Young Hoon Yoon1, Ki Wan Park1, Seung Hun Lee1, Hee Sung Park1, Jae Won Chang1, Bon Seok Koo1
1Department of Otorhinolaryngology-Head and Neck Surgery, Research Institute for Medical Sciences, School of Medicine, Chungnam National University, Daejeon, Korea
Tóm tắt
AbstractObjectivesProton‐pump inhibitor (PPI) prescribing practices in laryngopharyngeal reflux disease (LPR) differ among physicians. We assessed the improvement in reflux symptom index (RSI) and reflux finding score (RFS) after treating LPR with three different regimens.DesignA prospective, double‐blind, randomized clinical trial.SettingChungnam national university hospital in Korea.ParticipantsFrom July 2015 to July 2017, 100 patients with LPR included in the study. The patients were prescribed one of the following regimens for 3 months: group A, ilaprazole 10 mg, once a day (QD), n = 29; group B, ilaprazole 10 mg, twice a day (BID), n = 27; and group C, ilaprazole 10 mg BID plus mosapride citrate 5 mg three times a day (TID), n = 44.Main outcome measuresThe total RSI and RFS scores and each subitems in RSI and FRS of the patients were evaluated.ResultsTotal RFS and RSI scores improved significantly at the 3‐month follow‐up in all groups, and the improvements were of similar magnitudes. Regarding the RFS, the degrees of improvement in vocal cord oedema (P = 0.002) and diffuse laryngeal oedema (P = 0.003) scores differed significantly among the three groups. Moreover, overweight or obese patients in group C showed the greatest improvement in RFS. However, age had no effect on treatment efficacy.ConclusionThree PPI therapeutic strategies showed similar efficacies against LPR according to total RFS and RSI scores. The addition of a prokinetic resulted in improvements in specific endoscopic findings, such as vocal cord oedema and diffuse laryngeal oedema. Furthermore, the addition of a prokinetic to PPI therapy was particularly beneficial for overweight or obese patients.
