Efficacy and Safety of Plant Stanols and Sterols in the Management of Blood Cholesterol Levels
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Lichtenstein, 2001, AHA Science Advisory: stanol/sterol ester-containing foods and blood cholesterol levels: a statement for healthcare professionals from the Nutrition Committee of the Council on Nutrition, Physical Activity, and Metabolism of the American Heart Association, Circulation, 103, 1177, 10.1161/01.CIR.103.8.1177
Jones, 2001, Plant sterols and their derivatives: the current spread of results, Nutr Rev, 59, 21, 10.1111/j.1753-4887.2001.tb01901.x
Plat, 2001, Effects of plant sterols and stanols on lipid metabolism and cardiovascular risk, Nutr Metab Cardiovasc Dis, 11, 31
Vahouny, 1981, Plant and marine sterols and cholesterol metabolism, 31
Vissers, 2000, Effect of plant sterols from rice bran oil and triterpene alcohols from sheanut oil on serum lipoprotein concentrations in humans, Am J Clin Nutr, 72, 1510, 10.1093/ajcn/72.6.1510
Heinemann, 1993, Comparison of intestinal absorption of cholesterol with different plant sterols in man, Eur J Clin Invest, 23, 827, 10.1111/j.1365-2362.1993.tb00737.x
Lütjohann, 1995, Sterol absorption and sterol balance in phytosterolemia evaluated by deuterium-labeled sterols: effect of sitostanol treatment, J Lipid Res, 36, 1763, 10.1016/S0022-2275(20)41495-6
Czubayko, 1991, A simplified micro-method for quantification of fecal excretion of neutral and acidic sterols for outpatient studies in humans, J Lipid Res, 32, 1861, 10.1016/S0022-2275(20)41640-2
von Bergmann, 1999, Metabolism and mechanism of action of plant sterols, Eur Heart J Suppl, 1, S45
Jones, 2000, Modulation of plasma lipid levels and cholesterol kinetics by phytosterol versus phytostanol esters, J Lipid Res, 41, 697, 10.1016/S0022-2275(20)32378-6
Normen, 2000, Soy sterol esters and beta-sitostanol ester as inhibitors of cholesterol absorption in human small bowel, Am J Clin Nutr, 71, 908, 10.1093/ajcn/71.4.908
Miettinen, 2000, Serum, biliary, and fecal cholesterol and plant sterols in colectomized patients before and during consumption of stanol ester margarine, Am J Clin Nutr, 71, 1095, 10.1093/ajcn/71.5.1095
Lee, 2001, Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption, Nat Genet, 27, 79, 10.1038/83799
Berge, 2000, Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters, Science, 290, 1771, 10.1126/science.290.5497.1771
Hendriks, 1999, Spreads enriched with three different levels of vegetable oil sterols and the degree of cholesterol lowering in normocholesterolaemic and mildly hypercholesterolaemic subjects, Eur J Clin Nutr, 53, 319, 10.1038/sj.ejcn.1600728
Vanhanen, 1994, Serum levels, absorption efficiency, faecal elimination and synthesis of cholesterol during increasing doses of dietary sitostanol esters in hypercholesterolaemic subjects, Clin Sci (Lond), 87, 61, 10.1042/cs0870061
Hallikainen, 2000, Plant stanol esters affect serum cholesterol concentrations of hypercholesterolemic men and women in a dose-dependent manner, J Nutr, 130, 767, 10.1093/jn/130.4.767
Morton, 1995, Intakes and major dietary sources of cholesterol and phytosterols in the British diet, J Hum Nutr Diet, 8, 429, 10.1111/j.1365-277X.1995.tb00338.x
Miettinen, 1990, Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population, Am J Epidemiol, 131, 20, 10.1093/oxfordjournals.aje.a115479
Normen, 2001, Plant sterol intakes and colorectal cancer risk in the Netherlands Cohort Study on diet and cancer, Am J Clin Nutr, 74, 141, 10.1093/ajcn/74.1.141
Vuoristo, 1994, Absorption, metabolism, and serum concentrations of cholesterol in vegetarians: effects of cholesterol feeding, Am J Clin Nutr, 59, 1325, 10.1093/ajcn/59.6.1325
Pollak, 1981, vol 10
Cater, 1998, Lowering serum cholesterol with plant sterols and stanols: historical perspectives, 6
