–1745. https://doi.org/10.1001/jama.1983.03330370053031

Kronsell A, Nordenskjöld A, Bell M et al (2021) The effect of anaesthetic dose on response and remission in electroconvulsive therapy for major depressive disorder: nationwide register-based cohort study. BJPsych Open 7:e71. https://doi.org/10.1192/bjo.2021.31

Blumberger DM, Seitz DP, Herrmann N et al (2017) Low medical morbidity and mortality after acute courses of electroconvulsive therapy in a population-based sample. Acta Psychiatr Scand 136:583–593. https://doi.org/10.1111/acps.12815

Ekstrand J, Fattah C, Persson M et al (2022) Racemic ketamine as an alternative to electroconvulsive therapy for unipolar depression: a randomized, open-label, non-inferiority trial (KetECT). Int J Neuropsychopharmacol 25:339–349. https://doi.org/10.1093/ijnp/pyab088

Semkovska M, McLoughlin DM (2010) Objective cognitive performance associated with electroconvulsive therapy for depression: a systematic review and meta-analysis. Biol Psychiatry 68:568–577. https://doi.org/10.1016/j.biopsych.2010.06.009

Rock PL, Roiser JP, Riedel WJ et al (2014) Cognitive impairment in depression: a systematic review and meta-analysis. Psychol Med 44:2029–2040. https://doi.org/10.1017/S0033291713002535

Espinoza RT, Kellner CH (2022) Electroconvulsive therapy. N Engl J Med 386:667–672. https://doi.org/10.1056/NEJMra2034954

Petrides G, Fink M, Husain MM et al (2001) ECT remission rates in psychotic versus nonpsychotic depressed patients: a report from CORE. J ECT 17:244–253. https://doi.org/10.1097/00124509-200112000-00003

Swedish National Board of Health and Welfare (2019) Nationella riktlinjer för vård vid depression och ångestsyndrom. https://www.socialstyrelsen.se/globalassets/sharepoint-dokument/artikelkatalog/nationella-riktlinjer/2019-5-13-enkatbilaga.pdf. Accessed 10 Aug 2022

Kaliora SC, Braga RJ, Petrides G et al (2013) The practice of electroconvulsive therapy in Greece. J ECT 29:219–224. https://doi.org/10.1097/YCT.0b013e31827e0d49

Lõokene M, Kisuro A, Mačiulis V et al (2014) Use of electroconvulsive therapy in the Baltic states. World J Biol Psychiatry 15:419–424. https://doi.org/10.3109/15622975.2013.866692

Martin BA, Delva NJ, Graf P et al (2015) Delivery of electroconvulsive therapy in Canada: a first national survey report on usage, treatment practice, and facilities. J ECT 31:119–124. https://doi.org/10.1097/YCT.0000000000000192

Schweder LJ, Lydersen S, Wahlund B et al (2011) Electroconvulsive therapy in Norway: rates of use, clinical characteristics, diagnoses, and attitude. J ECT 27:292–295. https://doi.org/10.1097/YCT.0b013e318208e24b

Nordanskog P, Hultén M, Landén M et al (2015) Electroconvulsive therapy in Sweden 2013: data from the national quality register for ECT. J ECT 31:263–267. https://doi.org/10.1097/YCT.0000000000000243

Baldessarini RJ, Tondo L, Vazquez GH et al (2012) Age at onset versus family history and clinical outcomes in 1,665 international bipolar-I disorder patients. World Psychiatry 11:40–46. https://doi.org/10.1016/j.wpsyc.2012.01.006

Jane Costello E, Erkanli A, Angold A (2006) Is there an epidemic of child or adolescent depression? J Child Psychol Psychiatry 47:1263–1271. https://doi.org/10.1111/j.1469-7610.2006.01682.x

Grover S, Raju V, Chakrabarti S et al (2021) Use of electroconvulsive therapy in adolescents: a retrospective study. Indian J Psychol Med 43:119–124. https://doi.org/10.1177/0253717620956730

Karayağmurlu A, Coşkun M, Elboğa G et al (2020) Efficacy and safety of electroconvulsive therapy in adolescents: a retrospective chart review study from turkey. J ECT 36:54–59. https://doi.org/10.1097/YCT.0000000000000602

Maoz H, Nitzan U, Goldwyn Y et al (2018) When can we predict the outcome of an electroconvulsive therapy course in adolescents? A retrospective study. J ECT 34:104–107. https://doi.org/10.1097/YCT.0000000000000469

UK ECT Review Group (2003) Efficacy and safety of electroconvulsive therapy in depressive disorders: a systematic review and meta-analysis. Lancet 361:799–808. https://doi.org/10.1016/S0140-6736(03)12705-5

Letemendia FJ, Delva NJ, Rodenburg M et al (1993) Therapeutic advantage of bifrontal electrode placement in ECT. Psychol Med 23:349–360. https://doi.org/10.1017/s0033291700028452

Sackeim HA, Prudic J, Devanand DP et al (1993) Effects of stimulus intensity and electrode placement on the efficacy and cognitive effects of electroconvulsive therapy. N Engl J Med 328:839–846. https://doi.org/10.1056/NEJM199303253281204

Nordanskog PN, Nordenskiöld A (2014) Ect, kliniska riktlinjer. Gothia Fortbildning, Stockholm

Bergsholm P, Bjølseth TM (2022) Dosing methods in electroconvulsive therapy: should the Scandinavian time-titration method be resumed? Nord J Psychiatry 76:170–176. https://doi.org/10.1080/08039488.2021.1946590

Kellner CH, Jørgensen MB (2022) Dosing methods in electroconvulsive therapy (ECT): towards the modal ECT technique. Nord J Psychiatry 76:159–161. https://doi.org/10.1080/08039488.2021.2012256

Sackeim HA, Prudic J, Nobler MS et al (2008) Effects of pulse width and electrode placement on the efficacy and cognitive effects of electroconvulsive therapy. Brain Stimul 1:71–83. https://doi.org/10.1016/j.brs.2008.03.001

Viswanathan M, Kennedy SM, McKeeman J et al (2020) Treatment of depression in children and adolescents: a systematic review [Internet]. Agency for Healthcare Research and Quality (US), Rockville (MD), 2020 Apr. Report No.: 20-EHC005-EF