Effects of time-restricted eating with different eating windows on human metabolic health: pooled analysis of existing cohorts
Tóm tắt
Time-restricted eating (TRE), a feasible form of intermittent fasting, has been proven to benefit metabolic health in animal models and humans. To our knowledge, specific guidance on the appropriate period for eating during TRE has not yet been promoted. Therefore, to compare and assess the relative effectiveness estimates and rankings of TRE with different eating windows on human metabolic health, we conducted a systematic review and network meta-analysis (NMA).
PubMed, EMBASE and the Cochrane Library were searched for randomized controlled trials that compared different eating windows on human metabolic health for adults. A Bayesian NMA was used to compare direct and indirect effects to determine the best different eating windows, and scientific evidence using GRADE.
Twenty-seven RCTs comparing TRE with different eating windows on human metabolic health were reviewed, and all were included in the NMA. Compared with the normal diet group (non-TRE), the TRE group has certain benefits in reducing weight and fasting insulin. In terms of reducing fasting insulin, the 18:6 group (eating time = 6 h) was better than the 14:10 group (eating time = 10 h) and 16:8 group (eating time = 8 h) (P < 0.05); The < 6 group (eating time < 6 h) was better than the 14:10 group (P < 0.05). In terms of reducing fasting glucose, the < 6 group was better than the 14:10 group (P < 0.05). There were no statistical variations in weight, HDL, TG, and LDL across the different modes of TRE (P > 0.05).
Our research showed that no particular metabolic advantages of various eating windows were found. Therefore, our results suggested that different eating windows could promote similar benefits for metabolic parameters.
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Tài liệu tham khảo
Seconda L, Baudry J, Alles B, Hamza O, Boizot-Szantai C, Soler LG, Galan P, Hercberg S, Lairon D, Kesse-Guyot E. Assessment of the Sustainability of the Mediterranean Diet Combined with Organic Food Consumption: An Individual Behaviour Approach, Nutrients, 9 (2017), https://doi.org/10.3390/nu9010061
Carter S, Clifton PM, Keogh JB. The effects of intermittent compared to continuous energy restriction on glycaemic control in type 2 Diabetes; a pragmatic pilot trial. Diabetes Res Clin Pract. 2016;122:106–12. https://doi.org/10.1016/j.diabres.2016.10.010
Catenacci VA, Pan Z, Ostendorf D, Brannon S, Gozansky WS, Mattson MP, Martin B, MacLean PS, Melanson EL. Troy Donahoo, a randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity. Obes (Silver Spring). 2016;24:1874–83. https://doi.org/10.1002/oby.21581
Harvie M, Wright C, Pegington M, McMullan D, Mitchell E, Martin B, Cutler RG, Evans G, Whiteside S, Maudsley S, Camandola S, Wang R, Carlson OD, Egan JM, Mattson MP, Howell A. The effect of intermittent energy and carbohydrate restriction v. daily energy restriction on weight loss and metabolic Disease risk markers in overweight women. Br J Nutr. 2013;110:1534–47. https://doi.org/10.1017/S0007114513000792
Harvie MN, Sims AH, Pegington M, Spence K, Mitchell A, Vaughan AA, Allwood JW, Xu Y, Rattray NJ, Goodacre R, Evans DG, Mitchell E, McMullen D, Clarke RB, Howell A. Intermittent energy restriction induces changes in breast gene expression and systemic metabolism. Breast Cancer Res. 2016;18:57. https://doi.org/10.1186/s13058-016-0714-4
