Efficacy and Safety of Secukinumab 150 mg with and Without Loading Regimen in Ankylosing Spondylitis: 104-week Results from MEASURE 4 Study

Alan Kivitz1, Ulf Wagner2, Eva Dokoupilová3, Jerzy Supronik4, Ruvie Martin5, Zsolt Talloczy5, Hanno B. Richards6, Brian Porter5
1Altoona Center for Clinical Research, Duncansville, USA
2University of Leipzig, Leipzig, Germany
3Medical Plus, s.r.o., Uherske Hradiste, and University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic
4NZOZ Centrum Medyczne Artur Racewicz, Bialystok, Poland
5Novartis Pharmaceuticals Corporation, East Hanover, USA
6Novartis Pharma AG, Basel, Switzerland

Tóm tắt

Từ khóa


Tài liệu tham khảo

Braun J, Sieper J. Ankylosing spondylitis. Lancet. 2007;369:1379–90.

Dougados M, Baeten D. Spondyloarthritis. Lancet. 2011;377:2127–37.

Garg N, van den Bosch F, Deodhar A. The concept of spondyloarthritis: where are we now? Best Pract Res Clin Rheumatol. 2014;28:663–72.

Braun J, van den Berg R, Baraliakos X, et al. 2010 update of the ASAS/EULAR recommendations for the management of ankylosing spondylitis. Ann Rheum Dis. 2011;70:896–904.

van der Heijde D, Ramiro S, Landewe R, et al. 2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis. Ann Rheum Dis. 2017;76:978–91.

Baeten D, Sieper J, Braun J, et al. Secukinumab, an interleukin-17A inhibitor, in ankylosing spondylitis. N Engl J Med. 2015;373:2534–48.

Braun J, Baraliakos X, Deodhar A, et al. Effect of secukinumab on clinical and radiographic outcomes in ankylosing spondylitis: 2-year results from the randomised phase III MEASURE 1 study. Ann Rheum Dis. 2017;76:1070–7.

Baraliakos X, Kivitz AJ, Deodhar A, et al. Long-term effects of interleukin-17A inhibition with secukinumab in active ankylosing spondylitis: 3-year efficacy and safety results from an extension of the phase 3 MEASURE 1 trial. Clin Exp Rheumatol. 2018;36:50–5.

Marzo-Ortega H, Sieper J, Kivitz AJ, et al. Secukinumab and sustained improvement in signs and symptoms of patients with active ankylosing spondylitis through 2 years: results from a phase III study. Arthritis Care Res (Hoboken). 2017;69:1020–9.

Marzo-Ortega H, Sieper J, Kivitz A, et al. Secukinumab provides sustained improvements in the signs and symptoms of active ankylosing spondylitis with high retention rate: 3-year results from the phase III trial, MEASURE 2. RMD Open. 2017. https://doi.org/10.1136/rmdopen-2017-000592 .

van der Linden S, Valkenburg HA, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum. 1984;27:361–8.

Garrett S, Jenkinson T, Kennedy LG, et al. A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol. 1994;21:2286–91.

World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA. 2013;310:2191–4.

Sieper J, Rudwaleit M, Baraliakos X, et al. The Assessment of SpondyloArthritis international Society (ASAS) handbook: a guide to assess spondyloarthritis. Ann Rheum Dis. 2009;68:1–ii44.

Braun J, Davis J, Dougados M, et al. First update of the international ASAS consensus statement for the use of anti-TNF agents in patients with ankylosing spondylitis. Ann Rheum Dis. 2006;65:316–20.

Ware JE Jr. SF-36 health survey update. Spine. 2000;25:3130–9.

Doward LC, Spoorenberg A, Cook SA, et al. Development of the ASQoL: a quality of life instrument specific to ankylosing spondylitis. Ann Rheum Dis. 2003;62:20–6.

Pavelka K, Kivitz A, Dokoupilova E, et al. Efficacy, safety, and tolerability of secukinumab in patients with active ankylosing spondylitis: a randomized, double-blind phase 3 study, MEASURE 3. Arthritis Res Ther. 2017;19:285.

Kivitz AJ, Gutierrez-Urena SR, Poiley J, et al. Peficitinib, a JAK inhibitor, in the treatment of moderate-to-severe rheumatoid arthritis in patients with an inadequate response to methotrexate. Arthritis Rheumatol. 2017;69:709–19.