Efficacy of folic acid supplementation in cardiovascular disease prevention: An updated meta-analysis of randomized controlled trials

McCully, 1969, Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis, Am J Pathol, 56, 111

Curro, 2009, Homocysteine-induced toxicity increases TG2 expression in Neuro2a cells, Amino Acids, 36, 725, 10.1007/s00726-008-0122-x

Welch, 1998, Homocysteine and atherothrombosis, N Engl J Med, 338, 1042, 10.1056/NEJM199804093381507

Ridker, 1999, Homocysteine and risk of cardiovascular disease among postmenopausal women, JAMA, 281, 1817, 10.1001/jama.281.19.1817

Iso, 2004, Serum total homocysteine concentrations and risk of stroke and its subtypes in Japanese, Circulation, 109, 2766, 10.1161/01.CIR.0000131942.77635.2D

2002, Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis, JAMA, 288, 2015, 10.1001/jama.288.16.2015

Jacob, 1994, Homocysteine increases as folate decreases in plasma of healthy men during short-term dietary folate and methyl group restriction, J Nutr, 124, 1072, 10.1093/jn/124.7.1072

Wilcken, 1997, The natural history of vascular disease in homocystinuria and the effects of treatment, J Inherit Metab Dis, 20, 295, 10.1023/A:1005373209964

Vermeulen, 2000, Effect of homocysteine-lowering treatment with folic acid plus vitamin B6 on progression of subclinical atherosclerosis: a randomised, placebo-controlled trial, Lancet, 355, 517, 10.1016/S0140-6736(99)07391-2

Hodis, 2009, High-dose B vitamin supplementation and progression of subclinical atherosclerosis: a randomized controlled trial, Stroke, 40, 730, 10.1161/STROKEAHA.108.526798

Lonn, 2006, Homocysteine lowering with folic acid and B vitamins in vascular disease, N Engl J Med, 354, 1567, 10.1056/NEJMoa060900

Toole, 2004, Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial, JAMA, 291, 565, 10.1001/jama.291.5.565

CM, 2008, Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial, JAMA, 299, 2027, 10.1001/jama.299.17.2027

Marti-Carvajal, 2009, Homocysteine lowering interventions for preventing cardiovascular events, Cochrane Database Syst Rev, CD006612

Higgins, 2008

Moher, 1999, Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Quality of reporting of meta-analyses, Lancet, 354, 1896, 10.1016/S0140-6736(99)04149-5

Higgins, 2002, Quantifying heterogeneity in a meta-analysis, Stat Med, 21, 1539, 10.1002/sim.1186

Higgins, 2003, Measuring inconsistency in meta-analyses, BMJ, 327, 557, 10.1136/bmj.327.7414.557

Greenland, 1985, Estimation of a common effect parameter from sparse follow-up data, Biometrics, 41, 55, 10.2307/2530643

Mantel, 1959, Statistical aspects of the analysis of data from retrospective studies of disease, J Natl Cancer Inst, 22, 719

Sterne, 2001, Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis, J Clin Epidemiol, 54, 1046, 10.1016/S0895-4356(01)00377-8

Liem, 2003, Secondary prevention with folic acid: effects on clinical outcomes, J Am Coll Cardiol, 41, 2105, 10.1016/S0735-1097(03)00485-6

Nanayakkara, 2009, Randomized placebo-controlled trial assessing a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on plasma asymmetric dimethylarginine concentration in mild to moderate CKD, Am J Kidney Dis, 53, 41, 10.1053/j.ajkd.2008.06.016

Rakhit, 2006, Effect of aggressive risk factor modification on cardiac events and myocardial ischaemia in patients with chronic kidney disease, Heart, 92, 1402, 10.1136/hrt.2005.074393

Mark, 1996, Lowered risks of hypertension and cerebrovascular disease after vitamin/mineral supplementation: the Linxian Nutrition Intervention Trial, Am J Epidemiol, 143, 658, 10.1093/oxfordjournals.aje.a008798

Schnyder, 2002, Effect of homocysteine-lowering therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after percutaneous coronary intervention: the Swiss Heart study: a randomized controlled trial, JAMA, 288, 973, 10.1001/jama.288.8.973

Righetti, 2003, Effects of folic acid treatment on homocysteine levels and vascular disease in hemodialysis patients, Med Sci Monit, 9, PI37

Righetti, 2006, Homocysteine-lowering vitamin B treatment decreases cardiovascular events in hemodialysis patients, Blood Purif, 24, 379, 10.1159/000093680

Lange, 2004, Folate therapy and in-stent restenosis after coronary stenting, N Engl J Med, 350, 2673, 10.1056/NEJMoa032845

Liem, 2004, Efficacy of folic acid when added to statin therapy in patients with hypercholesterolemia following acute myocardial infarction: a randomised pilot trial, Int J Cardiol, 93, 175, 10.1016/j.ijcard.2003.02.001

