Efficacy of oxytocics on reducing intraoperative blood loss during abdominal myomectomy: A systematic review and meta-analysis of randomized placebo-controlled trials

Kongnyuy, 2014, Interventions to reduce haemorrhage during myomectomy for fibroids, Cochrane Database Syst Rev Celik, 2003, Use of a single preoperative dose of misoprostol is efficacious for patients who undergo abdominal myomectomy, Fertil Steril, 79, 1207, 10.1016/S0015-0282(03)00076-1 Thomas, 2010, Abdominal myomectomy–a safe procedure in an ambulatory setting, Fertil Steril, 94, 2277, 10.1016/j.fertnstert.2010.02.019 Sangha, 2015, Myomectomy to conserve fertility: seven-year follow-up, J Obstet Gynaecol Can, 37, 46, 10.1016/S1701-2163(15)30362-5 Ahmed, 2020, Effect of oxytocin infusion on reducing blood loss during abdominal myomectomy: a randomized controlled trial, J Pak Med Assoc, 70, 969 Clark, 2009, Oxytocin: new perspectives on an old drug, Am J Obstet Gynecol, 200, 35, 10.1016/j.ajog.2008.06.010 Atashkhoei, 2017, Effect of oxytocin infusion on reducing the blood loss during abdominal myomectomy: a double-blind randomised controlled trial, Bjog, 124, 292, 10.1111/1471-0528.14416 Taher, 2021, Evaluating efficacy of intravenous carbetocin in reducing blood loss during abdominal myomectomy: a randomized controlled trial, Fertil Steril, 115, 793, 10.1016/j.fertnstert.2020.09.132 Aslan Çetin, 2019, Oxytocin infusion reduces bleeding during abdominal myomectomies: a randomized controlled trial, Arch Gynecol Obstet, 299, 151, 10.1007/s00404-018-4944-9 Sallam, 2017, Intravenous carbetocin to decrease blood loss during open myomectomy: a randomized placebo-controlled study, Int J Reprod Contracept Obstet Gynecol, 7, 27, 10.18203/2320-1770.ijrcog20175827 Nasr Al-Deen, 2020, Effect of oxytocin infusion on reducing the blood loss during abdominal myomectomy: a randomized double-Blind controlled trial, Evid Based Women’s Health J, 10, 144 Mohamed Ahmed, 2020, Effect of oxytocin infusion on reducing blood loss during abdominal myomectomy, Al-Azhar Med J, 49, 797, 10.21608/amj.2020.68847 Moher, 2009, Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement, PLoS Med, 6, 10.1371/journal.pmed.1000097 Higgins J GS, editors. Cochrane handbook for systematic reviews of interventions version 5.1.0 [Internet]. [updated March 2011]. The Cochrane Collaboration, www.handbook.cochrane.org-AAf. Schmitz, 2020, [CNGOF guidelines for clinical practice: revision of the methodology], Gynecol Obstet Fertil Senol, 48, 3 Sterne, 2019, RoB 2: a revised tool for assessing risk of bias in randomised trials, Bmj, 366, l4898, 10.1136/bmj.l4898 Egger, 1997, Bias in meta-analysis detected by a simple, graphical test, Bmj, 315, 629, 10.1136/bmj.315.7109.629 Higgins, 2003, Measuring inconsistency in meta-analyses, Bmj, 327, 557, 10.1136/bmj.327.7414.557 Salati, 2019, Prophylactic oxytocin for the third stage of labour to prevent postpartum haemorrhage, Cochrane Database Syst Rev, 4 Yamaguchi, 2011, Serum oxytocin concentrations in elective caesarean delivery: a randomized comparison of three infusion regimens, Int J Obstet Anesth, 20, 224, 10.1016/j.ijoa.2011.03.004 Weston, 2003, Myometrial microvascular endothelial cells express oxytocin receptor, Bjog, 110, 149, 10.1046/j.1471-0528.2003.02259.x Wang, 2004, A simplified method to decrease operative blood loss in laparoscopic-assisted vaginal hysterectomy for the large uterus, J Am Assoc Gynecol Laparosc, 11, 370, 10.1016/S1074-3804(05)60053-9 Busnelli, 2010, Oxytocin-induced cell growth proliferation in human myometrial cells and leiomyomas, Fertil Steril, 94, 1869, 10.1016/j.fertnstert.2009.10.064 Lee, 1998, Oxytocin receptor and its messenger ribonucleic acid in human leiomyoma and myometrium, Am J Obstet Gynecol, 179, 620, 10.1016/S0002-9378(98)70054-7 Rath, 2009, Prevention of postpartum haemorrhage with the oxytocin analogue carbetocin, Eur J Obstet Gynecol Reprod Biol, 147, 15, 10.1016/j.ejogrb.2009.06.018 Agostini, 2005, Oxytocin during myomectomy: a randomized study, Eur J Obstet Gynecol Reprod Biol, 118, 235, 10.1016/j.ejogrb.2004.06.032 Hunter, 1992, Effect of carbetocin, a long-acting oxytocin analog on the postpartum uterus, Clin Pharmacol Ther, 52, 60, 10.1038/clpt.1992.103 Helal, 2010, Preliminary uterine artery ligation versus pericervical mechanical tourniquet in reducing hemorrhage during abdominal myomectomy, Int J Gynaecol Obstet, 108, 233, 10.1016/j.ijgo.2009.09.022 van der Nelson, 2017, Carbetocin versus oxytocin for prevention of post-partum haemorrhage at caesarean section in the United Kingdom: an economic impact analysis, Eur J Obstet Gynecol Reprod Biol, 210, 286, 10.1016/j.ejogrb.2017.01.004 Matthijsse, 2022, Cost-effectiveness analysis of carbetocin versus oxytocin for the prevention of postpartum hemorrhage following vaginal birth in the United Kingdom, J Med Econ, 25, 129, 10.1080/13696998.2022.2027669 Samy, 2020, Perioperative nonhormonal pharmacological interventions for bleeding reduction during open and minimally invasive myomectomy: a systematic review and network meta-analysis, Fertil Steril, 113, 224, 10.1016/j.fertnstert.2019.09.016