Grundy, 1969, The interaction of cholesterol absorption and cholesterol synthesis in man, J Lipid Res, 10, 304, 10.1016/S0022-2275(20)43088-3
Grundy, 1977, Determination of cholesterol absorption in man by intestinal perfusion, J Lipid Res, 18, 263, 10.1016/S0022-2275(20)41706-7
Mattson, 1977, Effect of plant sterol esters on the absorption of dietary cholesterol, J Nutr, 107, 1139, 10.1093/jn/107.7.1139
Jones, 1999, Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men, Am J Clin Nutr, 69, 1144, 10.1093/ajcn/69.6.1144
Williams, 1999, Plant stanol ester and bran fiber in childhood: effects of lipids, stool weight and stool frequency in preschool children, J Am Coll Nutr, 18, 572, 10.1080/07315724.1999.10718891
Tammi, 2000, Plant stanol ester margarine lowers serum total and low-density lipoprotein cholesterol concentrations of healthy children: the STRIP Project, J Pediatr, 136, 503, 10.1016/S0022-3476(00)90014-3
Matvienko, 2002, A single daily dose of soybean phytosterols in ground beef decreases serum total cholesterol and LDL cholesterol in young, mildly hypercholesterolemic men, Am J Clin Nutr, 76, 57, 10.1093/ajcn/76.1.57
Plat, 2000, Effects on serum lipids, lipoproteins and fat soluble antioxidant concentrations of consumption frequency of margarines and shortenings enriched with plant stanol esters, Eur J Clin Nutr, 54, 671, 10.1038/sj.ejcn.1601071
Plat, 2000, Vegetable oil based versus wood based stanol ester mixtures: effects on serum lipids and hemostatic factors in non-hypercholesterolemic subjects, Atherosclerosis, 148, 101, 10.1016/S0021-9150(99)00261-0
Jones, 1998, Short-term administration of tall oil phytosterols improves plasma lipid profiles in subjects with different cholesterol levels, Metabolism, 47, 751, 10.1016/S0026-0495(98)90041-5
Mensink, 2002, Effects of plant stanol esters supplied in a low-fat yoghurt on serum lipids and lipoproteins, non-cholesterol sterols and fat soluble antioxidant concentrations, Atherosclerosis, 160, 205, 10.1016/S0021-9150(01)00562-7
Niinikoski, 1997, Cholesterol-lowering effect and sensory properties of sitostanol ester margarine in normocholesterolemic adults, Scand J Nutr, 41, 9
Mussner, 2002, Effects of phytosterol ester-enriched margarine on plasma lipoproteins in mild to moderate hypercholesterolemia are related to basal cholesterol and fat intake, Metabolism, 51, 189, 10.1053/meta.2002.29988
Hallikainen, 1999, Effects of 2 low-fat stanol ester-containing margarines on serum cholesterol concentrations as part of a low-fat diet in hypercholesterolemic subjects, Am J Clin Nutr, 69, 403, 10.1093/ajcn/69.3.403
Sierksma, 1999, Spreads enriched with plant sterols, either esterified 4,4-dimethylsterols or free 4-desmethylsterols, and plasma total- and LDL-cholesterol concentrations, Br J Nutr, 82, 273, 10.1017/S0007114599001476
Weststrate, 1998, Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects, Eur J Clin Nutr, 52, 334, 10.1038/sj.ejcn.1600559
Miettinen, 1994, Dietary sitostanol related to absorption, synthesis and serum level of cholesterol in different apolipoprotein E phenotypes, Atherosclerosis, 105, 217, 10.1016/0021-9150(94)90052-3
Davidson, 2001, Safety and tolerability of esterifed phytosterols administered in reduced-fat spread and salad dressing to healthy adult men and women, J Am Coll Nutr, 20, 307, 10.1080/07315724.2001.10719051
Vanhanen, 1993, Serum cholesterol, cholesterol precursors, and plant sterols in hypercholesterolemic subjects with different apoE phenotypes during dietary sitostanol ester treatment, J Lipid Res, 34, 1535, 10.1016/S0022-2275(20)36946-7
Homma, 2000, Cholesterol and apolipoprotein-lowering effect of plant stanol ester in healthy Japanese men and women, J Jpn Soc Nutr Food Sci, 53, 155, 10.4327/jsnfs.53.155
