Effects of turmeric on uremic pruritus in end stage renal disease patients: a double-blind randomized clinical trial

Manenti L, Tansinda P, Vaglio A (2009) Uraemic pruritus: clinical characteristics, pathophysiology and treatment. Drugs 69(3):251–263

Narita I, Iguchi S, Omori K, Gejyo F (2008) Uremic pruritus in chronic hemodialysis patients. J Nephrol 21(2):161–165

Grob JJ, Revuz J, Ortonne JP, Auquier P, Lorette G (2005) Comparative study of the impact of chronic urticaria, psoriasis and atopic dermatitis on the quality of life. Br J Dermatol 152:289–295

Marquez D, Ramonda C, Lauxmann JE, Romero CA, Vukelic VL, Martinatto C, Barron B, Novoa PA, Peixoto AJ, Orías M (2012) Uremic pruritus in hemodialysis patients: treatment with desloratidine versus gabapentin. J Bras Nefrol 34(2):148–152

Vila T, Gommer J, Scates AC (2008) Role of gabapentin in the treatment of uremic pruritus. Ann Pharmacother 42(7):1080–1084

Murphy M, Reaich D, Pai P, Finn P, Carmichael AJ (2003) A randomized, placebo-controlled, double-blind trial of ondansetron in renal itch. Br J Dermatol 148(2):314–317

Silva SR, Viana PC, Lugon NV, Hoette M, Ruzany F, Lugon JR (1994) Thalidomide for the treatment of uremic pruritus: a crossover randomized double-blind trial. Nephron 67(3):270–273

Wikstrom B, Gellert R, Ladefoged SD, Danda Y, Akai M, Ide K, Ogasawara M (2005) Kappa-opioid system in uremic pruritus: multicenter, randomized, double-blind, placebo-controlled clinical studies. J Am Soc Nephrol 16(12):3742–3747

Ko MJ, Yang JY, Wu HY, Hu FC, Chen SI, Tsai PJ, Jee SH, Chiu HC (2011) Narrowband ultraviolet B phototherapy for patients with refractory uraemic pruritus: a randomized controlled trial. Br J Dermatol 165(3):633–639

Kuypers DR, Claes K, Evenepoel P, Maes B, Vanrenterghem Y (2004) A prospective proof of concept study of the efficacy of tacrolimus ointment on uraemic pruritus (UP) in patients on chronic dialysis therapy. Nephrol Dial Transplant 19(7):1895–1901

Chiu YL, Chen HY, Chuang YF, Hsu SP, Lai CF, Pai MF, Yang SY, Peng Y (2008) Association of uraemic pruritus with inflammation and hepatitis infection in haemodialysis patients. Nephrol Dial Transplant 23(11):3685–3689

Chen HY, Chiu YL, Hsu SP, Pai MF, Lai CF, Yang JY, Peng YS, Tsai TJ, Wu KD (2010) Elevated C-reactive protein level in hemodialysis patients with moderate/severe uremic pruritus: a potential mediator of high overall mortality. QJM 103(11):837–846

Kimmel M, Alscher DM, Dunst R, Braun N, Machleidt C, Kiefer T, Stulten C, van der Kuip H, Pauli-Magnus C, Raub U, Kuhlmann U, Mettang T (2006) The role of micro-inflammation in the pathogenesis of uraemic pruritus in haemodialysis patients. Nephrol Dial Transplant 21(3):749–755

Baliga MS, Katiyar SK (2006) Chemoprevention of photocarcinogenesis by selected dietary botanicals. Photochem Photobiol Sci 5(2):243–253

Aggarwal BB, Sundaram C, Malani N, Ichikawa H (2007) Curcumin: the Indian solid gold. Adv Exp Med Biol 595:1–75

Roberto M, Roberta F, Rekha B, Colin JG (2000) Curcumin, an antioxidant and anti-inflammatory agent induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radic Biol Med 28:1303–1312