Kirkham AA, Parr EB, Kleckner AS. Cardiometabolic health impacts of time-restricted eating: implications for type 2 Diabetes, cancer and Cardiovascular Diseases. Curr Opin Clin Nutr Metab Care. 2022;25:378–87. https://doi.org/10.1097/MCO.0000000000000867
Parvaresh A, Razavi R, Abbasi B, Yaghoobloo K, Hassanzadeh A, Mohammadifard N, Safavi SM, Hadi A, Clark CCT. Modified alternate-day fasting vs. calorie restriction in the treatment of patients with metabolic syndrome: a randomized clinical trial. Complement Ther Med. 2019;47:102187. https://doi.org/10.1016/j.ctim.2019.08.021
Christensen RAG, Kirkham AA, Eating T-R. A novel and simple dietary intervention for primary and secondary Prevention of Breast Cancer and Cardiovascular Disease. Volume 13. Nutrients; 2021. https://doi.org/10.3390/nu13103476
Liu L, Chen W, Wu D, Hu F. Metabolic efficacy of time-restricted eating in adults: a systematic review and Meta-analysis of Randomized controlled trials. J Clin Endocrinol Metab. 2022;107:3428–41. https://doi.org/10.1210/clinem/dgac570
Moon S, Kang J, Kim SH, Chung HS, Kim YJ, Yu JM, Cho ST, Oh CM, Kim T. Beneficial effects of Time-restricted eating on metabolic Diseases: a systemic review and Meta-analysis. Nutrients. 2020;12. https://doi.org/10.3390/nu12051267
Queiroz JDN, Macedo RCO, Dos Santos GC, Munhoz SV, Machado CLF, de Menezes RL, Menzem EN, Moritz CEJ, Pinto RS, Tinsley GM, de Oliveira AR. Cardiometabolic effects of early v. delayed time-restricted eating plus energetic restriction in adults with overweight and obesity: an exploratory randomised clinical trial. Br J Nutr. 2022;1–13. https://doi.org/10.1017/S0007114522001581
Carlson O, Martin B, Stote KS, Golden E, Maudsley S, Najjar SS, Ferrucci L, Ingram DK, Longo DL, Rumpler WV, Baer DJ, Egan J, Mattson MP. Impact of reduced meal frequency without caloric restriction on glucose regulation in healthy, normal-weight middle-aged men and women, metabolism: clinical and experimental, (2007) 1729–34.
Gill S, Panda S. A Smartphone App reveals erratic diurnal eating patterns in humans that can be modulated for Health benefits, Cell Metabol, (2015) 789–98.
Moro T, Tinsley G, Longo G, Grigoletto D, Bianco A, Ferraris C, Guglielmetti M, Veneto A, Tagliabue A, Marcolin G, Paoli A. Time-restricted eating effects on performance, immune function, and body composition in elite cyclists: a randomized controlled trial. J Int Soc Sports Nutr. 2020;17:65. https://doi.org/10.1186/s12970-020-00396-z
Stote KS, Baer DJ, Spears K, Paul DR, Harris GK, Rumpler WV, Strycula P, Najjar SS, Ferrucci L, Ingram DK, Longo DL, Mattson MP. A controlled trial of reduced meal frequency without caloric restriction in healthy, normal-weight, middle-aged adults, the American journal of clinical nutrition, (2007) 981–8.
Tinsley GM, Moore ML, Graybeal AJ, Paoli A, Kim Y, Gonzales JU, Harry JR, VanDusseldorp TA, Kennedy DN, Cruz MR. Time-restricted feeding plus resistance training in active females: a randomized trial. Am J Clin Nutr. 2019;110:628–40. https://doi.org/10.1093/ajcn/nqz126
Che T, Yan C, Tian D, Zhang X, Liu X, Wu Z. Time-restricted feeding improves blood glucose and insulin sensitivity in overweight patients with type 2 Diabetes: a randomised controlled trial. Nutr Metab (Lond). 2021;18:88. https://doi.org/10.1186/s12986-021-00613-9
Cienfuegos S, Gabel K, Kalam F, Ezpeleta M, Wiseman E, Pavlou V, Lin S, Oliveira ML, Varady KA. Effects of 4- and 6-h time-restricted feeding on Weight and Cardiometabolic Health: a randomized controlled trial in adults with obesity. Cell Metab. 2020;32:366–378e363. https://doi.org/10.1016/j.cmet.2020.06.018
Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement. Open Med. 2009;3:e123–130.
