Efficient isolation of interstitial fibroblasts directly from mouse kidneys or indirectly after ex vivo expansion

Beliakova-Bethell, 2014, The effect of cell subset isolation method on gene expression in leukocytes, Cytometry A, 85, 94, 10.1002/cyto.a.22352 Broeker, 2020, Different subpopulations od kidney interstitial cells produce erythropoietin and factors supporting tissue oxygenation in response to hypoxia in vivo, Kidney Int., 98, 918, 10.1016/j.kint.2020.04.040 Bussolati, 2013, Renal CD133(+)/CD73(+) progenitors produce erythropoietin under hypoxia and prolyl hydroxylase inhibition, J. Am. Soc. Nephrol., 24, 1234, 10.1681/ASN.2012080772 Chang, 2016, DNA methyltransferase inhibition restores erythropoietin production in fibrotic murine kidneys, J. Clin. Invest., 126, 721, 10.1172/JCI82819 Conway, 2020, Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease, J. Am. Soc. Nephrol., 31, 2833, 10.1681/ASN.2020060806 Geng, 2021, Receptor-mediated mitophagy regulates EPO production and protects against renal anemia, Elife, 10, e64480, 10.7554/eLife.64480 Higashi, 2019, Expression profiling of fibroblasts in chronic and acute disease models reveals novel pathways in kidney fibrosis, J. Am. Soc. Nephrol., 30, 80, 10.1681/ASN.2018060644 Hirano, 2017, Renal anemia model mouse established by transgenic rescue with erythropoietin gene lacking kidney-specific regulatory elements, Mol. Cell. Biol., 37, 10.1128/MCB.00451-16 Kramann, 2015, Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis, Cell Stem Cell, 16, 51, 10.1016/j.stem.2014.11.004 Kuppe, 2021, Decoding myofibroblast origins in human kidney fibrosis, Nature, 589, 281, 10.1038/s41586-020-2941-1 Miyauchi, 2021, Renal interstitial fibroblasts coproduce erythropoietin and renin under anaemic conditions, EBioMedicine, 64, 103209, 10.1016/j.ebiom.2021.103209 Obara, 2008, Repression via the GATA box is essential for tissue-specific erythropoietin gene expression, Blood, 111, 5223, 10.1182/blood-2007-10-115857 Pan, 2011, Isolation and characterization of renal erythropoietin-producing cells from genetically produced anemia mice, PLoS One, 6, e25839, 10.1371/journal.pone.0025839 Plotkin, 2006, Mesenchymal cells from adult kidney support angiogenesis and differentiate into multiple interstitial cell types including erythropoietin-producing fibroblasts, Am. J. Physiol. Ren. Physiol., 291, F902, 10.1152/ajprenal.00396.2005 Sato, 2019, An immortalized cell line derived from erythropoietin-producing (REP) cells demonstrates their potential to transform into myofibroblasts, Sci. Rep., 9, 11254, 10.1038/s41598-019-47766-5 Sato, 2019, Alteration of the DNA methylation signature of renal erythropoietin-producing cells governs the sensitivity to drugs targeting the hypoxia-response pathway in kidney disease progression, Front. Genet., 10, 1134, 10.3389/fgene.2019.01134 Souma, 2013, Plasticity of renal erythropoietin-producing cells governs fibrosis, J. Am. Soc. Nephrol., 24, 1599, 10.1681/ASN.2013010030 Souma, 2016, Erythropoietin synthesis in renal myofibroblasts is restored by activation of hypoxia signaling, J. Am. Soc. Nephrol., 27, 428, 10.1681/ASN.2014121184 Suzuki, 2013, Erythropoietin production in neuroepithelial and neural crest cells during primitive erythropoiesis, Nat. Commun., 4, 2902, 10.1038/ncomms3902 Suzuki, 2016, Efficacy estimation of erythropoiesis-stimulating agents using erythropoietin-deficient anemic mice, Haematologica, 101, e356, 10.3324/haematol.2015.140814 Suzuki, 2016, Roles of renal erythropoietin-producing (REP) cells in the maintenance of systemic oxygen homeostasis, Pflugers Arch., 469, 3, 10.1007/s00424-015-1740-2 Yamazaki, 2013, A mouse model of adult-onset anaemia due to erythropoietin deficiency, Nat. Commun., 4, 1950, 10.1038/ncomms2950 Yamazaki, 2021, Defining the functionally sufficient regulatory region and liver-specific roles of the erythropoietin gene by transgene complementation, Life Sci., 269, 119075, 10.1016/j.lfs.2021.119075