Effects of vitamin D supplementation on body fat accumulation, inflammation, and metabolic risk factors in obese adults with low vitamin D levels — Results from a randomized trial

Fox, 2007, Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study, Circulation, 116, 39, 10.1161/CIRCULATIONAHA.106.675355

Hotamisligil, 2006, Inflammation and metabolic disorders, Nature, 444, 860, 10.1038/nature05485

Savage, 2007, Disordered lipid metabolism and the pathogenesis of insulin resistance, Physiol Rev, 87, 507, 10.1152/physrev.00024.2006

Earthman, 2012, The link between obesity and low circulating 25-hydroxyvitamin D concentrations: considerations and implications, Int J Obes, 36, 387, 10.1038/ijo.2011.119

Caron-Jobin, 2011, Elevated serum 25(OH)D concentrations, vitamin D, and calcium intakes are associated with reduced adipocyte size in women, Obesity, 19, 1335, 10.1038/oby.2011.90

Cheng, 2010, Adiposity, cardiometabolic risk, and vitamin D status: the Framingham Heart Study, Diabetes, 59, 242, 10.2337/db09-1011

Kremer, 2009, Vitamin D status and its relationship to body fat, final height, and peak bone mass in young women, J Clin Endocrinol Metab, 94, 67, 10.1210/jc.2008-1575

Kamei, 1993, Vitamin-D receptor gene-expression is up-regulated by 1, 25-dihydroxyvitamin-D3 in 3t3-L1 preadipocytes, Biochem Biophys Res Commun, 193, 948, 10.1006/bbrc.1993.1717

Mai, 2012, Cross-sectional and prospective cohort study of serum 25-hydroxyvitamin D level and obesity in adults: the HUNT study, Am J Epidemiol, 175, 1029, 10.1093/aje/kwr456

Mattila, 2007, Serum 25-hydroxyvitamin D concentration and subsequent risk of type 2 diabetes, Diabetes Care, 30, 2569, 10.2337/dc07-0292

Gagnon, 2012, Low serum 25-hydroxyvitamin D is associated with increased risk of the development of the metabolic syndrome at five years: results from a national, population-based prospective study (The Australian Diabetes, Obesity and Lifestyle Study: AusDiab), J Clin Endocrinol Metab, 97, 1953, 10.1210/jc.2011-3187

Forman, 2008, Plasma 25-hydroxyvitamin D levels and risk of incident hypertension among young women, Hypertension, 52, 828, 10.1161/HYPERTENSIONAHA.108.117630

Zittermann, 2009, Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers, Am J Clin Nutr, 89, 1321, 10.3945/ajcn.2008.27004

Nagpal, 2009, A double-blind, randomized, placebo-controlled trial of the short-term effect of vitamin D3 supplementation on insulin sensitivity in apparently healthy, middle-aged, centrally obese men, Diabet Med, 26, 19, 10.1111/j.1464-5491.2008.02636.x

von Hurst, 2010, Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient — a randomised, placebo-controlled trial, Br J Nutr, 103, 549, 10.1017/S0007114509992017

Lind, 1987, Blood pressure is lowered by vitamin D (alphacalcidol) during long-term treatment of patients with intermittent hypercalcaemia. A double-blind, placebo-controlled study, Acta Med Scand, 222, 423, 10.1111/j.0954-6820.1987.tb10959.x

Pfeifer, 2001, Effects of a short-term vitamin D(3) and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women, J Clin Endocrinol Metab, 86, 1633

Jorde, 2009, Supplementation with cholecalciferol does not improve glycaemic control in diabetic subjects with normal serum 25-hydroxyvitamin D levels, Eur J Nutr, 48, 349, 10.1007/s00394-009-0020-3

Rosenblum, 2012, Calcium and vitamin D supplementation is associated with decreased abdominal visceral adipose tissue in overweight and obese adults, Am J Clin Nutr, 95, 101, 10.3945/ajcn.111.019489

Positano, 2004, An accurate and robust method for unsupervised assessment of abdominal fat by MRI, J Magn Reson Imaging, 20, 684, 10.1002/jmri.20167

Maersk, 2012, Sucrose-sweetened beverages increase fat storage in the liver, muscle, and visceral fat depot: a 6-mo randomized intervention study, Am J Clin Nutr, 95, 283, 10.3945/ajcn.111.022533

Provencher, 1993, Estimation of metabolite concentrations from localized in vivo proton NMR spectra, Magn Reson Med, 30, 672, 10.1002/mrm.1910300604

Maunsell, 2005, Routine isotope-dilution liquid chromatography–tandem mass spectrometry assay for simultaneous measurement of the 25-hydroxy metabolites of vitamins D2 and D3, Clin Chem, 51, 1683, 10.1373/clinchem.2005.052936

Hojskov, 2010, High-throughput liquid–liquid extraction and LCMSMS assay for determination of circulating 25(OH) vitamin D3 and D2 in the routine clinical laboratory, Clin Chim Acta, 411, 114, 10.1016/j.cca.2009.10.010

Matthews, 1985, Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man, Diabetologia, 28, 412, 10.1007/BF00280883

Abraha, 2010, Modified intention to treat reporting in randomised controlled trials: systematic review, BMJ, 340, c2697, 10.1136/bmj.c2697

Daly, 2009, Long-term effect of calcium-vitamin D(3) fortified milk on blood pressure and serum lipid concentrations in healthy older men, Eur J Clin Nutr, 63, 993, 10.1038/ejcn.2008.79

Jorde, 2010, No improvement in cardiovascular risk factors in overweight and obese subjects after supplementation with vitamin D3 for 1year, J Intern Med, 267, 462, 10.1111/j.1365-2796.2009.02181.x

Ponda, 2012, Vitamin D may not improve lipid levels: a serial clinical laboratory data study, Circulation, 126, 270, 10.1161/CIRCULATIONAHA.111.077875

Jorde, 2010, No effect of supplementation with cholecalciferol on cytokines and markers of inflammation in overweight and obese subjects, Cytokine, 50, 175, 10.1016/j.cyto.2009.12.006

Pittas, 2007, The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults, Diabetes Care, 30, 980, 10.2337/dc06-1994

Tai, 2008, Glucose tolerance and vitamin D: effects of treating vitamin D deficiency, Nutrition, 24, 950, 10.1016/j.nut.2008.04.009

Blumberg, 2006, Complex role of the vitamin D receptor and its ligand in adipogenesis in 3T3-L1 cells, J Biol Chem, 281, 11205, 10.1074/jbc.M510343200

Narvaez, 2009, Lean phenotype and resistance to diet-induced obesity in vitamin D receptor knockout mice correlates with induction of uncoupling protein-1 in white adipose tissue, Endocrinology, 150, 651, 10.1210/en.2008-1118

Ding, 2012, Vitamin D signalling in adipose tissue, Br J Nutr, 1

Szczepaniak, 1999, Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo, Am J Physiol, 276, E977

Bhatia, 2012, Non-alcoholic fatty liver disease: a new and important cardiovascular risk factor?, Eur Heart J, 33, 1190, 10.1093/eurheartj/ehr453

Targher, 2007, Associations between serum 25-hydroxyvitamin D3 concentrations and liver histology in patients with non-alcoholic fatty liver disease, Nut Metab Cardiovasc Dis, 17, 517, 10.1016/j.numecd.2006.04.002

Roth, 2012, Vitamin D deficiency in obese rats exacerbates nonalcoholic fatty liver disease and increases hepatic resistin and Toll-like receptor activation, Hepatology, 55, 1103, 10.1002/hep.24737