Page MJ, Moher D, McKenzie JE. Introduction to preferred reporting items for systematic reviews and meta-analyses 2020 and implications for research synthesis methodologists. Res Synth Methods. 2022;13:156–63. https://doi.org/10.1002/jrsm.1535
R. G, Network meta-analysis, electrical networks and graph theory, Res Synthesis Methods, (2012) 312–24.
Puhan MA, Schunemann HJ, Murad MH, Li T, Brignardello-Petersen R, Singh JA, Kessels AG, Guyatt GH, Group GW. A GRADE Working Group approach for rating the quality of treatment effect estimates from network meta-analysis, BMJ, 349 (2014) g5630, https://doi.org/10.1136/bmj.g5630
Anton SD, 2, Lee SA, Donahoo WT, McLaren C, Manini T, Leeuwenburgh C, 2, Pahor M. The Effects of Time Restricted Feeding on Overweight, Older Adults: A Pilot Study, Nutrients, (2019) 1500.
Chow LS, Manoogian ENC, Alvear A, Fleischer JG, Thor H, Dietsche K, Wang Q, Hodges JS, Esch N, Malaeb S, Harindhanavudhi T, Nair KS, Panda S, Mashek DG. Time-Restricted Eating effects on body composition and metabolic measures in humans who are overweight: a feasibility study, obesity (Silver Spring), 28 (2020) 860–9, https://doi.org/10.1002/oby.22756
Sutton EF, Beyl R, Early KS, Cefalu WT, Ravussin E, Peterson CM. Early Time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with Prediabetes. Cell Metab. 2018;27:1212–1221e1213. https://doi.org/10.1016/j.cmet.2018.04.010
Wilkinson13 MJ, Manoogian ENC23, Zadourian1 A, Lo1 H, Fakhouri2 S, Shoghi2 A, Wang2 X, Fleischer2 JG, Navlakha S2, Panda24 S. P.R. Taub1, Ten-Hour Time-Restricted Eating Reduces Weight, Blood Pressure, and Atherogenic Lipids in Patients with Metabolic Syndrome, Cell Metabolism, (2020) 92–104(e105).
Paoli A, Tinsley G, Bianco A, Moro T. The Influence of Meal Frequency and Timing on Health in Humans: The Role of Fasting, Nutrients, 11 (2019), https://doi.org/10.3390/nu11040719
W. K.L., The metabolic syndrome: evolving evidence that thiazolidinediones provide rational therapy, Diabetes Obes Metabolism, (2006) 365–80.
Wang F, Han L, Hu D. Fasting insulin, insulin resistance and risk of Hypertension in the general population: a meta-analysis. Clin Chim Acta. 2017;464:57–63. https://doi.org/10.1016/j.cca.2016.11.009
Jones R, Pabla P, Mallinson J, Nixon A, Taylor T, Bennett A, Tsintzas K. Two weeks of early time-restricted feeding (eTRF) improves skeletal muscle insulin and anabolic sensitivity in healthy men. Am J Clin Nutr. 2020;112:1015–28. https://doi.org/10.1093/ajcn/nqaa192
Berglund L, Brunzell JD, Goldberg AC, Goldberg IJ, Sacks F, Murad MH, Stalenhoef AF, s., Endocrine. Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline, J Clin Endocrinol Metab, 97 (2012) 2969–2989, https://doi.org/10.1210/jc.2011-3213
Flanagan A, Bechtold DA, Pot GK, Johnston JD. Chrono-nutrition: from molecular and neuronal mechanisms to human epidemiology and timed feeding patterns. J Neurochem. 2021;157:53–72. https://doi.org/10.1111/jnc.15246
Ruddick-Collins LC, Morgan PJ, Johnstone AM. Mealtime: a circadian disruptor and determinant of energy balance? J Neuroendocrinol. 2020;32:e12886. https://doi.org/10.1111/jne.12886
Poggiogalle E, Jamshed H, Peterson CM. Circadian regulation of glucose, lipid, and energy metabolism in humans. Metabolism. 2018;84:11–27. https://doi.org/10.1016/j.metabol.2017.11.017
Palomar-Cros A, Srour B, Andreeva VA, Fezeu LK, Bellicha A, Kesse-Guyot E, Hercberg S, Romaguera D, Kogevinas M, Touvier M. Associations of meal timing, number of eating occasions and night-time fasting duration with incidence of type 2 Diabetes in the NutriNet-Sante cohort. Int J Epidemiol. 2023. https://doi.org/10.1093/ije/dyad081
A GRADE Working Group approach for. Rating the quality of treatment effect estimates from network meta-analysis. BMJ. 2015;350:h3326. https://doi.org/10.1136/bmj.h3326
Xu S, Qiu Y, Tao J. The challenges and optimization of cell-based therapy for Cardiovascular Disease. J Transl Int Med. 2021;9:234–8. https://doi.org/10.2478/jtim-2021-0017
Chen M, Chen W. Single-nucleotide polymorphisms in Medical Nutritional Weight loss: challenges and future directions. J Transl Int Med. 2022;10:1–4. https://doi.org/10.2478/jtim-2022-0002
Xie SY, Ye Z. Y, Randomized controlled trial for time-restricted eating in healthy volunteers without obesity, Nat Commun, (2022).
