Effects of the dietary inclusion of a probiotic or prebiotic on florfenicol pharmacokinetic profile in broiler chicken

Journal of Animal Physiology and Animal Nutrition - Tập 104 Số 2 - Trang 549-557 - 2020
Samy A. Elgeddawy1, Hazem M. Shaheen2, Yasser El‐Sayed3, Magdy Abd El-Aziz4, Ashraf Darwish1, Dalia H. Samak3, Gaber El‐Saber Batiha2, Rehab Mady2, May Bin‐Jumah5, Ahmed A. Allam6, Mahmoud Alagawany7, Ayman E. Taha8, Amany El‐Mleeh9, Sabry A.A. El-Sayed10, Mohamed E. Abd El‐Hack7, Shaaban S. Elnesr11
1Unit of Pharmacology, Department of Chemistry, Animal Health Research Institute, Giza, Egypt
2Department of Pharmacology, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt
3Department of Veterinary Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt
4Department of Pharmacology, Faculty of Veterinary Medicine, Kafrelsheikh University, Damanhour, Egypt
5Biology Department, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia
6Department of Zoology, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt
7Department of Poultry, Faculty of Agriculture, Zagazig University, Zagazig, Egypt
8Department of Animal Husbandry and Animal Wealth Development, Faculty of Veterinary Medicine, Alexandria University, Edfina, Egypt
9Department of Pharmacology, Faculty of Veterinary Medicine, Menoufia University, Menoufia, Egypt
10Department of Nutrition and Clinical Nutrition, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt
11Department of Poultry Production, Faculty of Agriculture, Fayoum University, Fayoum, Egypt

Tóm tắt

AbstractWe evaluated the effect of prebiotic or probiotic as feed additives on florfenicol kinetic in broilers feed. Unsexed two hundred, thirty‐five‐day‐old broiler chickens, were put in four equal groups (n = 50). The first group was administrated florfenicol intravenous at 30 mg/kg body weight (BW) only once dosage without pre‐ or probiotic administration to determine the bioavailability. While, the second group was administrated florfenicol (intracrop routes; a dosage of 30 mg/kg BW for five progressive days) without pre‐ or probiotic co‐administration. The third and the fourth groups were administrated the same dose of florfenicol (intracrop route) for five successive days, followed by 10 days of prebiotic or probiotic treatment respectively. The plasma florfenicol % was identified by high‐pressure liquid chromatography (HPLC) after the first florfenicol administration (intravenous or intracrop routes) in all groups. Then, the residual levels of florfenicol were determined in liver, kidney and muscle tissues from the second, third and fourth groups which were exposed to florfenicol orally. Our results demonstrated that broilers pre‐treated with prebiotic or probiotic significantly increased Cmax, AUC0–t, AUC0–inf as well as AUMC values, while significant drop was recorded in V/F and CL/F. Prebiotic or probiotic influenced the cumulative effect of florfenicol in liver and kidney tissues of treated birds.

Từ khóa


Tài liệu tham khảo

10.1111/jpn.12522

10.1111/jpn.13049

10.1016/j.cbi.2019.108863

10.1080/00071669708418013

10.1007/s11356-018-1687-x

10.3390/ani9080573

10.1016/j.fct.2010.08.039

10.1111/j.1365-2125.1994.tb04266.x

10.1016/0009-8981(72)90432-9

10.1577/H08-014.1

10.1111/j.1574-695X.2007.00264.x

Duan C., 2019, Chitosan as a preservative for fruits and vege: A review on chemistry and antimicrobial properties, Journal of Bioresources and Bioproducts, 4, 11, 10.21967/jbb.v4i1.189

10.1080/00071669888656

10.1017/S1751731118002732

10.1186/s40168-017-0315-1

10.1007/s11676-017-0457-9

10.1016/j.anaerobe.2010.10.004

10.1016/j.anifeedsci.2006.05.010

10.1136/vr.101155

10.1093/ps/82.4.613

10.1016/S0009-9236(98)90151-5

10.1016/j.ejps.2019.04.003

10.1128/AAC.47.2.820-823.2003

10.1111/j.1365-2885.2011.01310.x

10.3382/japr/pfw073

10.1093/ps/82.4.627

10.1128/AAC.47.8.2703-2705.2003

10.1016/j.ttbdis.2017.11.003

10.1017/S1751731119002891

10.1093/ajcp/28.1.56

10.1046/j.1365-2885.1997.00095.x

10.2307/1592511

10.1046/j.1365-2885.2003.00495.x

10.1016/S0034-5288(02)00033-4

Soomro R. N., 2019, Impact of restricting feed and probiotic supplementation on growth performance, mortality and carcass traits of meat‐type quails, Animal Science Journal, 2019, 1

10.1007/s11259-018-9724-2

10.1292/jvms.57.363

10.2165/00003088-200038020-00002

10.1111/jvp.12020

10.1080/09540105.2018.1463972

10.1124/jpet.102.046532

10.1016/j.aaf.2018.01.004

10.1111/j.1365-2125.2003.02047.x

10.1016/j.aaf.2018.05.005

10.1016/j.cmpb.2010.01.007

10.2174/138920008784220664

Thông tin
Thông tin xuất bản

Journal of Animal Physiology and Animal Nutrition

Tập 104 Số 2

549-557

Thông tin tác giả