Electro-conductive and temperature-sensitive poly(N-isopropylacrylamide) composite hydrogels with improved mechanical properties

Akimoto J, Nakayama M, Okano T (2014) Temperature-responsive polymeric micelles for optimizing drug targeting to solid tumors. J Control Release 193:2–8. https://doi.org/10.1016/j.jconrel.2014.06.062 Alzari V, Nuvoli D, Scognamillo S, Piccinini M, Gioffredi E, Malucelli G, Marceddu S, Sechi M, Sanna V, Mariani A (2011) Graphene-containing thermoresponsive nanocomposite hydrogels of poly(N-isopropylacrylamide) prepared by frontal polymerization. J Mater Chem 21:8727–8733. https://doi.org/10.1039/c1jm11076d Chen Z, To JWF, Wang C, Lu Z, Liu N, Chortos A, Pan L, Wei F, Cui Y (2014) A three-dimensionally interconnected carbon nanotube-conducting polymer hydrogel network for high-performance flexible battery electrodes. Adv Energy Mater 4:1400207. https://doi.org/10.1002/aenm.201400207 Chen Y, Kang S, Yu JR, Wang Y, Zhu J, Hu ZM (2019) Tough robust dual responsive nanocomposite hydrogel as controlled drug delivery carrier of asprin. J Mech Behav Biomed 92:179–187. https://doi.org/10.1016/j.jmbbm.2019.01.017 Chuang WJ, Chiu WY, Tai HJ (2012) Temperature-dependent conductive composites: poly(N-isopropylacrylamide-co-N-methylol acrylamide) and carbon black composite films. J Mater Chem 22:20311. https://doi.org/10.1039/c2jm33601d Depa K, Strachota A, Slouf M, Brus J, Cimrova V (2017) Synthesis of conductive doubly filled poly(N-isopropylacrylamide)-polyaniline-SiO2 hydrogels. Sens Actuators B-Chem 244:616–634. https://doi.org/10.1016/j.snb.2016.12.121 Fan SJ, Tang QW, Wu JH, Hu D, Sun H, Lin JM (2008) Two-step synthesis of polyacrylamide/poly(vinyl alcohol)/polyacrylamide/graphite interpenetrating network hydrogel and its swelling, conducting and mechanical properties. J Mater Sci 43:5898–5904. https://doi.org/10.1007/s10853-008-2855-z Gil E, Hudson S (2004) Stimuli-reponsive polymers and their bioconjugates. Prog Polym Sci 29:1173–1222. https://doi.org/10.1016/j.progpolymsci.2004.08.003 Guan Y, Zhang Y (2011) PNIPAM microgels for biomedical applications: from dispersed particles to 3D assemblies. Soft Matter 7:6375. https://doi.org/10.1039/c0sm01541e Gulyuz U, Okay O (2015) Self-healing poly(N-isopropylacrylamide) hydrogels. Eur Polym J 72:12–22. https://doi.org/10.1016/j.eurpolymj.2015.09.002 Haq MA, Su Y, Wang D (2017) Mechanical properties of PNIPAM based hydrogels: a review. Mater Sci Eng C 70:842–855. https://doi.org/10.1016/j.msec.2016.09.081 He X, Han H, Liu L, Shi W, Lu X, Dong J, Yang W, Lu X (2019) Self-assembled microgels for sensitive and low-fouling detection of streptomycin in complex media. ACS Appl Mater Inter 11:13676–13684. https://doi.org/10.1021/acsami.9b00277 Hummers WS Jr, Offeman RE (1958) Preparation of graphitic oxide. J Am Chem Soc 80:1339–1339. https://doi.org/10.1021/ja01539a017 Li X, Serpe MJ (2016) Understanding the shape memory behavior of self-bending materials and their use as sensors. Adv Funct Mater 26:3282–3290. https://doi.org/10.1002/adfm.201505391 Lin JM, Tang QW, Wu JH, Li QH (2010) A Multifunctional hydrogel with high-conductivity, pH-responsive, and release properties from polyacrylate/polyptrrole. J Appl Polym Sci 116:1376–1383. https://doi.org/10.1002/app.31642 Lin HT, Li MS, Ding LY, Huang J (2019) A Fiber Optic biosensor based on hydrogel-immobilized enzyme complex for continuous determination of cholesterol and glucose. Appl Biochem Biotech 187:1569–1580. https://doi.org/10.1007/s12010-018-2897-x Liu T, Huang M, Li X, Wang C, Gui C-X, Yu Z-Z (2016) Highly compressible anisotropic graphene aerogels fabricated by directional freezing for efficient absorption of organic liquids. Carbon 100:456–464. https://doi.org/10.1016/j.carbon.2016.01.038 Liu W, Zhang XY, Wei G, Su ZQ (2018) Reduced Graphene Oxide-Based Double Network Polymeric Hydrogels for