Vanstone, 2002, Unesterified plant sterols and stanols lower LDL-cholesterol concentrations equivalently in hypercholesterolemic persons, Am J Clin Nutr, 76, 1272, 10.1093/ajcn/76.6.1272
Hallikainen, 2000, Comparison of the effects of plant sterol ester and plant stanol ester-enriched margarines in lowering serum cholesterol concentrations in hypercholesterolaemic subjects on a low-fat diet, Eur J Clin Nutr, 54, 715, 10.1038/sj.ejcn.1601083
Miettinen, 1995, Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population, N Engl J Med, 333, 1308, 10.1056/NEJM199511163332002
Gylling, 1999, Retinol, vitamin D, carotenes and alpha-tocopherol in serum of a moderately hypercholesterolemic population consuming sitostanol ester margarine, Atherosclerosis, 145, 279, 10.1016/S0021-9150(99)00078-7
Gylling, 1997, Reduction of serum cholesterol in postmenopausal women with previous myocardial infarction and cholesterol malabsorption induced by dietary sitostanol ester margarine: women and dietary sitostanol, Circulation, 96, 4226, 10.1161/01.CIR.96.12.4226
Christiansen, 2001, Cholesterol-lowering effect of spreads enriched with microcrystalline plant sterols in hypercholesterolemic subjects, Eur J Nutr, 40, 66, 10.1007/s003940170017
Volpe, 2001, Effects of yoghurt enriched with plant sterols on serum lipids in patients with moderate hypercholesterolaemia, Br J Nutr, 86, 233, 10.1079/BJN2001395
Raeini-Sarjaz, 2002, No changes in serum fat-soluble vitamin and carotenoid concentrations with the intake of plant sterol/stanol esters in the context of a controlled diet, Metabolism, 51, 652, 10.1053/meta.2002.32021
Neil, 2001, Randomised controlled trial of use by hypercholesterolaemic patients of a vegetable oil sterol-enriched fat spread, Atherosclerosis, 156, 329, 10.1016/S0021-9150(00)00653-5
Gylling, 1999, Cholesterol reduction by different plant stanol mixtures and with variable fat intake, Metabolism, 48, 575, 10.1016/S0026-0495(99)90053-7
Nguyen, 1999, Cholesterol-lowering effect of stanol ester in a US population of mildly hypercholesterolemic men and women: a randomized controlled trial, Mayo Clin Proc, 74, 1198, 10.4065/74.12.1198
Andersson, 1999, Cholesterol-lowering effects of a stanol ester-containing low-fat margarine used in conjunction with a strict lipid-lowering diet, Eur Heart J Suppl, 1, S80
Blair, 2000, Incremental reduction of serum total cholesterol and low-density lipoprotein cholesterol with the addition of plant stanol ester-containing spread to statin therapy, Am J Cardiol, 86, 46, 10.1016/S0002-9149(00)00976-0
Tikkanen, 2001, Effect of a diet based on low-fat foods enriched with nonesterified plant sterols and mineral nutrients on serum cholesterol, Am J Cardiol, 88, 1157, 10.1016/S0002-9149(01)02053-7
Noakes, 2002, An increase in dietary carotenoids when consuming plant sterols or stanols is effective in maintaining plasma carotenoid concentrations, Am J Clin Nutr, 75, 79, 10.1093/ajcn/75.1.79
Gylling, 1994, Serum cholesterol and cholesterol and lipoprotein metabolism in hypercholesterolaemic NIDDM patients before and during sitostanol ester-margarine treatment, Diabetologia, 37, 773, 10.1007/BF00404334
Nigon, 2001, Plant sterol-enriched margarine lowers plasma LDL in hyperlipidemic subjects with low cholesterol intake: effect of fibrate treatment, Clin Chem Lab Med, 39, 634, 10.1515/CCLM.2001.103
Maki, 2001, Lipid responses to plant-sterol-enriched reduced-fat spreads incorporated into a National Cholesterol Education Program Step I diet, Am J Clin Nutr, 74, 33, 10.1093/ajcn/74.1.33
Nestel, 2001, Cholesterol-lowering effects of plant sterol esters and non-esterified stanols in margarine, butter and low-fat foods, Eur J Clin Nutr, 55, 1084, 10.1038/sj.ejcn.1601264
Gylling, 1996, Effects of inhibiting cholesterol absorption and synthesis on cholesterol and lipoprotein metabolism in hypercholesterolemic non-insulin-dependent diabetic men, J Lipid Res, 37, 1776, 10.1016/S0022-2275(20)39121-5