Liu HY, Huang D, Yang C, Wei S, Zhang X, Guo P, Lin D, Xu J, Li B, He C, He H, Liu J, Shi S, Xue L, Zhang Y. Calorie restriction with or without time-restricted eating in weight loss. N Engl J Med. Apr 2022;21:1495–504. https://doi.org/10.1056/NEJMoa2114833
Kulovitz MG, Kravitz LR, Mermier C, Gibson AL, Conn CA, Kolkmeyer D, Kerksick CM. Potential role of meal frequency as a strategy for weight loss and health in overweight or obese adults, Nutrition, (2014) 386–92.
Kord-Varkaneh H, Salehi-Sahlabadi A, Tinsley GM, Santos HO, Hekmatdoost A. Effects of time-restricted feeding (16/8) combined with a low-sugar diet on the management of non-alcoholic fatty Liver Disease: a randomized controlled trial. Nutrition. 2023;105:111847. https://doi.org/10.1016/j.nut.2022.111847
Moro T, Tinsley G, Pacelli FQ, Marcolin G, Bianco A, Paoli A. Twelve months of Time-restricted eating and resistance training improves inflammatory markers and cardiometabolic risk factors. Med Sci Sports Exerc. 2021;53:2577–85. https://doi.org/10.1249/MSS.0000000000002738
Kotarsky CJ, Johnson NR, Mahoney SJ, Mitchell SL, Schimek RL, Stastny SN, Hackney KJ. Time-restricted eating and concurrent exercise training reduces fat mass and increases lean mass in overweight and obese adults. Physiol Rep. 2021;9:e14868. https://doi.org/10.14814/phy2.14868
He M, Wang J, Liang Q, Li M, Guo H, Wang Y, Deji C, Sui J, Wang YW, Liu Y, Zheng Y, Qian B, Chen H, Ma M, Su S, Geng H, Zhou WX, Guo X, Zhu WZ, Zhang M, Chen Z, Rensen PCN, Hui CC, Wang Y, Shi B. Time-restricted eating with or without low-carbohydrate diet reduces visceral fat and improves metabolic syndrome: a randomized trial. Cell Rep Med. 2022;3:100777. https://doi.org/10.1016/j.xcrm.2022.100777
Brady AJ, Langton HM, Mulligan M, Egan B. Effects of 8 wk of 16:8 time-restricted eating in male Middle- and Long-Distance runners. Med Sci Sports Exerc. 2021;53:633–42. https://doi.org/10.1249/MSS.0000000000002488
Lin YJ, Wang YT, Chan LC, Chu NF. Effect of time-restricted feeding on body composition and cardio-metabolic risk in middle-aged women in Taiwan. Nutrition. 2022;93:111504. https://doi.org/10.1016/j.nut.2021.111504
Cai H, Qin YL, Shi ZY, Chen JH, Zeng MJ, Zhou W, Chen RQ, Chen ZY. Effects of alternate-day fasting on body weight and dyslipidaemia in patients with non-alcoholic fatty Liver Disease: a randomised controlled trial. BMC Gastroenterol. 2019;19:219. https://doi.org/10.1186/s12876-019-1132-8
Lowe DA, Wu N, Rohdin-Bibby L, Moore AH, Kelly N, Liu YE, Philip E, Vittinghoff E, Heymsfield SB, Olgin JE, Shepherd JA, Weiss EJ. Effects of Time-restricted eating on weight loss and other metabolic parameters in women and men with overweight and obesity: the TREAT Randomized Clinical Trial. JAMA Intern Med. 2020;180:1491–9. https://doi.org/10.1001/jamainternmed.2020.4153
