Hiệu quả và tính an toàn của cangrelor so với ticagrelor ở bệnh nhân nhồi máu cơ tim ST chênh lên (STEMI): một đánh giá hệ thống và phân tích tổng hợp
Tóm tắt
Đánh giá hệ thống và phân tích tổng hợp này nhằm mục đích so sánh hiệu quả và tính an toàn của cangrelor so với ticagrelor ở những bệnh nhân nhồi máu cơ tim ST chênh lên (STEMI) đã trải qua can thiệp theo đường xuyên thành mạch.
Các cơ sở dữ liệu PubMed, Embase, Scopus, Web of Science, Cochrane CENTRAL, và ClinicalTrials.gov đã được tìm kiếm để thu thập các nghiên cứu so sánh trực tiếp hoặc thay thế liên quan. Kết quả chính là tỷ lệ phản ứng tiểu cầu cao (HPR) tại các khoảng thời gian cụ thể sau khi ngừng tiêm cangrelor trong 24 giờ đầu. Các kết quả thứ hai bao gồm nguy cơ hình thành cục máu đông, tỷ lệ tử vong do tất cả các nguyên nhân và chảy máu. Tỷ lệ odds biến thiên (OR) được tính toán bằng cách sử dụng mô hình ngẫu nhiên.
Từ khóa
#cangrelor #ticagrelor #nhồi máu cơ tim ST chênh lên #phân tích tổng hợp #hiệu quả #tính an toànTài liệu tham khảo
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