Blomqvist, 1993, Effect of sitostanol ester on composition and size distribution of LDL and HDL, Nutr Metab Cardiovasc Dis, 3, 158
Hendriks, 2003, Safety of long-term consumption of plant sterol esters-enriched spread, Eur J Clin Nutr, 57, 681, 10.1038/sj.ejcn.1601598
Denke, 1995, Lack of efficacy of low-dose sitostanol therapy as an adjunct to a cholesterol-lowering diet in men with moderate hypercholesterolemia, Am J Clin Nutr, 61, 392, 10.1093/ajcn/61.2.392
Ostlund, 1999, Sitostanol administered in lecithin micelles potently reduces cholesterol absorption in human subjects, Am J Clin Nutr, 70, 826, 10.1093/ajcn/70.5.826
Meguro, 2001, Solubilization of phytosterols in diacylglycerol versus triacylglycerol improves the serum cholesterol-lowering effect, Eur J Clin Nutr, 55, 513, 10.1038/sj.ejcn.1601173
Becker, 1993, Treatment of severe familial hypercholesterolemia in childhood with sitosterol and sitostanol, J Pediatr, 122, 292, 10.1016/S0022-3476(06)80136-8
Geelen, 2002, Apolipoprotein E polymorphism and serum lipid response to plant sterols in humans, Eur J Clin Invest, 32, 738, 10.1046/j.1365-2362.2002.01061.x
Jenkins, 2001, Effect of a very-high-fiber vegetable, fruit, and nut diet on serum lipids and colonic function, Metabolism, 50, 494, 10.1053/meta.2001.21037
Vuorio, 2000, Stanol ester margarine alone and with simvastatin lowers serum cholesterol in families with familial hypercholesterolemia caused by the FH-North Karelia mutation, Arterioscler Thromb Vasc Biol, 20, 500, 10.1161/01.ATV.20.2.500
Bradford, 1991, Expanded Clinical Evaluation of Lovastatin (EXCEL) study results, I: efficacy in modifying plasma lipoproteins and adverse event profile in 8245 patients with moderate hypercholesterolemia, Arch Intern Med, 151, 43, 10.1001/archinte.1991.00400010067008
Jones, 1998, Comparative dose efficacy study of atorvastatin versus simvastatin, pravastatin, lovastatin, and fluvastatin in patients with hypercholesterolemia (the CURVES study) [published correction appears in Am J Cardiol. 1998;82:128], Am J Cardiol, 81, 582, 10.1016/S0002-9149(97)00965-X
Gylling, 1995, The effect of cholesterol absorption inhibition on low density lipoprotein cholesterol level, Atherosclerosis, 117, 305, 10.1016/0021-9150(95)05566-F
Gylling, 2002, LDL cholesterol lowering by bile acid malabsorption during inhibited synthesis and absorption of cholesterol in hypercholesterolemic coronary subjects, Nutr Metab Cardiovasc Dis, 12, 19
Moghadasian, 1997, “Tall oil”-derived phytosterols reduce atherosclerosis in ApoE-deficient mice, Arterioscler Thromb Vasc Biol, 17, 119, 10.1161/01.ATV.17.1.119
Ntanios, 1998, Dietary sitostanol reduces plaque formation but not lecithin cholesterol acyl transferase activity in rabbits, Atherosclerosis, 138, 101, 10.1016/S0021-9150(98)00008-2
Volger, 2001, Dietary vegetable oil and wood derived plant stanol esters reduce atherosclerotic lesion size and severity in apoE*3-Leiden transgenic mice, Atherosclerosis, 157, 375, 10.1016/S0021-9150(00)00750-4
Moghadasian, 1999, Proatherogenic and antiatherogenic effects of probucol and phytosterols in apolipoprotein E-deficient mice: possible mechanisms of action, Circulation, 99, 1733, 10.1161/01.CIR.99.13.1733
Moghadasian, 1999, Lack of regression of atherosclerotic lesions in phytosterol-treated apo E-deficient mice, Life Sci, 64, 1029, 10.1016/S0024-3205(99)00029-6
Shepherd, 1995, Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia, N Engl J Med, 333, 1301, 10.1056/NEJM199511163332001
Downs, 1998, Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS: Air Force/Texas Coronary Atherosclerosis Prevention Study, JAMA, 279, 1615, 10.1001/jama.279.20.1615
Law, 1994, By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischaemic heart disease?, BMJ, 308, 367, 10.1136/bmj.308.6925.367
