Efficacy of traditional herbal medicine versus transcatheter arterial chemoembolization in postsurgical patients with hepatocellular carcinoma: A retrospective study

Bray, 2018, Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, CA A Cancer J. Clin., 68, 394, 10.3322/caac.21492 Villanueva, 2019, Hepatocellular carcinoma, N. Engl. J. Med., 380, 1450, 10.1056/NEJMra1713263 Bruix, 2014, Hepatocellular carcinoma: clinical frontiers and perspectives, Gut, 63, 844, 10.1136/gutjnl-2013-306627 Xu, 2019, Risk factors, patterns, and outcomes of late recurrence after liver resection for hepatocellular carcinoma: a multicenter study from China, JAMA Surg., 154, 209, 10.1001/jamasurg.2018.4334 Hasegawa, 2013, Comparison of resection and ablation for hepatocellular carcinoma: a cohort study based on a Japanese nationwide survey, J. Hepatol., 58, 724, 10.1016/j.jhep.2012.11.009 Zhang, 2015, Appropriate treatment strategies for intrahepatic recurrence after curative resection of hepatocellular carcinoma initially within the Milan criteria: according to the recurrence pattern, Eur. J. Gastroenterol. Hepatol., 27, 933, 10.1097/MEG.0000000000000383 Shi, 2014, Preoperative transarterial chemoembolization and resection for hepatocellular carcinoma: a nationwide Taiwan database analysis of long-term outcome predictors, J. Surg. Oncol., 109, 487, 10.1002/jso.23521 Sun, 2016, Postoperative adjuvant transcatheter arterial chemoembolization after R0 hepatectomy improves outcomes of patients who have hepatocellular carcinoma with microvascular invasion, Ann. Surg Oncol., 23, 1344, 10.1245/s10434-015-5008-z Lencioni, 2016, Lipiodol transarterial chemoembolization for hepatocellular carcinoma: a systematic review of efficacy and safety data, Hepatology, 64, 106, 10.1002/hep.28453 Burrel, 2012, Survival of patients with hepatocellular carcinoma treated by transarterial chemoembolisation (TACE) using Drug Eluting Beads. Implications for clinical practice and trial design, J. Hepatol., 56, 1330, 10.1016/j.jhep.2012.01.008 Kim, 2011, Adjuvant hepatic arterial infusional chemotherapy with 5-fluorouracil and cisplatin after curative resection of hepatocellular carcinoma, Oncology, 81, 184, 10.1159/000333827 Liao, 2015, Adjunctive traditional Chinese medicine therapy improves survival of liver cancer patients, Liver Int., 35, 2595, 10.1111/liv.12847 Yang, 2020, Efficacy of traditional Chinese Medicine combined with chemotherapy in patients with non-small cell lung cancer (NSCLC): a meta-analysis of randomized clinical trials, Support. Care Canc., 10.1007/s00520-020-05433-w Cao, 2013, Ethyl acetate extraction from a Chinese herbal formula, Jiedu Xiaozheng Yin, inhibits the proliferation of hepatocellular carcinoma cells via induction of G0/G1 phase arrest in vivo and in vitro, Int. J. Oncol., 42, 202, 10.3892/ijo.2012.1703 Ling, 2014, The roles of traditional Chinese medicine in gene therapy, J. Integr. Med., 12, 67, 10.1016/S2095-4964(14)60019-4 Sun, 2018, A cohort study to examine the use of Chinese herbal medicine in combination with conventional therapies for patients with hepatocellular carcinoma in China, Integr. Canc. Ther., 17, 902, 10.1177/1534735418775819 Ting, 2015, Preventive and therapeutic role of traditional Chinese herbal medicine in hepatocellular carcinoma, J. Chin. Med. Assoc., 78, 139, 10.1016/j.jcma.2014.09.003 Wang, 2013, Traditional herbal medicine: a review of potential of inhibitory hepatocellular carcinoma in basic research and clinical trial, Evid. Based Complement. Alternat. Med. Bruix, 2005, Management of hepatocellular carcinoma, Hepatology, 42, 1208, 10.1002/hep.20933 Harrell, 1996, Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors, Stat. Med., 15, 361, 10.1002/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4 Pencina, 2004, Overall C as a measure of discrimination in survival analysis: model specific population value and confidence interval estimation, Stat. Med., 23, 2109, 10.1002/sim.1802 Tsuyoshi, 2013, Prevention of recurrence after curative treatment for hepatocellular carcinoma, Surg. Today, 43, 1347, 10.1007/s00595-012-0473-5 Pinna, 2018, Liver transplantation and hepatic resection can achieve cure for hepatocellular carcinoma, Ann. Surg., 268, 868, 10.1097/SLA.0000000000002889 Calderaro, 2019, Intra-tumoral tertiary lymphoid structures are associated with a low risk of early recurrence of hepatocellular carcinoma, J. Hepatol., 70, 58, 10.1016/j.jhep.2018.09.003 Peng, 2013, Radiofrequency ablation with or without transcatheter arterial chemoembolization in the treatment of hepatocellular carcinoma: a prospective randomized trial, J. Clin. Oncol., 31, 426, 10.1200/JCO.2012.42.9936 Tanaka, 1999, Use of transcatheter arterial infusion of anticancer agents with lipiodol to prevent recurrence of hepatocellular carcinoma after hepatic resection, Hepato-Gastroenterology, 46, 1083 Xie, 2019, Adjuvant trans-arterial chemoembolization after hepatectomy significantly improves the prognosis of low-risk patients with R0-stage hepatocellular carcinoma, Canc. Manag. Res., 11, 4065 Sergio, 