Pressure and Temperature Sensing. Sensors 18:3162. https://doi.org/10.3390/s18093162 Lo CW, Zhu DF, Jiang HR (2011) An infrared-light responsive graphene-oxide incorporated poly(N-isopropylacrylamide) hydrogel nanocomposite. Soft Matter 7:5604–5609. https://doi.org/10.1039/c1sm00011j Ma XM, Li YH, Wang WC, Ji Q, Xia YZ (2013) Temperature-sensitive poly(N-isopropylacrylamide)/graphene oxide nanocomposite hydrogels by in situ polymerization with improved swelling capability and mechanical behavior. Eur Polym J 49:389–396. https://doi.org/10.1016/j.eurpolymj.2012.10.034 Ma H, Zhang H, Cao J, Tong M, Zhao J, Li Y, Xu H, Wu W (2019) Temperature-responsive and piezoresistive performances of poly(N-isopropylacrylamide)-grafted reduced graphene oxide smart fiber. Compos Sci Technol 169:186–194. https://doi.org/10.1016/j.compscitech.2018.11.004 Moghadam S, Larson RG (2017) Assessing the efficacy of poly(N-isopropylacrylamide) for drug delivery applications using molecular dynamics simulations. Mol Pharm 14:478–491. https://doi.org/10.1021/acs.molpharmaceut.6b00942 Nagase K, Okano T (2016) Thermoresponsive-polymer-based materials for temperature-modulated bioanalysis and bioseparations. J Mater Chem B 4:6381–6397. https://doi.org/10.1039/c6tb01003b Nagase K, Yamato M, Kanazawa H, Okano T (2018) Poly(N-isopropylacrylamide)-based thermoresponsive surfaces provide new types of biomedical applications. Biomaterials 153:27–48. https://doi.org/10.1016/j.biomaterials.2017.10.026 Qiu L, Liu D, Wang Y, Cheng C, Zhou K, Ding J, Truong VT, Li D (2014) Mechanically robust, electrically conductive and stimuli-responsive binary network hydrogels enabled by superelastic graphene aerogels. Adv Mater 26:3333–3337. https://doi.org/10.1002/adma.201305359 Shi Y, Ma C, Peng L, Yu G (2015) Conductive “Smart” hybrid hydrogels with PNIPAM and nanostructured conductive polymers. Adv Funct Mater 25:1219–1225. https://doi.org/10.1002/adfm.201404247 Takahashi H, Okano T (2019) Thermally-triggered fabrication of cell sheets for tissue engineering and regenerative medicine. Adv Drug Deliver Rev 138:276–292. https://doi.org/10.1016/j.addr.2019.01.004 Torgut G, Biryan F, Demirelli K (2019) Effect of graphite particle fillers on dielectric and conductivity properties of poly(NIPAM-co-HEMA). B Mater Sci 42:244. https://doi.org/10.1007/s12034-019-1915-0 Tripathi SN, Saini P, Gupta D, Choudhary V (2013) Electrical and mechanical properties of PMMA/reduced graphene oxide nanocomposites prepared via in situ polymerization. J Mater Sci 48:6223–6232. https://doi.org/10.1007/s10853-013-7420-8 Wei YB, Zeng Q, Wang M, Huang JZ, Guo XR, Wang LS (2019) Near-infrared light-responsive electrochemical protein imprinting biosensor based on a shape memory conducting hydrogel. Biosens Bioelectron 131:156–162. https://doi.org/10.1016/j.bios.2019.02.015 Xu Y, Sheng K, Li C, Shi G (2010) Self-assembled graphene hydrogel via a one-step hydrothermal process. ACS Nano 4:4324–4330. https://doi.org/10.1021/nn101187z Zhang HB, Zheng WG, Yan Q, Yang Y, Wang JW, Lu ZH, Ji GY, Yu ZZ (2010) Electrically conductive polyethylene terephthalate/graphene nanocomposites prepared by melt compounding. Polymer 51:1191–1196. https://doi.org/10.1016/j.polymer.2010.01.027 Zhang EZ, Wang T, Lian CX, Sun WX, Liu XX, Tong Z (2013) Robust and thermo-response graphene-PNIPAm hybrid hydrogels reinforced by hectorite clay. Carbon 62:117–126. https://doi.org/10.1016/j.carbon.2013.06.003 Zhang XP, Liu D, Yang L, Zhou LM, You TY (2015) Self-assembled three-dimensional graphene-based materials for dye adsorption and catalysis. J Mater Chem A 3:10031–10037. https://doi.org/10.1039/c5ta00355e Zhu AF, Shi Z, Jin JH, Li G, Jiang JM (2012) Synthesis and properties of polyacrylamide-based conducting gels with enhanced mechanical strength. J Macromol Sci B 51:2183–2190. https://doi.org/10.1080/00222348.2012.669679