Mensink, 1992, Effect of dietary fatty acids on serum lipids and lipoproteins: a meta-analysis of 27 trials, Arterioscler Thromb, 12, 911, 10.1161/01.ATV.12.8.911
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III), 2001, Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP), JAMA, 285, 2486, 10.1001/jama.285.19.2486
Sanders, 2000, The safety evaluation of phytosterol esters, part 6: the comparative absorption and tissue distribution of phytosterols in the rat, Food Chem Toxicol, 38, 485, 10.1016/S0278-6915(00)00021-1
Aringer, 1979, Side-chain cleavage of 4-cholesten-3-one, 5-cholesten-3 alpha-ol, beta-sitosterol, and related steroids in endocrine tissues from rat and man, J Steroid Biochem, 11, 1271, 10.1016/0022-4731(79)90196-1
Hepburn, 1999, Safety evaluation of phytosterol esters, part 2: subchronic 90-day oral toxicity study on phytosterol esters—a novel functional food, Food Chem Toxicol, 37, 521, 10.1016/S0278-6915(99)00030-7
Turnbull, 1999, 13-Week oral toxicity study with stanol esters in rats, Regul Toxicol Pharmacol, 29, 216, 10.1006/rtph.1999.1291
Waalkens-Berendsen, 1999, Safety evaluation of phytosterol esters, part 3: two-generation reproduction study in rats with phytosterol esters—a novel functional food, Food Chem Toxicol, 37, 683, 10.1016/S0278-6915(99)00056-3
Whittaker, 1999, Two-generation reproductive toxicity study of plant stanol esters in rats, Regul Toxicol Pharmacol, 29, 196, 10.1006/rtph.1999.1288
Slesinski, 1999, Developmental toxicity study of vegetable oil-derived stanol fatty acid esters, Regul Toxicol Pharmacol, 29, 227, 10.1006/rtph.1999.1292
Malini, 1993, Effect of beta-sitosterol on uterine biochemistry: a comparative study with estradiol and progesterone, Biochem Mol Biol Int, 31, 659
Mellanen, 1996, Wood-derived estrogens: studies in vitro with breast cancer cell lines and in vivo in trout, Toxicol Appl Pharmacol, 136, 381, 10.1006/taap.1996.0046
MacLatchy, 1995, The phytoestrogen beta-sitosterol alters the reproductive endocrine status of goldfish, Toxicol Appl Pharmacol, 134, 305, 10.1006/taap.1995.1196
Baker, 1999, Safety evaluation of phytosterol esters, part 1: assessment of oestrogenicity using a combination of in vivo and in vitro assays, Food Chem Toxicol, 37, 13, 10.1016/S0278-6915(98)00101-X
Turnbull, 1999, Short-term tests of estrogenic potential of plant stanols and plant stanol esters, Regul Toxicol Pharmacol, 29, 211, 10.1006/rtph.1999.1290
Hepburn, 2001, The assessment of phytosterols and phytosterol-esters for potential mutagenic activity, Toxicologist, 60, 412
Wolfreys, 2002, Safety evaluation of phytosterol esters, part 7: assessment of mutagenic activity of phytosterols, phytosterol esters and the cholesterol derivative, 4-cholesten-3-one, Food Chem Toxicol, 40, 461, 10.1016/S0278-6915(01)00099-0
Weststrate, 1999, Safety evaluation of phytosterol esters, part 4: faecal concentrations of bile acids and neutral sterols in healthy normolipidaemic volunteers consuming a controlled diet either with or without a phytosterol ester-enriched margarine, Food Chem Toxicol, 37, 1063, 10.1016/S0278-6915(99)00102-7
Suzuki, 1986, Characterization of cytotoxic steroids in human faeces and their putative role in the etiology of human colonic cancer, Cancer Lett, 33, 307, 10.1016/0304-3835(86)90070-4
Kaul, 1987, Genotoxicity of two fecal steroids in murine colonic epithelium assessed by the sister chromatid exchange technique, Mutagenesis, 2, 441, 10.1093/mutage/2.6.441
Wolfreys, 2001, The assessment of the cholesterol breakdown product 4-cholesten-3-one for potential mutagenic activity, Toxicologist, 60, 412
Gylling, 1999, Serum sterols during stanol ester feeding in a mildly hypercholesterolemic population, J Lipid Res, 40, 593, 10.1016/S0022-2275(20)32138-6