2008, Transcatheter arterial chemoembolization (TACE) in hepatocellular carcinoma (HCC): the role of angiogenesis and invasiveness, Am. J. Gastroenterol., 103, 914, 10.1111/j.1572-0241.2007.01712.x Chen, 2012, Preventive effects of jiedu granules combined with cinobufacini injection versus transcatheter arterial chemoembolization in post-surgical patients with hepatocellular carcinoma: a case-control trial, Chin. J. Integr. Med., 18, 339, 10.1007/s11655-012-1083-1 Lazuardi, 2019, Adjuvant transcatheter arterial chemoembolization after radical resection of hepatocellular carcinoma patients with tumor size less than 5cm: a retrospective study, Scand. J. Gastroenterol., 54, 617, 10.1080/00365521.2019.1607896 Chen, 2013, Lipiodolized transarterial chemoembolization in hepatocellular carcinoma patients after curative resection, J. Canc. Res. Clin. Oncol., 139, 773, 10.1007/s00432-012-1343-7 Zhai, 2013, Traditional herbal medicine in preventing recurrence after resection of small hepatocellular carcinoma: a multicenter randomized controlled trial, J Integr Med, 11, 90, 10.3736/jintegrmed2013021 Xu, 2019, Chinese herbal medicine (Chaihu-Huaji decoction) alleviates postembolization syndrome following transcatheter arterial chemoembolization and improves survival in unresectable hepatocellular cancer: a retrospective study, Evid. Based Complement. Alternat. Med. Cai, 2016, Neuroprotective effect of Shenqi Fuzheng injection pretreatment in aged rats with cerebral ischemia/reperfusion injury, Neural Regen. Res., 11, 94, 10.4103/1673-5374.175052 Lee, 2007, Regulatory effects of Codonopsis lanceolata on macrophage-mediated immune responses, J. Ethnopharmacol., 112, 180, 10.1016/j.jep.2007.02.026 Cho, 2015, Low serum interleukin-6 levels as a predictive marker of recurrence in patients with hepatitis B virus related hepatocellular carcinoma who underwent curative treatment, Cytokine, 73, 245, 10.1016/j.cyto.2015.02.027 Wang, 2016, Prognostic and therapeutic values of tumor necrosis factor-alpha in hepatocellular carcinoma, Med. Sci. Mon. Int. Med. J. Exp. Clin. Res., 22, 3694 Dubois-Pot-Schneider, 2014, Inflammatory cytokines promote the retrodifferentiation of tumor-derived hepatocyte-like cells to progenitor cells, Hepatology, 60, 2077, 10.1002/hep.27353 Fang, 2015, Inhibitory effects and mechanism of total saponins from Codonopsis pilosula on human hepatocellular carcinoma SMMC-7721 cells, China Pharm., 26, 1356 Qi, 2010, Proteomic characterization of the cellular response to chemopreventive triterpenoid astragaloside IV in human hepatocellular carcinoma cell line HepG2, Int. J. Oncol., 36, 725 Lv, 2012, The Chinese herbal decoction danggui buxue tang inhibits angiogenesis in a rat model of liver fibrosis, Evid. Based Complement. Alternat. Med., 10.1155/2012/284963 Liu, 2016, PPARγ activation reduces ischemia/reperfusion-induced metastasis in a murine model of hepatocellular carcinoma, Exp. Ther. Med., 11, 387, 10.3892/etm.2015.2934 Tamagawa, 2008, Hepatic ischemia-reperfusion increases vascular endothelial growth factor and cancer growth in rats, J. Surg. Res., 148, 158, 10.1016/j.jss.2007.12.787 Xie, 2018, Paeoniflorin protects against liver ischemia/reperfusion injury in mice via inhibiting HMGB1-TLR4 signaling pathway, Phytother Res., 32, 2247, 10.1002/ptr.6161 Arii, 1996, Overexpression of matrix metalloproteinase 9 gene in hepatocellular carcinoma with invasive potential, Hepatology, 24, 316, 10.1002/hep.510240206 Lu, 2014, Paeoniflorin inhibited the tumor invasion and metastasis in human hepatocellular carcinoma cells, Bratisl. Lek. Listy, 115, 427 Sohn, 2016, Effect of oral antiviral treatment on long-term outcomes of radiofrequency ablation therapy for hepatitis B virus-related hepatocellular carcinoma, Oncotarget, 7, 47794, 10.18632/oncotarget.10026 Chen, 2006, Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level, J. Am. Med. Assoc., 295, 65, 10.1001/jama.295.1.65 Zhang, 2018, 42,573 cases of hepatectomy in China: a multicenter retrospective investigation, Sci. China Life Sci., 61, 660, 10.1007/s11427-017-9259-9 Jun, 2012, Independent factors and predictive score for extrahepatic metastasis of hepatocellular carcinoma following curative hepatectomy, Oncol., 17, 963, 10.1634/theoncologist.2011-0447 Ye, 2017, Efficacy of postoperative adjuvant transcatheter arterial chemoembolization in hepatocellular carcinoma patients with microvascular invasion, World J. Gastroenterol., 23, 7415, 10.3748/wjg.v23.i41.7415 Wang, 2019, Does microvascular invasion in Barcelona Clinic Liver Cancer stage A multinodular hepatocellular carcinoma indicate early-stage behavior?, Ann. Transl. Med., 7, 428, 10.21037/atm.2019.08.114 Lei, 2016, Nomogram for preoperative estimation of microvascular invasion risk in hepatitis B virus-related hepatocellular carcinoma within the milan criteria, JAMA Surg, 151, 356, 10.1001/jamasurg.2015.4257 Zhong, 2019, Prognostic nomogram incorporating inflammatory cytokines for overall survival in patients with aggressive non-Hodgkin's lymphoma, EBioMedicine, 41, 167, 10.1016/j.ebiom.2019.02.048