Efficacy of Cilostazol in Prevention of Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage: A Meta-Analysis

Broderick, 1994, Initial and recurrent bleeding are the major causes of death following subarachnoid hemorrhage, Stroke, 25, 1342, 10.1161/01.STR.25.7.1342 Etminan, 2011, Effect of pharmaceutical treatment on vasospasm, delayed cerebral ischemia, and clinical outcome in patients with aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis, J Cereb Blood Flow Metab, 31, 1443, 10.1038/jcbfm.2011.7 Petruk, 1988, Nimodipine treatment in poor-grade aneurysm patients, J Neurosurg, 68, 505, 10.3171/jns.1988.68.4.0505 Macdonald, 2011, Clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid haemorrhage undergoing surgical clipping: a randomised, double-blind, placebo-controlled phase 3 trial (CONSCIOUS-2), Lancet Neurol, 10, 618, 10.1016/S1474-4422(11)70108-9 Budohoski, 2014, The pathophysiology and treatment of delayed cerebral ischaemia following subarachnoid haemorrhage, J Neurol Neurosurg Psychiatry, 85, 1343, 10.1136/jnnp-2014-307711 Francoeur, 2016, Management of delayed cerebral ischemia after subarachnoid hemorrhage, Crit Care, 20, 277, 10.1186/s13054-016-1447-6 Liu, 2006, Cilostazol (Pletal®): A Dual Inhibitor of Cyclic Nucleotide Phosphodiesterase Type 3 and Adenosine Uptake, Cardiovasc Drug Rev, 19, 369, 10.1111/j.1527-3466.2001.tb00076.x Yamaguchi-Okada, 2009, Multifaceted Effects of Selective Inhibitor of Phosphodiesterase III, Cilostazol, for Cerebral Vasospasm after Subarachnoid Hemorrhage in a Dog Model, Cerebrovasc Dis, 28, 135, 10.1159/000223439 Matsumoto, 1999, Comparative study of antiplatelet drugs in vitro: distinct effects of cAMP-elevating drugs and GPIIb/IIIa antagonists on thrombin-induced platelet responses, Thromb Res, 95, 19, 10.1016/S0049-3848(98)00189-3 Choi, 2002, Neuroprotective Effect of Cilostazol against Focal Cerebral Ischemia via Antiapoptotic Action in Rats, J. Pharmacol. Exp. Ther, 300, 10.1124/jpet.300.3.787 Hasegawa, 2011, Apoptotic Mechanisms for Neuronal Cells in Early Brain Injury After Subarachnoid Hemorrhage, 43 Matsuda, 2016, Effect of Cilostazol on Cerebral Vasospasm and Outcome in Patients with Aneurysmal Subarachnoid Hemorrhage: A Randomized, Double-Blind, Placebo-Controlled Trial, Cerebrovasc Dis, 42, 97, 10.1159/000445509 Kimura, 2015, Cilostazol Administration with Combination Enteral and Parenteral Nutrition Therapy Remarkably Improves Outcome After Subarachnoid Hemorrhage, 147 Senbokuya, 2013, Effects ofcilostazol on cerebral vasospasm after aneurysmal subarachnoid hemorrhage: a multicenter prospective, randomized, open-label blinded end point trial, J Neurosurg, 118, 121, 10.3171/2012.9.JNS12492 Suzuki, 2011, Cilostazol Improves Outcome after Subarachnoid Hemorrhage: A Preliminary Report, Cerebrovasc Dis, 32, 89, 10.1159/000327040 Yoshimoto, 2009, Cilostazol may prevent cerebral vasospasm following subarachnoid hemorrhage, Neurol Med Chir (Tokyo), 49, 235, 10.2176/nmc.49.235 Diringer, 2011, Critical Care Management of Patients Following Aneurysmal Subarachnoid Hemorrhage: Recommendations from the Neurocritical Care Society's Multidisciplinary Consensus Conference, Neurocrit Care, 15, 211, 10.1007/s12028-011-9605-9 Ba, 2014, Effect of cilostazol pretreatment on the PARP/AIF-mediated apoptotic pathway in rat cerebral ischemia-reperfusion models, Exp Ther Med, 7, 1209, 10.3892/etm.2014.1551 Ota, 2008, Cilostazol Inhibits Oxidative Stress-Induced Premature Senescence Via Upregulation of Sirt1 in Human Endothelial Cells, Arterioscler Thromb Vasc Biol, 28, 1634, 10.1161/ATVBAHA.108.164368 Park, 2011, HO-1 Induced by Cilostazol Protects Against TNF-α-associated Cytotoxicity via a PPAR-γ-dependent Pathway in Human Endothelial Cells, Korean J Physiol Pharmacol, 15, 83, 10.4196/kjpp.2011.15.2.83 Niu, 2014, Effect of cilostazol in patients with aneurysmal subarachnoid hemorrhage: Asystematic review and meta-analysis, J Neurol Sci, 336, 146, 10.1016/j.jns.2013.10.027 Boulouis, 2017, Treatment of cerebral vasospasm following aneurysmal subarachnoid haemorrhage: a systematic review and meta-analysis, Eur Radiol, 27, 3333, 10.1007/s00330-016-4702-y