Björkhem, 1995, Inborn errors in bile acid biosynthesis and storage of sterols other than cholesterol, Vol 2, 2073
Lu, 2001, Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively, Am J Hum Genet, 69, 278, 10.1086/321294
Lütjohann, 1996, Phytosterolaemia in a Norwegian family: diagnosis and characterization of the first Scandinavian case, Scand J Clin Lab Invest, 56, 229, 10.3109/00365519609088612
Lütjohann, 1997, Phytosterolaemia: diagnosis, characterization and therapeutical approaches, Ann Med, 29, 181, 10.3109/07853899708999333
Stalenhoef, 2001, Effect of plant sterol-enriched margarine on plasma lipids and sterols in subjects heterozygous for phytosterolaemia, J Intern Med, 249, 163, 10.1046/j.1365-2796.2001.00788.x
Berge, 2002, Heritability of plasma noncholesterol sterols and relationship to DNA sequence polymorphism in ABCG5 and ABCG8, J Lipid Res, 43, 486, 10.1016/S0022-2275(20)30155-3
Sudhop, 2002, Serum plant sterols as a potential risk factor for coronary heart disease, Metabolism, 51, 1519, 10.1053/meta.2002.36298
Plat, 2001, Effects of diets enriched with two different plant stanol ester mixtures on plasma ubiquinol-10 and fat-soluble antioxidant concentrations, Metabolism, 50, 520, 10.1053/meta.2001.22509
Kritchevsky, 1999, Beta-carotene, carotenoids and the prevention of coronary heart disease, J Nutr, 129, 5, 10.1093/jn/129.1.5
Expert Panel of the Diet and Cancer Project, 1997, 412
Institute of Medicine, 2000, 342
Riedl, 1999, Some dietary fibers reduce the absorption of carotenoids in women, J Nutr, 129, 2170, 10.1093/jn/129.12.2170
Schlagheck, 1997, Olestra dose response on fat-soluble and water-soluble nutrients in humans, J Nutr, 127, 1646S, 10.1093/jn/127.8.1646S
Elinder, 1995, Probucol treatment decreases serum concentrations of diet-derived antioxidants, Arterioscler Thromb Vasc Biol, 15, 1057, 10.1161/01.ATV.15.8.1057
Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group, 1994, The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers, N Engl J Med, 330, 1029, 10.1056/NEJM199404143301501
Greenberg, 1996, Mortality associated with low plasma concentration of beta carotene and the effect of oral supplementation, JAMA, 275, 699, 10.1001/jama.1996.03530330043027
Omenn, 1996, Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease, N Engl J Med, 334, 1150, 10.1056/NEJM199605023341802
Hennekens, 1996, Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease, N Engl J Med, 334, 1145, 10.1056/NEJM199605023341801
Lee, 1999, Beta-carotene supplementation and incidence of cancer and cardiovascular disease: the Women's Health Study, J Natl Cancer Inst, 91, 2102, 10.1093/jnci/91.24.2102
1984, Lipid Research Clinics Coronary Primary Prevention Trial results, 1: reduction in incidence of coronary heart disease, JAMA, 251, 351, 10.1001/jama.1984.03340270029025
1984, Lipid Research Clinics Coronary Primary Prevention Trial results, II: the relationship of reduction in incidence of coronary heart disease to cholesterol lowering, JAMA, 251, 365, 10.1001/jama.1984.03340270043026
Lipid Research Clinics Investigators, 1992, The Lipid Research Clinics Coronary Primary Prevention Trial: results of 6 years of post-trial follow-up, Arch Intern Med, 152, 1399, 10.1001/archinte.1992.00400190041009
Wilt, 1999, Beta-sitosterol for the treatment of benign prostatic hyperplasia: a systematic review, BJU Int, 83, 976, 10.1046/j.1464-410x.1999.00026.x
Awad, 2000, Phytosterols as anticancer dietary components: evidence and mechanism of action, J Nutr, 130, 2127, 10.1093/jn/130.9.2127
Anttolainen, 2001, Characteristics of users and nonusers of plant stanol ester margarine in Finland: an approach to study functional foods, J Am Diet Assoc, 1011365
LaRosa, 1999, Effect of statins on risk of coronary disease: a meta-analysis of randomized controlled trials, JAMA, 282, 2340, 10.1001/jama.282.24.2340