Jamshed H, Steger FL, Bryan DR, Richman JS, Warriner AH, Hanick CJ, Martin CK, Salvy SJ, Peterson CM. Effectiveness of early time-restricted eating for weight loss, Fat loss, and Cardiometabolic Health in adults with obesity: a Randomized Clinical Trial. JAMA Intern Med. 2022;182:953–62. https://doi.org/10.1001/jamainternmed.2022.3050
Lao BN, Luo JH, Xu XY, Fu LZ, Tang F, Ouyang WW, Xu XZ, Wei MT, Xiao BJ, Chen LY, Wu YF, Liu XS. Time-restricted feeding’s effect on overweight and obese patients with chronic Kidney Disease stages 3–4: a prospective non-randomized control pilot study. Front Endocrinol (Lausanne). 2023;14:1096093. https://doi.org/10.3389/fendo.2023.1096093
Haganes KL, Silva CP, Eyjolfsdottir SK, Steen S, Grindberg M, Lydersen S, Hawley JA, Moholdt T. Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: a randomized controlled trial. Cell Metab. 2022;34:1457–1471e1454. https://doi.org/10.1016/j.cmet.2022.09.003
Manoogian ENC, Zadourian A, Lo HC, Gutierrez NR, Shoghi A, Rosander A, Pazargadi A, Ormiston CK, Wang X, Sui J, Hou Z, Fleischer JG, Golshan S, Taub PR, Panda S. Feasibility of time-restricted eating and impacts on cardiometabolic health in 24-h shift workers: the Healthy heroes randomized control trial. Cell Metab. 2022;34:1442–1456e1447. https://doi.org/10.1016/j.cmet.2022.08.018
Andriessen C, Fealy CE, Veelen A, van Beek SMM, Roumans KHM, Connell NJ, Mevenkamp J, Moonen-Kornips E, Havekes B, Schrauwen-Hinderling VB, Hoeks J, Schrauwen P. Three weeks of time-restricted eating improves glucose homeostasis in adults with type 2 Diabetes but does not improve insulin sensitivity: a randomised crossover trial. Diabetologia. 2022;65:1710–20. https://doi.org/10.1007/s00125-022-05752-z
Thomas EA, Zaman A, Sloggett KJ, Steinke S, Grau L, Catenacci VA, Cornier MA, Rynders CA. Early time-restricted eating compared with daily caloric restriction: a randomized trial in adults with obesity. Obes (Silver Spring). 2022;30:1027–38. https://doi.org/10.1002/oby.23420
Phillips NE, Mareschal J, Schwab N, Manoogian ENC, Borloz S, Ostinelli G, Gauthier-Jaques A, Umwali S, Gonzalez Rodriguez E, Aeberli D, Hans D, Panda S, Rodondi N, Naef F, Collet TH. The Effects of Time-Restricted Eating versus Standard Dietary Advice on Weight, Metabolic Health and the Consumption of Processed Food: A Pragmatic Randomised Controlled Trial in Community-Based Adults, Nutrients, 13 (2021), https://doi.org/10.3390/nu13031042
Rona A, Robertson TM, Denise RM, Johnston JD. A pilot feasibility study exploring the effects of a moderate time-restricted feeding intervention on energy intake, adiposity and metabolic physiology in free-living humans. J Nutritional Sci. 2018;7:e22.