Liem, 2005, Secondary prevention with folic acid: results of the Goes extension study, Heart, 91, 1213, 10.1136/hrt.2004.035030

Wrone, 2004, Randomized trial of folic acid for prevention of cardiovascular events in end-stage renal disease, J Am Soc Nephrol, 15, 420, 10.1097/01.ASN.0000110181.64655.6C

Bonaa, 2006, Homocysteine lowering and cardiovascular events after acute myocardial infarction, N Engl J Med, 354, 1578, 10.1056/NEJMoa055227

Zoungas, 2006, Cardiovascular morbidity and mortality in the Atherosclerosis and Folic Acid Supplementation Trial (ASFAST) in chronic renal failure: a multicenter, randomized, controlled trial, J Am Coll Cardiol, 47, 1108, 10.1016/j.jacc.2005.10.064

Jamison, 2007, Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trial, JAMA, 298, 1163, 10.1001/jama.298.10.1163

Vianna, 2007, Uremic hyperhomocysteinemia: a randomized trial of folate treatment for the prevention of cardiovascular events, Hemodial Int, 11, 210, 10.1111/j.1542-4758.2007.00171.x

Ebbing, 2008, Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: a randomized controlled trial, JAMA, 300, 795, 10.1001/jama.300.7.795

Potena, 2008, Long-term effect of folic acid therapy in heart transplant recipients: follow-up analysis of a randomized study, Transplantation, 85, 1146, 10.1097/TP.0b013e31816b2602

Baker, 2002, Blind comparison of folic acid and placebo in patients with ischemic heart disease: an outcome trial, Circulation, 106, A 3642

2010, B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial: a randomised, double-blind, parallel, placebo-controlled trial, Lancet Neurol, 9, 855, 10.1016/S1474-4422(10)70187-3

Armitage, 2010, Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors: a randomized trial, JAMA, 303, 2486, 10.1001/jama.2010.840

Galan, 2010, Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a randomised placebo controlled trial, BMJ, 341, c6273, 10.1136/bmj.c6273

Bostom, 2011, Homocysteine-lowering and cardiovascular disease outcomes in kidney transplant recipients: primary results from the Folic Acid for Vascular Outcome Reduction in Transplantation trial, Circulation, 123, 1763, 10.1161/CIRCULATIONAHA.110.000588

Imasa, 2009, Folic acid-based intervention in non-ST elevation acute coronary syndromes, Asian Cardiovasc Thorac Ann, 17, 13, 10.1177/0218492309102494

House, 2010, Effect of B-vitamin therapy on progression of diabetic nephropathy: a randomized controlled trial, JAMA, 303, 1603, 10.1001/jama.2010.490

Heinz, 2010, B vitamins and the risk of total mortality and cardiovascular disease in end-stage renal disease: results of a randomized controlled trial, Circulation, 121, 1432, 10.1161/CIRCULATIONAHA.109.904672

Hassan, 2004, Homocysteine is a risk factor for cerebral small vessel disease, acting via endothelial dysfunction, Brain, 127, 212, 10.1093/brain/awh023

Shirodaria, 2007, Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease, Circulation, 115, 2262, 10.1161/CIRCULATIONAHA.106.679084

Yang, 2006, Improvement in stroke mortality in Canada and the United States, 1990 to 2002, Circulation, 113, 1335, 10.1161/CIRCULATIONAHA.105.570846

Lieb, 2009, Multimarker approach to evaluate correlates of vascular stiffness: the Framingham Heart Study, Circulation, 119, 37, 10.1161/CIRCULATIONAHA.108.816108

Menon, 2006, Relationship between homocysteine and mortality in chronic kidney disease, Circulation, 113, 1572, 10.1161/CIRCULATIONAHA.105.570127

Mikael, 2006, Elevated homocysteine reduces apolipoprotein A-I expression in hyperhomocysteinemic mice and in males with coronary artery disease, Circ Res, 98, 564, 10.1161/01.RES.0000204825.66410.0b

Liao, 2006, Hyperhomocysteinemia decreases circulating high-density lipoprotein by inhibiting apolipoprotein A-I Protein synthesis and enhancing HDL cholesterol clearance, Circ Res, 99, 598, 10.1161/01.RES.0000242559.42077.22

Qujeq, 2001, Correlation between total homocysteine, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol in the serum of patients with myocardial infarction, Clin Biochem, 34, 97, 10.1016/S0009-9120(01)00187-4

Bostom, 1996, Elevated plasma lipoprotein(a) and coronary heart disease in men aged 55 years and younger. A prospective study, JAMA, 276, 544, 10.1001/jama.1996.03540070040028

Nissen, 2006, Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial, JAMA, 295, 1556, 10.1001/jama.295.13.jpc60002