Goel A, Kunnumakkara AB, Aggarwal BB (2008) Curcumin as “Curecumin”: from kitchen to clinic. Biochem Pharmacol 75(4):787–809

Hatcher H, Planalp R, Cho J, Torti FM, Torti SV (2008) Curcumin: from ancient medicine to current clinical trials. Cell Mol Life Sci 65:1631–1652

Duo LJ (1987) Electrical needle therapy of uremic pruritus. Nephron 47(3):179–183

He X-G, Lin L-Z, Lian L-Z, Lindenmaier M (1998) Liquid chromatography- electrospray mass spectrometric analysis of curcuminoids and sesquiterpenoids in turmeric (Curcuma longa). J Chromatogr A 818:127–132

Wikström B (2007) Itchy skin—a clinical problem for haemodialysis patients. Nephrol Dial Transplant 22(Suppl 5):3–7

Duque MI, Thevarajah S, Chan YH, Tuttle AB, Freedman BI, Yosipovitch G (2006) Uremic pruritus is associated with higher kt/V and serum calcium concentration. Clin Nephrol 66(3):184–191

Fallahzadeh MK, Roozbeh J, Geramizadeh B, Namazi MR (2011) Interleukin-2 serum levels are elevated in patients with uremic pruritus: a novel finding with practical implications. Nephrol Dial Transplant 26(10):3338–3344

Narita I, Alchi B, Omori K, Sato F, Ajiro J, Saga D, Kondo D, Skatsume M, Maruyama S, Kazama JJ, Akazawa K, Gejyo F (2006) Etiology and prognostic significance of severe uremic pruritus in chronic hemodialysis patients. Kidney Int 69(9):1626–1632

Floege J, Schäffer J, Koch KM, Shaldon S (1992) Dialysis related amyloidosis: a disease of chronic retention and inflammation? Kidney Int Suppl 38:78–85

Yeun JY, Levine RA, Mantadilok V, Kaysen GA (2000) C-Reactive protein predicts all-cause and cardiovascular mortality in hemodialysis patients. Am J Kidney Dis 35(3):469–476

Tripepi G, Mallamaci F, Zoccali C (2005) Inflammation markers, adhesion molecules, and all-cause and cardiovascular mortality in patients with ESRD: searching for the best risk marker by multivariate modeling. J Am Soc Nephrol 16(Suppl 1):83–88

Lugon JR (2005) Uremic pruritus: a review. Hemodial Int 9(2):180–188

Aoki R, Kawamura T, Goshima F, Ogawa Y, Nakae S, Nakao A, Moriishi K, Nishiyama Y, Shimada S (2013) Mast cells play a key role in host defense against herpes simplex virus infection through TNF-α and IL-6 production. J Invest Dermatol 133:2170–2179

Abbas AK, Murphy KM, Sher A (1996) Functional diversity of helper T lymphocytes. Nature 383:787–793

Jurenka JS (2009) Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev 14(2):141–153

Aggarwal BB, Gupta SC, Sung B (2013) Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers. Br J Pharmacol 169:1672–1692

Hanai H, Iida T, Takeuchi K, Watanabe F, Maruyama Y, Andoh A, Tsujikawa T (2006) Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol 4(12):1502–1506

Ukil A, Maity S, Karmakar S, Datta N, Vedasiromoni JR, Das PK (2003) Curcumin, the major component of food flavour turmeric, reduces mucosal injury in trinitrobenzene sulphonic acid-induced colitis. Br J Pharmacol 139(2):209–218

Fan X, Zhang C, Liu DB, Yan J, Liang HP (2013) The clinical applications of curcumin: current state and the future. Curr Pharm Des 19(11):2011–2031

Gunal AI, Ozalp G, Yoldas TK, Gunal SY, Kirciman E, Celiker H (2004) Gabapentin therapy for pruritus in haemodialysis patients: a randomized, placebo-controlled, double-blind trial. Nephrol Dial Transplant 19(12):3137–3139